Liver surface depressions in the presence of diaphragmatic muscular bands on trans-illumination.

Traditional descriptions of liver anatomy refer to a smooth, convex surface contacting the diaphragm. Surface depressions are recognized anatomic variants. There are many theories to explain the cause of the depressions. We discuss the theory that these are caused by hypertrophic muscular bands in the diaphragm.

[Burnout, anxiety, insomnia and depressive symptoms among French outpatient physicians in the second wave of COVID-19: Comparison between general practitioners and specialists]. / Santé mentale des médecins libéraux français pendant la deuxième vague de COVID 19.

INTRODUCTION: The 2019 coronavirus (COVID-19) pandemic has caused a public health crisis worldwide. Concerns have been expressed about the rapid deterioration of mental health among primary care physicians among whom burnout already had a high prevalence prior to the pandemic. However, there is little data on private doctors during the pandemic. France experienced a second wave with a second lockdown. We aimed to assess and compare physicians' burnout, anxiety and depression symptoms and insomnia between general practitioners (GP) and all other private specialists during the second Covid-19 wave. METHODS: We conducted an online survey of private practitioners registered on Doctolib® (n=32,655), the interface software most used by private practitioners for booking medical appointments in France. Doctors were invited by email to complete an online survey in November 2020. Inclusions were closed on 1st December. The 2nd lockdown lasted from 30th October to 15th December 2020. We used the Copenhagen Burnout Inventory (CBI) to assess burnout syndrome. A mean score of>50 in at least one subscale defined burnout. The Hospital Anxiety and Depression Scale assessed anxiety and depression symptoms. We used two cut-offs, 8 (>7) and 11 (>10), as both are validated in the ability to find cases. The Insomnia Severity Index (ISI) measures sleep-related complaints among physicians (cut-off >7). To link variations in the psychological scales to the COVID-19 pandemic, one of the items asked explicitly whether participants considered that "the COVID-19 epidemic we are currently experiencing is a source of excess stress, psychological suffering or burnout". Approval for this study was obtained from the local institutional review board of the University of Paris-Saclay, France. The questionnaires were collected anonymously. Statistical significance was tested using the chi-square test and student's t-test to compare the prevalence between GPs and other specialities. Subsequently, logistic regression models were run for statistically significant associations. RESULTS: 1992 physicians replied, a response rate of 12.8% of those who received the invitation email. Among them, 79.4% suffered from psychological distress (symptoms of anxiety or depression or burnout), of which 71.3% suffered from burnout, 26.7% from depressive symptoms, 58.9% from anxiety symptoms and 45.8% from insomnia. There was no difference in gender between GPs and specialists, but there was an age difference (P<0.001). GPs had a higher prevalence of burnout (OR=1.33 CI95 [1.09;1.63]) and took more psychotropic drugs (1.38 CI95 [1.05;1.81]). They were also more likely to perceive their stress as work-related (OR=1.50 CI95 [1.23;1.81]) or COVID-19-related (OR=1.43 CI95 [1.16;1.77]). CONCLUSION: Our study is the first to assess the mental health of private practitioners in the second wave in association with COVID-19 stress. Firstly, GPs who provide primary care have a significantly higher burnout rate than other doctors. Secondly, COVID-19 stress is associated with more significant psychological distress. Thirdly, almost 80% of the private doctors surveyed suffer from psychological pain, and 71% suffer from burnout. This study has strengths and limitations. Firstly, this study assesses mental health and stress related to its COVID-19 association. Second, this is the largest population of private physicians during the COVID-19 pandemic. The low response rate is the main limit of this study. The alarming rates of psychological distress among private doctors and, in particular, GPs should lead to intervention to help doctors reduce stress, burnout and other mental disorders. This study gives a picture of the situation during the second wave and the lock-in, and we need to be cautious with the next waves.

Safety and Efficacy Study of the Application of Redensified Cross-Linked Hyaluronic Acid for Filling Gluteal Volume and Cellulite Depressions.

