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1.
J Pediatr (Rio J) ; 2024 Jul 02.
Article in English | MEDLINE | ID: mdl-38968956

ABSTRACT

OBJECTIVES: In the clinical routine of pediatricians, height is the most reliable indicator for assessing growth. However, there are situations where it is not possible to measure this parameter directly, making the estimation of height or length a useful alternative. The main goal of this study is to identify which segmental measure, including upper arm length (UAL), tibial length (TL), and knee-heel length (KHL), provides the stature estimate that most closely approximates directly measured height in the study participants. METHODS: Analytical cross-sectional study of the anthropometric and segmental measures of 248 participants, aged 0 to 14 years old, using Stevenson's and Kihara's equations to estimate indirectly measured height. RESULTS: The segmental measure that provided a measurement that deviated the least from the actual height was the KHL, followed by TL, both calculated using Stevenson's equations. CONCLUSION: The use of segmental measures to infer a child's stature is valuable in clinical practice, particularly in bedridden and incapacitated patients. Based on the present findings, the KHL and TL segments yielded more accurate results than the UAL.

2.
Clin Nutr ESPEN ; 62: 234-240, 2024 Aug.
Article in English | MEDLINE | ID: mdl-38848220

ABSTRACT

BACKGROUND & AIMS: In children with Cerebral palsy (CP) bone deformities create a difficulty in the collection of height measures by direct methods. Body segments are an alternative to study for anthropometric evaluation in children with CP. Motor compromise affects growth in these children. To our knowledge, no equations have been developed to estimate height that consider the level of involvement of children with CP. The aim was to develop equations to estimate height using segmental measures for children with cerebral palsy (CP). METHODS: This was a cross-sectional study. The sample consisted of children and adolescents with CP of both sexes from 2 to 19 years old from five cities in Argentina. Children whose height and knee-heel height (KH) could be measured were included. Height, KH, and clinical covariables were collected. Linear regression models with height as the dependent variable and KH as predictors adjusted for significant covariates were developed and compared for R2, adjusted R2, and the root mean square of the error. RESULTS: 242 children and adolescents (mean age 9 ± 4 years) with a confirmed diagnosis of CP were included. The interaction between height and other variables such KH, sex, GMFCS, and age was analyzed. Two equations were developed to estimate height according to GMFCS level (GMFCS Level I-III: H = 1.5 × KH(cm) + 2.28 × age(years) + 51; GMFCS Level IV-V: H = 2.13 × KH (cm)+ 0.91 × age(years) + 37). The concordance correlation coefficient between estimated and observed height was 0.95 (95%CI [0.94; 0.96]). CONCLUSION: Height in children and adolescents with CP can be predicted using KH, GMFCS, and age. The equations and software can estimate height when this cannot be obtained directly.


Subject(s)
Body Height , Cerebral Palsy , Humans , Cerebral Palsy/physiopathology , Adolescent , Female , Child , Male , Cross-Sectional Studies , Child, Preschool , Software , Anthropometry , Argentina , Young Adult , Linear Models
3.
J. pediatr. (Rio J.) ; 100(3): 277-282, May-June 2024. graf
Article in English | LILACS-Express | LILACS | ID: biblio-1558330

ABSTRACT

Abstract Objective: To develop growth charts for weight-for-age, height-for-age, and body mass index (BMI)-for-age for both genders aged 2 to 18 years for Brazilian patients with Williams-Beuren Syndrome (WBS). Methods: This is a multicenter, retrospective, and longitudinal study, data were collected from the medical records of boys and girls with a confirmed diagnosis of WBS in three large university centers in the state of Sao Paulo, Brazil. Growth charts stratified by gender and age in years were developed using LMSchartmaker Pro software. The LMS (Lambda Mu Sigma) method was used to model the charts. The quality of the settings was checked by worm plots. Results: The first Brazilian growth charts for weight-for-age, height-for-age, and BMI-for-age stratified by gender were constructed for WBS patients aged 2 to 18 years. Conclusion: The growth charts developed in this study can help to guide family members and to improve the health care offered by health professionals.

