Immune-related thyroid dysfunction in patients with non-small cell lung cancer.

Background: Immune-related thyroid dysfunction (irTD) is a common immune-related adverse event (irAE). The potential biomarkers of irTDs and their impact on the clinical outcomes of patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs) remain unclear. We aimed to identify potential biomarkers of irTDs and reveal the association between irTDs and the clinical outcomes in patients with NSCLC treated with ICIs. Methods: We conducted a retrospective study on 126 patients with NSCLC, who were treated with pembrolizumab, sintilimab, atezolizumab, or camrelizumab, as first-line therapy, at the First Affiliated Hospital, College of Medicine, Zhejiang University, between July 2019 and February 2023. Anti-thyroid antibodies (ATAs), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb), serum interleukin-6 (IL-6), thyroid ultrasonography, overall survival (OS), and progression-free survival (PFS) were the main indicators. Results: Most (92.9%) irTD cases occurred no later than one year after ICIs initiation. Patients with irTDs had higher positive rates for ATAs and TPOAb [33.3% vs. 1.3%, and 30.3% vs. 1.3%, both P<0.01, odds ratio (OR) =39.81, and OR =35.46, respectively]. Irregular echo pattern and diffuse changes were more common in patients with irTDs (70.7% vs. 47.2%, and 19.5% vs. 1.4%, P<0.05 and P<0.01, OR =2.70, and OR =17.21, respectively). OS and PFS were similar in patients with and without irTDs (P>0.05). Conclusions: The ATAs, TPOAb, and abnormal thyroid ultrasonographic findings (irregular echo patterns and diffuse changes) are potential biomarkers of irTDs. Patients with NSCLC treated with ICIs (pembrolizumab, sintilimab, atezolizumab, and camrelizumab) who developed irTDs had no advantage in terms of clinical outcomes compared to euthyroid patients.

Apresentando Victor Tausk / Introducing Victor Tausk / Présentation de Victor Tausk

Este artigo busca situar Victor Tausk, clássico autor da psicanálise, dentro do movimento psicanalítico a partir de análises históricas, por meio do entrelaçamento de textos. Tausk, advogado, também atuou com jornalismo e literatura, escrevendo poemas, contos e peças de teatro; conhece Freud a partir de uma crise de depressão que atravessa. A partir daí, a psicanálise passa a fazer parte de sua vida pessoal e profissional. No entanto, seu suicídio fez com que seu nome fosse parar nos limbos da história da psicanálise, como se jamais tivesse existido. Reconstruímos a biografia de Tausk, retirando-o desse lugar em que se encontrava e abordamos outros elementos necessários para constituir o mapa das posições de Tausk na história da psicanálise. Em posse desses elementos, apresentamos uma visão clara do que foram os dez anos de presença de Tausk no movimento psicanalítico de Viena. Esperamos que este artigo traga ao leitor atento um vislumbre da vida e da obra deste grande psicanalista e lhe acenda a curiosidade para buscar lê-lo.

This paper aims to situate Victor Tausk, classic author of psychoanalysis, within the psychoanalytic movement from historical analysis, through the interweaving of texts. Tausk, a lawyer, also worked with journalism and literature, writing poems, short stories, and plays; he meets Freud when he falls ill with a depression crisis. From then on, psychoanalysis became part of his personal and professional life. However, his suicide sent his name into limbo in the history of psychoanalysis, as if it had never existed. We reconstructed his biography, bring him from this place where he was and approached other elements necessary to constitute the map of his positions in the history of psychoanalysis. With these elements in hand, we present a clear idea of what were the ten years of his presence in the Vienna psychoanalytic movement. We hope that this article will bring the attentive reader a glimpse of this great psychoanalyst's life and work and spark his curiosity to seek to read him.

Cet article cherche à situer Victor Tausk, auteur classique de la psychanalyse, dans le mouvement psychanalytique à partir de l'analyse historique, à partir d'une lecture croisée des textes qui se réfèrent à lui. Tausk, formé en droit, ayant exercé dans cette profession, ayant également travaillé comme journaliste, écrivit des poèmes, des nouvelles et des pièces de théâtre. Il rencontre Freud lors d'une crise de dépression qu'il traverse. Dès lors, la psychanalyse fait partie de sa vie personnelle et professionnelle. Cependant, son suicide jette son nom dans les limbes de la psychanalyse, comme s'il n'avait jamais existé. Nous avons reconstruit la biographie de Tausk, en le retirant de ce lieu où il se trouvait et avons abordé d'autres éléments nécessaires pour constituer la charte des positions de Tausk dans l'histoire de la psychanalyse. Nous espérons que cet article apporte au lecteur attentif un aperçu de la vie et de l'œuvre de ce grand psychanalyste et suscitera sa curiosité pour chercher à le lire.

