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Objective To evaluate the value of bedside ultrasound-measured antral cross-sectional area (CSA) in diagnosing an empty stomach in patients with chronic hepatitis B.Methods One hundred and fifty-nine patients with chronic hepatitis B,aged 18-64 yr,with body height＞150 cm,weighing 45-110 kg,were enrolled in this study.The antero-posterior diameter and craniocaudal diameter of the gastric antrumn were measured by bedside ultrasound when patients were in the supine position,and CSA was calculated.Gastroscope negative pressure was used to suction fluid from stomach at the end of gastroscopy,and the fluid volume was recorded,and gastric fluid volume ≤0.8 ml/kg was defined as the standard for empty stomach.Results The cut-off value of CSA measured by bedside ultrasound in diagnosing an empty stomach was 440 mm2,with sensitivity 85.07％,specificity 80.95％,positive predictive value 96.61％,negative predictive value 45.95％,coincidence rate 84.52％.Conclusion The cut-off value of bedside ultrasound-measured CSA in diagnosing an empty stomach is 440 mm2 for the patients with chronic hepatitis B.
ABSTRACT
Objective To summarize and analyze related examinations of chronic hepatitis B so as to find out the best detection method,which could also improve the diagnostic accuracy rate of chronic hepatitis B.Methods The clinical material of 238 patients with chronic hepatitis B (liver disease group) from March 2012 to November 2013 were studied by using the regression analysis,and meanwhile 238 cases of normal healthy people were selected as control group,the two groups' blood routine,routine biochemical indicators and new biochemical indexes were carefully studied and analyzed,and the positive rates and accuracy of using the biochemical indexes to diagnose chronic hepatitis B were also studied.Results The leukocyte count,neutrophil count and platelet count in liver disease group were respectively (5.10 ± 1.79) ×109/L,0.558 4 ± 0.123 2 and(101.38 ± 79.55) × 109/L,which were all significant lower than those in control group[(6.83 ± 1.45) × 109/L,0.617 8 ± 0.090 1 and (172.29 ± 43.22) × 109/L (P＜ 0.05),and lymph cells were 0.367 7 ± 0.121 0 which were significantly more than that in control group (0.303 9 ± 0.064 5) (P ＜ 0.05).The total bilimbin and alanine aminotransferase in liver disease group were (22.47 ± 7.28)μ mol/Land (97.01 ± 14.18) U/L which were significantly higher than those in control group (15.88 ± 5.19) μ mol/Land (29.87 ± 9.16) U/L (P＜ 0.05),while the albumin,albumin and globubin ratio were significantly lower than that in control group [(38.28 ± 5.77) g/L vs.(45.23 ± 2.34) g/L,1.32 ± 0.21 vs.1.59 ± 0.23] (P ＜0.05) ; adenosine deaminase,5'-nudeotidase,total bile acid,leucine aminopeptidase in liver disease group were significantly higher than that in control group [(24.30 ± 13.12) U/L vs.(9.21 ±2.72) U/L,(12.82 ±12.21) U/L vs.(5.22 ±2.39)U/L,(61.28 ±30.09) mol/L vs.(5.70 ±2.78) mol/L,(64.80 ± 19.21) U/L vs.(41.23 ± 11.32) U/L] (P ＜ 0.05),while transferrin and prealbumin (PA) were significantly lower than that in control group [(17.43 ±8.23) μmol/L vs.(32.44 ±6.90) μmol/L,(123.28 ± 22.31) mg/L vs.(324.20 ± 34.88) mg/L] (P ＜ 0.05); PA and ADA's positive rates were 91.7％and 82.3％ respectively,and the areas under the curve of the two groups were 0.92 and 0.95 respectively.Conclusions It is probably of great help and reference for doctors to accurately assess the liver functions,diagnose and treat chronic hepatitis B patients that using blood routine examinations and the conventional biochemical indexes.
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Objective:In order to explore the AICD happening in PBMC and the situation of peripheral blood lymphocyte subsets in chronic/ chronic severe hepatitis B Methods:The peripheral blood mononuclear cells of patients with chronic /chronic severe hepatitis B were cultured with PHA P for 72 h Then the apoptosis of PBMC was assayed by flow cytometry The peripheral blood lymphocyte subsets of patients with chronic /chronic severe hepatitis B were assayed by flow cytometry and automatic blood analyzer Results:The percentage of apoptotic PBMC in chronic hepatitis B group was higher than that in chronic severe hepatitis B group(P
