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Internist (Berl) ; 56(5): 566-72, 2015 May.
Article in German | MEDLINE | ID: mdl-25874738

ABSTRACT

A 73-year-old female patient who had received a liver and kidney transplantation presented with symptomatic pancytopenia and right-sided upper abdominal pain. The histological investigation of a bone marrow biopsy showed the extremely rare manifestation of a disseminated Merkel cell carcinoma with infiltration of the bone marrow and suppression of hematopoiesis. Also a Coombs test positive hemolytic anemia did not show a significant response to high-dose steroid therapy. Palliative chemotherapy with carboplatin and etoposide at reduced dosage had to be terminated due to deterioration of the patient's general condition. The patient died 2 days after initiation of chemotherapy.


Subject(s)
Abdominal Pain/etiology , Carcinoma, Merkel Cell/diagnosis , Carcinoma, Merkel Cell/etiology , Epistaxis/etiology , Kidney Transplantation/adverse effects , Liver Transplantation/adverse effects , Aged , Antineoplastic Agents/therapeutic use , Carcinoma, Merkel Cell/drug therapy , Combined Modality Therapy/adverse effects , Diagnosis, Differential , Epistaxis/diagnosis , Fatal Outcome , Female , Humans , Recurrence
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