4.
Anat Cell Biol ; 2024 May 31.
Article in English | MEDLINE | ID: mdl-38817052

ABSTRACT

Intrauterine alcohol exposure delays bone maturation and intensifies osteoporosis and fracture risk. As most studies emphasize the neurological aspects of intrauterine alcohol exposure, there is a lack of research on the implications pertaining to osseous tissue. Previous studies investigated these effects in fetuses, with limited studies on postnatal life. Postnatal studies are crucial since peak bone growth occurs during adolescence. This study aimed at assessing the effects of prenatal alcohol exposure on the humerus proximal and distal growth plate chondrocytes in 3-week-old rats. Sprague Dawley rats (n=9) were assigned to either the ethanol group (n=3), saline (n=3), and untreated (n=3) group and time-mated. Once pregnant, as confirmed by the presence of a copulation plug, the former 2 groups were treated with 0.015 ml/g of 25.2% ethanol and 0.9% saline. The untreated group received no treatment. The left humeri belonging to 6 pups per group were used. Serial sections were cut with a microtome at 5 µm thickness. These sections were stained with haematoxylin and eosin for assessment of normal morphology or immunolabeled with anti-Ki-67 and transforming growth factor ß-1 (TGFß-1) antibody. Prenatal alcohol exposure adversely effected the growth plate sizes and the number of cells in the proliferative zone. Fewer TGFß-1 immunopositive and proliferative chondrocytes were found using the anti-Ki-67 antibody. This may explain the growth retardation in offspring exposed to gestational alcohol, showing that gestational alcohol exposure inhibits cell proliferation, aiding the diminished stature.

5.
J Oral Rehabil ; 51(7): 1193-1201, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38570928

ABSTRACT

BACKGROUND: Upper oesophageal sphincter (UES) serves as an important anatomical and functional landmark during swallowing. However, the precise UES location before and during swallowing has not been well established. OBJECTIVE: This study aimed to determine upper oesophageal sphincter (UES) location and displacement during swallowing accounting for sex, age, and height in healthy adults using 320-row area detector computed tomography (320-ADCT). METHODS: Ninety-four healthy adults (43 males; 22-90 years) underwent 320-ADCT scanning while swallowing one trial of 10 mL honey thick barium. UES location at bolus hold and at maximum displacement and vertical displacement during swallowing were identified using the coordinates and the section classification of vertebrae (VERT scale). The differences and correlations of UES location and distance in terms of sex, age, and height were analysed using Mann-Whitney U test and Spearman's correlation coefficient. RESULTS: UES locations at bolus hold and at maximum displacement were significantly lower and UES vertical displacement was significantly larger in males than in females (p < .001). UES location at bolus hold became lower with increasing age (r = -.312, p = .002), but the negative correlation was low at maximum displacement (r = -.230, p = .026), resulting in larger vertical distance with ageing. UES locations showed high negative correlation at bolus hold with height (r = -.715, p < .001), and showed moderate negative correlation at maximum displacement with height (r = -.555, p < .001), although this effect was unclear when analysed by sex. CONCLUSION: Males showed lower UES location and larger displacement than females. The impact of age was evident with lower location before swallowing and larger displacement during swallowing. Differences observed by sex were not completely explained by using the VERT scale to adjust for height.


Subject(s)
Deglutition , Esophageal Sphincter, Upper , Humans , Male , Female , Adult , Middle Aged , Deglutition/physiology , Esophageal Sphincter, Upper/physiology , Esophageal Sphincter, Upper/diagnostic imaging , Aged , Aged, 80 and over , Young Adult , Tomography, X-Ray Computed , Healthy Volunteers , Sex Factors
6.
Article in English | MEDLINE | ID: mdl-38632016

