[Adverse effects of the tezacaftor/ivacaftor/elexacaftor combination that may lead to discontinuation: About a series of 10 cases]. / Effets indésirables de l'association tezacaftor/ivacaftor/elexacaftor pouvant mener à un arrêt de traitement : à propos d'une série de 10 cas.

INTRODUCTION: Cystic fibrosis transmembrane regulator (CFTR) channel modulators (ivacaftor, lumacaftor, tezacaftor and elexacaftor) represent a major advance in the management of cystic fibrosis. However, few data are available on the real-life safety profile of these medications, in particular on adverse events that may lead to their discontinuation. The aim of this study is to describe the characteristics and evolution of adverse reactions to the tezacaftor/ivacaftor/elexacaftor combination that led to discontinuation and were reported to the Centre régional de pharmacovigilance (CRPV) in Rennes (France). MATERIALS AND METHODS: A retrospective study was conducted from December 2021 to May 2023, focusing on cases of discontinuation of the tezacaftor/ivacaftor/elexacaftor combination due to the occurrence of one or more adverse effects, and reported to the CRPV of Rennes, France. RESULTS: Ten cases of drug discontinuation were reported to the Rennes CRPV (6 women/4 men). Adverse effects mainly involved neuropsychiatric disorders (n=6), followed by liver disorders (n=2), ear, nose and throat disorders (n=1), and digestive disorders (n=1). The average duration of treatment at discontinuation was 339.8 [39-668] days. The drug was reintroduced in 7 patients on average 48.7 [7-123] days after discontinuation, with a dosage adjustments (n=4) consisting of changes in dosing times or a reduction in daily doses, with varying success in alleviating adverse symptoms depending on the case. CONCLUSION: This small case series suggests that neuropsychiatric adverse effects may occur more frequently than initially described after initiation of tezacaftor/ivacaftor/elexacaftor, and should be carefully screened and monitored. Dosage or administration schedule modifications may be considered for patients experiencing these adverse effects. Further pharmacovigilance studies are needed to better understand the adverse effect profiles of "caftors", their possible risk factors, and the impact of adjusting dosing modalities.

A superação à família monogâmica é pela coletividade! Parentalidades não-monogâmicas de pessoas sexo-gênero-diversas / The overcoming of the monogamous family is through the community! Non-monogamous parenting of sex-gender-diverse people

Resumo Pessoas sexo-gênero-diversas e que são não-monogâmicas tensionam a cisnormatividade e a mononormatividade. Em termos científicos, há uma nebulosidade quanto aos arranjos parenterais dessas pessoas. Assim, esta etnografia objetiva compreender a percepção de pessoas sexo-gênero-diversas não-monogâmicas sobre parentalidades. O referencial teórico utilizado partiu dos estudos não-monogâmicos, amor e sexualidade das Ciências Sociais e Humanas em Saúde da Saúde Coletiva, e o metodológico da etnografia digital. O trabalho de campo ocorreu entre 2021 e 2022, em um grupo on-line do WhatsApp. A observação participante foi empregada no grupo e foram realizadas entrevistas on-line semiestruturadas. Emergiram duas categorias: a) Os nós das parentalidades não-monogâmicas e b) As parentalidades coletivas. Na primeira, se explora a importância do vínculo nas redes afetivas e expõe as barreiras desses arranjos familiares. Já na segunda, se descreve a importância do viver em comunidade, bem como o resgate à ancestralidade indígena e negra. O resgate à ancestralidade e às formas de se viver em comunidade ganham relevo à medida que se compreende a importância que estes possuem na vivência das parentalidades de pessoas sexo-gênero-diversas e que são não-monogâmicas.

Abstract Sex-gender-diverse and non-monogamous strain cisnormativity and mononormativity. In scientific terms, the parenting arrangements of these people are uncertain. Thus, this ethnography aims to understand the perception of non-monogamous sex-gender-diverse people about parenting. The theoretical framework adopted is derived from non-monogamous studies, love and sexuality from the Social and Human Sciences in Public Health and the digital ethnography methodological framework. Fieldwork occurred from 2021 to 2022 through an online WhatsApp group. Participant observation was employed in the group, and semi-structured online interviews were held. Two categories emerged: a) The non-monogamous parenting nodes and b) Collective parenting. In the first, the importance of bonds in affective networks is explored, and the barriers to these family arrangements are exposed. The second describes the importance of living in a community, and Indigenous and Black ancestry is revived. The revived ancestry and ways of living in a community gain importance as we understand their relevance in the experience of parenting for sex-gender-diverse people who are non-monogamous.

Current Status of PRP Manufacturing Requirements & European Regulatory Frameworks: Practical Tools for the Appropriate Implementation of PRP Therapies in Musculoskeletal Regenerative Medicine.

Providing accurate and up-to-date practical tools enabling oversight of platelet-rich plasma (PRP) legislation and of the appropriate standards to be implemented for its manufacture and use in Europe is a demanding task. This is due to rapid medico-technological advancements, slowness and disparity in legislation updates and enforcement between member states, and many reported gray-zone practices, notably for autologous PRP use. The levels of risk associated with blood manipulation processes generally dictate the manufacturing requirements for PRP preparations, which have gradually shifted toward good manufacturing practices (GMP) for standardization and overall quality enhancement. This work firstly outlines Western European and Swiss legislation for PRP products/preparations, providing key simplified information and recommendations for medical doctors seeking to implement this biological-based therapy for safe use in hospital settings, clinics, or private offices. This work secondly shows the importance of PRP-based product manufacturing standardization, which subsequently enables sound clinical evaluation of therapeutic interventions. Although the applicable legal bases provide guidelines for GMP manufacturing infrastructure and basic process design, paramount importance is set on the definition of workflows, technical specifications, and key parameters for PRP preparation and delivery. Overall, the development of simple and robust technologies and processes for PRP preparation is critical for guaranteeing the high therapeutic quality of the intervention, in collaboration with qualified GMP manufacturing platforms. Importantly, this work aims to serve as a practical tool for clinicians based in Western Europe who are willing to appropriately (i.e., administratively and technically) implement autologous PRP treatments in musculoskeletal regenerative medicine workflows, to ensure they make informed and optimal regulatory or process-based decisions.

