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1.
Rev. colomb. ciencias quim. farm ; 49(1): 171-182, Jan.-Apr. 2020. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1144345

ABSTRACT

SUMMARY Currently, there is a growing interest in identifying alternative sources of fatty acids due to the present increasing demand for oil-rich botanicals in industrial applications. The main objective of this work was to identify the fatty acid compositions of ether extracts of dried leaves of Bryophyllum pinnatum Lam., Ficus exasperata Vahl., Gossypium herbaceum Linn. and Hilleria latifolia (Lam.) H. Walt. The fatty acids were analyzed by gas chromatography with flame ionization detector. Among the evaluated ether extracts, the higher contents of saturated fatty acids were found in H. latifolia (27.96%) with the principal presence of stearic acid compared to the content of the saturated fatty acids in B. pinnatum (0.53%), F. exasperata (0.04%) and G. herbaceum (0.47%). Equally, the result showed that H. latifolia contained the highest percentage of unsaturated fatty acids with the predominant presence of oleic acid with the amount of 41.04%. Linoleic acid was also found to have the highest value in H. latifolia with the amount of 20.41%. Stearic acid, oleic acid, and linoleic acid were found in all the samples. The extract of H. latifolia contained a healthy mixture of different types of fatty acids thus suggesting it as a probable source of suitable fatty acids.


RESUMEN Actualmente, existe un creciente interés en identificar fuentes alternativas de ácidos grasos debido a la creciente demanda actual de productos botánicos ricos en aceite en aplicaciones industriales. El objetivo principal de este trabajo fue identificar las composiciones de ácidos grasos de extractos de éter de hojas secas de Bryophyllum pinnatum Lam., Ficus exasperata Vahl., Gossypium herbaceum Linn. y Hilleria latifolia (Lam.) H. Walt. Los ácidos grasos fueron analizados por cromatografía de gases con detector de ionización de llama. Entre los extractos de éter evaluados, los mayores contenidos de ácidos grasos saturados se encontraron en H. latifolia (27,96%) con presencia principal de ácido esteárico en comparación con el contenido de los ácidos grasos saturados en B. pinnatum (0,53%), F. exasperata (0,04%) y G. herbaceum (0,47%). Igualmente, el resultado mostró que la H. latifolia contenía el mayor porcentaje de ácidos grasos insaturados con presencia predominante de ácido oleico con una cantidad de 41,04%. También se encontró que el ácido linoleico tiene el valor más alto en H. latifolia con una cantidad de 20,41%. Se encontró ácido esteárico, ácido oleico y ácido linoleico en todas las muestras. El extracto de H. latifolia contenía una mezcla saludable de diferentes tipos de ácidos grasos, lo que sugiere que es una fuente probable de ácidos grasos adecuados.

2.
Food Chem Toxicol ; 112: 134-144, 2018 Feb.
Article in English | MEDLINE | ID: mdl-29288758

ABSTRACT

Ficus exasperata Vahl, commonly known as sandpaper, is a terrestrial Afro-tropical tree used in popular medicine. Despite the existence of some works on the biological activities of this species, its chemical composition is still poorly known. The aim of this study was to extend the knowledge on the phytochemistry and biological properties of this species. Aqueous extracts from F. exasperata leaves and stem bark were analysed. Thirty-one phenolic compounds, comprising cinnamoyl derivatives, flavonoid-O-glycosides, flavonoid-mono-C-glycosides, flavonoid-di-C-glycosides and one furanocoumarin, were determined by HPLC-DAD-ESI/MSn and UPLC-ESI-QTOF-MS, 26 of them being reported for the first time in this species. The profile of organic acids, characterized by HPLC-UV, was also reported for the first time. The best radical scavenging activity was observed for the aqueous extract from leaves (IC50 values of 222.5, 510.0 and 50.0 µg/mL against DPPH•, •NO and O2•-, respectively). In addition, both aqueous extracts of the leaves and stem bark displayed a weak effect on α-amylase, and no cytotoxicity against gastric adenocarcinoma cell line, AGS. This study contributes to the valorisation of these vegetal materials, which may have application in functional foods and/or nutraceuticals.


