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1.
Sci Rep ; 14(1): 16335, 2024 Jul 15.
Article in English | MEDLINE | ID: mdl-39009677

ABSTRACT

The technology of building a retaining roadway along goaf or a protecting roadway with a small coal pillar has been developed and applied for many years, and a satisfactory supporting effect has been obtained in medium-thick coal seam and thin coal seam mining. However, the gob-side roadway or small coal pillar mining in a thick coal seam is still subjected to technical problems occasioned by factors such as high roadway, high support pressure beside roadway, and waste of coal resources. To solve these problems, the author proposes an innovative technology of coal-free mining: the technology of driving roadway along goaf with a flexible formwork pre-cast wall. The article utilizes the 3503 and 3505 working faces of Wangzhuang Coal Industry Group as the research background, and comprehensively introduces the principle of the technology and the overburden rock movement law. Through theoretical calculations and numerical simulations, the support resistance and support parameters of flexible formwork pre-cast walls have been determined and successfully performed in industrial practice. The results indicate that the combination of the flexible mould pre-cast wall coal pillar-free mining technology and roof cutting process is more conducive to the maintenance of the roadway in the lower working face, and effectively reduces the stress and deformation of the surrounding rock. The roof and floor of the drivage roadway move, and the deformation of the two sides is small; furthermore, the overall roadway retention effect is satisfactory, which meets the requirements of mining in the lower working face. The coal pillar pertaining to the 20 m section of the 5 m high mining height face was recovered for Wangzhuang Coal Mine, and the recovery rate of the coal resources and the driving speed of the roadway were improved. The proposed method can be popularised and applied in this mine and even in the mining of 15# large-height coal seams in the two cities.

2.
Front Psychol ; 15: 1386937, 2024.
Article in English | MEDLINE | ID: mdl-39021660

ABSTRACT

In a prior study we demonstrated that the presence of face masks impairs the human capability of accurately inferring emotions conveyed through facial expressions, at all ages. The degree of impairment posed by face covering was notably more pronounced in children aged between three and five years old. In the current study, we conducted the same test as a follow-up after one year from the onset of the COVID-19 pandemic, when the requirement of wearing face masks was holding in almost all circumstances of everyday life when social interactions occur. The results indicate a noteworthy improvement in recognizing facial expressions with face masks among children aged three to five, compared to the pre-pandemic settings. These findings hold a significant importance, suggesting that toddlers effectively mitigated the social challenges associated with masks use: they overcame initial environmental limitations, improving their capability to interpret facial expressions even in the absence of visual cues from the lower part of the face.

3.
Geriatr Psychol Neuropsychiatr Vieil ; 22(2): 200-208, 2024 Jun 01.
Article in French | MEDLINE | ID: mdl-39023155

ABSTRACT

Younger adults have difficulties identifying emotional facial expressions from faces covered by face masks. It is important to evaluate how face mask wearing might specifically impact older people, because they have lower emotion identification performance than younger adults, even without face masks. We compared performance of 62 young and 38 older adults in an online task of emotional facial expression identification using masked or unmasked pictures of faces with fear, happiness, anger, surprise, and neutral expression, from different viewpoints. Face masks affected performance in both age groups, but more so in older adults, specifically for negative emotions (anger, fear), in favour of the saliency hypothesis as an explanation for the positive advantage. Additionally, face masks more affected emotion recognition on profile than on three-quarter or full-face views. Our results encourage using clearer and full-face expressions when dealing with older people while wearing face masks.


