ABSTRACT
Eighteen jirds were equally distributed in two treated and one control groups. The commercial products to the fenbendazole base (10mg) and the association of febantel (1.5mg), pirantel (1.44mg) and praziquantel (0.5mg) were orally administred in the concentration of 0.1ml in each group. The effectiveness of febendazole against oxiurids was 81.8%, 65.0 and 38.7% and for the association of febantel, pirantel and praziquantel was 72.7%, 73.8% and 51.0% on days 7, 14 and 21, respectively. Three applications of that dose of the tested medications, within intervals of 10 days, associated to hygiene, are recommended.(AU)
Subject(s)
Anthelmintics/administration & dosage , Anthelmintics/adverse effects , Pyrantel Pamoate/administration & dosage , Praziquantel/administration & dosage , GerbillinaeABSTRACT
O parasitismo por nematódeos gastrintestinais constitui uma importante causa de danos à saúde e de perdas econômicas na produção de pequenos ruminantes. O modelo laboratorial para estudos de nematódeos de ruminantes utilizando gerbis (Meriones unguiculatus) torna-se mais adequado quando estes animais são imunossuprimidos. Os corticosteróides são drogas freqüentemente usadas na imunossupressão de animais de biotério. O índice de eficiência bionutricional é considerado um parâmetro efetivo para avaliar os efeitos de tratamentos sobre a performance nutricional dos animais. O objetivo deste trabalho foi avaliar a eficiência bionutricional de gerbis imunossuprimidos e infectados experimentalmente com larvas de nematódeos de ovinos. Os resultados indicaram que os animais que receberam a droga apresentaram maior número de nematódeos à necropsia que o grupo de animais apenas infectados. Não foi observado efeito nocivo da infecção sobre a performance dos animais. Os animais não infectados e que receberam a droga metilprednisolona tiveram performance significativamente menor que os não infectados que não receberam a mesma.(AU)
The gastrointestinal parasitism by nematodes constitutes an important cause of damages to the health and of economical losses in the production of small ruminants. Studies with nematodes of ruminants using jirds (Meriones unguiculatus) as a laboratorial model become more appropriate when the animals are immunossupressed. Corticosteroids are drugs quite used in the immunossuppression of biotery animals. The bio-nutritional efficiency index is considered an effective parameter to evaluate the effect of treatments on the animal nutritional performance. The objective of this work was to evaluate the bio-nutritional efficiency index of jirds immunossupressed and infected experimentally with larves of sheep nematodes. The results indicated that the animals that received the drug presented a major number of nematodes in necropsia in relation to the group of animals just infected. There was not harmful effect of infection on the performance of animals. The noninfected animals and treated with the drug methylprednisolone had a performance significantly lower than the noninfected animals and without drug application.(AU)