ABSTRACT
INTRODUCTION AND AIMS: Posttransplantation diabetes mellitus (PTDM) is a serious long-term complication that has a negative impact on graft and patient survival. The purpose of the present study was to describe the incidence of PTDM in a Mexican cohort and evaluate its association with a previous family history of diabetes (FHD). METHODS: A retrospective single-center cohort study was conducted on patients undergoing liver transplantation (LT). The primary outcome was time from LT to PTDM. The diagnosis of PTDM was established using the ADA criteria. A mediation analysis that used adjusted Cox regression models and considered pretransplant prediabetes a mediator was performed, to determine the total effect and direct effect of FHD on PTDM. RESULTS: A total of 152 patients were included, with a median follow-up time of 41 months; 19.2% (nâ¯=â¯29) had pretransplant diabetes. During the follow-up time, 15% of patients developed PTDM (nâ¯=â¯23), with an incidence rate of 4.71 cases/100 person-years. PTDM was significantly higher in patients with FHD, compared with those with no FHD (8.72 cases/100 person-years vs 2.04 cases/100 person-years, respectively; pâ¯=â¯0.001). The adjusted hazard ratio of PTDM for FHD was 4.14 (95% CI 1.60-10.7), pâ¯=â¯0.005) and 3.48 (95% CI 1.35-9.01, pâ¯=â¯0.010), when further controlled for pretransplant prediabetes. CONCLUSION: The occurrence of PTDM was similar to that reported in most international studies. As with type 2 diabetes, family history plays an important role in the development of PTDM, even after accounting for pretransplant prediabetes. Patients with FHD should undergo a stricter metabolic program.
ABSTRACT
Se realizó un estudio descriptivo y transversal de 55 pacientes miopes atendidos en la consulta de Oftalmología del Policlínico Alberto Fernández Montes de Oca del municipio de San Luis, de la provincia de Santiago de Cuba, desde enero hasta junio de 2013, con vistas a caracterizarles según determinadas variables clinicoepidemiológicas. En la serie predominaron el nivel escolar secundario (34,5 por ciento), el grupo etario de 11-20 años (32,7 por ciento) y la miopía simple (65,4 por ciento). Por otra parte, 56,4 por cientoantecedentes familiares de la enfermedad(AU)
A descriptive and cross-sectional study of 55 myopic patients assisted in the Ophthalmology service of Alberto Fernández Montes de Oca Polyclinic in San Luis municipality, Santiago de Cuba was carried out, from January to June, 2013, aimed at characterizing them according to certain clinical epidemiological variables. In the series basic secondary school students (34.5 percent), the 11 to 20 age group (32.7 percent) and the simple myopia (65.4 percent) prevailed. On the other hand, 56.4 percent of those affected presented family history of the disease(AU)
Subject(s)
Humans , Male , Female , Myopia , Family , Eye Diseases, Hereditary , Refractive Errors , Primary Health Care , Epidemiology, Descriptive , Cross-Sectional StudiesABSTRACT
Se realizó un estudio descriptivo y transversal de 55 pacientes miopes atendidos en la consulta de Oftalmología del Policlínico "Alberto Fernández Montes de Oca" del municipio de San Luis, de la provincia de Santiago de Cuba, desde enero hasta junio de 2013, con vistas a caracterizarles según determinadas variables clinicoepidemiológicas. En la serie predominaron el nivel escolar secundario (34,5 %), el grupo etario de 11-20 años (32,7 %) y la miopía simple (65,4 %). Por otra parte, 56,4 % de los afectados presentaron antecedentes familiares de la enfermedad.
A descriptive and cross-sectional study of 55 myopic patients assisted in the Ophthalmology service of "Alberto Fernández Montes de Oca" Polyclinic in San Luis municipality, Santiago de Cuba was carried out, from January to June, 2013, aimed at characterizing them according to certain clinical epidemiological variables. In the series basic secondary school students (34.5%), the 11 to 20 age group (32.7%) and the simple myopia (65.4%) prevailed. On the other hand, 56.4% of those affected presented family history of the disease.