"Find Me" and "Eat Me" signals: tools to drive phagocytic processes for modulating antitumor immunity.

Phagocytosis, a vital defense mechanism, involves the recognition and elimination of foreign substances by cells. Phagocytes, such as neutrophils and macrophages, rapidly respond to invaders; macrophages are especially important in later stages of the immune response. They detect "find me" signals to locate apoptotic cells and migrate toward them. Apoptotic cells then send "eat me" signals that are recognized by phagocytes via specific receptors. "Find me" and "eat me" signals can be strategically harnessed to modulate antitumor immunity in support of cancer therapy. These signals, such as calreticulin and phosphatidylserine, mediate potent pro-phagocytic effects, thereby promoting the engulfment of dying cells or their remnants by macrophages, neutrophils, and dendritic cells and inducing tumor cell death. This review summarizes the phagocytic "find me" and "eat me" signals, including their concepts, signaling mechanisms, involved ligands, and functions. Furthermore, we delineate the relationships between "find me" and "eat me" signaling molecules and tumors, especially the roles of these molecules in tumor initiation, progression, diagnosis, and patient prognosis. The interplay of these signals with tumor biology is elucidated, and specific approaches to modulate "find me" and "eat me" signals and enhance antitumor immunity are explored. Additionally, novel therapeutic strategies that combine "find me" and "eat me" signals to better bridge innate and adaptive immunity in the treatment of cancer patients are discussed.

The discovery of archaea: from observed anomaly to consequential restructuring of the phylogenetic tree.

Observational and experimental discoveries of new factual entities such as objects, systems, or processes, are major contributors to some advances in the life sciences. Yet, whereas discovery of theories was extensively deliberated by philosophers of science, very little philosophical attention was paid to the discovery of factual entities. This paper examines historical and philosophical aspects of the experimental discovery by Carl Woese of archaea, prokaryotes that comprise one of the three principal domains of the phylogenetic tree. Borrowing Kuhn's terminology, this discovery of a major biological entity was made during a 'normal science' project of building molecular taxonomy for prokaryotes. Unexpectedly, however, an observed anomaly instigated the discovery of archaea. Substantiation of the existence of the new archaeal entity and consequent reconstruction of the phylogenetic tree prompted replacement of a long-held model of a prokarya and eukarya bipartite tree of life by a new model of a tripartite tree comprising of bacteria, archaea, and eukarya. This paper explores the history and philosophical implications of the progression of Woese's project from normal science to anomaly-instigated model-changing discovery. It is also shown that the consequential discoveries of RNA splicing and of ribozymes were similarly prompted by unexpected irregularities during normal science activities. It is thus submitted that some discoveries of factual biological entities are triggered by unforeseen observational or experimental anomalies.

Carl Wernicke of the Wernicke Area: A Historical Review.

The Wernicke area, also known as Brodmann area 22, is located in the posterior segment of the superior temporal gyrus in the dominant hemisphere. Carl Wernicke, a German neurologist, described this area in 1874. The life story of Carl Wernicke, a 19th-century medical genius, remains an inspiration for all neuroscientists even a hundred years later. We outline Wernicke's life story and academic achievements in neurosurgery, neurology, and psychiatry. We explore his remarkable ability to turn his many setbacks into steps forward, his controversial foray into psychiatry, and his wide-ranging set of contributions, including his work on external ventricular drainage for hydrocephalus and encephalopathy; his description of the eponymous Wernicke area; and his field-defining work on aphasia. This historical review attempts to bring to life a seminal figure in the neurosciences, providing an insight into his visionary thought process.

Refractive outcomes of small lenticule extraction (SMILE) Pro® with a 2 MHz femtosecond laser.

PURPOSE: To evaluate the initial visual outcomes of Small Incision Lenticule Extraction (SMILE) Pro® using a 2 MHz femtosecond laser (VisuMax 800, Carl Zeiss Meditec) and to assess the efficacy, safety, predictability, accuracy, and complication rate. METHODS: This retrospective analysis included eyes which underwent the SMILE Pro® procedure using VisuMax 800 femtosecond laser to correct myopia. All surgeries were performed by one surgeon (DB). Follow-up was conducted 3 months postoperatively to evaluate visual outcomes after neuroadaptation, corrected visual acuity (CDVA) and intra- and postoperative complications. RESULTS: One hundred and fifty-two eyes of 82 patients (mean age 31 ± 6 years) results at 3 months are presented. The mean spherical equivalent (SE) was - 4.44 ± 1.86 D preoperatively while -0.24 ± 0.32 D postoperatively. 99% of eyes achieved SE within ± 1.0 D of attempted correction and 91% were within ± 0.5 D. Efficacy index was 0.93 while the safety index was 1. No complications occurred intra- or postoperatively. No eyes lost more than 1 line of their preoperative CDVA. All highly myopic eyes (- 6.25 to - 10.00 D; n = 18) achieved 20/20 at 3 months postoperatively and were within 0.5 D from the attempted SE and no eyes lost more than 1 line of CDVA. CONCLUSION: The SMILE Pro® is a safe, efficient, and predictable procedure for the treatment of myopia and myopic astigmatism, with comparable results of conventional SMILE surgery. High myopic eyes achieve better results than low and moderate myopia. No complications were recorded in our patients.

JAK2, CALR, and MPL Mutation Profiles in Colombian patients with BCR-ABL Negative Myeloproliferative Neoplasms.