Subject(s)
Emotions , Facial Expression , Facial Recognition , Masks , Humans , Aged , Male , Female , Adult , Young Adult , Aged, 80 and over , Middle Aged
4.
Int Ophthalmol ; 44(1): 328, 2024 Jul 18.
Article in English | MEDLINE | ID: mdl-39023647

ABSTRACT

PURPOSE: To evaluate the eyelid features' changes after N95 face mask (FM) usage in healthcare workers through the new type of Coronavirus Disease 2019 (COVID-19) pandemic and make a comparison with home-office workers as a control group with a computer vision algorithm. MATERIALS AND METHODS: Sixty healthcare workers and forty control participants with similar demographic features included. Standardized biometric photographs which were taken before and after the COVID-19 pandemic, analyzed by the ImageJ program (NIH, Bethesda, Md.) software. The distances between the central light reflex on the cornea and the upper (UE) and lower eyelid (LE) were recorded as the marginal reflex distances. (MRD1, MRD2 respectively) Parameters of pretarsal show (PTS) of UE and brow pupil diameter (BPD) were analyzed for both of the eyes. RESULTS: There were no significant differences among the groups' measurements before the COVID-19 pandemic. In healthcare workers' group after the pandemic, values of MRD1, PTS, BPD showed a significant decrease in their right eye (p = 0.001, p = 0.002, p = 0.001 respectively) and same values reduced in the left eyes as well when compared with pre-pandemic measurements. (p = 0.048, p = 0.001, p = 0.001 respectively) PTS and BPD values were decreased for both right and left eyes of the controls. (p = 0.044, p = 0.001 and p = 0.001, p = 0.001 respectively) MRD1 measurements after the pandemic showed no difference either in the right or left eyes of the control group after the pandemic. (p = 0.071 and p = 0.065 respectively). DISCUSSION: Results showed that both BPD and PTS values decreased independently from the previous FM usage in both of the groups. Even though MRD1 values remained within the normal values, a significant decrease was detected in the healthcare workers group which suggested the cause was newly developed upper eyelid (UE) dermatochalasis after long hours of FM usage. Although it is hard to make a truly objective evaluation both usage of standardized biometric photographs and a computer-based measurement system makes the results reliable.


Subject(s)
COVID-19 , Eyelids , Health Personnel , SARS-CoV-2 , Humans , COVID-19/epidemiology , Male , Female , Adult , Middle Aged , N95 Respirators , Pandemics , Masks
5.
J Gen Psychol ; : 1-28, 2024 Jul 18.
Article in English | MEDLINE | ID: mdl-39023941

ABSTRACT

Affective feelings naturally infuse individuals' perceptions, serving as valid windows onto the real world. The affective realism hypothesis further explains how these feelings work: as properties of individuals' perceptual experiences, these feelings influence perception. Notably, this hypothesis based on affective feelings with different valences has been substantiated, whereas the existing evidence is not compelling enough. Moreover, whether specific affective feelings can be experienced as properties of target perception remains unclear. Addressing these two issues deepens our understanding of the nature of emotional representation. Hence, we investigated the affective realism hypothesis based on affective feelings with different valences and specific emotions, comparing it with the affective misattribution hypothesis. In Experiment 1, we examined the effects of affective feelings with various valences on targets' perception through the AM (1a) and CFS paradigms (1b). In Experiment 2, we investigated the effects of affective feelings with anger, sadness, and disgust using similar methods. Results from Experiments 1a and 1b consistently indicated significant differences in valence ratings of neutral faces under emotional contexts with varying valences. Experiment 2a revealed significant differences in specific emotion ratings of neutral faces under different specific emotional contexts in the AM paradigm, whereas such differences were not observed in the CFS paradigm in Experiment 2b. We concluded that affective feelings with different valences, rather than specific emotions, can be experienced as inherent properties of target perception, validating the affective realism hypothesis. These findings supported the view that the nature of emotional representation should be described as affective dimensions.

