1.
Methods Enzymol
; 90 Pt E: 82-7, 1982.
Article
in English
| MEDLINE
| ID: mdl-6218378
2.
Z Naturforsch C Biosci
; 36(9-10): 798-803, 1981.
Article
in English
| MEDLINE
| ID: mdl-7029940
ABSTRACT
Clotrimazole and triadimefon are known as potent inhibitors of ergosterol synthesis in pathogenic yeast and fungi, respectively. As their mode of action generally the inhibition of sterol desmethylation reactions is accepted. We report about a second effect, a "feed-back" inhibition of 3-hydroxy-3-methyl-glutaryl (HMG)-CoA-reductase by accumulation of ergosterol precursors. Addition of lanosterol to intact cells leads to an inhibition of HMG-CoA-reductase as well, but not to fungistatic effects. From the reported data the influences of clotrimazole and triadimefon have to be considered as an inhibition of desmethylation reactions involved in ergosterol synthesis of yeast and fungi with a concomitant decreased production of mevalonate.
Subject(s)
Clotrimazole/pharmacology , Hydroxymethylglutaryl CoA Reductases/metabolism , Imidazoles/pharmacology , Saccharomyces cerevisiae/enzymology , Triazoles/pharmacology , Cell Fractionation , Ergosterol/pharmacology , Kinetics , Lanosterol/pharmacology , Microsomes/enzymology
3.
J Antibiot (Tokyo)
; 28(8): 611-2, 1975 Aug.
Article
in English
| MEDLINE
| ID: mdl-1158784
4.
FEBS Lett
; 46(1): 106-8, 1974 Sep 15.
Article
in English
| MEDLINE
| ID: mdl-4278943
Subject(s)
Clostridium/enzymology , Phosphofructokinase-1/metabolism , Phosphotransferases/metabolism , Cell-Free System , Clostridium/drug effects , Clostridium/metabolism , Fructose/metabolism , Fructose/pharmacology , Gluconates/metabolism , Gluconates/pharmacology , Glucose/metabolism , Glucose/pharmacology , Phosphoenolpyruvate , Pyruvates/metabolism , Pyruvates/pharmacology , Species Specificity , Sucrose/metabolism , Sucrose/pharmacology , Ultrasonics
5.
Arch Mikrobiol
; 87(3): 189-202, 1972.
Article
in English
| MEDLINE
| ID: mdl-4404815