Significant increase in the number of occupational exposures reported to the Dutch Poisons Information Centre (2016-2022): the importance of poison centre data in health surveillance.

INTRODUCTION: Exposure to hazardous substances in the workplace can result in injuries and fatalities. This study aimed to investigate the characteristics and trend of occupational exposures reported to the Dutch Poisons Information Centre and to investigate whether the COVID-19 pandemic had an impact on the trend. METHODS: A retrospective analysis of all acute occupational exposures reported to the Dutch Poisons Information Centre between 1 January 2016 and 31 December 2022 was performed. Data on patient and exposure characteristics, symptoms and treatment recommendations were analyzed. RESULTS: Between 2016 and 2022, the Dutch Poisons Information Centre received 5,508 calls regarding acute occupational exposures. The annual number of calls on acute occupational exposures almost doubled over the years studied (from 475 in 2016 to 936 in 2022). During and after the COVID-19 pandemic (March 2020-December 2022), the number of calls stabilized, but the upward trend was not significantly affected. There were an estimated 0.20 calls per 1,000 human exposure calls per month (95 per cent confidence interval: -0.14; 0.53). Victims were often exposed through multiple routes, with inhalation being the most common route (44 per cent), followed by ocular (32 per cent) and dermal contact (30 per cent). Acids (1,138 exposures) and alkalis (912 exposures) were often involved. The Dutch Poisons Information Centre had information on 6,334 patients, although the total number of exposed patients was not known as some victims did not seek medical assistance, or were treated by healthcare professionals who did not consult our Centre. At the time of contact, 13 per cent (n = 795) of the patients reported no symptoms, 76 per cent (n = 4,805) reported mild to moderate symptoms and 3 per cent (n = 183) reported potentially severe symptoms. Information on symptoms was missing for 9 per cent (n = 551) of the patients. Hospital observation and treatment were recommended for 5 per cent (n = 325) of the patients. DISCUSSION: This study highlights the necessity for poisoning prevention strategies to reduce the number of work-related incidents involving hazardous substances. CONCLUSION: The continuing increase in the number of workplace incidents involving hazardous substances is of concern. A comprehensive and multidisciplinary approach should be taken to gain a full understanding of occupational exposure to hazardous substances and to identify risk factors.

Determination of the urinary concentrations of six bisphenols in public servants by online solid-phase extraction-liquid chromatography tandem mass spectrometry.

Bisphenols are widely used as monomers and additives in plastic production. Thus, bisphenol A (BPA) and its most prominent substitutes have been detected in many environmental and human samples. This study proposes an online solid-phase extraction analytical methodology coupled to liquid chromatography with tandem mass spectrometry for the determination of six bisphenols (BPA and bisphenols F (BPF), S (BPS), AF (BPAF), B (BPB), and E (BPE)) in urine samples as an efficient and automated methodology. The method was developed and validated for all bisphenols with good recoveries (92-112%) and repeatability (RSD ≤ 10%) despite the variable matrix effects, except BPAF (which would require a dedicated internal standard), achieving method quantification limits in the 0.05-2.2 ng mL-1 range. The methodology was subsequently applied to 435 urine samples from a non-occupational exposure population (civil servants for the regional government) from Santiago de Compostela (Galicia, Spain). Only BPA, BPF, and BPS were positively detected; the last two presented higher detection frequencies than BPA. When the urinary concentrations are extrapolated to human intake and compared to the European Food Safety Agency (EFSA) tolerable daily intake (TDI) of 2 × 10-4 µg kg-1 day-1 (TDI), all BPA positively identified samples would surpass this threshold. Although no TDI exists currently for the other two identified bisphenols, it is evident that human exposure to bisphenols should be limited. Finally, the results stratification by gender revealed higher levels of exposure to BPF in the women group.

Migration characteristics and risk assessment of chemical hazardous substances in infant teether toys.