6.
ACS Appl Mater Interfaces ; 16(28): 36471-36478, 2024 Jul 17.
Article in English | MEDLINE | ID: mdl-38955805

ABSTRACT

In the development of back electrodes for perovskite solar cells (PSCs), the major challenges are stability and cost. To address this, we present an innovative approach: Simultaneous evaporation of two independently controlled sources of metal materials was performed to achieve a uniform distribution of the alloy electrodes. In this study, Ag-Cu alloys (the molar ratio of Ag/Cu is 7/3) with a high-index crystal face (111) and a work function matching perovskite were prepared using a codeposition technique. These properties mitigate nonradiative carrier recombination at the interface and reduce the energy barrier for carrier migration. Consequently, compared to Ag based PSCs (22.77%), the implementation of Ag-Cu alloy (Ag/Cu is 7/3)-based PSCs resulted in a power conversion efficiency of 23.72%. In a 1500 h tracking test in ambient air, the Ag-Cu alloy (Ag/Cu is 7/3)-based PSCs maintained their initial efficiency of 86%. This can be attributed to almost no migration of elements from the Ag-Cu alloy electrode to the perovskite layer. Our work presents a vital strategy for improving the stability of PSCs and reducing the costs associated with the back electrode in PSCs.

7.
Proc Natl Acad Sci U S A ; 121(28): e2321346121, 2024 Jul 09.
Article in English | MEDLINE | ID: mdl-38954551

ABSTRACT

How does the brain process the faces of familiar people? Neuropsychological studies have argued for an area of the temporal pole (TP) linking faces with person identities, but magnetic susceptibility artifacts in this region have hampered its study with fMRI. Using data acquisition and analysis methods optimized to overcome this artifact, we identify a familiar face response in TP, reliably observed in individual brains. This area responds strongly to visual images of familiar faces over unfamiliar faces, objects, and scenes. However, TP did not just respond to images of faces, but also to a variety of high-level social cognitive tasks, including semantic, episodic, and theory of mind tasks. The response profile of TP contrasted with a nearby region of the perirhinal cortex that responded specifically to faces, but not to social cognition tasks. TP was functionally connected with a distributed network in the association cortex associated with social cognition, while PR was functionally connected with face-preferring areas of the ventral visual cortex. This work identifies a missing link in the human face processing system that specifically processes familiar faces, and is well placed to integrate visual information about faces with higher-order conceptual information about other people. The results suggest that separate streams for person and face processing reach anterior temporal areas positioned at the top of the cortical hierarchy.


Subject(s)
Magnetic Resonance Imaging , Temporal Lobe , Humans , Magnetic Resonance Imaging/methods , Temporal Lobe/physiology , Temporal Lobe/diagnostic imaging , Male , Female , Adult , Facial Recognition/physiology , Brain Mapping/methods , Recognition, Psychology/physiology , Face/physiology , Young Adult , Pattern Recognition, Visual/physiology
8.
J Hazard Mater ; 477: 135308, 2024 Jul 23.
Article in English | MEDLINE | ID: mdl-39053070

ABSTRACT

In the natural environment, a symphony of environmental factors including sunlight exposure, current fluctuations, sodium chloride concentrations, and sediment dynamics intertwine, potentially magnifying the impacts on the aging process of disposable face masks (DFMs), thus escalating environmental risks. Employing Regular Two-Level Factorial Design, the study scrutinized interactive impacts of ultraviolet radiation, sand abrasion, acetic acid exposure, sodium chloride levels, and mechanical agitation on mask aging. Aging mechanisms and environmental risks linked with DFMs were elucidated through two-dimensional correlation analyses and risk index method. Following a simulated aging duration of three months, a single mask exhibited the propensity to release a substantial quantity of microplastics, ranging from 38,800 ± 360 to 938,400 ± 529 particles, and heavy metals, with concentrations from 0.06 ± 0.02 µg/g (Pb) to 29.01 ± 1.83 µg/g (Zn). Besides, specific contaminants such as zinc ions (24.24 µg/g), chromium (VI) (4.20 µg/g), thallium (I) (0.92 µg/g), tetracycline (0.51 µg/g), and acenaphthene (1.73 µg/g) can be adsorbed significantly by aged masks. The study elucidates pivotal role of interactions between ultraviolet radiation and acetic acid exposure in exacerbating the environmental risks associated with masks, while emphasizing the pronounced influence of many other interactions. The research provides a comprehensive understanding of the intricate aging processes and ensuing environmental risks posed by DFMs, offering valuable insights essential for developing sustainable management strategies in aquatic ecosystems.

