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Dtsch Med Wochenschr ; 131(19): 1085-8, 2006 May 12.
Article in German | MEDLINE | ID: mdl-16685629

ABSTRACT

HISTORY AND ADMISSION FINDINGS: A 71-year-old woman presented with suspected tuberculosis. She reported having productive coughs, unwanted weight loss and subfebrile temperature in the preceding 3 months. She was known to have chronic obstructive pulmonary disease treated with corticoids given systemically and by inhalation. She was a heavy smoker. INVESTIGATIONS: Computed tomography revealed a left apical lung abscess. In the further course of the disease magnetic resonance imaging of the head demonstrated multiple abscesses in both cerebral hemispheres and an abscess, 3.4 cm in diameter, in the right side of the cerebellum, as well as a intra-orbital tumor on the right. Needle aspirate of the eyeball grew Nocardia farcinica. TREATMENT AND COURSE: Over 3 weeks antimicrobial treatment was given with imipenem and amikacin, followed by oral cotrimoxazole for 12 months. The abscesses completely regressed and after 12 months no recurrence was demonstrated either radiologically or clinically. CONCLUSION: Although nocardiasis is rare in Germany it must be included in the differential diagnosis of pneumonia with abscesses. This is especially so if acid-fast bacilli are found. As the resistance pattern of N. farcinica to antibiotics varies, early treatment is essential with antibiotics to which it is sensitive.


Subject(s)
Brain Abscess/microbiology , Cerebellar Diseases/microbiology , Lung Abscess/microbiology , Nocardia Infections/complications , Orbital Diseases/microbiology , Pneumonia, Bacterial/complications , Aged , Amikacin/therapeutic use , Anti-Bacterial Agents/therapeutic use , Biopsy, Needle/methods , Brain Abscess/drug therapy , Brain Abscess/pathology , Cerebellar Diseases/drug therapy , Cerebellar Diseases/pathology , Diagnosis, Differential , Drug Therapy, Combination , Female , Humans , Imipenem/therapeutic use , Lung Abscess/drug therapy , Lung Abscess/pathology , Magnetic Resonance Imaging , Nocardia Infections/diagnosis , Nocardia Infections/drug therapy , Orbital Diseases/drug therapy , Orbital Diseases/pathology , Pneumonia, Bacterial/diagnosis , Pneumonia, Bacterial/drug therapy , Tomography, X-Ray Computed , Treatment Outcome , Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use
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