Medical Distrust Among Kidney Transplant Candidates.

BACKGROUND: Medical distrust may hinder kidney transplantation (KT) access. Among KT candidates evaluated for waitlisting, we identified factors associated with high distrust levels and quantified their association with waitlisting. METHODS: Among 812 candidates (2018-2023), we assessed distrust using the Revised Health Care System Distrust Scale across composite, competence, and values subscales. We used linear regression to quantify the associations between candidate and neighborhood-level factors and distrust scores. We used Cox models to quantify the associations between distrust scores and waitlisting. RESULTS: At KT evaluation, candidates who were aged 35-49 years (difference = 1.97, 95% CI: 0.78-3.16), female (difference = 1.10, 95% CI: 0.23-1.97), and Black (difference = 1.47, 95% CI: 0.47-2.47) were more likely to report higher composite distrust score. For subscales, candidates aged 35-49 were more likely to have higher competence distrust score (difference = 1.14, 95% CI: 0.59-1.68) and values distrust score (difference = 0.83, 95% CI: 0.05-1.61). Race/ethnicity (Black, difference = 1.42, 95% CI: 0.76-2.07; Hispanic, difference = 1.52, 95% CI: 0.35-2.69) was only associated with higher values distrust scores. Female candidates reporting higher rescaled values distrust scores (each one point) had a lower chance of waitlisting (aHR = 0.78, 95% CI: 0.63-0.98), whereas this association was not observed among males. Similarly, among non-White candidates, each 1-point increase in both rescaled composite (aHR = 0.87, 95% CI: 0.77-0.99) and values (aHR = 0.82, 95% CI: 0.68-0.99) distrust scores was associated with a lower chance of waitlisting, while there was no association among White candidates. CONCLUSION: Female, younger, and non-White candidates reported higher distrust scores. Values distrust may contribute to the long-standing racial/ethnic and gender disparities in access to KT. Implementing tailored strategies to reduce distrust in transplant care may improve KT access for groups that experience persistent disparities.

Time and memory distrust shape the dynamics of recollection and belief-in-occurrence.

The current study examined how people's metamemory judgments of recollection and belief-in-occurrence change over time. Furthermore, we examined to what extent these judgments are affected by memory distrust - the subjective appraisal of one's memory functioning - as measured by the Memory Distrust Scale (MDS) and the Squire Subjective Memory Scale (SSMQ). Participants (N = 234) studied pictorial stimuli and were tested on some of these stimuli later in the same session, but were tested on other stimuli 1, 2, 4, 8, and 17 days later. Recollection and belief ratings were correlated highly and followed similar declining patterns over time. However, belief decreased relatively more slowly than recollection, such that the discrepancy between recollection and belief increased over time. Memory distrust moderated the association between recollection and belief, with this association being weaker among people who reported greater (versus lower) memory distrust. Memory distrust also interacted with retention period to predict memory judgments. Two measures of memory distrust diverged in their predictive power. In particular, only the MDS predicted the spontaneous reporting of nonbelieved memories. Our results provide support to the theoretical perspective that belief-in-occurrence is a summative judgment informed not only by recollective phenomenology but also by metamemorial beliefs.

Marginalisation and distrust in the context of the COVID-19 vaccination programme: experiences of communities in a northern UK city region.