ABSTRACT

BACKGROUND: The calculation of body height in the intensive care unit is essential for obtaining the ideal body weight, which is used to program the tidal volume and establish objective and effective pulmonary ventilation. The objective of the study was to determine the interrater reliability of a tool for measuring body height in adult patients in an intensive care unit (ICU) in southwestern Colombia. METHODS: This cross-sectional observational study was conducted between January and May 2021, following the recommendations of the COSMIN protocol. Two physiotherapists in the roles of observer/evaluator measured the heights of 106 patients upon admission to the ICU with a previously designed. The sample size was calculated based on Pearson's correlation coefficient. For interrater reliability, the intraclass correlation coefficient (ICC) was used, and Bland-Altman analysis was used to assess concordance. The 95% confidence interval was established, and a P value <0.05 indicated statistical significance. RESULTS: A total of 106 individuals with a mean age of 59.3 years were included; the mean body height was 158.5 cm for women. The interrater reliability of the measurement of height was excellent (global ICC of 0.99, P = 0.000), and an almost perfect positive correlation was obtained between the raters for both women and men (R = 0.99). CONCLUSIONS: Excellent interrater/interobserver reliability was obtained for the measurement of body height in the ICU. This research highlights the importance of protocolizing the measurement of height in critical patients with valid and reliable instruments.

7.
Acad Forensic Pathol ; 14(1): 10-20, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38505639

ABSTRACT

Objectives: To predict body height using hand length and hand breadth in pharmacy and nursing students at Misrake Ghion College, Northeast Ethiopia. Methods: A cross-sectional prospective study was conducted from October 15 to January 20, 2021. The study was carried out on 316 students (160 males and 156 females). The study participants were from the Amhara ethnic groups, with the age range of 18 to 25 years. Body height, hand length, and hand breath were measured and analyzed using SPSS version 23. The strength of association was evaluated using correlation analysis. The significance level was set at p < 0.05. A paired sample t test was performed. Regression equations were derived using simple and multiple linear regression analysis. Results: Hand length and hand breadth had a positive significant correlation with body height in both male and females. In both males and females, left hand length had a strong significant correlation (males r = 0.768, females r = 0.670), followed by right hand length (males r = 0.711, females r = 0.626). Regarding hand length, right hand breadth (males r = 0.671, female r = 0.438) and left hand length (males r = 0.504, females r = 0.525). There was a significant bilateral difference in hand length and hand breadth on its right and left sides (p < 0.05). Simple and multiple regression equations were formulated for each sex. Conclusion: In both males and females, body height can be estimated from hand length and breadth using simple or multiple regression equations.

8.
JSES Int ; 8(2): 335-342, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38464453

ABSTRACT

Background: In reverse shoulder arthroplasty (RSA), the ideal combination of baseplate lateralization (BL), glenosphere size (GS), and glenosphere overhang (GOH) with a commonly used 145° neck shaft angle (NSA) is unclear. This is the first study evaluating correlations of body height (BH), humeral head size (HS), glenoid height (GH), and association of gender with best glenoid configurations for range of motion (ROM) maintaining anatomic lateralization (aLAT) for optimized muscle length in 145° and less distalized 135° RSA. Methods: In this computer model study, 22 computed tomographies without joint narrowing were analyzed (11 male/female). A standardized semi-inlay 145° platform stem was combined with 20 glenoid configurations (baseplate [B] 25, 25 + 3/+6 lateralized [l], 29, 29 + 3/6l combined with glenosphere 36, 36 + 2 eccentric [e], 36 + 3l, 39, 39 + 3e, 39 + 3l , 42, 42 + 4e). Abduction-adduction, flexion-extension, external rotation-internal rotation, total ROM (TROM), and total notching relevant (TNR) ROM were computed, best TROM models respecting aLAT (-1 mm to +1 mm) and HS/GH recorded. Second, the 145° models (Ascend Flex stem; Stryker, Kalamazoo, MI, USA) were converted and compared to a 135° inlay RSA (New Perform stem; Stryker, Kalamazoo, MI, USA) maintaining GOH (6.5-7 mm) and aLAT. Results: Best 145° models had eccentric glenospheres (mean BL: 3.5 mm, GOH 8.8 mm, GS 38.1 mm, distalization 23 mm). The 135° models had concentric glenospheres, mean BL 3.8 mm, GOH 6.9 mm, GS 39.7 mm, and distalization 14.1 mm. HS showed the strongest positive correlation with BL in 145° and 135° models (0.65/0.79). Despite reduced GOH in smaller females with a 135° NSA, adduction, external rotation, extension, TNR ROM, and TROM were significantly increased (P = .02, P = .005, P = .005, P = .004, P = .003), abduction however reduced (P = .02). The same trends were seen for males. Conclusion: HS is a practical measure in surgery or preoperatively, and the strong positive correlation with BL is a useful planning aid. Despite reduction of GOH, conversion to a less distalized 135° NSAinlay design is powerful to maintain and even significantly increase all components of TNR ROM (extension/external rotation/adduction) in small females with the drawback of reduced abduction which may however be compensated by scapula motion. Lateralization with a less distalized 135° RSA optimizes muscle length, may facilitate subscapularis repair, and maintains highest rigid body motion.