PURPOSE: To test the efficacy and safety of cross-linked hyaluronic acid application for filling buttocks and cellulite depressions and its permanence over time. METHODS: For a period of a year, 25 patients were applied redensified cross-linked hyaluronic acid in the gluteal area. These patients were all 23-45-year-old women with little fat to be removed. The product used is composed of hyaluronic acid with high cross-linking and redensification which allows it to maintain shape and durability over time. All patients underwent tumescent anesthesia with neuroleptic sedation in the operating room. The procedure was regarded as minimal (container, sterile gloves, and surgical field). The amount applied for gluteal augmentation varied from 50 to 100 ml per application area and according to the patient's needs. For the filling of cellulite depressions, the application was up to 3 cc per depression and up to a total of 40 ml. The maximum volume used per patient in the buttocks did not exceed 200 ml, and it did not exceed 40 ml in cellulite depressions. RESULTS: A group of patients was treated in the upper and middle third of the buttocks in superficial and deep subcutaneous layers and in cellulite depressions. Very good results have been obtained without any major complications. CONCLUSIONS: The use of redensified cross-linked hyaluronic acid of non-animal origin is therefore an option for gluteal augmentation and cellulite depressions. Although the product degrades over time, after 12 months, 44% of treated patients rated their results as highly or very much improved, 36% as improved, 16% rated the improvement as poor, and one patient (4%) was dissatisfied. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Factors associated with voice-related quality of life among patients with temporomandibular disorders

Abstract Research would be important for obtaining a better understanding of voice complaints among patients with temporomandibular disorders (TMD). Objective The identification of predictors of voice disorders associated with TMD pain was made according to Diagnostic Criteria for TMD (DC/TMD) Axis I. Methodology Functional limitations were measured using the Jaw Functional Limitation Scales for mastication (JFLS-M), jaw mobility (JFLS-JM), and verbal and emotional expression (JFLS-VEE). Patients also completed the Hospital Anxiety and Depression Scale (HADS). The primary outcome was social-emotional and physical functioning as indicated by scores on the Voice-Related Quality of Life (V-RQOL) questionnaire. Multiple linear regression was used to model the relationship between the domains on the V-RQOL questionnaire and scores on the HADS and JFLS after adjusting for age, gender, DC/TMD diagnosis, pain intensity, and time since pain onset. Results The HADS-D (B=-1.15; 95% CI, -1.718 to -0.587; p<.001) and JFLS-VEE (B=-0.22; 95% CI, -0.40 to -0.06; p=.008) were significant predictors of scores on the V-RQOL questionnaire. Conclusion Higher scores on depression measures and limitations in verbal and emotional expression could exacerbate voice problems among TMD pain patients. Future research should promote multidisciplinary treatments for TMD pain-related voice disorders.

Association Between Mode of Delivery and Postpartum Depression: A Cross-Sectional Study in Saudi Arabia.

Background This study was conducted to explore the association between postpartum depression (PPD) and mode of delivery in pregnant women. Methods This cross-sectional study was conducted in the western region of Saudi Arabia, among 173 women from the general population who met the inclusion criteria and participated in the study from April to September 2022. The Edinburgh Postnatal Depression Scale (EPDS) was used to assess PPD. Statistical analysis was performed using R version 3.6.3 (R Foundation for Statistical Computing, Vienna, Austria). Counts and percentages were used for categorical variables, and means ± standard deviation were used for continuous variables. Hypothesis testing was done at a significance level of 5%. Results It was reported by 59.5% of the respondents to be having depression. Compared to respondents who reported elective cesarean or natural delivery, those who reported emergency cesarean delivery had significantly higher average EPDS scores (p = 0.036). Positive correlations were found between depression scores and all Postpartum Bonding Questionnaire (PBQ) subscales, suggesting that higher PBQ subscale scores were associated with a greater risk of depression as determined by the EPDS questionnaire. In addition, a higher prevalence of PPD was associated with the presence of chronic illnesses (p = 0.016). Conclusion Our study indicated that although there was no correlation between mode of delivery and PPD, emergency cesarean section could contribute to PPD. Furthermore, other factors such as chronic illness and educational level can affect the risk of PPD.

Topographic hydro-conditioning to resolve surface depression storage and ponding in a fully distributed hydrologic model.