BACKGROUND: There are clear inequalities in COVID - 19 vaccination rates amongst marginalised groups, with lower rates for some minoritised ethnic and religious groups, younger people, those living in more deprived areas, and with lower socio-economic status. Existing research focuses on psychological and socio-economic factors that influence vaccine uptake and does not explore broader social and historical contexts. Understanding inequalities in COVID-19 vaccine uptake requires a critical examination of the drivers of, and barriers to, vaccination. METHODS: We present findings from a co-designed qualitative research study undertaken during the COVID-19 pandemic. Focus groups and interviews were used to examine the context underpinning responses to the COVID-19 vaccination in Greater Manchester, particularly focussing on experiences of marginalisation. Thematic framework analysis was used to analyse the data. RESULTS: We found that the public's responses to the COVID-19 vaccination programme are intertwined with a longstanding history of institutional distrust and disenfranchisement, resulting from experiences of marginalisation and social inequalities. This was exacerbated further by the disproportionate impacts of the COVID-19 pandemic on minoritised ethnic groups, younger people, and those with existing health conditions. CONCLUSIONS: Histories of structural inequalities experienced by minoritised groups invoked feelings of suspicion and scepticism at the motivations of the agencies behind the vaccination rollout. This highlights the need for a contextualised analysis of attitudes to vaccines, considering pre-existing inequalities, which may be especially relevant for conceptualising public responses to the vaccination programme. Finally, our study shows the important ways in which public (dis)trust can impact public health policies. We recommend this should be incorporated into responses to future public health crises.

The Connection between Neurophysiological Correlates of Trust and Distrust and Isolated HEXACO Dimensions.

Trust and distrust are constructs that have provoked and undergone lots of discussion in the fields of sociology and psychology. However, to our knowledge, there is little agreement about how these constructs should be treated in the future. The present study tries to help in this discussion by re-analyzing prior neurophysiological data highlighting differences between trust and distrust by connecting these data with two distinct personality dimensions. Thus, the objective was to analyze the connection between neurophysiological trust/distrust processing and distinct HEXACO personality dimensions. Differences were found in the event-related potentials (ERPs) calculated for visual presentations of political institution words and brand names, which were evaluated with respect to trust and distrust by button presses. Two time points (330 ms and 780 ms) showed brain activity differences between trust and distrust related to the two word categories at frontal electrode locations. For this study, these findings were taken and connected to HEXACO-60 personality inventory results collected from prior participants. Statistical analysis revealed a significant interaction between the ERPs and two HEXACO personality dimensions concerning trusted brands at the later time point (780 ms) at the right frontal electrode location F8. This result is taken as neurophysiological evidence that parameter values of the personality traits honesty-humility and agreeableness have an influence on brain functions related to trusted brands.

Trusted Sources of Information and COVID-19 Vaccination Among Black Adults in Chicago.

PURPOSE: Examine trust in sources of COVID-19 information and vaccination status. DESIGN: Cross-sectional. SETTING: Chicago, Illinois. SUBJECTS: Convenience sample of 538 Black adults surveyed between September 2021 and March 2022. MEASURES: Trust in sources of COVID-19 information, COVID-19 vaccination. ANALYSIS: Using latent class analysis, we identified classes of trust in sources of COVID-19 information. We considered predictors of class membership using multinomial logistic regression and examined unadjusted and adjusted associations between trust class membership and COVID-19 vaccination while accounting for uncertainty in class assignment. RESULTS: Our analytic sample (n = 522) was predominantly aged 18-34 (52%) and female (71%). Results suggested a four-class solution: (1) low trust, (2) high trust in all sources, (3) high trust in doctor and government, and (4) high trust in doctor, faith leader, and family. Unadjusted odds of vaccination were greater in the high trust in all sources (OR 2.0, 95% CI 1.2-3.2), high trust in doctor and government (OR 2.7, 95% CI 1.4-5.3), and high trust in doctor, faith leader, and family classes (OR 2.1, 95% CI 1.2, 3.9) than the low trust class. However, these associations were not significant after adjustment for sociodemographic and health status factors. CONCLUSION: Although COVID-19 vaccination varied across trust classes, our adjusted findings do not suggest a direct association between trust and vaccination, reflecting complexities in the vaccine decision-making process.

The mediating role of physician trust in the relationship between medical mistrust and health-care system distrust.