9.
Econ Hum Biol ; 53: 101371, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38428380

ABSTRACT

The human growth process is influenced not only by genetic factors but also by environmental factors. Therefore, regional differences in mean body heights may exist within a population or a state. In the present study, we described and evaluated the regional trends in mean body heights in the nine Austrian provinces over a period spanning more than four decades. Body height data of 1734569 male conscripts born in Austria with Austrian citizenship between 1961 and 2002 were anonymized and analyzed. From 1961 to 2002 birth cohorts, an overall increase in the mean body height of Austrian recruits was observed, although regional differences were evident. Regions with shorter body heights in the 1961-1963 birth cohorts showed a particularly pronounced increase in mean body heights. Meanwhile, the course of body height growth in the capital city, Vienna, was striking, where the highest body heights were documented for the 1961-1963 birth cohorts. In Vienna, mean body heights continued to decline until the 1984 birth cohort and increased again from the 1988 birth cohorts. In addition to economic factors, increased stress factors in an urban environment and a form of urban penalty are discussed as causes.


Subject(s)
Body Height , Military Personnel , Humans , Austria , Male , Military Personnel/statistics & numerical data , Young Adult , Socioeconomic Factors , Adult
10.
J Cardiothorac Surg ; 19(1): 65, 2024 Feb 06.
Article in English | MEDLINE | ID: mdl-38321519

ABSTRACT

BACKGROUND: Pectus excavatum (PE) is the most common congenital abnormality of the chest wall. Most patients with PE have slim bodies. Some studies have been conducted on the physical growth of children and adolescents who underwent the Nuss procedure. This study aimed to evaluate body measurement changes in adult patients with PE after the Nuss procedure. METHODS: A total of 272 adult PE patients, who underwent the Nuss procedure and pectus bars removal from August 2014 to December 2020, were evaluated retrospectively. Body measurement [body height (BH), body weight (BW), and body mass index (BMI)] of the patients were collected before Nuss repair and after bar removal. We used the interquartile range (IQR) to identify and exclude outliers. Associations between changes in body measurement and clinical and radiological features were evaluated. RESULTS: The BH, BW and BMI showed significantly increased after pectus bar removal, compared to pre-Nuss procedure parameters (BH 173.8 ± 5.9 cm vs. 173.9 ± 5.9 cm, P < 0.001; BW 60.3 ± 8.1 kg vs. 61.1 ± 8.8 kg, P = 0.005; BMI 19.9 ± 2.2 kg/m2 vs. 20.1 ± 2.4 kg/m2, P = 0.02). The same result were observed in the male subgroup, the HI ≥ 4 group and the male subgroup within the HI ≥ 4 group. CONCLUSIONS: The BH, BW and BMI were significantly increased after completing surgical correction of PE using the Nuss procedure, particularly in young males and patients with more pronounced deformities.


Subject(s)
Funnel Chest , Thoracic Wall , Adult , Child , Adolescent , Humans , Male , Funnel Chest/surgery , Retrospective Studies , Thoracic Wall/surgery , Body Mass Index , Body Weight , Treatment Outcome
11.
J Pers Med ; 14(2)2024 Feb 15.
Article in English | MEDLINE | ID: mdl-38392642