Background: Among the chronic myeloproliferative neoplasms (MPNs) not associated with BCR-ABL mutations are polycythemia vera, primary myelofibrosis, and essential thrombocythemia. These diseases are caused by mutations in genes, such as the JAK2, MPL, and CALR genes, which participate in regulating the JAK-STAT signaling pathway. Objective: This study aimed to establish the frequencies of mutations in the JAK2, MPL, and CALR genes in a group of Colombian patients with a negative clinical diagnosis of BCR-ABL chronic myeloproliferative neoplasms. Methods: The JAK2 V617F and MPL W515K mutations and deletions or insertions in exon 9 of the CALR gene were analyzed in 52 Colombian patients with polycythemia vera, primary myelofibrosis, and essential thrombocythemia. Results: The JAK2V617F mutation was carried by 51.9% of the patients, the CALR mutation by 23%, and the MPL mutation by 3.8%; 23% were triple-negative for the mutations analyzed. In these neoplasms, 6 mutation types in CALR were identified, one of which has not been previously reported. Additionally, one patient presented a double mutation in both the CALR and JAK2 genes. Regarding the hematological results for the mutations, significant differences were found in the hemoglobin level, hematocrit level, and platelet count among the three neoplasms. Conclusion: Thus, this study demonstrates the importance of the molecular characterization of the JAK2, CALR and MPL mutations in Colombian patients (the genetic context of which remains unclear in the abovementioned neoplasms) to achieve an accurate diagnosis, a good prognosis, adequate management, and patient survival.

Antecedentes: Entre las neoplasias mieloproliferativas crónicas no asociadas con mutaciones BCR-ABL se encuentran la policitemia vera, la mielofibrosis primaria y la trombocitemia esencial. Estas enfermedades están causadas por mutaciones en genes, como los genes JAK2, MPL y CALR, que participan en la regulación de la vía de señalización JAK-STAT. Objetivo: Establecer las frecuencias de mutaciones en los genes JAK2, MPL y CALR en un grupo de pacientes colombianos con diagnóstico clínico negativo de NMP BCR-ABL. Metodos: Se analizaron las mutaciones y deleciones o inserciones JAK2 V617F y MPL W515K en el exón 9 del gen CALR en 52 pacientes colombianos con policitemia vera, mielofibrosis primaria y trombocitemia esencial. Resultados: La mutación JAK2V617F la portaban el 51.9% de los pacientes, la mutación CALR el 23.0% y la mutación MPL el 3.8%; El 23.0% fueron triple negativos para las mutaciones analizadas. En estas neoplasias se identificaron seis tipos de mutación en CALR, uno de los cuales no ha sido reportado previamente. Además, un paciente presentó una doble mutación tanto en el gen CALR como en el JAK2. En cuanto a los resultados hematológicos para las mutaciones, se encontraron diferencias significativas en el nivel de hemoglobina, el nivel de hematocrito y el recuento de plaquetas entre las tres neoplasias. Conclusiones: Así, este estudio demuestra la importancia de la caracterización molecular de las mutaciones JAK2, CALR y MPL en pacientes colombianos (cuyo contexto genético aún no está claro en las neoplasias antes mencionadas) para lograr un diagnóstico certero, un buen pronóstico, un manejo adecuado y una mejoría del paciente. supervivencia.

Lost in translation: the history of the Ebers Papyrus and Dr. Carl H. von Klein.

While the Ebers Papyrus is understood to be one of the oldest and most complete contemporaneous perspectives on Ancient Egyptian healing practices, nothing has yet been said about the biography of its first English-language translator, Dr. Carl H. von Klein. A German immigrant and surgeon in the American Midwest, von Klein spent twenty-some years meticulously translating and annotating the Papyrus, but ultimately his manuscript was destroyed. In this paper, we examine the societal- and personal-scale forces that thwarted his efforts to transform our understanding of the history of medicine.

The I Ching as a Potential Jungian Application: History and Practice.

Swiss psychiatrist Carl Jung had a lifelong interest in the I Ching after discovering it in 1919. Jung's interest in the I Ching is arguably more practical than purely theoretical or intellectual, and references to I Ching divination appear frequently in his various publications, seminars, letters and clinical practice records. After a few observations on the history of the study of the I Ching in China, the author categorizes Jung's three uses of the I Ching as physical use (to preview future potentials of outer reality), psychological use (to reveal one's psychological state), and psychical approach (to engage with the divine through ""["shen", spiritual agencies]). Finally, the author discusses the current Jungian engagement by demonstrating clinical cases in contemporary times. Some Jungian analysts practise I Ching divination to obtain insights into the physical and psychological state of therapeutic relationships and for personal development. This paper is a historical and critical engagement of the Jungian practice of I Ching divination.

Le psychiatre suisse Carl Jung s'est intéressé tout au long de sa vie au Yi-King après l'avoir découvert en 1919. L'intérêt de Jung pour le Yi-King est sans doute plus pratique que purement théorique ou intellectuel, et des références à la divination avec le Yi-King apparaissent fréquemment dans ses diverses publications, séminaires, lettres et écrits en lien avec la pratique clinique. Après quelques observations sur l'histoire de l'étude du Yi-King en Chine, je classe les trois utilisations du Yi-King par Jung: l'utilisation physique (pour avoir un aperçu des potentiels futurs de la réalité extérieure), l'utilisation psychologique (pour révéler son propre état psychologique) et l'approche psychique (pour s'impliquer avec le divin à travers '神' [Shen, instances spirituelles]). Enfin, je traite de l'engagement jungien actuel en apportant des cas cliniques de l'époque contemporaine. Certains analystes jungiens pratiquent la divination avec le Yi-King pour obtenir des éclairages sur l'état physique et psychologique des relations thérapeutiques et pour le développement personnel. Cet article est un engagement historique et critique de la pratique jungienne de la divination avec le Yi-King.