Relações entre Paixão pelo Trabalho, Bem-Estar e Autoeficácia Ocupacional em Treinadores Esportivos / Relationship between Passion for Work, Well-Being and Occupational Self-Efficiency in Sports Coaches / Relaciones entre la pasión por el trabajo, el bienestar y la autoeficiencia laboral en los entrenadores deportivos

O objetivo deste estudo foi verificar as associações entre a paixão pelo trabalho, bem-estar e autoeficácia ocupacional em treinadores esportivos. Participaram do estudo 139 treinadores de ambos os sexos (71,2% masculino). Foram observados efeitos positivos da paixão harmoniosa sobre afetos positivos e autoeficácia ocupacional, e efeitos negativos sobre afetos negativos. A paixão obsessiva predisse positivamente os afetos negativos. Ainda, identificou-se o papel mediador dos afetos positivos na relação entre paixão harmoniosa e autoeficácia ocupacional. Corroborando as hipóteses teóricas, os resultados sugerem a importância do envolvimento harmonioso com a atividade profissional, seu potencial sobre experiências de emoções positivas e percepção de competência para o enfrentamento dos desafios profissionais.

The aim of this study was to verify the associations between passion for work, well-being and occupational self-efficacy in sports coaches. 139 coaches of both sexes participated (71.2% male). Positive effects of harmonious passion have been observed on positive affects and occupational self-efficacy, and negative effects on negative affects. Obsessive passion positively predicted negative affects. Still, the mediating role of positive affects in the relationship between harmonious passion and occupational self-efficacy was identified. Corroborating the theoretical hypotheses, the results suggest the importance of harmonious involvement with professional activity, its potential on positive emotional experiences and perception of competence to face professional challenges.

El objetivo de este estudio fue verificar las asociaciones entre la pasión por el trabajo, el bienestar y la autoeficacia laboral en entrenadores deportivos. Participaron 139 entrenadores de ambos sexos (71,2% hombres). Se han observado efectos positivos de la pasión armoniosa sobre los afectos positivos y la autoeficacia ocupacional, y efectos negativos sobre los afectos negativos. La pasión obsesiva predijo positivamente los afectos negativos. Aún así, se identificó el papel mediador de los afectos positivos en la relación entre la pasión armoniosa y la autoeficacia ocupacional. Corroborando las hipótesis teóricas, los resultados apuntan a la importancia de la implicación armónica con la actividad profesional, su potencialidad sobre experiencias emocionales positivas y percepción de competencia para afrontar retos profesionales.

Pesquisacaminhante: a pesquisa ação-participante (PAP) como método de pesquisa longitudinal / Walker research: the Action-Participant Research (PAP) as a longitudinal research method / Investigación walker: la Investigación Acción-Participante (PAP) como método de investigación longitudinal

Este artigo relata uma pesquisa ação-participante longitudinal realizada desde 2016 até 2021 com mulheres indígenas Xokleng/Laklãnõ que vivem no contexto urbano de Blumenau, SC. Analisa a trama afetiva que compôs esta caminhada de seis anos e traça a configuração do método que denominamos de pesquisacaminhante para demarcar a temporalidade e o lugar das pesquisadoras, das pesquisadoras-participantes e sua intencionalidade, de fortalecer a luta e a resistência dessas que vivem na cidade de Blumenau, uma cidade de origem germânica e marcadamente "branca". Como instrumento, foram utilizados entrevistas, fotografias, diversos encontros pela cidade e participação em eventos oficiais e, principalmente, encontros constantes entre as pesquisadoras, nos quais elas puderam se expressar como mulheres indígenas. O referencial teórico é a psicologia sócio-histórica, com base nas reflexões de Vigotski e Spinoza, utilizando o afeto como bússola das ações. O método revelou potência para contribuir com a práxis da psicologia social, destacando aquelas voltadas às comunidades tracionais. (AU)

This article reports a longitudinal participant-action research carried out from 2016 to 2021 with indigenous women Xokleng/Laklãnõ who live in the urban context of Blumenau, SC. Analyzes the affective plot that composed this walk of six years and outlines the configuration of the method we call walking research to demarcate the temporality and the place of researchers, researcher-participants and their intention to strengthen the struggle and resistance those who live in the city of Blumenau, a city of German origin and markedly "white". As instrument, interviews, photographs, various meetings around the city and participation in official events were used. and, mainly, constant meetings between the researchers, in which they could express themselves as women indigenous. The theoretical reference is socio-historical psychology, based on the reflections of Vigotski and Spinoza, using the affection as a compass of actions. The method revealed power to contribute to the practice of social psychology, highlighting those aimed at traditional communities. (AU)

Este artículo reporta una investigación longitudinal de acción participante realizada de 2016 a 2021 con mujeres indígenas Xokleng/Laklãnõ que viven en el contexto urbano de Blumenau, SC. Analiza la trama afectiva que compuso este paseo de seis años y esboza la configuración del método que llamamos walking research para demarcar la temporalidad y el lugar de los investigadores, los investigadores-participantes y su intención de fortalecer la lucha y la resistencia los que viven en a ciudad de Blumenau, ciudad de origen alemán y marcadamente "blanca". Como se utilizó el instrumento, entrevistas, fotografías, diversos encuentros por la ciudad y participación en actos oficiales, y, principalmente, encuentros constantes entre las investigadoras, en las que pudieran expresarse como mujeres indígena. El referente teórico es la psicología sociohistórica, a partir de las reflexiones de Vigotski y Spinoza, utilizando la el afecto como brújula de acciones. El método reveló poder contribuir a la práctica de la psicología social, destacando los destinados a las comunidades tradicionales. (AU)

[Phytotherapeutic treatments of gynecological diseases and fertility disorders in cattle - a veterinary historical analysis]. / Phytotherapeutische Behandlungen gynäkologischer Erkrankungen und Fruchtbarkeitsstörungen von Rindern ­ eine veterinärhistorische Analyse.