OBJECTIVE: This study was carried out to determine the mediating role of physician trust in the relationship between medical mistrust and health-care system distrust. MATERIALS AND METHODS: The "Health Care Systems Distrust Scale", which consists of 10 questions, the "Medical Mistrust Scale", which consists of 17 questions, the "Physician Trust Scale", which consists of 11 questions. The statistical analysis was performed using the SPSS 26.0 program. RESULTS: Health-care system distrust was positively correlated with medical mistrust and negatively correlated with physician trust. There was a negative relationship between medical mistrust and physician trust. Physician trust mediates the effect of medical mistrust on health-care system distrust. In other words, it was determined that the mediating effect of physician trust was significant. CONCLUSION: Addition of physician trust to medical mistrust decreases the negative effects of health-care system distrust. Medical mistrust must be addressed at multiple levels of society, including government, policy, and health-care systems.

OBJETIVO: Este estudio se llevó a cabo para determinar el papel mediador de la confianza del médico en la relación entre la desconfianza médica y la desconfianza en el sistema de salud. MATERIALES Y MÉTODOS: La "Escala de desconfianza en los sistemas de atención médica", que consta de 10 preguntas, la "Escala de desconfianza médica", que consta de 17 preguntas, la "Escala de confianza del médico", que consta de 11 preguntas. El análisis estadístico se realizó mediante el programa SPSS 26.0. RESULTADOS: La desconfianza en el sistema de salud se correlacionó positivamente con la desconfianza médica y negativamente con la confianza en los médicos. Hubo una relación negativa entre la desconfianza médica y la confianza en el médico. La confianza del médico media el efecto de la desconfianza médica en la desconfianza de los sistemas de atención médica. En otras palabras, se determinó que el efecto mediador de la confianza en el médico fue significativo. CONCLUSIÓN: La adición de la confianza del médico a la desconfianza médica disminuye los efectos negativos de la desconfianza en el sistema de atención médica. La desconfianza médica debe abordarse en múltiples niveles de la sociedad, incluido el gobierno, las políticas y los sistemas de atención médica.

Corrigendum: Acceptance, initial trust formation, and human biases in artificial intelligence: focus on clinicians.

[This corrects the article DOI: 10.3389/fdgth.2022.966174.].

Trust and distrust in food among non-dependent elderly people in Spain. Study on socio-cultural representations through the analysis of cultural domains.

The social and cultural representations of food are essential when it comes to understanding the perception of risk and the trust/distrust that people place on it. In this paper, we analyse the attributes and categories that non-dependent older people aged 65 and over living in Spain use when talking about trust/distrust in relation to food. In order to explore how they manifest different social meanings, we have conducted a study based on an analysis of cultural domains. The results of examining free-listing and pile-sort techniques were triangulated with the narratives obtained from interviews, life histories, food diaries and participatory workshops. The ethnographic research was conducted between June 2021 and June 2022 in the autonomous communities of Andalusia and Catalonia as well as the Valencian Community. Understanding the criteria for trust and distrust through the analysis of cultural domains allows us to better comprehend what food risks are perceived by older people and what value they place on food safety in their food choices. This study aims to provide qualified input for the development of healthier eating habits with recommendations for making ageing an easier process.

Ethical Challenges of Advances in Vaccine Delivery Technologies.

Strategies to address misinformation and hesitancy about vaccines, including the fear of needles, and to overcome obstacles to access, such as the refrigeration that some vaccines demand, strongly suggest the need to develop new vaccine delivery technologies. But, given widespread distrust surrounding vaccination, these new technologies must be introduced to the public with the utmost transparency, care, and community involvement. Two emerging technologies, one a skin-patch vaccine and the other a companion dye and detector, provide excellent examples of greatly improved delivery technologies for which such a careful approach should be developed in order to increase vaccine uptake. Defusing fears and conspiracy mongering must be a key part of their rollout.

The Patients' Presupposed Distrust to Doctors in China: An Explanatory Sequential Mixed Methods Study.