El psiquiatra suizo Carl Jung se interesó durante toda su vida por el I Ching tras descubrirlo en 1919. Podría decirse que el interés de Jung por el I Ching es más práctico que puramente teórico o intelectual, y las referencias a la adivinación con el I Ching aparecen con frecuencia en sus diversas publicaciones, seminarios, cartas y registros de práctica clínica. Luego de algunas observaciones sobre la historia del estudio del I Ching en China, el autor categoriza los tres usos que Jung daba al I Ching en: uso físico (para prever potenciales futuros de la realidad exterior), uso psicológico (para revelar el propio estado psicológico) y abordaje psíquico (para relacionarse con lo divino a través del "神"["shen", agencias espirituales]). Por último, el autor analiza la utilización Junguiana actual mediante la demostración de casos clínicos en la época contemporánea. Algunos analistas Junguianos practican la adivinación I Ching para obtener información acerca del estado físico y psicológico de las relaciones terapéuticas y para su desarrollo personal. Este artículo es un compromiso histórico y crítico de la práctica Junguiana de la adivinación I Ching.

An Introduction and Brief Overview of Psychoanalysis.

The field of psychology has been shaped by the views and perspectives of Sigmund Freud and his former students: Carl Jung, Alfred Adler, Erik Erikson, and Karen Horney. These psychologists and their respective schools of thought provide distinct views on psychology and influences on personality and psychosocial development. The foundation for psychoanalysis was laid by Freud, his work on the unconscious mind, and his emphasis on early childhood experiences. His students also made substantial contributions that expanded, sharpened, and challenged his theories. This review will begin by highlighting the work of Sigmund Freud; it will then compare his theories with the theories of his students. This review will introduce and bring attention to the most important figures of psychoanalysis and give a brief overview of their theories.

Effects of Prolonged Serum Calcium Suppression during Extracorporeal Cardiopulmonary Resuscitation in Pigs.

Controlled reperfusion by monitoring the blood pressure, blood flow, and specific blood parameters during extracorporeal reperfusion after cardiac arrest has the potential to limit ischemia-reperfusion injury. The intracellular calcium overload as part of the ischemia-reperfusion injury provides the possibility for the injury to be counteracted by the early suppression of serum calcium with the aim of improving survival and the neurological outcome. We investigated the effects of prolonged serum calcium suppression via sodium citrate during extracorporeal resuscitation using the CARL protocol (CARL-controlled automated reperfusion of the whole body) compared to a single-dose approach in a porcine model after prolonged cardiac arrest. A control group (N = 10) was resuscitated after a 20 min cardiac arrest, initially lowering the intravascular calcium with the help of a single dose of sodium citrate as part of the priming solution. Animals in the intervention group (N = 13) received additional sodium citrate for the first 15 min of reperfusion. In the control group, 9/10 (90.0%) animals survived until day 7 and 7/13 (53.8%) survived in the intervention group (p = 0.09). A favorable neurological outcome on day 7 after the cardiac arrest was observed in all the surviving animals using a species-specific neurological deficit score. The coronary perfusion pressure was significantly lower with a tendency towards more cardiac arrhythmias in the intervention group. In conclusion, a prolonged reduction in serum calcium levels over the first 15 min of reperfusion after prolonged cardiac arrest tended to be unfavorable regarding survival and hemodynamic variables compared to a single-dose approach in this animal model.

"Not by a Decree of Fate:" Ellen Richards, Euthenics, and the Environment in the Progressive Era.

In 1904, Ellen Richards introduced "euthenics." By 1912, Lewellys Barker, director of medicine and physician-in-chief at Johns Hopkins Hospital, would tell the New York Times that the "task of eugenics" and the "task of euthenics" was the "Task for the Nation." Alongside the emergence of hereditarian eugenics, where fate was firmly rooted in heredity, this article places euthenics into the same Progressive Era demands for the scientific management over environmental issues like life and labor, health and hygiene, sewage and sanitation. I argue that euthenics not only heralded women as leaders in the quest for what Richards and eugenicists termed "racial improvement," but also aimed to make reforms through environmental and educational changes rather than hereditary interventions. Seeking to recuperate the figure of Ellen Richards in the history of science, I place Richards and her euthenics more into the debate over eugenics rather than over the emergence of home economics. Building on the work of Donald Opitz, Staffan Bergwik, and Brigette Van Tiggelen, this article shows, first, how Richards' career threads the needle between the home and the laboratory as sites of science making, not as separate spheres but as overlapping realms, and helps recover how domestic concerns shaped the focus of the life sciences. Second, this article shows how euthenics shaped eugenics by looking at the writings of American eugenicists Charles Davenport, Paul Popenoe, and David Starr Jordan. Third, the article describes how euthenics took root in new academic departments of domestic science, home economics, and departments child welfare and family life in the 1920 and 1930s, most notably the department of euthenics at the Kansas State Agricultural College from 1926 and the Institute of Euthenics at Vassar College after 1923.