Land surface depressions play a central role in the transformation of rainfall to ponding, infiltration and runoff, yet digital elevation models (DEMs) used by spatially distributed hydrologic models that resolve land surface processes rarely capture land surface depressions at spatial scales relevant to this transformation. Methods to generate DEMs through processing of remote sensing data, such as optical and light detection and ranging (LiDAR) have favored surfaces without depressions to avoid adverse slopes that are problematic for many hydrologic routing methods. Here we present a new topographic conditioning workflow, Depression-Preserved DEM Processing (D2P) algorithm, which is designed to preserve physically meaningful surface depressions for depression-integrated and efficient hydrologic modeling. D2P includes several features: (1) an adaptive screening interval for delineation of depressions, (2) the ability to filter out anthropogenic land surface features (e.g., bridges), (3) the ability to blend river smoothing (e.g., a general downslope profile) and depression resolving functionality. From a case study in the Goodwin Creek Experimental Watershed, D2P successfully resolved 86% of the ponds at a DEM resolution of 10 m. Topographic conditioning was achieved with minimum impact as D2P reduced the number of modified cells from the original DEM by 51% compared to a conventional algorithm. Furthermore, hydrologic simulation using a D2P processed DEM resulted in a more robust characterization on surface water dynamics based on higher surface water storage as well as an attenuated and delayed peak streamflow.

Psychological aspects and psychotherapy for TRD.

Treatment-resistant depression (TRD) refers to depression that persists even after the patient has undergone adequate trials of two or more antidepressants at appropriate doses and duration. While there may be controversy around this definition, it reflects the real-world clinical situation where drug therapy is often the primary treatment strategy for major depressive disorder. It's important to note that when a patient is diagnosed with TRD, a comprehensive evaluation of their psychosocial aspects should be carried out. Appropriate psychosocial interventions should also be provided to address the patient's needs. Various psychotherapy models have been proven effective in treating TRD, but not all of them have undergone empirical testing. As a result, some psychotherapy models may be underestimated in treating TRD. Clinicians should consult reference materials and assess the patient's psychosocial aspects to select the most appropriate psychotherapy model for TRD patients. Collaboration with psychologists, social workers, and occupational therapists can also provide valuable input in the decision-making process. This ensures that TRD patients receive comprehensive and effective care.

The Bioactive Dietary Polyphenol Preparation Alleviates Depression and Anxiety-Like Behaviors by Modulating the Regional Heterogeneity of Microglia Morphology.

SCOPE: The goal of this study is to investigate the effects of a bioactive dietary polyphenol preparation (BDPP), which is made up of grape-derived polyphenols, on microglial responses, as well as the underlying molecular mechanisms in depression and anxiety-like behaviors. METHODS AND RESULTS: The study finds that treatment with BDPP significantly decreases depression-like and anxiety-like behaviors induced by chronic stress in mice, while leaving their locomotor activity unaffected. The study also finds that BDPP treatment reverses microglia activation in the amygdala and hippocampal formation, regions of the brain involved in emotional regulation, from an amoeboid shape to ramified shape. Additionally, BDPP treatment modulates the release of pro-inflammatory cytokines such as interleukin-6 via high mobility box 1 protein and the receptor for advanced glycation end products (HMGB1-RAGE) signaling pathway in activated microglia induced by chronic stress. CONCLUSION: The findings suggest regional heterogeneity in microglial responses following chronic stress in subregions of the corticolimbic circuit. Specifically, activation of the immune-inflammatory HMGB1-RAGE pathway may provide a new avenue for preventing the manifestation of psychiatric impairments including stress-induced anxiety- and depression-like behavior, using bioactive and bioavailable polyphenols.

Absence of ST-Segment Elevation in Inferior and Lateral Leads in Patients With Complete Right Bundle Branch Block Is an Index of Underlying Cardiac Pathology.

A recent report called attention to the nature of the ST-segment elevation (STSE) in some or all inferior and/or lateral electrocardiogram (ECG) leads (i.e., I, II, III, aVL, aVF, V5, and V6), which are frequently encountered in patients with stable or transient complete right bundle branch block (RBBB). These STSEs represent secondary repolarization changes due to late depolarization RBBB alterations; are stable over the course of many years in patients with RBBB; and do not reflect cardiac pathology, as the automated ECG interpretation algorithms erroneously indicate. Indeed, the absence of such STSEs in patients with RBBB suggests the presence of underlying acute or old myocardial infarction, acute myocardial ischemia, or left ventricular hypertrophy and thus constitute an as yet undescribed ECG index of cardiovascular pathology.

Outcomes in ED patients with non-specific ECG findings and low high-sensitivity troponin.