Purpose: The aim of this study was to investigate the current status of patients' presupposed distrust, and to clarify the causes of high presupposed distrust. Patients and Methods: An explanatory sequential mixed methods study was conducted using a two-stage design. The first phase was a quantitative cross-sectional survey, a total of 384 patients by convenience sampling completed the survey. Study instruments including demographic and clinical characteristics sheet, patients' presupposed distrust scale. In the qualitative phase, 16 patients on the basis of their mean score for all PPDS items were higher than 4 were identified as extreme cases participated in one-to-one semi-structured interviews. Results: The total item mean score for all patients on PPDS was 3.59(3.18, 4.09), which above the median range of the PPDS (item mean score of 3). Personal income level and educational level were significant predictive influencing factors of patients' presupposed distrust, which could explain 17.347% of the variance. The reasons of high patients' presupposed distrust were as follows: moral character, health knowledge, patient perceptions, and the social circumstance. Conclusion: The level of patients' presupposed distrust was high, which needs to be further decreased. Demographic and clinical variables (personal income level, educational level) are identified to be the major contributing factors. The main causes for the formation of the high patients' presupposed distrust are patients internal factors and social circumstance.

Patient-centered or population-centered? How epistemic discrepancies cause harm and sow mistrust.

Medical distrust is often conceived of as a problem of misinformation or ignorance. In this paper, I depart from this framework, attributing distrust instead to epistemic divergence between lay people and experts. Using data from a contraceptive side effects Facebook group and in-depth physician interviews, I find that providers employ a "body-as-subject" lens informed by population-health goals, while group members employ a "body-as-agent" lens that privileges individuality and bodily autonomy. Provider epistemologies are privileged, creating epistemic injustice and harm for patients. Ultimately, this erodes trust in providers and the medical community more broadly.

COVID-19 vaccine hesitancy among American Indian and Alaska native college students: the roles of discrimination, historical trauma, and healthcare system distrust.

For American Indians and Alaska Native (AIAN) and other communities of color, experiences with discrimination and historical trauma may contribute to healthcare system distrust and negatively affect health care decisions, including vaccination. A saturated path analysis was conducted to examine the direct and indirect associations of thoughts regarding historical losses (of culture, language, and traditional ways) and AIAN racial discrimination with historical loss associated distress, healthcare system distrust, and COVID-19 vaccine hesitancy among AIAN college students (N = 391). Historical loss thoughts and experiences with racial discrimination were strongly associated with each other, and both were uniquely associated with greater historical loss associated distress. In turn, historical loss associated distress was associated with greater healthcare system distrust, which in turn was associated with greater likelihood of being COVID-19 vaccine hesitant. While further research is needed, the findings suggest that to address health disparities for AIAN people it is necessary to consider how to best overcome healthcare system distrust and factors that contribute to it, including historical trauma and contemporary experiences with discrimination.

Continuity of Trust: Health Systems' Role in Advancing Health Equity Beyond the COVID-19 Pandemic.

Given COVID-19's disproportionate impact on populations that identify as Black, Indigenous, and People of Color (BIPOC) in the United States, researchers and advocates have recommended that health systems and institutions deepen their engagement with community-based organizations (CBOs) with longstanding relationships with these communities. However, even as CBOs leverage their earned trust to promote COVID-19 vaccination, health systems and institutions must also address underlying causes of health inequities more broadly. In this commentary, we discuss key lessons learned about trust from our participation in the U.S. Equity-First Vaccination Initiative, an effort funded by The Rockefeller Foundation to promote COVID-19 vaccination equity. The first lesson is that trust cannot be "surged" to meet the needs of the moment until it is no longer deemed important; rather, it must predate and outlast the crisis. Second, to generate long-term change, health systems cannot simply rely on CBOs to bridge the trust gap; instead, they must directly address the root causes of this gap among BIPOC populations.

Longitudinal Associations Between Interpersonal Distrust and Social Aggression During College: Disentangling the Within-Person Process from Stable Between-Person Differences.

