1.
Chinese Traditional and Herbal Drugs
; (24): 1262-1264, 2014.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-854585
ABSTRACT
Objective: To study the effects of physical properties and technological factors of Chinese matiria medica powder on the quality of the tablet, and to optimize the direct compression tableting technology. Methods: Using Chuanshenfang extract as a model drug, uniform design was applied to optimizing the direct compression tableting process. Results: Tablet quality was affected by pressure, particle size, and water content. The optimal process parameters were pressure of 1300 kg, particle size of 125 μm, and water content of 4.5%. Conclusion: The direct compression tableting process could be predicted and adjusted according to the physical properties of powders so that the quality stability and homogeneity of tablet are ensured.