INTRODUCTION: Fertility problems are the main reasons for culling dairy cows. Diseases of the female genital tract are also often the cause of antibiotic or hormonal treatments in bovine practices. The use of medicinal plants could expand the available therapeutics. The aim of the work was to analyze historical literature before the introduction of antibiotics in veterinary reproductive medicine. Five books in German language, published in Germany and Switzerland between 1878 and 1921, and one handwritten therapy booklet by the rural veterinarian Carl Ammann-Honegger (1879-1960) were systematically examined regarding the descriptions (AW) on gynecological diseases. The herbal and additional ingredients of the recipe, the target animal species, the type of administration and the indication were recorded in detail for each AW. The six literature sources contained a total of 103 AW (79 administered orally, 13 locally, and 11 both orally and locally). Almost two thirds of the AW (61) were based on a mixture of different plants (two to seven plants), and one third of the AW (31) on a single plant. A total of 55 plants were recorded. The most frequently mentioned medical plants were plants of the genus Juniperus (J. communis L. (19 AW), J. sabina L. (13 AW)) and Linum usitatissimum L. (18 AW), Matricaria chamomilla L. (13 AW) and Gentiana lutea L. (12 AW). The treatment of the Retentio secundinarum was the most frequently mentioned indication (44 AW), followed by parturition preparation (17 AW) and endometritis treatment (15 AW). The most frequently recorded plants can be divided based on their ingredients and their effect into (a) energy- and protein-rich forage plants, (b) generally appetizing, digestive- and metabolism-enhancing plants, (c) medical plants with a specific gynecological organotrophic effect and (d) according to current knowledge, predominantly toxic plants. Besides the antimicrobial active immunity to defence against bacterial infections, a stable barrier funcion of the endometrium contributes to uterine health. The plants classified under (a) - (c) have at least the potential for a positive effect on the immune system and the endometrial barrier function and thus contribute indirectly to the uterine health.

INTRODUCTION: Les problèmes de fertilité sont les principales raisons de la mise à la réforme des vaches laitières. Les maladies de l'appareil génital femelle sont également souvent à l'origine de traitements antibiotiques ou hormonaux dans les pratiques bovines. L'utilisation de plantes médicinales pourrait élargir les thérapeutiques disponibles. L'objectif de ce travail était d'analyser la littérature historique avant l'introduction des antibiotiques en médecine de la reproduction vétérinaire. Cinq livres en langue allemande, publiés en Allemagne et en Suisse entre 1878 et 1921, et un livret thérapeutique écrit à la main par le vétérinaire rural Carl Ammann-Honegger (1879­1960) ont été systématiquement examinés en ce qui concerne les descriptions d'utilisation (AW) sur les maladies gynécologiques. Les herbes et les ingrédients supplémentaires de la recette, l'espèce animale cible, le type d'administration et l'indication ont été enregistrés en détail pour chaque AW. Les six sources de littérature contenaient un total de 103 AW (79 administrées par voie orale, 13 par voie locale et 11 par voie orale et locale). Près de deux tiers des AW (61) étaient basés sur un mélange de différentes plantes (deux à sept plantes), et un tiers des AW (31) sur une seule plante. Au total, 55 plantes ont été enregistrées. Les plantes médicinales les plus fréquemment mentionnées étaient les plantes du genre Juniperus (J. communis L. (19 AW), J. sabina L. (13 AW)) et Linum usitatissimum L. (18 AW), Matricaria chamomilla L. (13 AW) et Gentiana lutea L. (12 AW). Le traitement du Retentio secundinarum a été l>indication la plus fréquemment mentionnée (44 AW), suivie de la préparation à la parturition (17 AW) et du traitement de l>endométrite (15 AW). Les plantes les plus fréquemment enregistrées peuvent être divisées, en fonction de leurs composants et de leurs effets, en (a) plantes fourragères riches en énergie et en protéines, (b) plantes généralement appétissantes, favorisant la digestion et le métabolisme, (c) plantes médicinales ayant un effet organotropique gynécologique spécifique et (d) selon les connaissances actuelles, plantes principalement toxiques. Outre l'effet antimicrobien, une capacité de défense stable de l'endomètre contribue à la santé utérine. Les plantes classées sous (a) - (c) ont au moins le potentiel d'un effet positif sur le système immunitaire et la fonction de défense de l'endomètre et contribuent ainsi indirectement à la santé utérine.

Quando se fecha os olhos e vê: por uma metodologia afetiva / When you close your eyes and see: for an affective methodology / Cuando cierras los ojos y ves: por una metodología afectiva

Decolonizar a construção de conhecimento é uma experiência de enfrentamento de um modo de 'fazer científico' que se tornou hegemônico nas universidades brasileiras, centralizado na razão cartesiana e pautado em métodos coloniais, rígidos e disciplinados. Apresento uma experiência metodológica de se fazer pesquisa guiada pelos afetos, inspirada na escrevivência de Conceição Evaristo, escritora, acadêmica e militante. Exponho, no presente artigo, o fluxo metodológico que foi acontecendo ao escrever a minha tese acreditando ter sido esse um caminho afetivo-metodológico. Tal fluxo metodológico se mostra pertinente, já que evidencia outra forma de construção de conhecimento pautado em bases contra-hegemônicas, quais sejam: a escolha de uma categoria de análise subjetiva (os afetos) e o desenvolvimento de uma análise subjetiva; a integração entre a pessoa que pesquisa e o material pesquisado; a interdisciplinaridade como forma de ampliação do olhar e, portanto, da pesquisa; a conexão entre os afetos e a escrita