Subject(s)
Ficus/chemistry , Free Radical Scavengers/pharmacology , Plant Bark/chemistry , Plant Extracts/chemistry , Plant Extracts/pharmacology , Plant Leaves/chemistry , Plant Stems/chemistry , Cell Line, Tumor , Chromatography, High Pressure Liquid/methods , Dietary Supplements , Dose-Response Relationship, Drug , Drug Screening Assays, Antitumor , Free Radical Scavengers/chemistry , Functional Food , Humans , Hypoglycemic Agents/pharmacology , Inhibitory Concentration 50 , Nitric Oxide/chemistry , Reproducibility of Results , Spectrometry, Mass, Electrospray Ionization/methods , Spectrophotometry, Ultraviolet , Superoxides/chemistry
3.
Article in English | MEDLINE | ID: mdl-22468006

ABSTRACT

The hypotensive and hypoglycaemic effects of Ficus exasperata (Vahl) (family: Moraceae) leaf aqueous extract (FEE) were investigated in experimental rat models. In this study, spontaneously-hypertensive rats (SHR) (type 1 diabetes), obese Zucker (type 2 diabetes) and Wistar rats were used. Three (A, B and C) groups of rats, each group consisting of 10 rats, were used. Group A Wistar rats received distilled water in quantities equivalent to the volume of streptozotocin (STZ) and FEE administered intraperitoneally to treated rats. Diabetes mellitus was induced in the SHR group B rats by multiple low-dose (MLD) intraperitoneal injections of STZ (40 mg/kg body weight) to induce type 1 diabetes. The animals in group C were the obese Zucker rats with non-insulin-independent diabetes mellitus (NDDM) (type 2 diabetes) on genetic basis. F. exasperata leaf aqueous extract (FEE, 100 mg/kg/day p.o.) was administered orally by orogastric intubation to fasted Groups B and C rats. In groups B and C rats, administration of FEE commenced 4 weeks post STZ injection, and continued for the next 4 consecutive weeks. Group A rats gave normal biochemical and morphological findings. Group B rats exhibited pronounced polyuria, hypoinsulinaemia, hyperlipidaemia and hyperglycaemia. These findings were also observed in group C rats, except that there was hyperinsilinaemia. Histopathological study of the aortic blood vessels showed extensive collagen fiber formation as well as perivascular fibrosis in both groups B and C rats. Four weeks of oral administration of F. exasperata leaf aqueous extract to diabetic groups of rats decreased blood glucose, blood pressure and lipid profiles. Administration of FEE (100 mg/kg p.o.) also restored the microanatomy of the blood vessels to almost normal levels. The findings of this study suggest that F. exasperata leaf aqueous extract possesses hypoglycaemic, hypotensive and hypolipidaemic properties. These findings lend biomedical and pharmacological support to the folkloric, ethnomedical uses of the plant in the management and/or control of diabetes and hypertension among the Yoruba-speaking people of Western Nigeria.


Subject(s)
Blood Glucose/drug effects , Blood Pressure/drug effects , Diabetes Mellitus, Experimental/drug therapy , Ficus/chemistry , Hypoglycemic Agents/pharmacology , Plant Extracts/pharmacology , Animals , Diabetes Mellitus, Experimental/blood , Enzyme-Linked Immunosorbent Assay , Female , Hypertension/drug therapy , Hypolipidemic Agents/pharmacology , Hypotension , Injections, Intraperitoneal , Insulin/blood , Lipids/blood , Male , Phytotherapy , Plant Extracts/administration & dosage , Plant Leaves/chemistry , Random Allocation , Rats , Rats, Wistar , Streptozocin , Water
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