ABSTRACT
Background: Evidence whether single “cognitive health” foods could prevent cognitive decline is limited. We investigated whether dietary intake of red wine, white wine, coffee, green tea, olive oil, fresh fish, fruits and vegetables, red meat and sausages, assessed by a single-food-questionnaire, would be associated with either incident Alzheimer’s dementia (AD) or verbal memory decline. Methods: Participants aged 75+ of the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) cohort were regularly followed over 10 years (n = 2622; n = 418 incident AD cases). Multivariable-adjusted joint modeling of repeated-measures and survival analysis was used, taking gender and Apolipoprotein E4 (APOE ε4) genotype into account as possible effect modifiers. Results: Only higher red wine intake was associated with a lower incidence of AD (HR = 0.92; P = 0.045). Interestingly, this was true only for men (HR = 0.82; P < 0.001), while in women higher red wine intake was associated with a higher incidence of AD (HR = 1.15; P = 0.044), and higher white wine intake with a more pronounced memory decline over time (HR = −0.13; P = 0.052). Conclusion: We found no evidence for these single foods to be protective against cognitive decline, with the exception of red wine, which reduced the risk for AD only in men. Women could be more susceptible to detrimental effects of alcohol.
Subject(s)
Alzheimer Disease/psychology , Cognition , Cognitive Aging/psychology , Food , Memory Disorders/psychology , Memory , Age Factors , Aged , Aged, 80 and over , Alzheimer Disease/diagnosis , Alzheimer Disease/epidemiology , Alzheimer Disease/prevention & control , Female , Food/adverse effects , Geriatric Assessment , Germany/epidemiology , Humans , Incidence , Male , Memory Disorders/diagnosis , Memory Disorders/epidemiology , Memory Disorders/prevention & control , Mental Status and Dementia Tests , Neuropsychological Tests , Prospective Studies , Protective Factors , Risk Factors , Sex Factors , Time Factors , WineABSTRACT
A doença de Alzheimer prejudica a cognição, a emoção, o comportamento, o desempenho funcional e o vínculo sociofamiliar dos idosos. O objetivo deste artigo é apresentar a intervenção da Reabilitação Neuropsicológica (RN) e da Terapia Cognitivo-Comportamental (TCC) aplicadas a pacientes com essa doença. O método do estudo é descritivo de investigação, análise e tratamento dos dados de acordo com a abordagem qualitativa de estudo de caso. Os instrumentos de avaliação empregados foram: Inventário Neuropsiquiátrico, Avaliação de Incapacidade na Demência, Escala de Cornell para Depressão, Escala de Depressão Geriátrica-15 e Inventário de Ansiedade. A intervenção compreendeu 6 meses de RN, e após essa, mais 6 meses de TCC. A discussão refere-se ao desempenho do idoso ao longo das técnicas da RN e da TCC. Os resultados mostram melhoria no estado de humor, comportamento e relacionamento familiar do paciente.(AU)
Alzheimer´s disease impairs cognition, emotion, behavior, function performance and the social-familiar vinculum of the old person. The objective of this article is to present interventions of neuropsychological rehabilitation (NR) and cognitive-behavioral therapy (CBT) for patients with this disease. The method is descriptive, with qualitative analyses of a case study. Evaluations used Neuropsychiatry Inventory, Disability Assessment for Dementia, Cornell Scale for Depression in Dementia, Geriatric Depression Scale -15 and Anxiety Inventory. The intervention was planned to have 6 months of NR, and 6 months of CBT. Patients performance during RN and CBT was discussed. Improvements of mood, behavior and family relationships were observed.(AU)
La enfermedad de Alzheimer afecta la cognición, la emoción, la conducta, el rendimiento funcional y los lazos sociales y familiares de los ancianos. El propósito de este artículo es presentar los planes de tratamientos e intervenciones de rehabilitación neuropsicológica (NR) y la terapia cognitivo-conductual (TCC) aplicada al paciente con esta enfermedad. El método de estudio es la investigación descriptiva, análisis y procesamiento de datos de acuerdo con el enfoque cualitativo de un estudio de caso. Los instrumentos de evaluación empleados fueron: Inventario Neuropsiquiátrico, Evaluación de la Discapacidad en la Demencia, Cornell Escala de Depresión Geriátrica-15 y el Inventario de Ansiedad Depresión Scale. La intervención constó de 6 meses de RN, y después de eso, otros 6 meses de TCC. La discusión se refiere a la actuación de la edad sobre el RN y el TCC. Los resultados muestran una mejora en el estado de ánimo, el comportamiento y la relación familiar de lo paciente.(AU)