Decolonizing the construction of knowledge is an experience of confronting a way of 'doing science' that has become hegemonic in Brazilian universities, centered on Cartesian reason and based on colonial, rigid, and disciplined methods. I present a methodological experience of doing research guided by affections, inspired by the "escrevivência" of the writer, academic and activist Conceição Evaristo. In this article, I will try to expose the methodological flow that took place when I was writing my thesis believing that this was an affective-methodological path. This methodological flow proves to be relevant as it shows another form of knowledge construction, founded on counter-hegemonic bases, namely: the choice of a subjective analysis category (affections) and the development of a subjective analysis; the integration between the person who researches and the researched material; the interdisciplinarity as a way of expanding the look and, therefore, the research; the connection between affections and writing

Descolonizar la construcción del conocimiento es una experiencia de enfrentamiento a una forma de 'hacer científico' que se ha tornado hegemónica en el ámbito universitario brasileño, una forma centrada en la razón cartesiana y fundamentada en métodos coloniales, rígidos y disciplinados. En este artículo presen-to una experiencia metodológica de investigación guiada por afectos e inspirada en la "escrevivência"de Conceição Evaristo, escritora, académica y activista. Intentaré exponer el flujo metodológico que orientó la elaboración de mi tesis, creyendo haber sido un camino afectivo-metodológico. Este flujo metodológico resulta relevante, puesto que muestra otra forma de construcción del conocimiento a partir de bases contra--hegemónicas, a saber: la elección de una categoría subjetiva de análisis (afectos) y el desarrollo de un análi-sis subjetivo; la integración entre la persona que investiga y el material investigado; la interdisciplinariedad como forma de ampliar la mirada y, por tanto, la investigación; la conexión entre los afectos y la escritura

Effect of Oral Prednisolone after Collagenase Injection for Dupuytren's Contracture: A Randomized, Controlled Trial with a 1-Year Follow-Up.

Introduction This study verified the effectiveness of oral prednisolone after collagenase clostridium histolyticum (CCH) (10 mg/day for 2 weeks) for Dupuytren's contracture with a 1-year follow-up. Materials and Methods This study included 31 patients with a contracture of the metacarpophalangeal joint of ≥ 30 degrees. A total of 16 patients were allocated randomly to treatment with prednisolone and 15 patients were treated without prednisolone (control group). Results At day 7, mean total active motion (TAM) was 235 degrees in the prednisolone group and 228 degrees in the control group. Mean Visual Analog Scale was 3.3 in the prednisolone group and 4.6 in the control group. There was significant difference between two groups. At day 30, mean TAM was 241 degrees in the prednisolone group and 233 degrees in the control group. There were significant difference between two groups The mean QuickDASH score was significantly higher in the control group (5.8 vs. 3.4). Recurrence was observed in 2/16 patients (13%) in the prednisolone group and 5/15 patients (33%) in the control group; there was no significant difference. Conclusion The administration of prednisolone decreased the likelihood of adverse effects, and also improved finger flexion range of motion and reduced pain after CCH.

Entramados afectivos en movimiento: redes de Economía Social y Solidaria en Uruguay

Se presenta la Red de Grupos de Mujeres Rurales y la Red de Agroecología del Uruguay analizadas como entramados comunitarios afectivos y solidarios que irrumpen en la esfera pública durante las últimas décadas, en búsqueda de soluciones colectivas para necesidades comunes. Ambas redes se caracterizan por reivindicar derechos e interpelar instituidos, particularmente en relación a temáticas medioambientales y de género. Desde metodologías cualitativas de investigación-acción se llevaron a cabo una veintena de entrevistas en profundidad individuales y colectivas, seis talleres, observación participante en espacios deliberativos y relevamiento de información secundaria. El artículo analiza las tensiones entre instituidos e instituyentes en ambas redes, así como también pone la mirada desde los afectos en la producción de lo común. La pertinencia del estudio de este tipo de redes adquiere particular relevancia en el contexto actual de crisis económica, social y sanitaria, dado que dentro de los hallazgos principales encontramos que la participación permite politizar la existencia y habilita formas de subjetivación alternativas a las hegemónicas.

The Network of Rural Women's Groups and the Agroecology Network of Uruguay are presented, analyzed as affective and supportive community networks that burst into the public sphere during the last decades, in search of collective solutions for common needs. Both networks are characterized by claiming rights and questioning instituted, particularly in relation to environmental and gender issues. From qualitative action research methodologies, a score of individual and collective in-depth interviews, six workshops, participant observation in daily spaces of the networks and the collection of secondary information were carried out. The article analyzes the tensions between instituted and instituting in both networks, from a point of view of the affects in the production of the common. The relevance of the study of this type of networks acquires particular relevance in the current context of economic, social and health crisis, since among the main findings we find that participation allows to politicize existence and enables alternative forms of subjectivation to the hegemonic ones.

São apresentadas a Rede de Grupos de Mulheres Rurais e a Rede de Agroecologia do Uruguai, analisadas como redes comunitárias afetivas e solidárias que irromperam na esfera pública nas últimas décadas em busca de soluções coletivas para necessidades comuns. Ambas as redes se caracterizam pela reivindicação de direitos e questionamentos instituídos, principalmente em relação às questões ambientais e de gênero. A partir de metodologias qualitativas de pesquisa-ação, foram realizadas uma pontuação de entrevistas individuais e coletivas em profundidade, seis oficinas, observação participante nos espaços cotidianos das redes e coleta de informações secundárias. O artigo analisa as tensões entre instituído e instituinte em ambas as redes, do ponto de vista dos afetos na produção do comum. A relevância do estudo deste tipo de redes adquire particular relevância no atual contexto de crise económica, social e de saúde, uma vez que entre os principais achados encontramos que a participação permite politizar a existência e possibilitar formas alternativas de subjetivação às hegemônicas.