ABSTRACT

This study aimed to compare the video laryngoscope views facilitated by curved blades 3 and 4 with an exploration of the relationship between these views and patient height. Conducted as a randomized controlled trial, this study enrolled adults scheduled for surgery under general anesthesia. Intubation procedures were recorded, and the percentage of glottic opening was measured before tube insertion. Multivariate analysis validated the impact of various factors, including blade size and patient height, on the percentage of glottic opening scores. A total of 192 patients were included. The median percentage of glottic opening scores for curved blades 3 and 4 were 100 and 83, respectively (p < 0.001). The unstandardized coefficient indicated a significant negative impact of blade 4 on the percentage of glottic opening scores (-13, p < 0.001). In the locally estimated scatterplot smoothing analysis, blade 3 exhibited a steady rise in glottic opening scores with increasing height, whereas blade 4 showed a peak followed by a decline around 185 cm. The unstandardized coefficient of height showed no significant association (0, p = 0.819). The study observed superior laryngoscopic views with blade 3 compared to blade 4. However, no significant association was found between laryngoscopic views and patient height.

12.
Cureus ; 16(1): e52653, 2024 Jan.
Article in English | MEDLINE | ID: mdl-38380207

ABSTRACT

OBJECTIVE: Although various methods have been identified for the appropriate tibial nail length, there are disadvantages such as extra time, radiation exposure, and additional cost. We aimed to predict the ideal length of the nail according to the patient's height and shoe size in the preoperative period to eliminate these disadvantages. MATERIALS AND METHODS: Between January 2018 and August 2023, the height and shoe size data of 71 patients who were diagnosed with tibial shaft fracture and had tibia intramedullary nail fixation were determined. A linear regression model was applied to the normally distributed data. The correlation coefficient between the variables was evaluated according to the Pearson correlation coefficient. RESULTS: While 1 1-centimeter (cm) increase in patient height causes an increase of 3.2 millimeters (mm) in nail length, it was found that it alone contributed by 89% to predicting the ideal nail length (p<0.001). An increase of 1 unit in shoe size (EU) causes an increase of 9 mm in nail length; its contribution to predicting the ideal nail length alone is 84% (p<0.001). In the evaluation of the patient's height and shoe size together, it was observed that they jointly contributed 91% to the accurate estimation of the nail length (p<0.001). CONCLUSION: It may be risky to determine the tibial nail length only by shoe size or the patient's height. However, the correlation between them is strong. Therefore, by estimating nail lengths before the operation, the ideal nail length can be found by making fewer fluoroscopy checks during the operation.

13.
Taiwan J Obstet Gynecol ; 63(1): 64-67, 2024 Jan.
Article in English | MEDLINE | ID: mdl-38216271

ABSTRACT

OBJECTIVE: Macrosomia is associated with increased risk of fetal and maternal complications such as trauma during birth, cesarean delivery, postpartum hemorrhage, and shoulder dystocia. Sonographic estimation of fetal weight is imprecise particularly in excessively large fetuses, prompting the need for additional measures to assess the feasibility of vaginal delivery of a macrosomic newborn and thus improve prenatal consultation. MATERIALS AND METHODS: This retrospective case-control study included women who delivered a singleton macrosomic newborn (birth weight>4,000 g), either vaginally (N = 762) or by urgent cesarean delivery during labor (N = 109). Using multivariable analysis, we examined correlations of maternal height≥170 cm and shoe size≥40 with successful vaginal delivery. RESULTS: Women who delivered vaginally had lower mean intrapartum BMI (p < 0.001) and lower rate of gestational diabetes (p = 0.003). Women with a shoe size≥40 were 2.2 times more likely to give birth vaginally. Cesarean section rate was 5.9 % among women with height≥170 cm and shoe size≥40; and 16.5 % among women with height<170 cm and shoe size<40. Multivariable analysis, adjusted for gestational diabetes, parity, and BMI, revealed that shoe size≥40 and maternal height≥170 cm correlated with success in vaginal delivery, OR = 3.1 (95%CI 1.3-7.3, p = 0.009). CONCLUSION: Shoe size and maternal height may help predict success of vaginal birth of the macrosomic newborns.