Teether is a special toy used for infants oral contact. In this paper, a residual and migration detection method was developed using gas chromatography-tandem mass spectrometry for 20 screened hazardous substances in teethers. Fifteen substances were detected in 59 samples, with residual amounts and detection rates ranging from 0.01 mg⋅kg-1 to 106.15 mg⋅kg-1 and from 3.39 % to 84.7 % respectively. Then, 12 substances were detected in simulated saliva at migration levels ranging from 0.0143 mg⋅kg-1 to 20.03 mg⋅kg-1, with detection rates ranging from 1.69 % to 76.3 %. Statistically, the average migration rate of each substance ranged from 8.18 % to 53.28 % depending on the properties of the substance and the sample. The exposure risk of infants to teethers was evaluated separately for two age groups. The hazard quotient (HQ) and hazard index (HI) values for the analytes were higher in the 3-12-month age group than in the 12-24-month age group. The HQ values of triphenylphosphine oxide, benzocaine, and N-methylformanilide were relatively high, with averages of 1.2 × 10-2, 2.5 × 10-3, and 1.6 × 10-3, respectively, and the max HI of the 12 substances was 0.04. The HI and HQ values of the analytes were all below 1, indicating that the non-carcinogenic risks of analytes in teethers are at an acceptable level.

Do hazardous substances in demolition waste hinder circular economy?

Hazardous substances in demolition waste are often deemed a barrier to a circular economy owing to concerns about their fate in recycled materials. However, with the growing demand for recycling materials, it is essential to find circular solutions for construction materials but still protect health and the environment by managing hazardous substances. In this study, selected hazardous substance groups were analysed from demolition waste samples. Most of the concentrations did not raise any concerns when the safety of recycling materials was considered. However, the detection limits of laboratory chemical analysis can be discussed, as bromine was found in samples by an X-ray fluorescence (XRF)-analyser, but only one laboratory detected brominated flame retardants (BRFs). New technologies and practices are needed to follow the chemical content of materials used in the construction phase. Detecting hazardous substances in recyclable materials is the only way to achieve harmless material cycles.

Alternatives for the administration of oral antineoplastics in patients with swallowing difficulties.

Oncology patients often experience swallowing difficulties, which can compromise adherence to treatment and consequently reduce its effectiveness. Improper handling of these hazardous drugs can lead to the risk of inhalation of particles or other exposures endangering the health of the persons involved such as nurses and pharmacists. The aim of this review is to analyse and update the recommendations for the manipulation of oral antineoplastic drugs in patients with swallowing difficulties. A literature review of articles, websites, guidelines and other documents published up to about the conditions of handling and administration of oral antineoplastic agents in oncology and oncohaematology was carried out. A table of 110 active principles was compiled. The information was grouped according to the name of the drug, instructions for oral and nasogastric tube administration and suggested recommendations. Among the drugs reviewed, 66.4% were suitable for dissolution. Although there is a lot of information in the literature, the nonstop development of new oncological drugs requires continuous updating. Therefore, we have collected the most recent data to provide a consultation tool for healthcare professionals and patients with swallowing difficulties.

This review can be used by all types of healthcare professionals, especially nurses, who handle oncological medicinal drugs. In addition, the safest handling methods for the worker have been recommended.

Near Infrared Light-Emitting Diodes Based on Colloidal InAs/ZnSe Core/Thick-Shell Quantum Dots.

Heavy-metal-free III-V colloidal quantum dots (QDs) exhibit promising attributes for application in optoelectronics. Among them, InAs QDs are demonstrating excellent optical performance with respect to absorption and emission in the near-infrared spectral domain. Recently, InAs QDs attained a substantial improvement in photoluminescence quantum yield, achieving 70% at a wavelength of 900 nm through the strategic overgrowth of a thick ZnSe shell atop the InAs core. In the present study, light-emitting diodes (LEDs) based on this type of InAs/ZnSe QDs are fabricated, reaching an external quantum efficiency (EQE) of 13.3%, a turn-on voltage of 1.5V, and a maximum radiance of 12 Wsr-1m-2. Importantly, the LEDs exhibit an extensive emission dynamic range, characterized by a nearly linear correlation between emission intensity and current density, which can be attributed to the efficient passivation provided by the thick ZnSe shell. The obtained results are comparable to state-of-the-art PbS QD LEDs. Furthermore, it should be stressed not only that the fabricated LEDs are fully RoHS-compliant but also that the emitting InAs QDs are prepared via a synthetic route based on a non-pyrophoric, cheap, and commercially available as precursor, namely tris(dimethylamino)-arsine.

Characterizing hazardous substances of shale gas wastewater from the upper Yangtze River: A focus on heavy metals and organic compounds.