JAK2, CALR, and MPL Mutation Profiles in Colombian patients with BCR-ABL Negative Myeloproliferative Neoplasms

Background: Among the chronic myeloproliferative neoplasms (MPNs) not associated with BCR-ABL mutations are polycythemia vera, primary myelofibrosis, and essential thrombocythemia. These diseases are caused by mutations in genes, such as the JAK2, MPL, and CALR genes, which participate in regulating the JAK-STAT signaling pathway. Objective: This study aimed to establish the frequencies of mutations in the JAK2, MPL, and CALR genes in a group of Colombian patients with a negative clinical diagnosis of BCR-ABL chronic myeloproliferative neoplasms. Methods: The JAK2 V617F and MPL W515K mutations and deletions or insertions in exon 9 of the CALR gene were analyzed in 52 Colombian patients with polycythemia vera, primary myelofibrosis, and essential thrombocythemia. Results: The JAK2V617F mutation was carried by 51.9% of the patients, the CALR mutation by 23%, and the MPL mutation by 3.8%; 23% were triple-negative for the mutations analyzed. In these neoplasms, 6 mutation types in CALR were identified, one of which has not been previously reported. Additionally, one patient presented a double mutation in both the CALR and JAK2 genes. Regarding the hematological results for the mutations, significant differences were found in the hemoglobin level, hematocrit level, and platelet count among the three neoplasms. Conclusion: Thus, this study demonstrates the importance of the molecular characterization of the JAK2, CALR and MPL mutations in Colombian patients (the genetic context of which remains unclear in the abovementioned neoplasms) to achieve an accurate diagnosis, a good prognosis, adequate management, and patient survival.

Antecedentes: Entre las neoplasias mieloproliferativas crónicas no asociadas con mutaciones BCR-ABL se encuentran la policitemia vera, la mielofibrosis primaria y la trombocitemia esencial. Estas enfermedades están causadas por mutaciones en genes, como los genes JAK2, MPL y CALR, que participan en la regulación de la vía de señalización JAK-STAT. Objetivo: Establecer las frecuencias de mutaciones en los genes JAK2, MPL y CALR en un grupo de pacientes colombianos con diagnóstico clínico negativo de NMP BCR-ABL. Metodos: Se analizaron las mutaciones y deleciones o inserciones JAK2 V617F y MPL W515K en el exón 9 del gen CALR en 52 pacientes colombianos con policitemia vera, mielofibrosis primaria y trombocitemia esencial. Resultados: La mutación JAK2V617F la portaban el 51.9% de los pacientes, la mutación CALR el 23.0% y la mutación MPL el 3.8%; El 23.0% fueron triple negativos para las mutaciones analizadas. En estas neoplasias se identificaron seis tipos de mutación en CALR, uno de los cuales no ha sido reportado previamente. Además, un paciente presentó una doble mutación tanto en el gen CALR como en el JAK2. En cuanto a los resultados hematológicos para las mutaciones, se encontraron diferencias significativas en el nivel de hemoglobina, el nivel de hematocrito y el recuento de plaquetas entre las tres neoplasias. Conclusiones: Así, este estudio demuestra la importancia de la caracterización molecular de las mutaciones JAK2, CALR y MPL en pacientes colombianos (cuyo contexto genético aún no está claro en las neoplasias antes mencionadas) para lograr un diagnóstico certero, un buen pronóstico, un manejo adecuado y una mejoría del paciente. supervivencia.

Terapia Centrada na Pessoa e Processo de Reorganização da Autoimagem e Autoestima: Pesquisa-Ação / Person-Centered Therapy and the Reorganizing Self-Image and Self-Esteem Process: Action Research / Terapia No Dirigida y el Proceso de Reorganización de la Autoimagen y la Autoestima: Investigación-Acción

Este artigo objetivou compreender o processo terapêutico proporcionado por uma prática interventiva de curta-duração centrada em pessoas com problemas de autoimagem corporal e autoestima. Seguindo um delineamento metodológico qualitativo, a pesquisa e as intervenções terapêuticas aconteceram sob a influência do desenho de pesquisa-ação. Trabalhou-se com as seguintes etapas: planejamento do processo terapêutico à luz das condições necessárias e suficientes para mudança de personalidade e as fases do processo terapêutico; desenvolvimento da prática de ajuda; monitoramento da ação a partir da supervisão, revisão dos atendimentos e entrevistas semiestruturadas com os participantes; análise fenomenológica empírica dos impactos afetivos da terapia a partir da perspectiva dos clientes atendidos; entendimento disso a partir do referencial rogeriano. Foram elaborados e discutidos os seguintes eixos temáticos relacionados ao processo terapêutico: fatores que levaram à busca por ajuda psicológica e constituíram a atmosfera terapêutica; significação negativa da experiência corporal; significação real da experiência de autoestima em relação ao corpo; mudanças de atitudes em relação à percepção de si e ao autocuidado. Concluiu-se que a terapia centrada na pessoa produziu impactos afetivos significativos que ajudaram esses clientes a lidar com suas experiências de imagem corporal e autoestima.