Subject(s)
Cesarean Section , Diabetes, Gestational , Pregnancy , Infant, Newborn , Female , Humans , Birth Weight , Retrospective Studies , Case-Control Studies , Shoes , Delivery, Obstetric , Fetal Macrosomia
14.
Int J Med Sci ; 21(3): 431-438, 2024.
Article in English | MEDLINE | ID: mdl-38250605

ABSTRACT

This prospective observational study investigated the optimal insertion depth of the central venous catheter through the right internal jugular vein using transesophageal echocardiography. After tracheal intubation, the anesthesiologist inserted a probe for esophageal echocardiography into the patient's esophagus. The investigators placed the catheter tip 2 cm above the superior edge of the crista terminalis with echocardiography, which was defined as the optimal point. We measured the inserted length of the catheter. Pearson correlation tests were performed with the measured optimal depth and some patient parameters. We made a new formula for placing the catheter at the optimal position. A total of 89 subjects were enrolled in this trial. The correlation coefficient between the measured optimal depth and the patient's parameters was the highest for patient height (0.703, p < 0.001). We made a new formula of 'height (cm)/10 - 1.5 cm'. The accuracy rate of this formula for the optimal zone was 71.9% (95% confidence interval; 62.4 - 81.4%), which was the highest among the previous formulas or guidelines when we compared. In conclusion, the central venous catheter tip was evaluated with transesophageal echocardiography, and we could make a new formula of 'height (cm)/10 - 1.5', which seemed to be better than other previous guidelines.


Subject(s)
Central Venous Catheters , Humans , Echocardiography , Echocardiography, Transesophageal , Heart Atria , Jugular Veins/diagnostic imaging , Prospective Studies
15.
Clin Genet ; 105(5): 533-542, 2024 05.
Article in English | MEDLINE | ID: mdl-38265109

ABSTRACT

Beckwith-Wiedemann syndrome (BWS) is an epigenetic overgrowth syndrome. Despite its distinctive growth pattern, the detailed growth trajectories of children with BWS remain largely unknown. We retrospectively analyzed 413 anthropometric measurements over an average of 4.4 years of follow-up in 51 children with BWS. We constructed sex-specific percentile curves for height, weight, and head circumference using a generalized additive model for location, scale, and shape. Males with BWS exhibited greater height at all ages evaluated, weight before the age of 10, and head circumference before the age of 9 than those of the general population. Females with BWS showed greater height before the age of 7, weight before the age of 4.5, and head circumference before the age of 7 than those of the general population. At the latest follow-up visit at a mean 8.4 years of age, bone age was significantly higher than chronological age. Compared to paternal uniparental disomy (pUPD), males with imprinting center region 2-loss of methylation (IC2-LOM) had higher standard deviation score (SDS) for height and weight, while females with IC2-LOM showed larger SDS for head circumference. These disease-specific growth charts can serve as valuable tools for clinical monitoring of children with BWS.


Subject(s)
Beckwith-Wiedemann Syndrome , Male , Child , Female , Humans , Beckwith-Wiedemann Syndrome/diagnosis , Beckwith-Wiedemann Syndrome/genetics , DNA Methylation/genetics , Genomic Imprinting , Retrospective Studies , Growth Charts , Growth Disorders , Republic of Korea/epidemiology
16.
J Pediatr (Rio J) ; 100(3): 277-282, 2024.
Article in English | MEDLINE | ID: mdl-38182127

ABSTRACT

OBJECTIVE: To develop growth charts for weight-for-age, height-for-age, and body mass index (BMI)-for-age for both genders aged 2 to 18 years for Brazilian patients with Williams-Beuren Syndrome (WBS). METHODS: This is a multicenter, retrospective, and longitudinal study, data were collected from the medical records of boys and girls with a confirmed diagnosis of WBS in three large university centers in the state of Sao Paulo, Brazil. Growth charts stratified by gender and age in years were developed using LMSchartmaker Pro software. The LMS (Lambda Mu Sigma) method was used to model the charts . The quality of the settings was checked by worm plots. RESULTS: The first Brazilian growth charts for weight-for-age, height-for-age, and BMI-for-age stratified by gender were constructed for WBS patients aged 2 to 18 years. CONCLUSION: The growth charts developed in this study can help to guide family members and to improve the health care offered by health professionals.