In the last decade, rapid shale gas exploration in upper Yangtze River ecological zone in China has led to increasing concerns about the environmental impact of shale gas wastewater (SGW). However, our understanding of the types of potential hazardous substances of SGW remains limited. In this study, eight SGW samples from three shale gas regions in upper Yangtze River: the Sichuan Basin, the Guizhou Plateau, and the Three Gorges Area were collected, and their general water quality, trace metals, and organic compounds were comprehensively analyzed. Our in-depth analysis detected 55 kinds of trace heavy metals, with 24 exceeding detection limits. Most of them were of the concentration below 100 µg/L. Concentrations of primary pollutants, including Cd, Cr, As, Pb, and Ni, remained below Integrated Wastewater Discharge Standard (GB 8978-1996), indicating minimal environmental risk. The organic analysis identified 45 to 104 kinds of volatile and semi-volatile organic compounds in SGW samples from different regions. SGW samples from the Sichuan Basin exhibited a balanced proportion of aliphatic and aromatic compounds, with oxygen and nitrogen-substituted heteroatomic compounds prevailing, while SGW samples from the Guizhou Plateau and the Three Gorges Area were dominated by aromatic compounds, particularly hydrocarbons. Several organic substances exhibited high response strengths across multiple SGW samples, including isoquinoline, dibenzylamine, 2,4-di-tert-butylphenol, 1,2,3,4-tetrahydro-naphthalene, and 1,2,3,4-tetrahydro-6-methyl-naphthalene. The Globally Harmonized System (GHS) of Classification and Labelling of Chemicals classified most high-response organics as high acute and chronic aquatic hazards. Our findings indicate that high salinity and a variety of high-risk organic pollutants, rather than heavy metals, are the primary pollutants in SGW, underscoring the urgency of safety management of SGW.

Experiment to Demonstrate Pesticide-Induced Antimicrobial Resistance (AMR): An Emerging Health Threat.

Background Pesticides, including insecticides, herbicides, and fungicides, are essential for global food production, boosting crop yields, and preventing disease transmission. However, their excessive and improper use raises concerns about potential long-term consequences, affecting microbial ecosystems and fostering antimicrobial resistance. Materials and methods The objective of the study was to identify the effect of the pesticide compound (Imidacloprid 17.1% w/w) on the ATCC Escherichia coli. An experiment was conducted on ATCC Escherichia coli 27852. A 0.5 McFarland suspension of the strain was incubated in the presence of a pesticide compound (Imidacloprid 17.1% w/w) at a dilution of 1:4, 1:8, and 1:16. at 370C. Antibiotic susceptibility for cefoxitin, ciprofloxacin, ceftazidime, amikacin, and imipenem was determined via the Kirby-Bauer disk diffusion test at intervals of 24 hours, 48 hours, seven days, and 21 days. The results were then compared to the standard zone of inhibition diameter for ATCC Escherichia coli 27852 by Clinical and Laboratory Standards Institute (CLSI) guidelines. Results No bacterial growth was detected at pesticide dilutions of 1:1 and 1:2, indicating their inability to tolerate high pesticide concentrations. However, growth became evident at a 1:4 dilution and beyond, with mutants thriving within the inhibition zone. The experiment caused significant alterations in the inhibition zone sizes for all antibiotics, especially notable with imipenem, amikacin, and ceftazidime compared to the initial zone size for ATCC Escherichia coli 27852. Conclusion Our study concludes that the pesticide (Imidacloprid 17.1% w/w) significantly influences antibiotic resistance, especially with carbapenems, aminoglycosides, and cephalosporins in the tested groups at various concentrations and durations of exposure.

[Research on quantitative evaluation of revise requirements of Specifications of Air Sampling for Hazardous Substances Monitoring in the Workplace (GBZ 159-2004)].

Objective: To conduct quantitative evaluation on the revise requirements of Specifications of Air Sampling for Hazardous Substances Monitoring in the Workplace (GBZ 159-2004) , clarify the problems and suggestions during its implementation for improvement, and provide a basis for the revision of the standard. Methods: From April to September 2021, stratified convenient sampling method was adopted and semi-open questionnaire was used to investigate the occupational health personnel in CDC, occupational prevention and control institutes, employers, third-party technical service institutions and universitie. The entropy weight of each index and the score based on entropy weight of GBZ 159 were calculated. Spearman rank correlation analysis was used to describe the correlation between the two indexes and radar chart was drawn for comprehensive evaluation. Results: A total of 151 questionnaires were received from the respondents, of which 147 were valid, with an effective recovery rate of 97.35%, involving 29 provinces, autonomous regions and municipalities. The median G scores of the necessity and urgency of GBZ 159 revision based on entropy weight were 2.84 and 3.17, respectively, and the difference was statistically significant (M=-25.50, P<0.001) . The trend of the score G of necessity and urgency based on entropy weight was basically the same for all secondary items (r(s)=0.9998, P<0.001) , and the score G of urgency based on entropy weight was higher than that of necessity. The highest score G of necessity and urgency based on entropy weight was "3.13 long time sampling", which were 7.56 and 8.23 respectively. This was followed by "3.12 short time sampling", which were 7.19 and 7.13 respectively. Conclusion: GBZ 159 has encountered some new problems and challenges in the implementation process, and some of its technical indicators have been out of line with the actual practice of occupational health at present. These are the two items that urgently needs to be revised and improved, such as "3.13 long time sampling" and "3.12 short time sampling" and other items need to be revised and improved.