Background: Although some emergency department risk stratification tools consider non-specific ECG findings as an aid in disposition decisions, their clinical value in patients with an initially low high-sensitivity cardiac troponin I (hsTnI) is unclear. Objective: Our purpose was to determine if non-specific ECG (ns-ECG) findings are associated with 30-day major adverse cardiac events (MACE) in ED patients presenting with suspected acute coronary syndromes (ACS) who have a low initial hsTnI. Methods: Using the prospective Siemens Atellica hsTnI Food and Drug Administration submission observational database, we conducted a retrospective cohort study of the association between ns-ECG findings (defined as left bundle branch block [LBBB], ST depression [STD], or T-wave inversions [TWI]) and 30-day MACE (death, myocardial infarction, heart failure hospitalization, or coronary revascularization). Eligible patients presented with suspected ACS to one of 29 US EDs from April 2015 to April 2016, had stable vital signs, a blood sample for hsTnI (Siemen's Atellica, Siemens Healthineers, Inc, Malvern, PA) obtained at 1, 3, and 6 hours after ED presentation, and were followed for 30 days. The relationship between 30-day outcome, initial hsTnI, and ns-ECG was evaluated using chi-square testing. Results: Of 2676 enrolled, 1313 patients met the inclusion criteria and are included in the analysis. Median (interquartile range) age was 62 years (54, 72), 54% were male, with 56% white, and 39% African American. Median (interquartile range) times from symptom onset to presentation and presentation to specimen collection were 92 (0, 216) and 146 (117, 177) minutes, respectively. The most common presenting symptoms were chest pain (84%), followed by dyspnea (9%). ECG findings were categorized as T-wave inversion or non-specific T wave changes (42%), ST depression ns-ECG ST changes (16%), or LBBB (2%). Thirty-day MACE occurred in 72 (5.5%) patients, with coronary revascularization (35 patients, 2.7%) and heart failure (25 patients, 1.9%) being the most frequent outcomes. In patients with an initial hsTnI below the limit of quantitation (LOQ) of 2.5 ng/L (n = 449), there was no association between ns-ECG changes and 30-day MACE (P = 0.42). If the hsTnI was ≥LOQ (2.5 ng/L), there were increased rates of 30-day MACE and ns-ECG findings (P = 0.01). Conclusion: In ED suspected ACS patients without unstable vital signs, and an initial hsTnI less than the LOQ (2.5 ng/L), ns-ECG findings are not associated with 30-day major adverse cardiac events. The use of ns-ECG findings in ACS disposition should be considered in the context of hsTnI levels.

A Narrative Review of the History of Burn-Related Depression and Stress Reactions.

While the roots of burn care date back several millennia, recognition and treatment of psychiatric trauma has had a more contemporary journey. Our understanding of burn care has evolved largely separately from our understanding of psychiatry; however, proper care of the burn patient relies on the comprehension of both disciplines. Historically, high burn mortality rates have caused clinicians to focus on the physiological causes of burn mortality. As burn care improved in the 20th century, providers began to focus on the long-term health outcomes of burn patients, including mitigating mental health consequences of trauma. This shift coincided with advances in our understanding of psychological sequelae of trauma. Subsequently, an association between burn trauma and mental illness began to emerge. The current standard of care is the result of thousands of years of evolving practices and theories, yet our understanding of the pathophysiology of depression among survivors of severe burn injury is far from complete. By taking measure of the past, we aim to provide context and evidence for our current standards and emphasize areas for future lines of research.

Anterior buccal mandibular depression: A descriptive study of CT findings.

Objective: This study aims to report the concurrence of the radiographic features of anterior buccal mandibular depressions (ABMDs) and anterior lingual mandibular depressions (ALMDs) by conventional computed tomography (CT) and cone beam CT scans. We also assess the effect of ABMDs and ALMDs on dental implant sites. Methods: A retrospective review of CT scans of the mandibles with ABMDs was conducted to assess the morphology, site, presence of foramina, ALMDs, and the integrity of the cortical plate. The superoinferior width of ABMD, the buccolingual depth, and mesiodistal length were measured and compared with the thickness of the cortical plate at the depression to the area superior to it. Results: Thirty-seven patients with 74 ABMDs were included in this study. All observed ABMDs occurred bilaterally, and ALMDs with ABMDs occurred in 13 sites (17.56%). In 20 (54%) cases, at least one foramen was noted. The buccal cortical bone was intact in all cases. The contents of ABMDs were found to be fatty. On an average, their superoinferior width was 7.1 mm, buccolingual depth 1.67 mm, and mesiodistal length 18.8 mm. The average buccal cortical bone plate thickness at the ABMD was 1.23 mm (range 0.4-1.9 mm), while the average buccal cortical bone plate thickness coronal to the ABMD was 1.34 mm (range 0.7-2.2 mm). The average buccolingual dimension of the mandible was 8.72 mm (range 4.15-13.4 mm) at ABMD sites without ALMD and 4.6 mm with ALMD (range 1.8-8 mm). Conclusion: When ALMD occurs in the presence of ABMD, the amount of bone available for implant placement is greatly reduced.

