ABSTRACT
Objective To explore the role of expression of membrane Fas(mFas)antigen and serum soluble Fas(sFas)in acute leukemia.Methods Strept avidin-biotin complex method of immunohistochemical staining assay and sandwich enzyme-linked immunosorbent assay(ELISA)were used to detect the expression of mFas antigen in bone marrow cells and serum sFas in 30 patients with acute leukemia in Binzhou Medical College Affiliatd Hospital from November 2001 to September 2002,which was compared with normal control group.The relation between expression of serum sFas and chemotherapy outcome were evaluated too.Results The expression of mFas antigen in ALL(5.62?2.27)% and ANLL(8.80?4.15)% were respectively and significantly lower than that in normal control group(28.75?11.20)%(P
