10 Simple Rules for a Supportive Lab Environment.

The transition to principal investigator (PI), or lab leader, can be challenging, partially due to the need to fulfil new managerial and leadership responsibilities. One key aspect of this role, which is often not explicitly discussed, is creating a supportive lab environment. Here, we present ten simple rules to guide the new PI in the development of their own positive and thriving lab atmosphere. These rules were written and voted on collaboratively, by the students and mentees of Professor Mark Stokes, who inspired this piece.

Attentional Control in Subclinical Anxiety and Depression: Depression Symptoms Are Associated With Deficits in Target Facilitation, Not Distractor Inhibition.

Mood and anxiety disorders are associated with deficits in attentional control involving emotive and non-emotive stimuli. Current theories focus on impaired attentional inhibition of distracting stimuli in producing these deficits. However, standard attention tasks struggle to separate distractor inhibition from target facilitation. Here, we investigate whether distractor inhibition underlies these deficits using neutral stimuli in a behavioral task specifically designed to tease apart these two attentional processes. Healthy participants performed a four-location Posner cueing paradigm and completed self-report questionnaires measuring depressive symptoms and trait anxiety. Using regression analyses, we found no relationship between distractor inhibition and mood symptoms or trait anxiety. However, we find a relationship between target facilitation and depression. Specifically, higher depressive symptoms were associated with reduced target facilitation in a task-version in which the target location repeated over a block of trials. We suggest this may relate to findings previously linking depression with deficits in predictive coding in clinical populations.

Centro-parietal EEG potentials index subjective evidence and confidence during perceptual decision making.

Recent studies suggest that a centro-parietal positivity (CPP) in the EEG signal tracks the absolute (unsigned) strength of accumulated evidence for choices that require the integration of noisy sensory input. Here, we investigated whether the CPP might also reflect the evidence for decisions based on a quantitative comparison between two sequentially presented stimuli (a signed quantity). We recorded EEG while participants decided whether the latter of two vibrotactile frequencies was higher or lower than the former in six variants of this task (n = 116). To account for biases in sequential comparisons, we applied a behavioral model based on Bayesian inference that estimated subjectively perceived frequency differences. Immediately after the second stimulus, parietal ERPs reflected the signed value of subjectively perceived differences and afterwards their absolute value. Strikingly, the modulation by signed difference was evident in trials without any objective evidence for either choice and correlated with choice-selective premotor beta band amplitudes. Modulations by the absolute strength of subjectively perceived evidence - a direct indicator of task difficulty - exhibited all features of statistical decision confidence. Together, our data suggest that parietal EEG signals first index subjective evidence, and later include a measure of confidence in the context of perceptual decision making.

Neuronal signatures of a random-dot motion comparison task.

The study of perceptual decision making has made significant progress owing to major contributions from two experimental paradigms: the sequential vibrotactile frequency comparison task for the somatosensory domain requiring working memory, and the random-dot motion task in the visual domain requiring evidence accumulation over time. On the one hand, electrophysiological recordings in nonhuman primates and humans have identified changes in firing rates and power modulations of beta band oscillations with the vibrotactile frequencies held in working memory, as well as with the mental operation required for decision making. On the other hand, firing rates and centro-parietal potentials were found to increase to a fixed level at the time of responding during the random-dot motion task, possibly reflecting an underlying evidence accumulation mechanism until a decision threshold is met. Here, to bridge these two paradigms, we presented two visual random-dot motion stimuli in a sequential comparison task while recording EEG from human volunteers. We identified a modulation of prefrontal beta band power that scaled with the level of dot motion coherence of the first stimulus during a short retention interval. Furthermore, beta power in premotor areas was modulated by participants' choices approximately 700 ms before responses were given via button press. At the same time, dot motion patches of the second stimulus evoked a pattern of broadband centro-parietal signal build-up till responses were made, whose peak varied with trial difficulty. Hence, we show that known modulations of beta power during working memory and decision making extend from the vibrotactile to the visual domain and provide support for the notion of evidence accumulation as an unconfined decision-making mechanism generalizing over distinct decision types.

Gamma and Beta Oscillations in Human MEG Encode the Contents of Vibrotactile Working Memory.

Ample evidence suggests that oscillations in the beta band represent quantitative information about somatosensory features during stimulus retention. Visual and auditory working memory (WM) research, on the other hand, has indicated a predominant role of gamma oscillations for active WM processing. Here we reconciled these findings by recording whole-head magnetoencephalography during a vibrotactile frequency comparison task. A Braille stimulator presented healthy subjects with a vibration to the left fingertip that was retained in WM for comparison with a second stimulus presented after a short delay. During this retention interval spectral power in the beta band from the right intraparietal sulcus and inferior frontal gyrus (IFG) monotonically increased with the to-be-remembered vibrotactile frequency. In contrast, induced gamma power showed the inverse of this pattern and decreased with higher stimulus frequency in the right IFG. Together, these results expand the previously established role of beta oscillations for somatosensory WM to the gamma band and give further evidence that quantitative information may be processed in a fronto-parietal network.

Autonomy, decisions, and free will.

Can humans make decisions? Can machines? What ethical questions arise from using robotics in the education of children? Or in elderly care? These were some of the topics of the interdisciplinary college (IK), which took place from the 25th of March to the 1st of April in Günne, next to Lake Möhne. During this one-week spring school, more than 40 well-known lecturers from around the globe gave 170 participants an insight into a cornucopia of topics surrounding "autonomy, decisions, and free will".