Accidental Intrathecal Vincristine Administration / 대한소아혈액종양학회지

Vincristine is a chemotherapeutic agent used in the treatment of various neoplastic diseases. Accidental intrathecal vincristine instillation is a fatal error. We report a case of a 6-year-old boy with acute lymphocytic leukemia who suffered an accidental intrathecal vincristine administration. He suffered a progressive ascending chemical meningoencephalitis followed by coma, and died at the 5th day after injection. Several previous reports of intrathecal vincristine instillation are reviewed.