There is a dearth of information on the relationship between interpersonal distrust and social aggression in the youth, although both may lead to negative interpersonal relationships. Furthermore, scholars have not explored whether interpersonal distrust influences later social aggression over time at the within-person level. This study used five wave longitudinal data to investigate the longitudinal association between interpersonal distrust and social aggression and the role of hostile attribution bias in this relationship; notably, it used a relatively rigorous approach-the random intercept cross-lagged panel model-to disentangle within-person processes from stable between-person differences. The final number of participants included 1053 undergraduate students (677 female students and 376 male students), and 64.3% were female students, with a mean age of 18.45 years (SD = 0.95) at first measurement. Participants completed assessments for interpersonal distrust, hostile attribution bias, and social aggression at five time points across 6-month intervals. At the within-person level, the results revealed that interpersonal distrust was a predictor of later social aggression and that hostile attribution bias acted as a longitudinal mediator in this relationship. This result indicates that to enhance interpersonal harmony and reduce individual hostility and aggression toward others, intervention programs should aim to reduce interpersonal distrust.

Conceptualizing and Measuring Trust, Mistrust, and Distrust: Implications for Advancing Health Equity and Building Trustworthiness.

Trust is vital to public confidence in health and science, yet there is no consensus on the most useful way to conceptualize, define, measure, or intervene on trust and its related constructs (e.g., mistrust, distrust, and trustworthiness). In this review, we synthesize literature from this wide-ranging field that has conceptual roots in racism, marginalization, and other forms of oppression. We summarize key definitions and conceptual frameworks and offer guidance to scholars aiming to measure these constructs. We also review how trust-related constructs are associated with health outcomes, describe interventions in this field, and provide recommendations for building trust and institutional trustworthiness and advancing health equity. We ultimately call for future efforts to focus on improving the trustworthiness of public health professionals, scientists, health care providers, and systems instead of aiming to increase trust in these entities as they currently exist and behave.

Trust or distrust? Neither! The right mindset for confronting disinformation.

A primary explanation for why individuals believe disinformation is the truth bias, a predisposition to accept information as true. However, this bias is context-dependent, as research shows that rejection becomes the predominant process in a distrust mindset. Consequently, trust and distrust emerge as pivotal factors in addressing disinformation. The current review offers a more nuanced perspective by illustrating that whereas distrust may act as an antidote to the truth bias, it can also paradoxically serve as a catalyst for belief in disinformation. The review concludes that mindsets other than those rooted solely in trust (or distrust), such as an evaluative mindset, may prove to be more effective in detecting and refuting disinformation.

Social Determinants of Health: Healthcare managers' COVID-19 experiences of poor governance, poverty and social media on health interventions.

Objectives: The COVID-19 pandemic has highlighted many barriers to healthcare including structural factors like poverty and governance, and intermediary factors such as service delivery, especially in low and middle-income countries where resources are limited. Social Determinants of Health like poverty, governance and access to basic services significantly affect the effectiveness of health interventions. This study aimed to explore healthcare managers' experiences of delivering health interventions during the COVID-19 pandemic in Gauteng Province, South Africa, using the Social Determinant of Health lens. Study design: Exploratory qualitative study. Methods: Online in-depth interviews were conducted with senior healthcare managers at the Gauteng Department of Health, to explore their experiences during COVID-19, using open-ended questions. The data was saturated with 13 respondents and was analyzed thematically and inductively in NVivo 10. Results: We identified four interrelated themes that adversely impacted health interventions from the manager's COVID-19 experiences: poor governance through non-service delivery, government distrust, poverty within communities and the influence of social media on societal values. Conclusion: The failure of the government to deliver community services leads to public distrust and in turn has a spill-over effect which constitutes a barrier to healthcare. COVID-19 has reaffirmed that poverty, poor governance and societal values (influenced by social media) are structural Social Determinants of Health that exacerbates the vulnerability of the poor during outbreaks. Poor governance and poverty limit behavioral options, trust and the effectiveness of health interventions. Social support is needed to assist the poor and vulnerable during outbreak. Finally, while social media messages negatively influenced health-seeking behaviors during COVID-19, they are also a potential tool to counter disease infodemics.