This article aimed to understand the therapeutic process provided by a short-term interventional practice centered on people with body self-esteem and self-image problems. Following a qualitative methodological design, the research and therapeutic interventions took place under the influence of the action research design. The following stages were used: planning the therapeutic process in light of the necessary and sufficient conditions for personality change and the therapeutic process phases; development of aid practice; action monitoring based on supervision, service review and semi-structured interviews with the participants; empirical phenomenological analysis of the affective impacts of therapy from the perspective of the clients assisted; understanding of this from the Rogerian framework. The following thematic axes related to the therapeutic process were elaborated and discussed: factors that led to the search for psychological help and constituted the therapeutic atmosphere; negative meaning of bodily experience; real meaning of the self-esteem experience in relation to the body; changes in attitudes towards self-perception and self-care. It was concluded that person-centered therapy produces significant affective impacts that helped these clients to deal with their body image and self-esteem experiences.

Este articulo tuvo como objetivo comprender el proceso terapéutico proporcionado por una práctica intervencionista de corta duración centrada en personas con problemas de autoimagen corporal y autoestima. Siguiendo un diseño metodológico cualitativo, la investigación y las intervenciones terapéuticas se desarrollaron bajo la investigación-acción. Se trabajó con los siguientes pasos: planificación del proceso terapéutico a la luz de las condiciones necesarias y suficientes para el cambio de personalidad y las fases del proceso terapéutico; desarrollo de prácticas de ayuda; seguimiento de la acción basado en la supervisión, revisión del servicio y entrevistas semiestructuradas con los participantes; análisis fenomenológico empírico de los impactos afectivos de la terapia desde la perspectiva de los clientes atendidos; comprensión de esto desde el referencial rogeriano. Fueron elaborados los siguientes ejes: factores que llevaron a búsqueda de ayuda psicológica y constituyen una atmósfera terapéutica; significado negativo de la experiencia corporal; significación real de la experiencia de la autoestima en relación con el cuerpo; cambios en las actitudes en relación con la autopercepción y autocuidado. Se concluyó que la terapia centrada en la persona produjo impactos afectivos significativos que ayudaron a estos clientes a lidiar con sus experiencias de imagen corporal y autoestima.

A permanência dos símbolos teriomórficos na arte e na psique / The permanence of sybols in artand in the psyque / La permanencia de los simlolos del teriomorfismo en elarte yen la psique

O artigo trata de símbolos teriomórficos­referidos a animais. A importância que exercem pode ser atestada pela permanência na arte (pinturas parietais até os grafites contemporâneos) e na psique. A perpetuação de símbolos e temas é tratada por estudos como os de Aby Warburg em história da arte, com as noções de Kulturgeschichte, Pathosformele Mnemosyne: a recorrência de temas, emoções e comportamentos revela a perpetuação de símbolos interligados à cultura. Essa recorrência simbólica, em termos psíquicos é entendida por C.G. Jung mediante as noções de arquétipo e inconsciente coletivo. Autores contemporâneos a Warburg e a Jung e seus respectivos conceitos, bem como a apresentação de algumas obras de arte, ilustram a importância dos símbolos teriomórficos .Aventa-se a hipótese de que seja uma necessidade psíquica de reunir a natureza biológica, sua força desejante instintiva com a esfera da mente e do sentido de ser constantemente renovada (AU).

Teriomorphicsymbols refer to animals. The importance they exercise can be demonstrated by the permanence of these symbols both in art (parietal paintings to contemporary graffiti) and in the psyche. The perpetuation of symbols and themes is dealt with by studies suchas those by Aby Warburg in art history: Kulturgeschichte, Pathosformel and Mnemosyne. The recurrence of themes, emotions and behaviors reveals the perpetuation of symbols intertwined with culture. This symbolic recurrence, in psychic terms, is understood by C.G. Jung through the notions of archetype and collective unconscious. Contemporary authors of Warburg and Jungand their respective concepts, as well as the presentation of some works of artillustratethe importance of teriomorphic symbols. It is hypothesized that it is a psychic need to unite the biological nature, its instinctive desiring force with the sphere of the mind and the sense of being constantly renewed (AU).

Los símbolos teriomorfosse refieren a los animales. La importancia que ejercen puede ser atestiguada por su permanencia en el arte (pinturas parietales hasta grafitis contemporáneos) y en la psiquis. La perpetuación de símbolos y temas es abordada por estudios como los de Aby Warburg en historia del arte: Kulturgeschichte, Pathosformel y Mnemosyne: la recurrencia de temas, emociones y comportamientos revela la perpetuación de símbolos entrelazados con la cultura. Esta recurrencia simbólica, en términos psíquicos, es comprendida por C.G. por Jung a través de las nociones de arquetipo e inconsciente colectivo. Autores contemporáneos de Warburg y Jungy sus respectivos conceptos,así como la presentación de algunas obras de arte, ilustran la importancia de los símbolos teriomorfos. Se plantea la hipótesis de que se trata de una necesidad psíquica de unir la naturaleza biológica, su fuerza instintiva deseante con la esfera de la mente y el sentido de renovarse constantemente (AU).

The State of Exception Between Schmitt and Agamben: On Topographies of Exceptionalism and the Constitutionality of COVID Quarantine Measures (with Examples from the Irish Context).