Artritis reumatoide: una visión general / Rheumatoid arthritis: A general vision

Introducción: Se han investigado y descrito numerosos tipos de artritis con el fin de clasificarlos en artritis no inflamatoria (osteoartritis) y artritis inflamatoria causada por cristales de depósito (seudogota, enfermedad del fosfato de calcio básico y gota), por bacterias e infecciones virales (Staphylococcus aureus, Neisseria gonorrohae, complicaciones de la enfermedad de Lyme, Parvovirus y Enterovirus) o por procesos autoinmunes. Objetivo: Presentar una visión global de la artritis reumatoide, con énfasis en el diagnóstico, fisiopatología y biomarcadores diagnósticos, pronósticos y predictivos en la artritis reumatoide, con el fin de contribuir la mejor atención de pacientes con enfermedades crónicas. Método: Se realizó una búsqueda bibliográfica relacionada con las palabras clave "artritis reumatoide" y otras variables de artritis. Se recuperaron 76 documentos que las incluían, de ellos utilizamos 42 que fueron útiles para el objetivo de la investigación. Conclusiones: El primer paso para un manejo efectivo de la enfermedad es un diagnóstico temprano y correcto, relacionado con que varios signos y síntomas también están asociados con otras enfermedades. Se debe incluir para este objetivo las estrategias de prevención de enfermedades, así como los programas de detección de personas en riesgo de desarrollarlas como el caso de la artritis reumatoide y la información de la enfermedad proporcionada a la población que pueden mejorar significativamente los parámetros epidemiológicos(AU)

Introduction: Numerous types of arthritis have been investigated and described in order to classify them into non-inflammatory arthritis (osteoarthritis) and inflammatory arthritis caused by deposition crystals (pseudogout, basic calcium phosphate disease, gout), by bacteria and viral infections (Staphylococcus aureus, Neisseria gonorrohae, complications of Lyme disease, Parvovirus, Enterovirus) or autoimmune processes. Objective: research is to present aspects related to the management of Digital Ulcers (DU) in scleroderma based on the experience of different authors, establishing a basis on which future research studies can be designed and improve the patient's quality of life. Method: A bibliographic search related to the keywords rheumatoid arthritis and other arthritis variables was carried out, recovering 76 documents that included them, of which we used 42 that were useful for the objective that we proposed, exposing the most prominent data in the investigation. Conclusions: The first step for an effective management of the disease is an early and correct diagnosis, related to the fact that several signs and symptoms are also associated with other diseases, disease prevention strategies as well as prevention programs should be included for this objective. detection of people at risk of developing them, as in the case of rheumatoid arthritis, monographs of the disease provided to the population can significantly improve epidemiological parameters(AU)

Ozone Therapy for Dermatological Conditions: A Systematic Review.

Background: Known in the past for its toxic aspect as the main urban pollutant, in the last few decades, ozone has been gaining greater visibility for its possible antimicrobial, antiviral, and antioxidant effects when used in human dermatological pathologies. Despite the reports of clinical benefits, the standard dosage for clinical efficacy and safety are yet not clear, nor are its means of application and its true acting mechanism. Objective: We conducted a review to determine the efficacy and safety of ozone therapy for a variety of dermatological conditions. Methods: We considered clinical trials (both randomized and non-randomized) published between December 2020 and March 2021 as long as they provided some PICO information, i.e., population (P), intervention (I), and study design. The skin dermatological conditions researched were: acne, dermatitis, psoriasis, systemic sclerosis, herpes, aging, ulcers, and skin scarring. Results: A total of 326 articles were identified and 150 remained after duplicates were removed. After titles, abstracts and full articles were read, 17 articles were included in the systematic review (with 643 patients). Conclusion: Ozone therapy seems promising for some dermatological conditions; however, the articles included in this review had methodological limitations and did not sufficiently demonstrate sound evidence for safe therapy. Therefore, more studies with better methodological standards and longer-term assessments of side effects should be conducted to achieve better standards and safety in ozone therapy for dermatological conditions.

Afectaciones físicas y psicológicas en personas pos-COVID-19 en Oaxaca, México / Post-COVID-19 physical and psychological effects on people in Oaxaca, Mexico / Efeitos físicos e psicológicos em pessoas pós-COVID-19 em Oaxaca, México

RESUMEN Introducción: La COVID-19 trajo consigo múltiples afectaciones sobre todo en el ámbito de la salud. Estas se manifiestan progresivamente en quienes la padecen con relación a los síntomas presentados, que se hacen visibles a corto y largo plazo a nivel físico y mental. Objetivo: Identificar las afectaciones físicas y psicológicas consecuencia de la COVID-19 en personas activas físicamente antes de la enfermedad, durante el periodo comprendido de enero a mayo de 2021. Método: Se utilizó la metodología cualitativa de corte descriptivo-interpretativo. Se empleó para el estudio una muestra de 5 adultos de 27 a 66 años de edad originarios de Juchitán, Oaxaca, México, los cuales fueron seleccionados a partir de los siguientes criterios: haber sido portadores, el nivel de gravedad (leve/moderado) y haber realizado actividad física constante antes de padecer COVID-19. Las técnicas para el acopio de información aplicadas fueron: la entrevista y el cuestionario. Resultados: Se evidenció una drástica disminución con relación a los componentes de la actividad física (tipo, frecuencia, intensidad y duración), así como la prevalencia de afectaciones psicológicas: estrés, depresión, ansiedad y miedo. En cuanto a las afectaciones a nivel físico se destacó la pérdida de peso y la fatiga (100 %), seguido por la caída del cabello (80 %) en los estudiados. Conclusiones: La disminución de la actividad física es consecuencia de la propia enfermedad, mientras que las afectaciones psicológicas son resultado de la incertidumbre que genera el padecimiento.