Physical activity in the treatment of depression in college students / Atividade física no tratamento da depressão em estudantes universitários / La actividad física en el tratamiento de la depresión en estudiantes universitarios

ABSTRACT Introduction: The mental health of college students is getting more and more attention from society. Physical exercise as a means of psychotherapy and mental health has become common at home and abroad. Objective: We explore the effect of prescribing physical exercise in the treatment of depression in college students. Methods: College students who had been diagnosed with depression were randomly divided into an observation group and a control group, each with 18 patients. The control group received drug treatment. The observation group received sports therapy in addition to drug therapy. Results: There was a statistically significant difference in HAMD scores between the observation and control groups in the first week (P<0.01). Conclusions: Exercise can play a role in treating depression patients rapidly, safely, and efficiently. Level of evidence II; Therapeutic studies - investigation of treatment results.

RESUMO Introdução: A saúde mental dos estudantes universitários está recebendo cada vez mais atenção da sociedade. O exercício físico como meio de psicoterapia e saúde mental tornou-se comum no país e no exterior. Objetivo: Exploramos o efeito da prescrição de exercícios físicos no tratamento da depressão em estudantes universitários. Métodos: Estudantes universitários com diagnóstico de depressão foram divididos randomicamente em grupo observação e grupo controle, cada um com 18 participantes. O grupo controle recebeu tratamento medicamentoso. O grupo observação recebeu terapia esportiva acrescida de terapia medicamentosa. Resultados: Verificou-se diferença estatisticamente significativa nos escores da HAM-D entre os grupos observação e controle na primeira semana (P < 0,01). Conclusões: Os exercícios podem ter um papel no tratamento de pacientes com depressão de forma rápida, segura e eficiente. Nível de Evidência II; Estudos terapêuticos - Investigação dos resultados do tratamento.

RESUMEN Introducción: La salud mental de los estudiantes universitarios recibe cada vez más atención por parte de la sociedad. El ejercicio físico como medio de psicoterapia y salud mental se ha convertido en algo habitual en el país y en el extranjero. Objetivo: Explorar el efecto de la prescripción de ejercicios físicos en el tratamiento de la depresión en estudiantes universitarios. Métodos: Estudiantes universitarios con diagnóstico de depresión fueron divididos aleatoriamente en un grupo de observación y un grupo de control, los cuales contaban con 18 participantes cada uno. El grupo de control recibió tratamiento farmacológico. El grupo de observación recibió terapia deportiva y terapia farmacológica. Resultados: Se comprobó una diferencia estadísticamente significativa en las puntuaciones de HAM-D entre los grupos de observación y control en la primera semana (P < 0,01). Conclusiones: La actividad física puede actuar en el tratamiento de pacientes con depresión de forma rápida, segura y eficaz. Nivel de Evidencia II; Estudios terapéuticos - Investigación de los resultados del tratamiento.

Gambling at the time of COVID-19: Results from interviews in an Italian sample of gamblers.

The coronavirus pandemic affected the life of those suffering from addictive behaviors often confined to prolonged periods of self-isolation. To explore the variation of symptoms related to gambling, 46 outpatients of the mental health services in the Trento Province were invited to take part in a phone interview at the start of the national lockdown. Although only 2.17% increased gambling activity during this period, half of the sample (50.00%) experienced irritability, mood fluctuation (43.48%) and anxiety (39.13%). Follow-up studies should assess modifications in their behaviors that occurred after the reopening of gambling venues.

Estimation of Infiltration Volumes and Rates in Seasonally Water-Filled Topographic Depressions Based on Remote-Sensing Time Series.