9.
Environ Pollut ; : 124611, 2024 Jul 23.
Article in English | MEDLINE | ID: mdl-39053806

ABSTRACT

Overexposure of sewage workers to bioaerosol released from wastewater treatment plants (WWTPs) can cause serious infections, but practical method for controlling their health risk is lacking. In this study, reverse quantitative microbial risk assessment was used to estimate the daily critical exposure time (CET) of sewage workers exposing to Staphylococcus aureus bioaerosol emitted by three emission sources facilities in a WWTP based on either U.S. EPA or WHO benchmark, and sensitivity analysis was conducted to analyze the influence of various parameters on the outcomes of CET. The results showed that the CET of females was always 1.12-1.29 times that of males. In addition, the CET after wearing face masks was 28.28-52.37 times as long as before. The working time can be determined based on the CET results of male workers wearing face masks exposed to the inverted-umbrella aeration tank (14.73-550.98 min for U.S. EPA benchmark and 55.07-1972.24 min for WHO benchmark). In each scenario, the variable parameter exposure concentration (ec) always showed the most influence on the CET results. After wearing the face masks, the removal fraction by employing face masks also had a significant effect on the results, only second to ec. Therefore, the wearing of face mask is the most convenient and effective measure to prolong the CET. Furthermore, practical methods to reducing bioaerosol concentration in WWTPs exposure are also necessary to extend CET and safeguard worker health. This study enriches the application range of reverse quantitative microbial risk assessment framework and provides theoretical support for stakeholders to establish reasonable working time threshold guidelines, and practical method and novel perspective to protect the on-site health risks of sewage workers exposing to various facilities.

10.
Dent Traumatol ; 2024 Jul 23.
Article in English | MEDLINE | ID: mdl-39041919

ABSTRACT

Bodybuilding and cross-training exercises bring health benefits. However, orofacial injuries can occur during practice. This study aimed to map, analyze, interpret, and synthesize data from studies on the main orofacial injuries resulting from bodybuilding and cross-training practices. This scoping review followed the Joanna Briggs Institute and PRISMA-ScR methods, with high-sensitivity searches in PubMed, Web of Science, Scopus, ScienceDirect, Embase, Virtual Health Library and the Google Scholar. Original scientific articles published up to May 2024 were included, which evaluated the presence of self-reported or professionally diagnosed orofacial injuries by bodybuilding and cross-training practitioners aged 18 years or older. Literature reviews, editorials, and guidelines were excluded. Tables and figures were used to map and summarize the results. Out of 30.485 potentially eligible articles, four were included. The main orofacial injuries identified in both bodybuilding and cross-training practitioners were dental damage (n = 4), temporomandibular joint (TMJ) disorders (n = 3), and traumas to oral soft tissues (n = 2) and facial soft tissues (n = 2). Dental damage and TMJ disorders were the most prevalent conditions among bodybuilding and cross-training practitioners. Therefore, dental damage and TMJ disorders were the most prevalent conditions among bodybuilding and cross-training practitioners. However, further prospective studies with more in-depth methodological designs and fewer biases are necessary.

11.
Front Transplant ; 3: 1366243, 2024.
Article in English | MEDLINE | ID: mdl-38993787

ABSTRACT

Background: Recipients of Vascularized Composite Allotransplants require effective immunosuppressive therapy to prevent graft rejection. This systematic review summarizes the current body of literature on immunosuppressive regimens used in face and hand transplants while summarizing their outcome in terms of rejection, renal failure, and infections. Methods: A systematic search of electronic databases was conducted to identify relevant studies from 1998 until July 1st, 2023. We included all studies that discussed immunosuppressive strategies in face and hand transplant recipients according to PRISMA. Results: The standard triple maintenance therapy was mostly adjusted due to nephrotoxicity or high incidence of rejection. The most common alternative treatments utilized were sirolimus (25/91; 27.5%) or everolimus (9/91; 9.9%) following hand- and photophoresis (7/45; 15.6%), sirolimus (5/45; 11.1%) or belatacept (1/45; 2.2%) following face transplantation. Episodes of rejection were reported in 60 (65.9%) of hand- and 33 (73%) of face transplant patients respectively. Graft loss of 12 (13.2%) hand and 4 (8.9%) face transplants was reported. Clinical CMV infection was observed in 6 (6.6%) hand and 7 (15.5%) face transplant recipients. Conclusions: Based on the herein presented data, facial grafts exhibited a heightened incidence of rejection episodes and CMV infections. Facial mucosa adds complexity to the immunological graft composition highlighting the need of individualized immunosuppressive regimens and further research.

