ABSTRACT
Objective To evaluate the clinical efficacy oftemozolomide (TMZ) and whole brain radiotherapy (WBRT) in the treatment of leptomeningeal metastases (LM) from non-small cell lung cancer (NSCLC).Methods The clinical data were retrospectively analyzed of the 19 patients with LM from NSCLC who had been treated from October 2007 to June 2016 at Guangdong Sanjiu Brain Hospital.Of them,10 were treated by a combination of TMZ+WBRT,and 9 by other therapies.The survival rate was determined by the Kaplan-Meier method and analyzed using the log-rank test.Results After treatment for 2 weeks,the illness was alleviated in 8,stable in 2 and progressive in 0 of the 10 patients receiving TMZ+WBRT,yielding a remission rate of 80％;the illness was alleviated in 5,stable in 3 and progressive in one of the 9 patients receiving other therapies,yielding a remission rate of 55.6％.The median overall survival was 8 months,the survival rate was 56.3％ at 6 months and 33.8％ at one year for those receiving TMZ+WBRT;the median overall survival was 7 months,the survival rate was 55.6％ at 6 months and 14.8％ at one year for those receiving other therapies.Conclusion Temozolomide and whole brain radiotherapy may prolong the survival time and improve the prognosis of patients with LM from NSCLC.
ABSTRACT
Colorectal cancer (CRC) is one of the most common malignancies in the world.Methylene tetrahydrofolate reductase (MTHFR) is a key enzyme of folate metabolism process.In recent years,many studies indicate that MTHFR polymorphisms are significantly associated with the morbidity,response to chemotherapy and prognosis of CRC,but conclusions are inconsistent and remain to be further confirmed.
ABSTRACT
Colorectal cancer (CRC) is one of the most common malignancies in the world.Methylene tetrahydrofolate reductase (MTHFR) is a key enzyme of folate metabolism process.In recent years,many studies indicate that MTHFR polymorphisms are significantly associated with the morbidity,response to chemotherapy and prognosis of CRC,but conclusions are inconsistent and remain to be further confirmed.
ABSTRACT
Objective To investigate the effect of comprehensive nursing intervention in transcervical fracture after operation. Methods A total of 64 cases of transcervical fracture were retrospectively analyzed from the ward of depart-ment of orthopedics in our hospital, from February 2010 to February 2014, with thirty-two patients in each group. The control group adopted routine postoperative nursing in department of orthopedics and the intervention group adopted comprehensive nursing intervention. Then the postoperative mental state, joint function, complications and quality of life were compared between the two groups. Results Four weeks after operation, 12 patients happened pressure sores, 13 patients happened constipation, 11 patients happened infection in control group, and 3 patients happened pressure sores, 4 patients happened constipation, 3 patients happened infection in intervention group, there were significantly differences between the two groups (χ2=5.12~6.40, P<0.05). The psychological state of anxiety and depression was compared between the two groups after 4 weeks, in control group, anxiety and depression was (43.69±5.47) and (42.34± 5.24), while in intervention group, anxiety and depression was (37.26 ±6.18) and (36.36 ±4.87), there were significantly difference between two groups (t=4.40, 4.72, P<0.01). The joint function was compared between the two groups after 4 weeks, Harris score in intervention group and control group was (64.35±9.27) and (56.26±8.35) respectively, there was significantly difference between the two groups (t=3.67, P<0.01), and HSS score in intervention group and control group was (88.67±12.26) and (81.33±13.31) respectively, there was significantly difference between the two groups (t=3.67, P<0.01). 4 weeks after operation, activities, sleep, pain, self-care was compared between the two groups, the score was (37.42±4.62), (39.62±3.13), (29.25±3.15), (29.32±3.14) respectively in the control group, while the score was(41.13±6.73), (43.34±4.28), (31.61±3.57), (32.57±4.32) in the intervention group, there were significantly differences between the two groups (t=2.80~3.96, P<0.01). Conclusion Comprehensive nursing intervention can effectively reduce the postoperative complications of femoral neck fracture, improve the psychological state and joint function, and it can also improve the quality of life.
