ABSTRACT
Background: Infectious canine hepatitis (ICH) is a systemic viral disease of dogs. It affects mainly unvaccinated dogs under the age of six months. Although clinical signs of ICH are not specific, the necropsy findings are sufficient to allow a presumptive diagnosis associated with epidemiology and clinical signs. Clinician should suspect the disease when two years-old dogs or younger present acute death with abdominal pain, neurological disorders and signs of bleeding. The objective of this study is to report an unusual case of ICH, describing the clinical and pathological findings in a geriatric dog with the disease. Case: A female Basset Hound dog, 9 year-old, was presented with intense vomiting and diarrhea in the last day. The animal was not vaccinated there was two years. The blood count revealed moderate leukocytosis by neutrophils and deviation to the left and to the right, and monocytosis, besides lymphopenia and eosinopenia. It was also possible to observe hyperproteinemia and plasma intensely jaundiced. The biochemical examination showed alterations in liver and kidney parameters. After three days of hospitalization, the patient was euthanized and submitted for necropsy. Macroscopic findings consisted of increased dark red liver, and fibrin strands in the capsular surface. There was a bloody fluid in the small intestine and stomach. Serous small intestine showed...(AU)
Subject(s)
Animals , Dogs , Hepatitis, Infectious Canine , Adenoviruses, Canine , Liver/pathology , Kidney/pathologyABSTRACT
Background: Infectious canine hepatitis (ICH) is a systemic viral disease of dogs. It affects mainly unvaccinated dogs under the age of six months. Although clinical signs of ICH are not specific, the necropsy findings are sufficient to allow a presumptive diagnosis associated with epidemiology and clinical signs. Clinician should suspect the disease when two years-old dogs or younger present acute death with abdominal pain, neurological disorders and signs of bleeding. The objective of this study is to report an unusual case of ICH, describing the clinical and pathological findings in a geriatric dog with the disease. Case: A female Basset Hound dog, 9 year-old, was presented with intense vomiting and diarrhea in the last day. The animal was not vaccinated there was two years. The blood count revealed moderate leukocytosis by neutrophils and deviation to the left and to the right, and monocytosis, besides lymphopenia and eosinopenia. It was also possible to observe hyperproteinemia and plasma intensely jaundiced. The biochemical examination showed alterations in liver and kidney parameters. After three days of hospitalization, the patient was euthanized and submitted for necropsy. Macroscopic findings consisted of increased dark red liver, and fibrin strands in the capsular surface. There was a bloody fluid in the small intestine and stomach. Serous small intestine showed...
Subject(s)
Animals , Dogs , Adenoviruses, Canine , Hepatitis, Infectious Canine , Liver/pathology , Kidney/pathologyABSTRACT
A hepatite infecciosa canina (HIC), causada pelo adenovírus canino tipo 1 (CAV-1), aguda ou crônica, é umadas doenças hepáticas mais freqüentes em cães, tendo como principal característica o seu alto potencial decontágio. Relatam-se dois casos de hepatite infecciosa canina, em cães, machos, filhotes de um e três meses deidade, os quais apresentaram a doença de forma aguda, ocasionando posteriormente o óbito dos pacientes.Em razão da inespecificidade dos sinais clínicos caracterizados por vômito, diarréia, apatia, anorexia e depressão,o diagnóstico definitivo foi obtido através de exame histopatológico. Ambos os casos apresentaramnecrose hepatocelular hemorrágica, degeneração hepatocelular severa e presença de corpúsculos de inclusãointranucleares grandes e anfofílicos, os quais confirmaram o diagnóstico da enfermidade.(AU)
The infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1), acute or chronic, is one ofthe most frequent liver diseases in dogs, whose main characteristic is a high potential for contagion. Reportedtwo cases of infectious canine hepatitis in dogs, males, and a babies of one e three months years, whichshowed the disease acutely, causing subsequent patient death. Due to the lack of specific clinical signs characterizedby vomiting, diarrhea, lethargy, anorexia and depression, the definitive diagnosis was obtained byhistopathology. Both cases had hemorrhagic hepatocellular necrosis, severe hepatocellular degeneration andthe presence of intranuclear inclusion bodies and large anfofílicos, which confirmed the diagnosis of disease.(AU)
Subject(s)
Animals , Dogs , Hepatitis, Infectious Canine/diagnosis , Adenoviruses, Canine , LiverABSTRACT
A hepatite infecciosa canina (HIC), causada pelo adenovírus canino tipo 1 (CAV-1), aguda ou crônica, é umadas doenças hepáticas mais freqüentes em cães, tendo como principal característica o seu alto potencial decontágio. Relatam-se dois casos de hepatite infecciosa canina, em cães, machos, filhotes de um e três meses deidade, os quais apresentaram a doença de forma aguda, ocasionando posteriormente o óbito dos pacientes.Em razão da inespecificidade dos sinais clínicos caracterizados por vômito, diarréia, apatia, anorexia e depressão,o diagnóstico definitivo foi obtido através de exame histopatológico. Ambos os casos apresentaramnecrose hepatocelular hemorrágica, degeneração hepatocelular severa e presença de corpúsculos de inclusãointranucleares grandes e anfofílicos, os quais confirmaram o diagnóstico da enfermidade.
The infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1), acute or chronic, is one ofthe most frequent liver diseases in dogs, whose main characteristic is a high potential for contagion. Reportedtwo cases of infectious canine hepatitis in dogs, males, and a babies of one e three months years, whichshowed the disease acutely, causing subsequent patient death. Due to the lack of specific clinical signs characterizedby vomiting, diarrhea, lethargy, anorexia and depression, the definitive diagnosis was obtained byhistopathology. Both cases had hemorrhagic hepatocellular necrosis, severe hepatocellular degeneration andthe presence of intranuclear inclusion bodies and large anfofílicos, which confirmed the diagnosis of disease.
Subject(s)
Animals , Dogs , Adenoviruses, Canine , Hepatitis, Infectious Canine/diagnosis , LiverABSTRACT
Caracterizou-se o efeito citopático produzido pela amostra de vírus respiratório sincicial bovino (BRSV) RC-98, isolada na Argentina, por meio de imunocitoquímica em cultivos de células da linhagem Hep-2. Um soro policlonal anti-BRSV foi utilizado para a imunocitoquímica em células Hep-2 infectadas. Sinais específicos do virus foram observados no citoplasma de um grande número de células, consistindo em inclusões citoplasmáticas e células sinciciais. Efeitos citopáticos distintos foram observados, com frequência, no núcleo das células infectadas, aparecendo como sinais específicos fortes, podendo corresponder a inclusões intranucleares. A presença de sinais intranucleares pode consistir uma característica particular da amostra RC98 do BRSV. (AU)