12.
IEEE Access ; 12: 49122-49133, 2024.
Article in English | MEDLINE | ID: mdl-38994038

ABSTRACT

There is a tendency for object detection systems using off-the-shelf algorithms to fail when deployed in complex scenes. The present work describes a case for detecting facial expression in post-surgical neonates (newborns) as a modality for predicting and classifying severe pain in the Neonatal Intensive Care Unit (NICU). Our initial testing showed that both an off-the-shelf face detector and a machine learning algorithm trained on adult faces failed to detect facial expression of neonates in the NICU. We improved accuracy in this complex scene by training a state-of-the-art "You-Only-Look-Once" (YOLO) face detection model using the USF-MNPAD-I dataset of neonate faces. At run-time our trained YOLO model showed a difference of 8.6% mean Average Precision (mAP) and 21.2% Area under the ROC Curve (AUC) for automatic classification of neonatal pain compared with manual pain scoring by NICU nurses. Given the challenges, time and effort associated with collecting ground truth from the faces of post-surgical neonates, here we share the weights from training our YOLO model with these facial expression data. These weights can facilitate the further development of accurate strategies for detecting facial expression, which can be used to predict the time to pain onset in combination with other sensory modalities (body movements, crying frequency, vital signs). Reliable predictions of time to pain onset in turn create a therapeutic window of time wherein NICU nurses and providers can implement safe and effective strategies to mitigate severe pain in this vulnerable patient population.

13.
Appl Clin Genet ; 17: 107-115, 2024.
Article in English | MEDLINE | ID: mdl-38983678

ABSTRACT

Introduction: There are more than 6000 genetic syndromes, therefore the recognition of facial patterns may present a challenge for clinicians. The 22q11.2 deletion syndrome (22q11.2 DS) and Williams syndrome (WS) are two different genetic syndromes but share some common phenotypic traits and subtle facial dysmorphisms. Therefore, any tool that would help clinicians recognize genetic syndromes would likely result in a more accurate diagnosis. Methods: The syndrome identification accuracy was compared between 2 different facial analysis algorithms (DeepGestalt and GestaltMatcher) of the Face2Gene (F2G) tool and a group of 9 clinicians with different levels of expertise before and after using F2G for a cohort of 64 Thai participants' frontal facial photos divided into 3 groups of 22q11.2 DS, WS and unaffected controls. Results: The higher accuracy from the DeepGestalt algorithm than from clinicians was demonstrated, especially when comparing between the two syndromes. The accuracy was highest when clinicians use the tool combined with their own decision-making process. The tool's second algorithm, GestaltMatcher revealed clear separation among these three groups of photos. Discussion: The result of F2G outperforming clinicians was not surprising. However, the highest increase in accuracy was with nondysmorphology clinicians using F2G. Conclusion: Face2Gene would be a useful tool to help clinicians in facial recognition of genetic syndromes, before ordering specific tests to confirm the definite diagnosis.

14.
Neuron ; 2024 Jun 27.
Article in English | MEDLINE | ID: mdl-38959893

ABSTRACT

Face processing is fundamental to primates and has been extensively studied in higher-order visual cortex. Here, we report that visual neurons in the midbrain superior colliculus (SC) of macaque monkeys display a preference for images of faces. This preference emerges within 40 ms of stimulus onset-well before "face patches" in visual cortex-and, at the population level, can be used to distinguish faces from other visual objects with accuracies of ∼80%. This short-latency face preference in SC depends on signals routed through early visual cortex because inactivating the lateral geniculate nucleus, the key relay from retina to cortex, virtually eliminates visual responses in SC, including face-related activity. These results reveal an unexpected circuit in the primate visual system for rapidly detecting faces in the periphery, complementing the higher-order areas needed for recognizing individual faces.

