ABSTRACT
No abstract available.
Subject(s)
Carcinoma, Basal Cell , Facial Dermatoses , Keratosis, Actinic , SkinABSTRACT
Favre-Racouchot syndrome (FRS) is a disorder consisting of solar elastosis with the presence of multiple cysts and open comedones. Although the exact mechanism of the condition is not known, FRS has been specifically connected to sun exposure, smoking and radiation exposure. The histological changes present in FRS reveal an atrophic epidermis and large masses of keratinous material, causing follicular plugging, as well as solar elastotic changes and possible basophilic degeneration of connective tissue. Herein, we report an unusual case of FRS concurrent with chronic granulomatous reaction and review relevant published works.
Subject(s)
Facial Dermatoses/complications , Granulomatous Disease, Chronic/complications , Aged , Diagnosis, Differential , Facial Dermatoses/pathology , Granulomatous Disease, Chronic/pathology , Humans , MaleABSTRACT
A 55-year-old Chinese man presented with an asymptomatic pedunculated elevation on his left lower eyelid which had been gradually increasing in size during the past three years. The patient was diagnosed with eyelid papilloma by pathological examination. Concomitantly, the patient developed open comedones with a bilateral linear distribution, along with oblique wrinkle lines in his infraorbital regions. These lesions were noninflammatory and remained unchanged for two years. To the best of our knowledge, this distribution of open comedones, especially in combination with eyelid papilloma, has not been reported previously in Favre-Racouchot syndrome.
ABSTRACT
Favre-Racouchot syndrome is a slowly progressive skin disease, which is characterised by grouped comedones occurring on solar damaged skin of elderly individuals. We describe a case of Favre- Racouchot syndrome in a 69-year-old man. He had multiple black comedones and yellowish nodules on both cheeks, with deep wrinkles and cutis rhomboidalis nuchae on the posterior of the neck. The excisional specimen, including comedones, revealed solar elastosis and dilated follicular cysts filled with keratinous material in the dermis. A biopsy specimen from a yellowish nodule showed a cystic structure with a corrugated luminal surface which was filled with keratinous material. Another biopsy specimen from protruding nodule showed the features of squamous cell carcinoma.
Subject(s)
Aged , Humans , Biopsy , Carcinoma, Squamous Cell , Cheek , Dermis , Facial Dermatoses , Follicular Cyst , Neck , Phenobarbital , Skin , Skin DiseasesABSTRACT
Favre-Racouchot syndrome is a cutaneous disease characterized by a degenerative process of dermis associated with comedones, furrows and nodules. It occurs on the face of aged men, a remarkable preference for the male, after prolonged exposure to sunlight. The pathogenesis of Favre-Racouchot syndrome is uncertain. The damage by UV exposure has been strongly suggested as a major cause. We present a typical case of Favre-Racouchot syndrome in a 65 year old male. The patient had numerous yellowish cysts, comedones and nodules on both cheeks. Histopathology of the lesion showed dilated pilosebaceous openings and large cyst-like spaces filled with multi-layered horny material in addition to pronounced solar elastosis in the dermis.
Subject(s)
Aged , Humans , Male , Cheek , Dermis , Facial Dermatoses , SunlightABSTRACT
Favre-Racouchot syndrome, also known as nodular elastosis with cysts and comedones, typically presents with large black open comedones, furrows, and nodules in the periorbital region and over the malar eminence. The pathogenesis of Favre-Racouchot syndrome is still uncertain. However it has been postulated that damage from ultraviolet radiation, combined with some unknown host predisposition, leads to the degeneration of the supporting dermal connective tissue. We report a case of Favre-Racouchot syndrome that developed on the applied area of topical corticosteroid for a preceding post-herpetic neuralgia lesion. This case is unique to suggest that the catabolic effect of corticosteroid is superimposed on the UV-induced degeneration of dermal connective tissue as a pathogenic mechanism of Favre-Racouchot syndrome.