In semi-arid ecoregions of temperate zones, focused snowmelt water infiltration in topographic depressions is a key, but imperfectly understood, groundwater recharge mechanism. Routine monitoring is precluded by the abundance of depressions. We have used remote-sensing data to construct mass balances and estimate volumes of temporary ponds in the Tambov area of Russia. First, small water bodies were automatically recognized in each of a time series of high-resolution Planet Labs images taken in April and May 2021 by object-oriented supervised classification. A training set of water pixels defined in one of the latest images using a small unmanned aerial vehicle enabled high-confidence predictions of water pixels in the earlier images (Cohen's Κ = 0.99). A digital elevation model was used to estimate the ponds' water volumes, which decreased with time following a negative exponential equation. The power of the exponent did not systematically depend on the pond size. With adjustment for estimates of daily Penman evaporation, function-based interpolation of the water bodies' areas and volumes allowed calculation of daily infiltration into the depression beds. The infiltration was maximal (5-40 mm/day) at onset of spring and decreased with time during the study period. Use of the spatially variable infiltration rates improved steady-state shallow groundwater simulations.

Autologous Fat Grafting with or without Processing: A Study in an Indian Clinical Context.

BACKGROUND: Although fat grafting has become an attractive method of correction of soft tissue deficiencies, variability in results exists. As the understanding of mechanism of survival of graft improves, the concepts regarding fat grafting change. There are many ways to process the aspirated fat with no clear method superior. AIM: The aim of this study was to evaluate the role of processing during autologous fat transfer. MATERIALS AND METHODS: The patients were serially divided into two groups, namely, A and B. Harvesting of lipoaspirate and injection of fat were same in both the groups. In group A, no processing was done. In group B, the fat was processed by sedimentation and injected. Patient satisfaction was assessed following the procedure and statistical analysis was done using the Mann-Whitney U-test. RESULTS: Young females between 21 and 30 years formed the majority of patients who opted for fat grafting procedure. Most of the procedures were performed for defects in the face (93.3%). The most common indication of fat grafting was contour deformities, with abdomen being the most preferred donor site. The mean patients' satisfaction following fat grafting without processing is 2.2 ± 0.68. The mean patients' satisfaction following fat grafting with processing is 2.53 ± 0.99. CONCLUSION: There was not a statistically significant difference in patient outcomes following fat grafting, with or without processing, in terms of patient satisfaction. Autologous fat grafting was found to be a safe procedure with no significant complications.

Focal Palatitis (Previously Focal Palatine Erosions) in Captive Cheetahs (Acinonyx jubatus).

Focal palatine erosion (FPE) is a misleading term that is used in the literature to describe inflammatory lesions associated with depressions of the palatal mucosa in cheetah. Cheetahs have large cheek teeth and these depressions are formed to accommodate them. Previously FPE was only described as a mandibular molar tooth malocclusion on the hard palate due to suspected rotation and super eruption of the mandibular molar teeth of cheetahs aged 18 months and older. Two hundred and fifty six cheetahs (135 male, 121 female), originating from two independent facilities, had their oral cavities evaluated as part of an annual health visit over a decade. Ninety-nine cheetahs were seen once, 59 cheetahs were seen twice, 33 were seen three times, 43 on four occasions, 16 on five occasions, 5 on six occasions, and 1 cheetah was seen seven times. Apart from these clinical cases a prospective study on 5 cheetah cubs (3 male and 2 female) was conducted to document their skull development and mandibular molar tooth eruption over a period of 25 months. Of the 261 cheetahs observed none developed rotation or super eruption of their mandibular molar teeth. The term FPE is a misnomer as these inflammatory lesions were found in palatal depressions opposing any of the cusps of all of the cheetah mandibular cheek teeth. It consisted mainly of deep ulcerations, inflammation and oedema and also micro abscess formation. In severe cases oro-nasal fistulas were present. Of all the depressions present on the cheetah's palate, the large one palatal to the 4th maxillary premolar tooth was most commonly affected. In the five cubs evaluated prospectively, focal palatitis was evident from the 7 month evaluation, before all the permanent teeth erupted. Conservative treatment of the inflamed depressions by removing the foreign material through curettage and copious flushing reduced the grade of the inflammation when observed on follow-up. Focal palatine erosion is an incorrect term used to describe focal palatitis that occurs randomly in cheetahs. This focal palatitis is often associated with foreign material trapped in the palatal depressions. Conservative management is sufficient to treat these animals without odontoplasties.

