ABSTRACT
Neuroimmunological anti-inflammation is one of the most successful areas of translational medicine in the past 50 years, leading directly to the success of anti-TNF biologics and vagal nerve stimulation therapy for anti-inflammation. The latter has many similarities with traditional acupuncture therapy and further research may reveal more intertwining and enlightenment to acupuncture. This paper briefly reviews the discovery and translational process of Cachectin/TNF, anti-TNF therapy, neural inflammatory reflex arc, vagus nerve stimulation therapy, and Stimulating Peripheral Activity to Relieve Condition (SPARC) project, and also summarizes the experience and lessons learned from the path of translational medicine in this field. The two key steps in the translational process are discussed in details. The purpose is to provide reference for the development of translational medicine in acupuncture. "Minimal injury with significant healing" should be considered as the principal hypothesis to further study the biological mechanism of acupuncture and it may result in more clinical translation in the future.
Subject(s)
Acupuncture Therapy , Acupuncture , Translational Science, Biomedical , Tumor Necrosis Factor Inhibitors , Tumor Necrosis Factor-alpha , Anti-Inflammatory AgentsABSTRACT
Se presenta una revision de la literatura sobre el Factor de Necrosis de los Tumores o Caquectina, con base en articulos publicados durante los anos 1986-1987, haciendo hincapie en las diferencias funcionales y moleculares entre el FNT Alfa, la Linfotoxina o FNT Beta y la caquectina. Se enfatizan los mecanismos del shock, de la necrosis tumoral y de la caquexia; se indican las propiedades antitumorales del FNT in vivo e in vitro y se esbozan esquemas terapeuticos experimentales que permiten colegir que el FNT tendra un papel importante en la inmunoterapia del cancer en el hombre
This is a review of the 1986-1987 Literature on the Tumor Necrosis Factor (TNF) or Cachectin, emphasizing functional and molecular differences among TNF alpha, Iymphotoxin or TNF beta and Cachectin. Mechanisms of shock, tumor necrosis and cachexia are discussed. In vivo and in vitro antitumoral properties of TNF are indicated, as well as some experimental therapeutic regimens. These facts allow the suggestion that TNF might become an important aid for Immunotherapy of cancer in humans.