Subject(s)
Body Height , Body Mass Index , Body Weight , Growth Charts , Williams Syndrome , Humans , Williams Syndrome/diagnosis , Male , Adolescent , Female , Child, Preschool , Brazil/epidemiology , Child , Body Height/physiology , Retrospective Studies , Longitudinal Studies , Reference Values , Sex Factors , Age Factors
17.
Folia Morphol (Warsz) ; 83(1): 139-145, 2024.
Article in English | MEDLINE | ID: mdl-36703543

ABSTRACT

BACKGROUND: A wealth of research suggests that taller individuals are healthier and live longer than their shorter counterparts, although conflicting results have been reported. This study aims to investigate whether taller individuals in Poland exhibit greater longevity compared to their shorter counterparts. MATERIALS AND METHODS: Data on declared height were collected from 848,860 adults who died in the years 2004-2008 in Poland. To eliminate the cohort effects, Z-values were computed. Pearson's correlation coefficients were calculated independently for males and females. Subsequently, one way ANOVA was performed. RESULTS: The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and r = -0.0038 in women) but significant (p = 0.023 and p = 0.022, respectively). CONCLUSIONS: Despite the significant correlation observed between the two variables, it should be noted that the relationship between height and longevity is very weak and tenuous. Overall, these results do not support the hypothesis that taller individuals have a longevity advantage. Further research is warranted to identify the underlying biological mechanisms driving this phenomenon as well as to explore additional variables affecting human longevity.


Subject(s)
Body Height , Longevity , Male , Adult , Humans , Female , Poland
18.
Clin Rheumatol ; 43(1): 387-392, 2024 Jan.
Article in English | MEDLINE | ID: mdl-37658934

ABSTRACT

INTRODUCTION/OBJECTIVES: This study aimed to evaluate the effect of canakinumab on growth parameters in children with familial Mediterranean fever (FMF). METHOD: We conducted a retrospective analysis of 946 pediatric FMF patients followed in our center, of whom 37 were treated with canakinumab for at least three doses. Patients were assessed for demographic, clinical, and genetic characteristics. Data of height and weight percentiles and Z scores were recorded before and after canakinumab treatment and compared. RESULTS: The study group comprised 37 FMF patients with treated canakinumab. The median age (IQR) at diagnosis and canakinumab initiation was 3.0 (2.0-4.3) years and 7.0 (3.6-10.1) years, respectively. The median weight scores and mean body mass index (BMI) values significantly increased after canakinumab treatment. There was no change in height scores following canakinumab treatment. CONCLUSION: Canakinumab treatment has improved off body weight and BMI parameters of FMF patients by controlling disease activity and inflammation. Key Points • To our knowledge, few studies in the literature evaluate the growth parameters of canakinumab treatment in FMF children. • Canakinumab treatment has been shown to affect body weight and BMI positively. • Long-term studies are needed for its effects on height.


Subject(s)
Familial Mediterranean Fever , Humans , Child , Child, Preschool , Familial Mediterranean Fever/drug therapy , Familial Mediterranean Fever/diagnosis , Colchicine/therapeutic use , Retrospective Studies , Antibodies, Monoclonal/therapeutic use , Treatment Outcome , Body Weight
19.
Rev. Nutr. (Online) ; 37: e230113, 2024. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1559156

ABSTRACT

ABSTRACT Objective Evaluate short stature as a possible explanation for obesity, and identify if consumption of energy, protein, carbohydrate, and lipids were associated to higher risk for obesity in Brazilian adults (20-59 y) living in household food insecurity. Methods Cross-sectional study from 2017/2018 Household Budget Survey (N=28,112). Food insecurity was measured with the Brazilian Household Food Insecurity Measurement Scale. Short stature was used as an indicator of malnutrition at the beginning of life, which characterizes metabolic alterations resulting from the presence of food insecurity (cuts off women ≤149cm; men ≤160cm). Body mass index (kg/m2) was estimated from self-reported weight and body height. The average food intake was estimated from a 24-hr recall. The weighted means and standard error of the food security/insecurity categories were assessed according to height, mean energy intake and protein(g), carbohydrate(g) and lipids(g) intake, stratified by gender and nutritional status. Results Both men and women with obesity and food insecurity had significantly lower average height in comparison with those in food security status (p-value <0.01). The prevalence of obesity 1 (BMI 30-34.9kg/m2) increased significantly with the food insecurity among women. There was a trend towards short stature among obese women from families with food insecurity, as well as lower intake of energy. Among both men and women, the lowest intakes of protein and the highest intake of carbohydrates were observed in the underweight group (BMI <18.5kg/m2). Conclusion In women, the risk of obesity may depend on the metabolic background, since who presents food insecurity and develop obesity have low stature and lower energy intake.