According to political philosopher Carl Schmitt (1888-1985), the emergency or State of Exception (Ausnahmezustand) is the ultimate test of political power and reveals in whom that power is vested. The State of Exception determines who is truly sovereign in a given state. Schmitt defines the sovereign act as a decision on the question of the exception, and further classifies sovereignty as a liminal term, a borderline concept (Grenzbegriff), suggesting a geometric metaphoricity underlying his conceptualization. On this theoretical basis, he develops the concept of decisionism, whereby the actual content or "what" of a decision is not the germane element, but rather the "who" of the decision and whether a given "who" (or decider) is the proper authority and possessor of the necessary sovereignty. This political philosophy is usually read in (and arguably tainted) by the immediate historical context in which it was conceived, namely 1930s Germany and the rise of National Socialism. Nevertheless, it has been reinvigorated recently as a paradigm used to explain government decisions taken under evolving COVID-19 pandemic conditions. The current use of Schmitt to understand the suspension of the normal order of things coincides with intense controversy about the work of one of his arch-critics-the surprising hero of the anti-lockdown anti-vaccination movement, Italian philosopher, Giorgio Agamben (1942 - ). The COVID State of Exception will be situated here between the competing philosophies of Schmitt and Agamben, with illustrative examples from, amongst other things, challenges to the Irish Constitution under pandemic conditions, in an attempt to reveal the rhetorical constructions of exceptionalism at work in political theory.

A permanência dos símbolos teriomórficos na arte e na psique / The permanence of teriomorphic symbols in art and in the psyche / La permanencia de los simbolos del teriomorfismo en el arte y en la psique

O artigo trata de símbolos teriomórficos referidos a animais. A importância que exercem pode ser atestada pela permanência na arte (pinturas parietais até os grafites contemporâneos) e na psique. A perpetuação de símbolos e temas é tratada por estudos como os de Aby Warburg em história da arte, com as noções de Kulturgeschichte, Pathosformele Mnemosyne: a recorrência de temas, emoções e comportamentos revela a perpetuação de símbolos interligados à cultura. Essa recorrência simbólica, em termos psíquicos é entendida por C.G. Jung mediante as noções de arquétipo e inconsciente coletivo. Autores contemporâneos a Warburg e a Jung e seus respectivos conceitos, bem como a apresentação de algumas obras de arte, ilustram a importância dos símbolos teriomórficos.Aventa-se a hipótese de que seja uma necessidade psíquica de reunir a natureza biológica, sua força desejante instintiva com a esfera da mente e do sentido de ser constantemente renovada (AU).

Teriomorphicsymbols refer to animals. The importance they exercise can be demonstrated by the permanence of these symbols both in art (parietal paintings to contemporary graffiti) and in the psyche. The perpetuation of symbols and themes is dealt with by studies suchas those by Aby Warburg in art history: Kulturgeschichte, Pathosformel and Mnemosyne. The recurrence of themes, emotions and behaviors reveals the perpetuation of symbols intertwined with culture. This symbolic recurrence, in psychic terms, is understood by C.G. Jung through the notions of archetype and collective unconscious. Contemporary authors of Warburg and Jungand their respective concepts, as well as the presentation of some works of artillustratethe importance of teriomorphic symbols. It is hypothesized that it is a psychic need to unite the biological nature, its instinctive desiring force with the sphere of the mind and the sense of being constantly renewed (AU).

Los símbolos teriomorfosse refieren a los animales. La importancia que ejercen puede ser atestiguada por su permanencia en el arte (pinturas parietales hasta grafitis contemporáneos) y en la psiquis. La perpetuación de símbolos y temas es abordada por estudios como los de Aby Warburg en historia del arte: Kulturgeschichte, Pathosformel y Mnemosyne: la recurrencia de temas, emociones y comportamientos revela la perpetuación de símbolos entrelazados con la cultura. Esta recurrencia simbólica, en términos psíquicos, es comprendida por C.G. por Jung a través de las nociones de arquetipo e inconsciente colectivo. Autores contemporáneos de Warburg y Jungy sus respectivos conceptos,así como la presentación de algunas obras de arte, ilustran la importancia de los símbolos teriomorfos. Se plantea la hipótesis de que se trata de una necesidad psíquica de unir la naturaleza biológica, su fuerza instintiva deseante con la esfera de la mente y el sentido de renovarse constantemente (AU).

Immunohistochemical analyses of paraffin-embedded sections after primary surgery or trimodality treatment in esophageal carcinoma.

Background: The microscopic tumor extension before, during or after radiochemotherapy (RCHT) and its correlation with the tumor microenvironment (TME) are presently unknown. This information is, however, crucial in the era of image-guided, adaptive high-precision photon or particle therapy. Materials and methods: In this pilot study, we analyzed formalin-fixed paraffin-embedded (FFPE) tumor resection specimen from patients with histologically confirmed squamous cell carcinoma (SCC; n = 10) or adenocarcinoma (A; n = 10) of the esophagus, having undergone neoadjuvant radiochemotherapy followed by resection (NRCHT + R) or resection (R)]. FFPE tissue sections were analyzed by immunohistochemistry regarding tumor hypoxia (HIF-1α), proliferation (Ki67), immune status (PD1), cancer cell stemness (CXCR4), and p53 mutation status. Marker expression in HIF-1α subvolumes was part of a sub-analysis. Statistical analyses were performed using one-sided Mann-Whitney tests and Bland-Altman analysis. Results: In both SCC and AC patients, the overall percentages of positive tumor cells among the five TME markers, namely HIF-1α, Ki67, p53, CXCR4 and PD1 after NRCHT were lower than in the R cohort. However, only PD1 in SCC and Ki67 in AC showed significant association (Ki67: p = 0.03, PD1: p = 0.02). In the sub-analysis of hypoxic subvolumes among the AC patients, the percentage of positive tumor cells within hypoxic regions were statistically significantly lower in the NRCHT than in the R cohort across all the markers except for PD1. Conclusion: In this pilot study, we showed changes in the TME induced by NRCHT in both SCC and AC. These findings will be correlated with microscopic tumor extension measurements in a subsequent cohort of patients.