ABSTRACT Introduction: COVID-19 brought with it multiple effects, especially in the field of health. These manifest progressively in those who suffer from it in relation to the symptoms presented, which become visible in the short and long term at a physical and mental level. Objective: To identify the physical and psychological effects caused by COVID-19 in physically active people before the disease, during the period from January to May 2021. Method: Was used a descriptive-interpretative qualitative methodology. A sample of 5 adults from 27 to 66 years of age from Juchitán, Oaxaca, Mexico was used on the study; who were selected based on the following criteria: having been COVID-19 carriers, level of severity (mild/moderate) and have performed constant physical activity before the infection. The techniques applied for collecting information were: the interview and the questionnaire. Results: A drastic decrease was evidenced in relation to the components of physical activity (type, frequency, intensity and duration), as well as the prevalence of psychological affectations: stress, depression, anxiety and fear. Regarding the effects at the physical level, weight loss and fatigue (100%) stood out, followed by hair loss (80%) in those studied. Conclusions: The decrease in physical activity is a consequence of the disease itself, while the psychological effects are the result of the uncertainty generated by the disease.

RESUMO Introdução: A COVID-19 trouxe consigo múltiplos efeitos, principalmente no campo da saúde. Estes manifestam-se progressivamente em quem a sofre em relação aos sintomas apresentados, que se tornam visíveis a curto e longo prazo a nível físico e mental. Objetivo: Identificar os efeitos físicos e psicológicos causados pela COVID-19 em pessoas fisicamente ativas antes da doença, durante o período de janeiro a maio de 2021. Método: Foi utilizada a metodologia qualitativa descritivo-interpretativa. Uma amostra de 5 adultos de 27 a 66 anos de Juchitán, Oaxaca, México foi utilizada para o estudo, que foram selecionados com base nos seguintes critérios: ter sido portadores, o nível de gravidade (leve/moderado) e ter realizado atividade física antes de sofrer de COVID-19. As técnicas de coleta de informações aplicadas foram: a entrevista e o questionário. Resultados: Evidenciou-se uma diminuição drástica em relação aos componentes da atividade física (tipo, frequência, intensidade e duração), bem como a prevalência de afetações psicológicas: estresse, depressão, ansiedade e medo. Quanto aos efeitos a nível físico, destacaram-se a perda de peso e a fadiga (100%), seguidas da queda de cabelo (80%) nos estudados. Conclusões: A diminuição da atividade física é consequência da própria doença, enquanto os efeitos psicológicos são decorrentes da incerteza gerada pela doença.

Guts Imbalance Imbalances the Brain: A Review of Gut Microbiota Association With Neurological and Psychiatric Disorders.

Over the last 10 years, there has been a growing interest in the relationship between gut microbiota, the brain, and neurologic-associated affections. As multiple preclinical and clinical research studies highlight gut microbiota's potential to modulate the general state of health state, it goes without saying that gut microbiota plays a significant role in neurogenesis, mental and cognitive development, emotions, and behaviors, and in the progression of neuropsychiatric illnesses. Gut microbiota produces important biologic products that, through the gut-brain axis, are directly connected with the appearance and evolution of neurological and psychiatric disorders such as depression, anxiety, bipolar disorder, autism, schizophrenia, Parkinson's disease, Alzheimer's disease, dementia, multiple sclerosis, and epilepsy. This study reviews recent research on the link between gut microbiota and the brain, and microbiome's role in shaping the development of the most common neurological and psychiatric illnesses. Moreover, special attention is paid to the use of probiotic formulations as a potential non-invasive therapeutic opportunity for prevention and management of neuropsychiatric-associated affections.

Hypoxic Incubation Conditions for Optimized Manufacture of Tenocyte-Based Active Pharmaceutical Ingredients of Homologous Standardized Transplant Products in Tendon Regenerative Medicine.

Human fetal progenitor tenocytes (hFPT) produced in defined cell bank systems have recently been characterized and qualified as potential therapeutic cell sources in tendon regenerative medicine. In view of further developing the manufacture processes of such cell-based active pharmaceutical ingredients (API), the effects of hypoxic in vitro culture expansion on key cellular characteristics or process parameters were evaluated. To this end, multiple aspects were comparatively assessed in normoxic incubation (i.e., 5% CO2 and 21% O2, standard conditions) or in hypoxic incubation (i.e., 5% CO2 and 2% O2, optimized conditions). Experimentally investigated parameters and endpoints included cellular proliferation, cellular morphology and size distribution, cell surface marker panels, cell susceptibility toward adipogenic and osteogenic induction, while relative protein expression levels were analyzed by quantitative mass spectrometry. The results outlined conserved critical cellular characteristics (i.e., cell surface marker panels, cellular phenotype under chemical induction) and modified key cellular parameters (i.e., cell size distribution, endpoint cell yields, matrix protein contents) potentially procuring tangible benefits for next-generation cell manufacturing workflows. Specific proteomic analyses further shed some light on the cellular effects of hypoxia, potentially orienting further hFPT processing for cell-based, cell-free API manufacture. Overall, this study indicated that hypoxic incubation impacts specific hFPT key properties while preserving critical quality attributes (i.e., as compared to normoxic incubation), enabling efficient manufacture of tenocyte-based APIs for homologous standardized transplant products.