"Serás-hétero-ou-não-serás": a lesbianidade nas Atas da Sociedade Psicanalítica de Viena / "You-will-be-straight-or-you-will-not-be": the lesbianity in the Minutes of the Vienna Psychoanalytic Society / "Tú-serás-heterosexual-o-no-serás": la lesbianidad en las Actas de la Sociedad Psicoanalítica de Viena / « Tu seras hétérosexuel(le) ou tu ne seras pas ¼: la lesbianité dans les Minutes de la Société psychanalytique de Vienne

Este artigo objetiva estudar os discursos dos primeiros psicanalistas sobre a lesbianidade, a partir de uma análise teórico-documental das Atas da Sociedade Psicanalítica de Viena. Investigando a problemática do desejo lésbico, buscamos contribuir com o reconhecimento dos limites e potencialidades das teorias psicanalíticas sobre o sexual. Para tanto, foram examinadas as duas principais hipóteses sobre o desejo lésbico desenvolvidas nas reuniões da Sociedade Psicanalítica de Viena e discutiu-se a origem das relações entre lesbianidade e masculinidade do ponto de vista psicanalítico, assinalando algumas questões que a lesbianidade pode formular sobre as relações entre a psicanálise e o patriarcado.

The present work aims to research the speeches of the first psychoanalysts on lesbianity, through a theoretical and documentary research of the Minutes of the Vienna Psychoanalytic Society. Investigating the question of the lesbian desire, the article intends to contribute with the acknowledgment of the limits and potentialities of the psychoanalytic sexual theories. To this end, the two main hypotheses about the lesbian desire developed at the meetings of the Vienna Psychoanalytic Society were examined and the origin of the associations between lesbianity and masculinity in the psychoanalytic point of view was discussed, pointing out some questions that lesbianity can formulate about the relations between psychoanalysis and patriarchy.

El presente trabajo objetiva estudiar los discursos de los primeros psicoanalistas sobre la lesbianidad, a través de un análisis teórico y documental de los registros de las Actas de la Sociedad Psicoanalítica de Viena. Investigando el problema del deseo lesbiano, buscamos contribuir con el reconocimiento de los límites y potencialidades de la teoría sexual. Con este fin, se examinaron las dos principales hipótesis sobre el deseo lesbiano desarrolladas en las reuniones de la Sociedad Psicoanalítica de Viena y se discutió el origen de las relaciones entre la lesbianidad y la masculinidad desde el punto de vista psicoanalítico, señalando algunas preguntas que la lesbianidad puede formular sobre las relaciones entre el psicoanálisis y el patriarcado.

Cet article étude les discours des premiers psychanalystes sur la lesbianité, à travers d'une analyse théorique et documentaire des Minutes de la Société psychanalytique de Vienne. En enquêtent sur le problème du désir lesbien, ce travail cherche à contribuer à la reconnaissance des limites et des potentialités de la théorie sexuelle. Pour ce faire, on a examiné les deux hypothèses sur le désir lesbien développées lors des réunions de la Société psychanalytique de Vienne et on a discuté sur l'origine des associations entre lesbianité et masculinité du point de vue psychanalytique, soulignant des questions que la lesbianité peut formuler sur les relations entre psychanalyse et patriarcat.

ATAS Acupuncture Reduces Chemotherapy Induced Fatigue in Breast Cancer Through Regulating ADROA1 Expression: A Randomized Sham-Controlled Pilot Trial.

OBJECTIVE: To investigate the feasibility and effectiveness of ATAS acupuncture (Acupoints-Time-Space Acupuncture) as a non-pharmacological intervention to prevent or relieve chemotherapy-induced fatigue in breast cancer patients undergoing taxane chemotherapy. METHODS: A pilot study in Kunming center with the aim of evaluating 40 patients randomized to 3 groups: ATAS, sham and non-acupuncture with an unequal randomization of 2:1:1. Participants with stage I-III breast cancer were scheduled to receive adjuvant EC4P4 chemotherapy. Participants in the ATAS and sham acupuncture arms received 20 sessions of acupuncture over 20 weeks, non-acupuncture arm received usual care. Evaluation scales, including VAS-F, MFI-20, HDAS, ISI, and blood samples were collected at four timepoints (T1-T4). mRNA sequencing was performed to detect the mechanism of acupuncture. RESULTS: A total of 581 sessions of acupuncture were performed on patients in the acupuncture group. There was no difference between the three groups in terms of clinical characteristics. Patients randomized to ATAS acupuncture had improved symptoms including fatigue, anxiety and insomnia during the whole process of chemotherapy compared with the other two groups. The VAS-F score of ATAS acupuncture group was decreased compared with non-acupuncture group (P=0.004). The score of MFI-20 in ATAS acupuncture group was kept at low level, while the other two groups' scores kept climbing during chemotherapy (P=0.016; P=0.028, respectively). The mechanism of ATAS acupuncture which reduced fatigue and depression may be related to ADROA1, by regulating cGMP/PKG pathway. CONCLUSION: This pilot study has demonstrated that ATAS acupuncture can significantly reduce fatigue induced by chemotherapy. TRIAL REGISTRATION: Chinese Clinical Trials Registry, ChiCTR-IPR-17,013,652, registered Dec 3, 2017. http://www.chictr.org.cn/. PROTOCOL VERSION: Version 3.2 dated from 2018/04/20.