The analytic methods of Groddeck and Jung in light of the philosophy of nature.

The philosophy of nature as Jung's background has been overlooked, despite its relevance for understanding the roots of analytical psychology. The German psychoanalyst Georg Groddeck shared such a background, so that a comparison is possible between his clinical view and Jung's. It is shown that natural philosophers Paracelsus, Johann von Goethe and Carl Gustav Carus had a major impact on Jung and Groddeck. Both of the latter followed Carus's theory of a creative, superindividual, and compensatory unconscious - continuing the Naturphilosophie tradition and rejecting reductionist biophysical medicine. Groddeck and Jung's holistic perspective led them to advocate natural healing, face-to-face dialectical analysis, and the uniqueness of each treatment. Thus, they were against using techniques, and instead established general methods for analytic therapy. Groddeck's thinking was closer to Jung's than to Freud's in both theory and practice. Therefore, two alternative strands should be considered within psychoanalysis: Freud's classical drive theory and Groddeck's underground two-person psychology. Thereby, Jung's analytic descendants and the relational psychoanalysts who stemmed from Groddeck's ideas could be regarded as 'cousins' due to the similarities arising from their common origin in the philosophy of nature.

La philosophie de la nature en tant que contexte pour Jung n'a pas été suffisamment prise en compte, alors qu'elle est incontournable pour comprendre les racines de la psychologie analytique. Le psychanalyste allemand Georg Groddeck partageait cet intérêt, et ainsi une comparaison est possible entre ses perspectives cliniques et celles de Jung. Il est montré que les philosophes de la nature, tels Paracelse, Johann von Goethe et Carl Gustav Carus, ont eu un impact considérable sur Jung et Groddeck. Ces deux derniers ont suivi la théorie de Carus d'un inconscient créatif, super-individuel et compensatoire, qui est dans la droite ligne de la tradition de la Naturphilosophie et rejette la médecine biophysique réductionniste. Les perspectives holistiques de Groddeck et de Jung les conduisirent à se faire les avocats de la guérison naturelle, de l'analyse dialectique en face à face et de la singularité de chaque cure. Ainsi, ils étaient opposés à l'utilisation de techniques, et au lieu de cela ils établirent plutôt des méthodes générales pour la thérapie analytique. La pensée de Groddeck était plus proche de celle de Jung que de celle de Freud, à la fois en théorie et en pratique. Ainsi, deux courants alternatifs devraient être pris en compte dans la psychanalyse: la théorie freudienne classique des pulsions et la psychologie « avant-garde ¼ à deux personnes. Ainsi, les descendants analytiques de Jung et les psychanalystes relationnels issus des idées de Groddeck pourraient être considérés comme 'cousins' du fait des similarités qui proviennent de leur origine commune dans la philosophie de la nature.

La filosofía de la naturaleza como antecedente en Jung ha sido subestimado, a pesar de su relevancia para la comprensión de las raíces de la psicología analítica. El psicoanalista alemán George Groddeck compartió dichos antecedentes, por lo cual es posible la comparación entre su perspectiva clínica y la de Jung. Se ha demostrado que los filósofos naturales Paracelso, Johan von Goethe, y Carl Gustav Carus han tenido un impacto importante en Jung y en Groddeck. Ambos han sido seguidores de la teoría de Carus de un inconsciente creativo, supraindividual y compensatorio - continuando con la tradición de la Naturphilosophie y rechazando a la medicina reduccionista y biofísica. Las perspectivas holísticas de Groddeck y Jung los condujeron a promover la sanación natural, el análisis dialéctico cara-a-cara y la singularidad de cada tratamiento. Así, ellos estaban en contra de usar técnicas, y en cambio establecieron métodos generales para la terapia analítica. El pensamiento de Groddeck fue más cercano a Jung que a Freud tanto en la teoría como en la práctica. De este modo, dos líneas de pensamiento alternativas deberían ser consideradas al interior del psicoanálisis: teoría clásica de las pulsiones de Freud, y la psicología de dos-personas de Groddeck. Por lo tanto, los descendientes analíticos de Jung y los psicoanalistas relacionales quienes surgen a partir de las ideas de Groddeck podrían ser considerados como 'primos' debido a las similitudes que emergen a partir de su origen común en la filosofía de la naturaleza.

A cartografia da psique: Jung e seu anagrama misterioso / Cartography of the Psyche: Jung and his mysterious anagram / La cartografía de la psique: Jung y su misterioso anagrama

Em 1916, Jung escreveu Sete Sermões aos Mortos e criou a mandala Systema Munditotius que, em conjunto, caracterizam-se como um mito gnóstico da criação. Os Sermões terminam com um anagrama que permaneceu sem resposta por mais de cem anos. Este artigo apresenta uma hipótese para decifrar esse enigma, buscando pistas na própria obra junguiana, enfatizando a importância da fantasia para a pesquisa teórica. Lendo com atenção, os Sermões e outras obras do mesmo período, os escritos posteriores e obtendo informações de seus comentadores, foi possível trazer respostas inusitadas ao desafio. O mistério de Jung reafirma sua busca ao longo da vida: a comunicação entre consciência e inconsciente. A partir de uma investigação sobre a influência da gnose, dos números e das coordenadas geográficas em sua obra, foi possível apreender respostas simbólicas, onde se representa a união dos opostos do psiquismo.