Contágios deleuzianos acerca do corpo da/na clínica / Contagios deleuzianos en el cuerpo de/en la clínica / Deleuzian contagions about the body of/in the clinic

A presente pesquisa propõe investigar o conceito de corpo no pensamento do filósofo Gilles Deleuze e suas possíveis interfaces com a clínica, tendo como intercessores alguns de seus diálogos com Nietzsche e Espinosa. Para isso, buscaram-se as definições de corpo segundo esses autores. Para o primeiro, o corpo é relação de forças, e, para o segundo, é caracterizado pelo seu poder de afecção. A partir da leitura de Deleuze sobre eles, a corporeidade pode ser entendida como processualidade, permeada pelos estados intensivos que perpassam os corpos. Os encontros teóricos de Deleuze fazem a clínica pensar de que forma o corpo pode ser instrumento de invenção de si, pois é daí que se dão os processos de subjetivação. A experimentação, assim, se constitui como compromisso ético de uma clínica que se inventa a cada encontro. Problematiza-se, então, a potência da clínica para lançar os corpos para o exercício da criação.(AU)

This research proposes to investigate the concept of the body according to the philosopher Gilles Deleuze and its possible interfaces with the clinic, using as intercessors some of his dialogues with Nietzsche and Espinosa. For this, we sought the definitions of body for Nietzsche and Espinosa. For the first, the body is a relation of forces, and for the second, it is characterized by its power of affection. Based on Deleuze's reading of them, corporality can be understood as processuality, permeated by the intensive states that pass through bodies. Deleuze's theoretical encounters make the clinic think about how the body can be an instrument of self-invention, as this is where the processes of subjectivity occur. Experimentation, therefore, constitutes an ethical compromise of a clinic that is invented at each meeting. Therefore, the potency to cast the bodies for the exercise of creation is problematized.(AU)

Esta investigación se propone indagar en el concepto de cuerpo en el pensamiento del filósofo Gilles Deleuze y sus posibles interfaces con la clínica, teniendo como intercesores algunos de sus diálogos con Nietzsche y Espinosa. Para ello se buscaron las definiciones de cuerpo según estos autores. Para el primero, el cuerpo es una relación de fuerzas, y para el segundo, se caracteriza por su poder de afecto. A partir de la lectura que hace Deleuze de ellos, la corporeidad puede entenderse como procesualidad, permeada por los estados intensivos que permean los cuerpos. Los encuentros teóricos de Deleuze hacen que la clínica reflexione sobre cómo el cuerpo puede ser un instrumento de autoinvención, ya que es aquí donde se producen los procesos de subjetivación. La experimentación, por tanto, constituye un compromiso ético de una clínica que se inventa en cada encuentro. Se cuestiona entonces el poder de la clínica para lanzar cuerpos para el ejercicio de la creación.(AU)

A importância da gramática dos afetos na aprendizagem / Importance of Affections Grammar on Pedagogical Practice / La importancia de la gramática de los afectos en el aprendizaje

Resumo O presente artigo teve por objetivo fazer uma abordagem de reflexão sobre a importância dos afetos na prática pedagógica, com o intuito de potenciar uma educação mais emotiva. Na perspetiva educativa, espera-se que a escola, na sua praxis nos diferentes espaços de ensino, consiga promover uma aprendizagem de excelência através de processos em que o aluno se aproprie, de forma autorregulada, dos conteúdos cognitivos. Tendo como referencial de abordagem as teorias de Vygotsky e Wallon, este contributo reflexivo realça a abrangência e pertinência para que este tema faça parte da agenda profissional de todos os que se dedicam à educação, com o objetivo de promover uma convivência de plena afetividade no processo de ensino e aprendizagem. Os comportamentos e atitudes são a essência na relação pedagógica e conferem um enorme impacto afetivo nos alunos, positivo ou negativo, dependendo da forma como essas interações são vivenciadas. Tendo em consideração a essencialidade da autorregulação da aprendizagem em contexto escolar, poder-se-á concluir que o afeto é o principal pilar da relação pedagógica, constituindo uma dimensão imprescindível na e para a educação de uma sociedade futura mais emotiva.

Abstract This article reflects on the importance of affections in pedagogical action, to promote emotional education. In the educational perspective, it is expected that the school, in its praxis in the different teaching spaces, can promote excellence on learning through processes in which the student appropriates, in a self-regulated way, the cognitive contents. Based on both Vygotsky and Walloon's theories, this reflective contribution emphasizes the scope and relevance of this topic as part of the professional agenda of all those involved in educational issues, promoting the coexistence of affect in teaching, and learning process. Behaviors and attitudes are the essence of the pedagogical relationship and convey a great affective impact on students, either positive or negative, depending on the way these interactions are experienced. Considering the significance of self-regulated learning in the school setting, it can be concluded that affection is the main foundation of pedagogical relationship, constituting an essential dimension of education for developing emotional skills in a future society.

Resumen El objetivo de este artículo fue reflexionar sobre la importancia de los afectos en la práctica pedagógica, con el fin de fomentar una educación más emocional. En la perspectiva educativa, se espera que la escuela, en su praxis en los diferentes espacios de enseñanza, pueda promover un aprendizaje de excelencia a través de procesos en que el alumno se apropie, de forma autorregulada, de los contenidos cognitivos. Con base en las teorías de Vygotsky y Wallon, esta contribución reflexiva subraya el alcance y la pertinencia de este tema como parte de la agenda profesional de todos los que se dedican a las cuestiones de la educación, con el objetivo de promover la coexistencia del afecto en el proceso de enseñanza y aprendizaje. Los comportamientos y las actitudes son la esencia de la relación pedagógica y confieren un gran impacto afectivo en los estudiantes, positivo o negativo, dependiendo de la forma en que se experimentan estas interacciones. Teniendo en cuenta la esencialidad de la autorregulación del aprendizaje en el contexto escolar, se puede concluir que el afecto es el pilar principal de la relación pedagógica, constituyendo una dimensión esencial en y para la educación de una sociedad futura más emocional.

