ABSTRACT
OBJECTIVES: To evaluate the possibility of determining the genetic profile of primary malignant tumors of the breast from specimens obtained by ultrasound-guided percutaneous biopsies during the diagnostic imaging workup. MATERIAL AND METHODS: This is a retrospective study in 13 consecutive patients diagnosed with invasive breast cancer by B-mode ultrasound-guided 12 G core needle biopsy. After clinical indication, the pathologist decided whether the paraffin block specimens seemed suitable (on the basis of tumor size, validity of the sample, and percentage of tumor cells) before sending them for genetic analysis with the MammaPrint® platform. RESULTS: The size of the tumors on ultrasound ranged from 0.6cm to 5cm. In 11 patients the preserved specimen was considered valid and suitable for use in determining the genetic profile. In 1 patient (with a 1cm tumor) the pathologist decided that it was necessary to repeat the core biopsy to obtain additional samples. In 1 patient (with a 5cm tumor) the specimen was not considered valid by the genetic laboratory. The percentage of tumor cells in the samples ranged from 60% to 70%. In 11/13 cases (84.62%) it was possible to do the genetic analysis on the previously diagnosed samples. CONCLUSION: In most cases, regardless of tumor size, it is possible to obtain the genetic profile from tissue specimens obtained with ultrasound-guided 12 G core biopsy preserved in paraffin blocks.
Subject(s)
Breast Neoplasms/genetics , Breast Neoplasms/pathology , Ultrasonography , Adult , Breast Neoplasms/diagnostic imaging , Female , Humans , Image-Guided Biopsy/methods , Middle Aged , Retrospective StudiesABSTRACT
A ressonância magnética mamária apresenta ótima sensibilidade para o diagnóstico do câncer de mama, detectando cânceres insuspeitos à mamografia, à ultra-sonografia e à palpação. É fundamental que se tenha acesso às lesões diagnosticadas apenas por esse método. Um exame ultra-sonografico dirigido à área da lesão da ressonância magnética só encontra a lesão em cerca de 23% dos casos. Os demais devem ser abordados com orientção pela ressonância magnética. A localização das lesões pela ressonância magnética é rotineira em alguns centros, mas ainda não é amplamente disponível no Brasil. Esse trabalho descreve uma técnica de localização pré-operatória (agulhamento) de lesões mamárias orientada pela ressonância magnética, com o objetivo de tornar essa técnica mais conhecida na comunidade da mastologia.
Magnetic resonance imaging of the breast has excellent sensibility, and is able to detect breast cancers that cannot be detected by mammography, ultrasound or physical examination. It is required, though, that detected lesions can be accessed for biopsy. Second-look sonography fails to demonstrate the lesion in up to 77% of the patients. The remainders will need a magnetic resonance guided procedure. These procedures are routinely performed in many centers, but still not widely available in our country. This paper describes the technique for magnetic resonance guided needle localization of breast lesions, with the purpose of making those involved with breast health care more familiar with it.