A Moderated Mediation Model of the Influence of Cynical Distrust, Medical Mistrust, and Anger on Vaccination Hesitancy in Nursing Staff.

During the pandemic, nurses experienced anger that stemmed from a sense of threat, frustration, or even a sense of injustice. The purpose of this study was to examine the relationship between vaccination hesitancy, anger, cynicism, and medical mistrust among nurses, as there are no relevant studies in the literature. This study was conducted online by completing self-report questionnaires. The Dimensions of Anger Reactions-5, the 8-item "Cynical Distrust" scale, and the Medical Mistrust Multiformat Scale were used. For vaccination hesitancy, two questions with a 5-point scale were used: one question examining hesitancy to get vaccinated with the COVID-19 vaccine, and another question examining hesitancy to get vaccinated with the influenza vaccine. In total, 387 nurses (66 men and 321 women) participated in this study. Nurses showed statistically greater hesitancy toward the COVID-19 vaccine compared to hesitancy toward the influenza vaccine. The variation in vaccine hesitancy was explained by the scores in the Medical Mistrust Multiformat Scale, the Dimensions of Anger Reactions, and the Cynical Distrust Scale. The Medical Mistrust Multiformat Scale mediated the relationship between the Cynical Distrust Scale and total vaccine hesitancy. The Dimensions of Anger Reactions Scale significantly moderated the indirect effect of the Cynical Distrust Scale on total vaccine hesitancy through the Medical Mistrust Multiformat Scale. In conclusion, it is highly likely that anger is involved in reported vaccine hesitancy both by activating schemas of distrust in others and by adopting anti-systemic views of mistrust in the medical system.

Becoming Trustworthy in Treating Patients With Borderline Personality Disorder.

No one doubts the importance of trust in psychotherapy, but few therapists think about the complexities of trusting relationships, and the trustworthiness that would justify trusting remains far from view. Fortunately, inasmuch as trusting and trustworthiness are inherently ethical concepts, contemporary philosophers have given trust the consideration it warrants. Integrating science and philosophy, the author reviews the broad scope and multifaceted nature of trust and trustworthiness, the social-cognitive development of trust, and the development of distrust in the context of borderline personality disorder. Without questioning therapists' character, the author makes the case for shifting the emphasis from the patient's distrust to the therapist's challenge to become trustworthy in the course of each treatment relationship and, more broadly, over the course of a professional career.

The need for an intersectionality framework in precision medicine research.

Precision medicine research has seen growing efforts to increase participation of communities that have been historically underrepresented in biomedical research. Marginalized racial and ethnic communities have received particular attention, toward the goal of improving the generalizability of scientific knowledge and promoting health equity. Against this backdrop, research has highlighted three key issues that could impede the promise of precision medicine research: issues surrounding (dis)trust and representation, challenges in translational efforts to improve health outcomes, and the need for responsive community engagement. Existing efforts to address these challenges have predominantly centered on single-dimensional demographic criteria such as race, ethnicity, or sex, while overlooking how these and additional variables, such as disability, gender identity, and socioeconomic factors, can confound and jointly impact research participation. We argue that increasing cohort diversity and the responsiveness of precision medicine research studies to community needs requires an approach that transcends conventional boundaries and embraces a more nuanced, multi-layered, and intersectional framework for data collection, analyses, and implementation. We draw attention to gaps in existing work, highlight how overlapping layers of marginalization might shape and substantiate one another and affect the precision-medicine research cycle, and put forth strategies to facilitate equitable advantages from precision-medicine research to diverse participants and internally heterogeneous communities.