15.
Sci Rep ; 14(1): 16790, 2024 Jul 22.
Article in English | MEDLINE | ID: mdl-39039112

ABSTRACT

Own child's face is one of the most socially salient stimuli for parents, and a faster search for it than for other children's faces may help provide warmer and more sensitive care. However, it has not been experimentally examined whether parents find their child's face faster. In addition, although own child's face is specially processed, the search time for own child's face may be similar to that for other socially salient stimuli, such as own or spouse's faces. This study tested these possibilities using a visual search paradigm. Participants (parents) searched for their child's, own, spouse's, other child's, same-sex adult's, or opposite-sex adult's faces as search targets. Our findings indicate that both mothers and fathers identified their child's face more quickly than other children's faces. Similarly, parents found their own and spouse's faces more quickly than other adults' faces. Moreover, the search time for family members' faces increased with the number of faces on the search display, suggesting an attentional serial search. These results suggest that robust face representations learned within families and close relationships can support reduced search times for family members' faces.


Subject(s)
Facial Recognition , Humans , Male , Female , Adult , Child , Face , Learning , Family/psychology , Reaction Time , Parents/psychology
16.
BMC Med Educ ; 24(1): 746, 2024 Jul 10.
Article in English | MEDLINE | ID: mdl-38987794

ABSTRACT

BACKGROUND: This study aimed to examine whether online interactive communication education using video materials was as effective as face-to-face education among healthcare college students. METHODS: The participants were healthcare college students who were enrolled in study programs to obtain national medical licenses. They participated in lectures and exercises on healthcare communication, both online (n = 139) and face-to-face (n = 132). Listening skills, understanding, and confidence in healthcare communication were assessed using a self-assessed tool. RESULTS: From the two-way ANOVA result, the interaction effects between group (online, face-to-face) and time (Time 1, Time 2, Time 3) were not statistically significant. The main effect of time increased significantly from Time1 to Time 3 on understanding of communication with patients (Hedges'g = 0.51, 95%CI 0.27-0.75), confidence in communication with patients (g = 0.40, 95%CI 0.16-0.64), and confidence in clinical practice (g = 0.49, 95%CI 0.25, 0.73), while the score of listening skills had no significant change (Hedges'g = 0.09, 95%CI - 0.03 to 0.45). CONCLUSIONS: The results show that online communication education with video materials and active exercises is as effective in improving students' confidence as face-to-face. It will be necessary to modify the content of this educational program to improve skills as well as confidence in communication. TRIAL REGISTRATION: Not Applicable.


Subject(s)
Communication , Humans , Pilot Projects , Male , Female , Young Adult , Video Recording , Education, Distance/methods , Adult
17.
Sci Rep ; 14(1): 16068, 2024 Jul 11.
Article in English | MEDLINE | ID: mdl-38992163

ABSTRACT

Impressions of trustworthiness are formed quickly from faces. To what extent are these impressions shared among observers of the same or different races? Although high consensus of trustworthiness evaluation has been consistently reported, recent studies suggested substantial individual differences. For instance, negative implicit racial bias and low contact experience towards individuals of the other race have been shown to be related to low trustworthiness judgments for other-race faces. This pre-registered study further examined the effects of implicit social bias and experience on trustworthiness judgments of other-race faces. A relatively large sample of White (N = 338) and Black (N = 299) participants completed three tasks: a trustworthiness rating task of faces, a race implicit association test, and a questionnaire of experience. Each participant rated trustworthiness of 100 White faces and 100 Black faces. We found that the overall trustworthiness ratings for other-race faces were influenced by both implicit bias and experience with individuals of the other-race. Nonetheless, when comparing to the own-race baseline ratings, high correlations were observed for the relative differences in trustworthiness ratings of other-race faces for participants with varied levels of implicit bias and experience. These results suggest differential impact of social concepts (e.g., implicit bias, experience) vs. instinct (e.g., decision of approach-vs-avoid) on trustworthiness impressions, as revealed by overall vs. relative ratings on other-race faces.


