ABSTRACT
BACKGROUND: Carcinoma breast is most common cancer and the leading cause of cancer related deaths in women, with a multifactorial aetiology. This case control study was aimed at studying the possible link of body fat with the pathogenesis of carcinoma breast. METHODS: A case control study extending over a period of two years (2015-2016) was conducted in which the body size and shape of 56 carcinoma breast cases was studied against 168 controls who had no breast disease. RESULTS: Fifty-six women suffering from carcinoma breast had a higher BMI and fat distributed in the abdominal area A high BMI was found to be protective in pre-menopausal women (OR= 0.14 by; 95% CI: 0.02-0.77) while it was a risk factor in post-menopausal women (OR=2.39 by; 95% CI: 1.02-5.55). Waist-to-hip ratio (WHR) of ≥0.9 was associated with an increased risk of carcinoma breast compared to WHR ≤0.8 (OR=3.857 by; 95% CI: 0.875-17.05). CONCLUSIONS: the results show there is an increased risk of carcinoma breast in women having more fat cantered around the abdomen.
Subject(s)
Adipose Tissue/diagnostic imaging , Body Mass Index , Breast Neoplasms/etiology , Obesity/complications , Aged , Breast Neoplasms/diagnosis , Breast Neoplasms/epidemiology , Case-Control Studies , Female , Humans , Middle Aged , Obesity/epidemiology , Pakistan/epidemiology , Retrospective Studies , Risk Factors , Waist-Hip RatioABSTRACT
Os objetivos deste estudo foram: a) verificar a prevalência de gordura corporal inadequada por meio do índice de massa corpórea (IMC), perímetro do abdômen (PAB) e gordura corporal relativa (G%), e indicadores bioquímicos de risco para doenças cardiovasculares;b) analisar quais indicadores de gordura corporal refletem melhor os fatores bioquímicos. Em 125 homens foram mensurados: IMC, G%, PAB, glicemia, triglicerídeos, colesterol total, lipoproteínas de alta densidade (HDL) e lipoproteínas de baixa densidade (LDL). Mais da metade da amostra (56,8%) apresentou baixos valores de HDL e elevadosvalores de IMC (58,4%) e G% (53,6%). Menor prevalência de sujeitos foi observada com elevados valores de LDL (40,8%), PAB (38,4%), triglicerídeos (34,8%), glicemia (27,2%) e colesterol total (15,2%). O PAB associou-se com quatro indicadores bioquímicos, enquanto que a G% com três e o IMC somente com dois. A prevalência dos fatores de risco foi elevada. O PAB >92cm mostrou-se o melhor indicador de gordura, apontando que os homens estão expostos a elevados valores de LDL, colesterol total, triglicerídeos e glicemia.
The objectives of this study were: a) to determine the prevalence of inadequate body fat determined based on body mass index (BMI), abdominal perimeter (AP) and relative body fat (%F), and biochemical indicators of cardiovascular risk, and b) to examine which bodyfat indicators better reflect the biochemical factors. BMI, %F, AP, glucose, triglycerides, total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were measured in 125 men. More than half the sample (56.8%) had low HDL and high BMI (58.4%) and %F (53.6%). There was a lower percentage of subjects with elevated LDL (40.8%), AP (38.4%), triglycerides (34.8%), glucose (27.2%), and total cholesterol (15.2%). AP was associated with four biochemical markers, whereas %F was associated with three and BMI with only two. The prevalence of risk factors was high. An AP >92 cm proved to be the best at indicator, demonstrating that men are exposed to high levels of LDL, total cholesterol, triglycerides, and glucose.