The moderating role of socially desirable responding in implicit-explicit attitudes toward asylum seekers.

Implicit and explicit attitudes correlate under certain conditions and researchers are interested in the moderating factors of this relationship. This paper explored the role of socially desirable responding in this relationship by testing the hypothesis that impression management (IM; i.e., deliberate response modification) and self-deceptive enhancement (SDE; i.e., positive self-bias) play moderating roles in the relationship of implicit-explicit attitudes toward asylum seekers in Australia. Seventy-four students responded to a battery of measures and the results revealed that IM (but not SDE) moderated this relationship to the extent that higher IM scores weakened the correspondence between implicit and explicit attitude scores. This suggests that attitudes toward asylum seekers might be susceptible to socially desirable response tendencies and in combination with the finding that IM was negatively related to explicit attitudes, it is argued that self-presentation concerns result in the deliberate attenuation of reported negative explicit attitudes.

Development of in situ product removal strategies in biocatalysis applying scaled-down unit operations.

An experimental platform based on scaled-down unit operations combined in a plug-and-play manner enables easy and highly flexible testing of advanced biocatalytic process options such as in situ product removal (ISPR) process strategies. In such a platform, it is possible to compartmentalize different process steps while operating it as a combined system, giving the possibility to test and characterize the performance of novel process concepts and biocatalysts with minimal influence of inhibitory products. Here the capabilities of performing process development by applying scaled-down unit operations are highlighted through a case study investigating the asymmetric synthesis of 1-methyl-3-phenylpropylamine (MPPA) using ω-transaminase, an enzyme in the sub-family of amino transferases (ATAs). An on-line HPLC system was applied to avoid manual sample handling and to semi-automatically characterize ω-transaminases in a scaled-down packed-bed reactor (PBR) module, showing MPPA as a strong inhibitor. To overcome the inhibition, a two-step liquid-liquid extraction (LLE) ISPR concept was tested using scaled-down unit operations combined in a plug-and-play manner. Through the tested ISPR concept, it was possible to continuously feed the main substrate benzylacetone (BA) and extract the main product MPPA throughout the reaction, thereby overcoming the challenges of low substrate solubility and product inhibition. The tested ISPR concept achieved a product concentration of 26.5 gMPPA · L-1 , a purity up to 70% gMPPA · gtot-1 and a recovery in the range of 80% mol · mol-1 of MPPA in 20 h, with the possibility to increase the concentration, purity, and recovery further. Biotechnol. Bioeng. 2017;114: 600-609. © 2016 Wiley Periodicals, Inc.

Tecnologia do Protocolo da UNICINe sua Contribuição à CCCI / UNICIN Protocol Technology and its Contribution to the CCCI / Tecnología del Protocolo de la UNICIN y su Contribución a la CCCI

O presente artigo apresenta a União das Instituições ConscienciocêntricasInternacionais (UNICIN) e o trabalho que vem sendo desenvolvido pelo Comitêde Protocolo, com ênfase na confecção de atas de reuniões, registro dasdecisões e acompanhamento das pendências. Apresenta-se a metodologia aplicadanos registros, o desassédio pela informação, que permite maior clareza eeficiência no processo administrativo de uma IC, além de ter importante papelna construção da holomemória da CCCI e da Conscienciologia(AU)

This article introduces Union of International ConscientiocentricInstitutions (UNICIN) and the work that has been developed by the ProtocolCommittee, with emphasis on the preparation of meetings minutes, registrationof decisions and the follow up of pending issues. It presents the appliedregistration methodology and the process of deintrusion through actualinformation. These procedures allow more explicitness and efficiency in theadministrative process of a Conscientiocentric Institution, in addition to playingan important role in registering holomemory of the International CosmoethicalConscientiological Community (CCCI) and of Conscientiology(AU)

El presente artículo presenta la Unión de las Instituiciones ConcienciocentricasInternacionales (UNICIN) y el trabajo que viene siendo desenvueltopor el Comité de Protocolo, con énfasis en la confección de actas de reuniones,registro de las decisiones y acompañamiento de las pendencias. Se presenta lametodología aplicada en los registros, el desasedio por la información, quepermite mayor clareza y eficiencia en el proceso administrativo de una IC,además de tener importante papel en la construcción de la holomemoria de laCCCI y de la Concienciología(AU)