RESUMO Objetivo Avaliar a baixa estatura como possível explicação para a obesidade, e identificar se o consumo de energia, proteína, carboidrato e lipídios esteve associado ao maior risco de obesidade em adultos brasileiros (20-59 anos) que vivem em domicílios em insegurança alimentar domiciliar. Métodos Estudo transversal realizado com dados da Pesquisa de Orçamentos Familiares 2017/2018 (N=28.112). A Insegurança alimentar domiciliar foi medida pela Escala Brasileira de Insegurança Alimentar. A baixa estatura (mulheres ≤149cm; homens ≤160cm) foi utilizada como indicador de alterações metabólicas decorrentes da presença de insegurança alimentar. O índice de massa corporal (kg/m2) foi estimado a partir do peso e altura autorreferidos. A média de ingestão alimentar foi estimada a partir do recordatório de 24 horas. As médias ponderadas e o erro padrão das categorias de segurança/insegurança alimentar foram avaliadas segundo estatura, médias de ingestão energéticas e de proteínas(g), carboidratos(g) e lipídios(g), estratificado por sexo e estado nutricional. Resultados Homens e mulheres com obesidade e insegurança alimentar apresentaram a média de estatura significativamente menor em comparação aqueles com segurança alimentar (p-valor <0,01). A prevalência de obesidade 1 (índice de massa corporal 30-34,9Kg/m2) aumentou significativamente com a insegurança alimentar entre as mulheres. Houve tendência de baixa estatura entre mulheres obesas de famílias com insegurança alimentar, bem como menor ingestão de energia. Entre homens e mulheres, a menor ingestão de proteína e a maior ingestão de carboidratos foram observadas no grupo de baixo peso (índice de massa corporal <18,5Kg/m2). Conclusão Nas mulheres, o risco de obesidade pode depender do metabolismo, pois quem apresenta insegurança alimentar e desenvolve obesidade possui baixa estatura e menor ingestão energética.

20.
BMC Musculoskelet Disord ; 24(1): 958, 2023 Dec 11.
Article in English | MEDLINE | ID: mdl-38082386

ABSTRACT

OBJECTIVES: To investigate how body height and trajectories of height from infancy through childhood and adolescence were associated with spinal pain in pre- and late adolescence. METHODS: This prospective study included 43,765 individuals born into The Danish National Birth Cohort (DNBC) from 1996 to 2003. DNBC-data were linked with health and social data identified from Statistics Denmark registers. Spinal pain was self-reported in both the 11-year- and 18-year follow-up of DNBC and classified according to severity. Body height was measured from birth and onwards and further modelled as distinct developmental height trajectories by using latent growth curve modelling. Associations were estimated by using multinomial logistic regression models. RESULTS: Taller body height in childhood and adolescence was associated with approximately 20% increased likelihood of spinal pain in pre- and late adolescence among girls compared to their peers in the normal height group. For boys, taller body height was associated with spinal pain by late adolescence only. Spinal pain in pre-adolescence almost doubled the likelihood of spinal pain in late adolescence regardless of body height at age 18. Height trajectories confirmed the relationship for girls with the tall individuals being most likely to have spinal pain in both pre- and late adolescence. CONCLUSION: Tall body height during childhood and adolescence predisposes to spinal pain among girls in both pre-and late adolescence, and among boys in late adolescence. Body height is a contributing factor to the pathogenesis of spinal pain in adolescence; however, the mechanisms may be related to growth velocity, but for now uncertain.


Subject(s)
Birth Cohort , Body Height , Male , Female , Humans , Adolescent , Cohort Studies , Prospective Studies , Pain , Denmark/epidemiology , Body Mass Index
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