Effect of cognitive behavioral therapy-based counseling on perceived stress in pregnant women with history of primary infertility: a controlled randomized clinical trial.

BACKGROUND: Given the prevalence of infertility and consequences of stress, anxiety, and depression during pregnancy and after childbirth, this study aimed to determine the effect of group cognitive behavioral therapy (CBT)-based counseling on perceived stress (primary outcome), anxiety, depression, and quality of life (QoL) of pregnant women with a history of primary infertility. METHOD: This controlled randomized clinical trial was conducted on 56 pregnant women with a history of primary infertility referred to Infertility Clinic of Al-Zahra Teaching Hospital of Tabriz. The participants were divided into the intervention (n = 28) and control (n = 28) groups using block randomization. The intervention group received group CBT-based counseling after the 14th week of the pregnancy: six in-person sessions and two telephone sessions once per week. The control group received routine care. The Perceived Stress Scale (PSS), Edinburgh Postnatal Depression Scale (EPDS), Van den Bergh's Pregnancy-Related Anxiety Questionnaire (PRAQ), and Quality of Life in Pregnancy (Gravidarum) (QOL-GRAV) were completed through interviews before and 4 weeks after the intervention by the researcher. RESULTS: There was not any between-group difference in socio-demographic characteristics, except the gestational age and husband educational level (p > 0.05). Both of these variables were adjusted in ANCOVA. After the intervention, the mean scores of perceived stress (mean difference: - 7.3; confidence interval: 95%, from - 0.9 to - 5.6; p < 0.001) and anxiety (mean difference:-14.7; confidence interval: 95%. from - 20.6 to - 8.8; p < 0.001) were significantly lower in the intervention group. The mean depression score in the intervention group was lower than the control; however, this between-group difference was not significant (mean difference: - 1.95; confidence interval: 95% from - 3.9 to 0.2; p = 0.052). The mean score of quality of life in pregnancy was significantly higher in the intervention group than the control (mean difference: - 5.4; confidence interval: 95% from 3.4 to 7.4; p < 0.001). CONCLUSION: CBT counseling can affect the perceived stress, anxiety, and quality of life of pregnant women with a history of primary infertility. As a result, this counseling approach is recommended along with other counseling approaches to improve the mental health of pregnant women with a history of infertility. TRIAL REGISTRATION: IRCT Registration Number: IRCT20111219008459N12 , registered on 10/11/ 2018.

Synoptic-scale precursors of landslides in the western Himalaya and Karakoram.

In the Upper Indus Basin (UIB), precipitation associated with synoptic-scale circulations impinges on the complex and steep orography of the western Himalaya and Karakoram. Heavy rainfall often falls over the foothills, frequently triggering landslides there. This study explores the role of these synoptic-scale circulations - extratropical western disturbances (WDs) and tropical depressions (TDs) - in producing the conducive conditions necessary to trigger landslides, using data from the NASA Global Landslide Catalog and WD and TD track databases. During the winter (October to April), UIB landslides peak in February and occur at a rate of 0.05 day-1, 61% of which are associated with the passage of a WD. They are most common when a WD is located within a few hundred kilometres of 30°N, and significantly rarer if the WD is north of 40°N. WDs provide moist southwesterly flow from the Arabian Sea and Mediterranean Sea to the UIB, resulting in large-scale precipitation, but landslide probability is not related to WD intensity. Non-WD winter landslides are associated with small-scale orographic precipitation that we hypothesise is due to cloudbursts. During the summer (May to September), UIB landslides peak in August and occur at a rate of 0.11 day-1, 60% of which are associated with TD activity. Many of these TDs are found over central India, slightly south of the climatological monsoon trough, where they provide strong monsoonal southeasterlies to the UIB flowing along the Himalayas. Increased landslide frequency is also associated with TD activity over the southern Bay of Bengal (BoB), and it is hypothesised that this is related to monsoon break conditions. Landslide frequency is significantly correlated with TD intensity. Non-TD landslides are associated with a northwestward extension of the monsoon trough, providing southeasterly barrier flow to the UIB. Implications for forecasting and climate change are discussed.