Subject(s)
Judgment , Trust , Humans , Male , Female , Trust/psychology , Adult , Young Adult , Racism/psychology , White People/psychology , Adolescent , Facial Recognition , Racial Groups/psychology , Social Perception , Face , Surveys and Questionnaires
18.
Sensors (Basel) ; 24(13)2024 Jul 05.
Article in English | MEDLINE | ID: mdl-39001147

ABSTRACT

With the development of data mining technology, the analysis of event-related potential (ERP) data has evolved from statistical analysis of time-domain features to data-driven techniques based on supervised and unsupervised learning. However, there are still many challenges in understanding the relationship between ERP components and the representation of familiar and unfamiliar faces. To address this, this paper proposes a model based on Dynamic Multi-Scale Convolution for group recognition of familiar and unfamiliar faces. This approach uses generated weight masks for cross-subject familiar/unfamiliar face recognition using a multi-scale model. The model employs a variable-length filter generator to dynamically determine the optimal filter length for time-series samples, thereby capturing features at different time scales. Comparative experiments are conducted to evaluate the model's performance against SOTA models. The results demonstrate that our model achieves impressive outcomes, with a balanced accuracy rate of 93.20% and an F1 score of 88.54%, outperforming the methods used for comparison. The ERP data extracted from different time regions in the model can also provide data-driven technical support for research based on the representation of different ERP components.


Subject(s)
Evoked Potentials , Facial Recognition , Humans , Evoked Potentials/physiology , Facial Recognition/physiology , Electroencephalography/methods , Algorithms , Face/physiology
19.
Conscious Cogn ; 123: 103726, 2024 Jul 06.
Article in English | MEDLINE | ID: mdl-38972288

ABSTRACT

In prosopagnosia, brain lesions impair overt face recognition, but not face detection, and may coexist with residual covert recognition of familiar faces. Previous studies that simulated covert recognition in healthy individuals have impaired face detection as well as recognition, thus not fully mirroring the deficits in prosopagnosia. We evaluated a model of covert recognition based on continuous flash suppression (CFS). Familiar and unfamiliar faces and houses were masked while participants performed two discrimination tasks. With increased suppression, face/house discrimination remained largely intact, but face familiarity discrimination deteriorated. Covert recognition was present across all masking levels, evinced by higher pupil dilation to familiar than unfamiliar faces. Pupil dilation was uncorrelated with overt performance across subjects. Thus, CFS can impede overt face recognition without disrupting covert recognition and face detection, mirroring critical features of prosopagnosia. CFS could be used to uncover shared neural mechanisms of covert recognition in prosopagnosic patients and neurotypicals.

20.
Article in English | MEDLINE | ID: mdl-38976140

ABSTRACT

The use of animal models continues to be essential for carrying out research into clinical phenomena, including addiction. However, the complexity of the clinical condition inevitably means that even the best animal models are inadequate, and this may go some way to account for the apparent failures of discoveries from animal models, including the identification of potential novel therapies, to translate to the clinic. We argue here that it is overambitious and misguided in the first place to attempt to model complex, multifacetted human disorders such as addiction in animals, and especially in rodents, and that all too frequently "validity" of such models is limited to superficial similarities, referred to as "face validity", that reflect quite different underlying phenomena and biological processes from the clinical situation. Instead, a more profitable approach is to identify (a) well-defined intermediate human behavioural phenotypes that reflect defined, limited aspects of, or contributors to, the human clinical disorder, and (b) to develop animal models that are homologous with those discrete human behavioural phenotypes in terms of psychological processes, and underlying neurobiological mechanisms. Examples of past and continuing weaknesses and suggestions for more limited approaches that may allow better homology between the test animal and human condition are made.

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