Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
Chemistry ; 23(25): 6048-6055, 2017 May 02.
Article in English | MEDLINE | ID: mdl-28181714

ABSTRACT

The ligation of gold(I) metalloamphiphiles with biomolecules is reported, using water-soluble AuI -N-alkynyl substituted maleimide complexes. For this purpose, two different polar ligands were applied: 1) a neutral, dendritic tetraethylene glycol-functionalized phosphane and 2) a charged, sulfonated N-heterocyclic carbene (NHC). The retro Diels-Alder reaction of a furan-protected maleimide gold(I) complex, followed by cycloaddition with a diene-functionalized biotin under mild conditions leads to a novel gold(I) metalloamphiphile. The strong streptavidin-biotin binding affinity in buffered aqueous solution of the resulting biotin alkynyl gold(I) phosphane conjugate remains intact. The cytotoxicity of the biotinylated gold(I) complex against a T47D human breast cancer cell line is higher than for cisplatin.

2.
J Mater Chem B ; 1(15): 2008-2012, 2013 Apr 21.
Article in English | MEDLINE | ID: mdl-32260888

ABSTRACT

We report the pH and ionic strength triggered self-assembly of polyanionic dendritic peptide amphiphiles into well-defined nanorods in water; by establishing state diagrams we show how frustrated growth is used as a sensitive tool in order to manipulate and control the one-dimensional supramolecular polymerisation processes.

SELECTION OF CITATIONS
SEARCH DETAIL
...