Eventos adversos del nimotuzumab en pacientes con tumor cerebral primario / Adverse events to the nimotuzumab in patients with primary cerebral tumor

Introducción: El nimotuzumab es un anticuerpo monoclonal empleado en el tratamiento de pacientes con tumor cerebral. Dada su novedad se justifica la realización de estudios de farmacovigilancia que avalen su seguridad. Objetivo: Caracterizar los eventos adversos relacionados con este medicamento en la práctica médica habitual. Métodos: Se realizó un estudio descriptivo y transversal de 41 pacientes con tumor cerebral primario tratados con nimotuzumab en el Departamento de Ensayos Clínicos del Hospital Provincial Docente Saturnino Lora Torres de Santiago de Cuba, desde mayo de 2017 hasta abril de 2019. Resultados: En la serie se identificaron 31 eventos adversos, de los cuales 17 eran conocidos y 14 desconocidos. Predominaron la cefalea (80,5 %), la debilidad en miembros inferiores (48,8 %) y la fosfatasa alcalina elevada (41,5 %). Cabe destacar que el total de los efectos no deseados se consideraron ligeros, según su intensidad; reversibles, según sus resultados y sin cambios, según la actitud respecto al medicamento. Conclusiones: Las características de los eventos adversos encontrados se asemejan a las descritas en otros estudios que también avalan la seguridad del fármaco.

Introduction: The nimotuzumab is a monoclonal antibody used in the treatment of patients with cerebral tumor. The realization of pharmaco surveillance studies that guaranteed its security is justified given its new features. Objective: To characterize the adverse events related to this medicine in the habitual medical practice. Methods: A descriptive and cross-sectional study of 41 patients with primary cerebral tumor treated with nimotuzumab in the Clinical Trial Department of Saturnino Lora Torres Teaching Provincial Hospital was carried out in Santiago de Cuba, from May, 2017 to April, 2019. Results: In the series 31 adverse events were identified, of which 17 were known and 14 were unknown. There was a prevalence of the headache (80.5 %), weakness in lower members (48.8 %) and the high alcaline phosphatase (41.5 %). It is necessary to highlight that all the non wanted effects were considered light according to the intensity; reversible, according to the results and without changes, according to the attitude regarding the medicine. Conclusions: The characteristics of the adverse events that were found resemble to those described in other studies that also guarantee the security of the drug.

Colloid cyst of the third ventricle: imaging findings with pathologic correlation

Colloid cysts of the third ventricle are benign tumors but potentially dangerous, as they frequentlyundergo undiagnosed. Despite being histologically benign, colloid cysts of the third ventricle can obstruct the foramen of Monro and produce intense hydrocephaly. These lesions are known as a major cause of sudden death, underscoring the importance of establishing diagnosis as soon as possible. Computed tomography and Magnetic Resonance are important for diagnosing these cysts. In the present case report, the authors describe the clinical, diagnostic imaging and pathological findings of a 19-year old male, with a 3 cm colloid cyst of the third ventricle. Patient died within few days following complications of obstruction of the foramen of Monro

Resección de lesiones cerebrales en area rolándica con mapeo cortical intraoperatorio* / Resection of brain lesions in rolandic area with intraoperative cortical mapping

Objetivo. Describir los resultados obtenidos con el mapeo cortical intraoperatorio en el tratamiento de los tumores rolándicos. Método. El estudio se realizó en 27 pacientes (mayo 2000 - mayo 2005) entre 27 y 78 años (16M-11F) con tumores intracraneanos ubicados en el área central. En todos los casos se efectuaron técnicas de localización funcional y se utilizaron potenciales evocados somatosensitivos intraoperatorios y estimulación cortical bipolar. Resultados. La resección fue total en 24 casos y subtotal en 3 casos. En los 23 pacientes que presentaban algún déficit motor previo a la cirugía se logró la mejoría en 17 de ellos, permaneciendo estables 5 y sólo 1 caso padeció un empeoramiento transitorio. Ningún paciente sin déficit previo lo padeció después. No se registraron complicaciones relacionadas con el procedimiento de localización. Conclusión. El mapeo cortical intraoperatorio es una técnica segura y confiable para la preservación de la corteza elocuente en la cirugía de tumores del área rolándica.

Objective: To describe the results obtained with intraoperative cortical mapping in the surgical treatment of rolandic tumors. Method: We studied 27 patients (may 2000-may 2005) between 27 and 78 years old (16 males-11 females) with intracranial tumors located in the rolandic area. In all cases we used techniques of functional localization and, intraoperative somatosensorial evoked potentials and bipolar cortical stimulation. Results: In 24 cases removal was total and in 3 cases was subtotal. Of the 23 cases with preoperative motor symptoms, postoperatively 17 were improved, 5 remained stable and 1 deteriorated transiently. No patient without preoperative deficits was worst. We did not have complications related to the localization procedure. Conclusion: Intraoperative cortical mapping is a safe and sound technique for the preservation of the eloquent cortex during surgery of rolandic tumors.