ABSTRACT
Bloodstream nontyphoidal salmonella (NTS) infection is rare, but its associated characteristics and microbiological features in immunocompromised patients are worth paying attention to, particularly for those receiving allogeneic hematopoietic stem cell transplantation (SCT). No studies so far have analyzed post-transplant bloodstream NTS infection. Therefore, we reviewed 423 adult patients undergoing allogeneic hematopoietic SCT from 2003 to 2014. Nine out of four hundred twenty-three patients (2.13%) developed post-transplant bloodstream NTS infection, including two patients who had subsequent or combined metastatic infections. The median age at SCT was 35 years (interquartile range, 29-46) among the nine patients with bloodstream NTS infection. Male patients were predominant (78%). The median onset of bloodstream NTS infection was at 315 days after SCT (range, 207-629). Multivariate analysis revealed that extensive chronic graft-versus-host disease (GVHD) (OR 8.054, p = 0.003) and nonmyeloablative transplant conditioning (OR 4.604, p = 0.037) were significant associated characteristics for NTS infection. Currently, there are no published data analyzing and exploring post-transplant bloodstream NTS infections in adult allogeneic hematopoietic SCT. Our study determined the associated characteristics and microbiological features for this infection.
Subject(s)
Hematopoietic Stem Cell Transplantation , Salmonella Infections , Salmonella , Transplantation Conditioning , Adult , Allografts , Female , Graft vs Host Disease/blood , Graft vs Host Disease/etiology , Graft vs Host Disease/microbiology , Humans , Male , Middle Aged , Salmonella Infections/blood , Salmonella Infections/etiology , Salmonella Infections/microbiology , Sex FactorsABSTRACT
La identificación precoz del trastorno por déficit de atención e hiperactividad (TDAH) permite implementar terapias oportunas, esto motivó a investigar la etiología del trastorno y las características asociadas durante la infancia y niñez. La información se recopiló con un cuestionario clínico del TDAH para padres. Participaron diez madres de 32 años de edad promedio. Los resultados demuestran que el trastorno es hereditario y además, existen factores de riesgo durante el embarazo y el nacimiento. Las características del TDAH en la infancia y niñez son nivel de actividad por encima de lo normal, inquietud para dormir, bastante insistentes para pedir algo, desarrollo motor grueso normal, pobre coordinación motora fina, tendencia a sufrir accidentes, desarrollo ligeramente precoz del lenguaje, progreso académico regular, repetición de grado, participación en programas especiales de educación, dificultad para conservar amistades y comportamiento pobremente dirigido por reglas.
The early identification of the attention deficit hyperactivity disorder (ADHD) allows the implementation of effective therapies; this fact causes the study of the etiology of the disorder and the associated characteristics during infancy and childhood. The data was gathered through a clinical questionnaire of the ADHD for parents. The subjects were ten mothers aged in average 32 years. The results show that the disorder is hereditary and besides, there are risk factors during pregnancy and birth. The associated characteristics of ADHD during infancy and childhood are a level of activity above the average, restless sleep, quiet insistent to ask for something, normal gross motor development, poor fine motor coordination, greater risk of accidental injury, slightly premature development of language, fair academic progress, repetition of a grade, involvement in special education programs, difficulty in keeping friends and poor rule-governed behavior.
