1.
J Med Chem
; 22(9): 1055-9, 1979 Sep.
Article
in English
| MEDLINE
| ID: mdl-114657
ABSTRACT
Alcohol, ketone, aldehyde, and oxime analogues of ambruticin (1) were prepared. The analogues were tested against Histoplasma capsulatum, Microsporum fulvum, Candida albicans, and Streptococcus pyogenes. Structure-activity relationships are described. Increasing the bulk of substituent at C1 and C5 reduces antifungal activity.
Subject(s)
Antifungal Agents/chemical synthesis , Alcohols/chemical synthesis , Alcohols/pharmacology , Aldehydes/chemical synthesis , Aldehydes/pharmacology , Bacteria/drug effects , Fungi/drug effects , Ketones/chemical synthesis , Ketones/pharmacology , Myxococcales , Oximes/chemical synthesis , Oximes/pharmacology , Pyrans/chemical synthesis , Structure-Activity Relationship
2.
J Med Chem
; 22(9): 1144-7, 1979 Sep.
Article
in English
| MEDLINE
| ID: mdl-114661
ABSTRACT
A series of ester and amide analogues of ambruticin (1) was prepared. The analogues were tested against Histoplasma capsulatum, Microsporum fulvum, Candida albicans and Streptococcus pyogenes. Structure-activity relationships are described.
Subject(s)
Amides/chemical synthesis , Antifungal Agents/chemical synthesis , Antifungal Agents/pharmacology , Bacteria/drug effects , Esters/chemical synthesis , Fungi/drug effects , Myxococcales , Pyrans/chemical synthesis , Pyrans/pharmacology , Structure-Activity Relationship
3.
J Antibiot (Tokyo)
; 32(4): 368-70, 1979 Apr.
Article
in English
| MEDLINE
| ID: mdl-112090
4.
J Org Chem
; 42(23): 3664-9, 1977 Nov 11.
Article
in English
| MEDLINE
| ID: mdl-410912
5.
J Med Chem
; 10(5): 888-90, 1967 Sep.
Article
in English
| MEDLINE
| ID: mdl-6057836