In 1916, Jung wrote Seven Sermons to the Dead and created the mandala Systema Munditotius which, taken together, are characterized as a gnostic creation myth. The Sermons end with an anagram that remained unanswered for over a hundred years. This article presents a hypothesis to decipher this enigma, looking for clues in the Jungian work itself, emphasizing the importance of fantasy for theoretical research. Reading carefully, the Sermons and other works from the same period, his late writings and getting information from his commentators, it was possible to bring up unusual answers to the challenge. Jung's mystery reaffirms his lifelong quest: the communication between ego and unconscious. From an investigation on the influence of gnosis, numbers and geographic coordinates in his work, it was possible to grasp symbolic answers, where the union of opposites of the psyche is represented.

En 1916, Jung escribió Siete Sermones a los Muertos, y creó la mandala Systema Munditotius, que en su conjunto se caracterizan como un mito gnóstico de la creación. Los Sermones terminan con un anagrama que permaneció sin respuesta durante más de cien años. Este artículo presenta una hipótesis para descifrar este enigma, buscando pistas en la propia obra junguiana, enfatizando la importancia de la fantasía para la investigación teórica. Mediante la lectura cuidadosa de los Sermones y otras obras del mismo período, sus escritos posteriores y la obtención de información de sus comentaristas, fue posible aportar respuestas inusuales al desafío. El misterio de Jung reafirma su búsqueda de toda la vida: la comunicación entre la conciencia y el inconsciente. A partir de una investigación sobre la influencia de la gnosis, los números y las coordenadas geográficas en su obra, fue posible aprehender respuestas simbólicas, donde se representa la unión de los opuestos de la psique.

Proposição de um modelo de pesquisa-ação para aprimorar práticas humanistas centradas na pessoa: apontamentos metodológicos / Proposition of an action-research model to improve person-centered humanistic practices: methodological appointments

Este artigo objetiva propor um modelo de pesquisa-ação para aprimorar práticas individuais, educacionais e grupais norteadas pelo referencial da Psicologia Humanista de Carl Rogers. Inicialmente, apresenta as pesquisas desenvolvidas por ele durante a construção do seu método interventivo, segundo um delineamento quase-experimental. Posteriormente, demonstra como Rogers contatou a ideia de pesquisa-ação elaborada por Kurt Lewin e indicou o paradigma fenomenológico e sua metodologia empírica como recursos qualitativos para desenvolver a Psicologia Humanista. Depois, apresenta em que consiste a pesquisa-ação. Em seguida, demonstra como tratar um objeto de estudo e intervenção no referencial rogeriano, organizando-o em um ciclo de pesquisa e ação mediante as etapas de: registro de ideias, teorias e conceitos; planejamento da ação; intervenção; monitoramento da ação com base na Versão de Sentido concebida por Mauro Amatuzzi; e avaliação da ação conforme o método fenomenológico empírico de Amedeo Giorgi. Esse modelo segue critérios metodológicos os quais possibilitam avanços na abordagem rogeriana, na medida em que investiga as implicações das práticas humanistas com certos tipos de experiências e as desenvolve quando necessário.

This article aims to propose an action-research model to improve individual, educational and group practices guided by the framework of Carl Rogers' Humanistic Psychology. Initially, it presents the research developed by Rogers during the construction of his interventionist method, according to a quasi-experimental design. Subsequently, we demonstrate how Rogers contacted the idea of action research developed by Kurt Lewin and indicated the phenomenological paradigm and its empirical methodology as qualitative resources to develop Humanistic Psychology. After that, we present what the action-research consists of. Finally, we demonstrate how to treat a study object and intervention in a Rogerian referential, organizing it in a cycle of research and action through the stages of the recording of ideas, theories, and concepts; action planning; intervention; action monitoring based on the Sense Version designed by Mauro Amatuzzi; and action evaluation according to the Amedeo Giogi's empirical phenomenological method. We conclude that this model follows methodological criteria, which enable advances in the Rogerian approach insofar as it investigates humanistic practices' implications with certain types of experiences and develops them when necessary.

L-Carnitine effect on induced hyperlipidemia on premature rats: fertility profile.

This study was designed to investigate the effect of hypercholesterolemia on the reproductive performance of premature male rats and to evaluate the influence of L-Carnitine (CAR) in maintaining their fertility. Sixty rats were divided randomly into three groups. Control group (CG n=20 rats), cholesterol feeding group 1 (CFG1 n=20 rats) fed 1.5% cholesterol with diet for one month, and cholesterol feeding group 2 (CFG2 n=20 rats) fed 1.5% cholesterol with diet + CAR 150 mg/kg body weight (B.W.) given by water for one month. Results showed a significant increase in body weight of CFG1 compared with CG and CFG2. The lipid profile of CFG1 after one month of feeding cholesterol showed a significant increase in serum cholesterol and triglyceride compared with CG and with the group that watered by CAR and CFG2. Results of sperms parameters in CGF2 showed a significant increase in sperms count with sperms live percentage and a significant decrease in sperms abnormalities percentage compared with CGF1 and CG. The hormonal profile showed a significant decrease in serum testosterone levels in rats from CFG1 compared with CFG2 and CG. In conclusion, CAR is a powerful antioxidant that can maintain the parameters of sperms of hypercholesterolemic premature rats, which may enhance the fertilizing ability of subfertile rats that may occur due to hyperlipidemia.