(In)tratável / (Un)tractable / (In)tractable

Em destaque, põe-se uma série de afetos e estranhezas. Coloca-se em relevo um conteúdo da ordem do sentir, do humano; traz-se à tona o que todos temos em comum, o fato de sermos corpos. Corpos que vibram e se reposicionam frente ao desconhecido. Deste modo, o objetivo é identificar quais as afetações que compõem o corpo dentro de uma Unidade de Terapia Intensiva Adulta de um hospital de ensino do interior do Estado do Rio Grande do Sul, Brasil. Trata-se então, de uma pesquisa qualitativa cartográfica, tendo como procedimento metodológico registros de diário de campo em consonância com o referencial teórico sobre o tema. Os resultados destacam as afetações do corpo em questão, caracterizando-se como um lócus latente, uma produção de movimentos em busca de tornar visível o que os olhos insistem em não ver.

Highlighted is a series of affections and strangeness. The content of the order of feeling, of the human, is emphasized; It brings out what we all have in common, the fact that we are bodies. Bodies that vibrate and reposition themselves against the unknown. Thus, the objective is to identify which affectations that make up the body within an Adult Intensive Care Unit of a teaching hospital in the state of Rio Grande do Sul, Brazil. Therefore, this is a qualitative cartographic research, having as methodological procedure field diary records in line with the theoretical framework on the subject. The results highlight the affects of the body in question, being characterized as a latent locus, a production of movements seeking to make visible what the eyes insist on not seeing.

Destaca una serie de afectos y extrañezas. Se enfatiza el contenido del orden de los sentimientos, del humano; Resalta lo que todos tenemos en común, el hecho de que somos cuerpos. Cuerpos que vibran y se recolocan contra lo desconocido. Por lo tanto, el objetivo es identificar qué afectaciones conforman el cuerpo dentro de una Unidad de Cuidados Intensivos para Adultos de un hospital universitario en el estado de Rio Grande do Sul, Brasil. Por lo tanto, esta es una investigación cartográfica cualitativa, que tiene como procedimiento metodológico registros de diario de campo en línea con el marco teórico sobre el tema. Los resultados resaltan los efectos del cuerpo en cuestión, caracterizándose como un lugar latente, una producción de movimientos que buscan hacer visible lo que los ojos insisten en no ver.

COVID-19 and Emotional Variables in a Sample of Chileans.

INTRODUCTION: During the Coronavirus (COVID-19) pandemic, a set of daily stressors are being experienced, all this affects people's mental health, leading them to have a set of emotional disturbances. Little is known about how people's age can influence their emotional well-being in the face of prolonged stress generate by the pandemic. OBJECTIVE: To clarify the presence of emotional aspects such as emotional expressiveness and the frequency of positive and negative affections in people with different age in times of crisis. METHODS: The final sample included 297 Chileans between 22 and 68 years old (M = 38.51, SD = 13.85), recruited through an online survey with the appropriate written informed consent. The study was carried out when the pandemic was spreading in Chile. RESULTS: The findings revealed age differences in emotional expressivity and the type of affections experienced. The expression of emotions was more affected by negative affections, the age and the gender of the people. While the avoidance of this emotional expression, by age and affections both positive and negative. Age was a significant predictor of emotional expressiveness. DISCUSSION: Findings suggests that the associations between both variables, varied according to the age group of the people. Furthermore, this finding proposes that although older people are facing the persistent and serious threat of COVID-19, they show better emotional functioning. Which would help to better understand the interaction of both positive and negative life experiences in times of crisis.

[Low-dose irradiation of non-malignant diseases: Did we throw the baby out with the bathwater?] / Irradiation à faible dose des affections non cancéreuses : avons-nous jeté le bébé avec l'eau du bain ?

The irradiation of non-malignant diseases, essentially for anti-inflammatory purpose, have been largely proposed and performed worldwide until the 1970-80s. At that time, the better assessment of the radio-induced malignancies, essentially in children and young patients, as well as the efficacy of the new anti-inflammatory drugs (steroids and non-steroids), led to the almost disappearance of those techniques, at least in France. In contrast, our German colleagues are still going on treating about 50,000 patients per year for non-malignant (more or less severe) diseases. After a short historical overview, the present article suggests that we were possibly going too far in the rejection of those low-dose irradiations for benign lesions. The recent emergence of new preclinical data, the better understanding of the risk of radio-induced secondary tumours (almost nil in the elderly), and the severity of some situations, such as the cytokine storm of the COVID-19, should probably lead us to reconsider those low - and sometimes very low (less than 1Gy) - irradiations for well-selected indications in the elderly.

[Particularities of psychiatric and dermatological comorbidity among medical students in Morocco: Multicenter study]. / Particularités de la comorbidité psychiatrique et dermatologique chez les étudiants en médecine au Maroc : étude multicentrique.

OBJECTIVES: To evaluate the prevalence and factors associated with dermatological conditions and to study the peculiarities of comorbidity between psychiatric disorders and dermatological conditions among medical students in Morocco. METHODS: This is a multicenter, descriptive, and analytical cross-sectional study over a period of 4 weeks during the month of February 2019. RESULTS: Six hundred and five students from the seven faculties of medicine of Morocco were included. Dermatological conditions were present in 15.5% (94) of students, acne being the most common condition (10.7%), followed by psoriasis in 1.65% of students as well as urticaria in 1.65%. Psychiatric disorders were present in 28% (168) of the students depression being the most common disorder (10.4%), followed by anxiety disorders (7.8%), comorbidity between depression and anxiety disorder (6.94%), and psychotic disorders (2.46%). Dermatological diseases were significantly and independently associated with the presence of a psychiatric disorder (0.0000) and marital status (P=0.0103). Suicide attempts and substance use are more common among medical students who have an association between psychiatric disorder and dermatological pathology compared to students with isolated dermatological conditions or students with isolated psychiatric disorders. CONCLUSION: Dermatological and psychiatric conditions are frequent and underestimated among medical students in Morocco. Dermatologic and psychiatric comorbidity is associated with a higher prevalence of psychoactive substance use and suicide attempts.