A WHO-led global strategy to control greenhouse gas emissions: a call for action.

BACKGROUND: Climate change, driven by anthropogenic greenhouse gas emissions, is among the greatest threats to human health. The World Health Organisation (WHO), has led global efforts to respond to emerging public health threats including the control of hazardous substances such as tobacco, alcohol, lead and asbestos, with remarkable health gains. BODY: Despite WHO's clear messaging on the enormous and growing health risks of climate change, greenhouse gases are not yet classified as hazardous substances, requiring control through a global strategy or framework. Additionally, WHO has not classified disease attributable to climate change as a result of the promulgation of these hazards as a Public Health Emergency of International Concern (PHEIC), despite the serious and preventable health risks it poses globally. Several historical precedents set the stage for WHO to declare excess greenhouse gases as health hazards, including the control of ozone-depleting substances and breast-milk substitutes where the public benefit of control exceeded the potential benefit of their promulgation. In addition, WHO's undertaking within the International Health Regulations to protect global health, providing imperative to declare climate change a PHEIC, with Tedros Adhanom Ghebreyesus, director-general of WHO, declaring: "The climate crisis is a health crisis, fuelling outbreaks, contributing to higher rates of noncommunicable diseases, and threatening to overwhelm our health workforce and health infrastructure". Importantly, the health sector, perhaps more than other sectors, has successfully overcome formidable, vested interests in combatting these threats to health. CONCLUSION: It is thus imperative that WHO make full use of their credibility and influence to establish a global framework for the control of greenhouse gases through the declaration of excess greenhouse gas emissions as a hazardous substance, and declaring climate change a PHEIC. Who else is better placed to drive the considerable societal transformation needed to secure a liveable future?

Umnutzung von Gewerbegebäuden in Wohnraum: Was ist bezüglich möglicher Schadstoffbelastungen in der Innenraumluft zu beachten?

The conversion of industrial buildings into residential space requires special consideration of the inherited building fabric and associated pollutants. Due to the previous industrial use at contaminated sites, certain pollutants may play a significant role that are normally not the focus of refurbishments activities of residential spaces. In order to comply with the increased requirements with respect to indoor air quality in residential spaces, and to avoid unnecessary efforts and costs of amendments to the refurbishment, the Indoor Air Hygiene Commission (IRK) provides advice on how to prepare the conversion of commercial buildings so that healthy living conditions are ensured.

Levels and control of welding fume exposure to total particulate, hexavalent chromium, and manganese in contracted activities in an oil refinery setting (2008-2018).

In response to increasing focus on occupational exposures to welding fume, a 10-year series of personal exposure measurements was analyzed for the two main welding processes (Shielded Metal Arc Welding or Stick and Tungsten Inert Gas welding or TIG) used in an oil refinery setting. Exposures from ancillary gouging and grinding were also analyzed. The operations were conducted under a permit-to-work system, which stipulated control measures in the form of ventilation and respiratory protective equipment (RPE) depending on the work environment, base metal, and welding process. The analysis focused on three health hazards of interest: total particulate (TP); hexavalent chromium (Cr (VI)); and manganese (Mn). The study's aims were the analysis of exposure levels related to operational conditions to verify the adequacy of required control measures and the generation of quantitative information for the development of predictive exposure models. Arithmetic mean exposures were 2.01 mg/m3 for TP (n = 94), 13.86 µg/m3 for Cr (VI) (n = 160), and 0.024 mg/m3 for Mn (n = 95). Requirements and practices for ventilation and use of RPE appeared adequate for maintaining exposure levels below maximum use concentrations. Predictive models for mean exposure levels were developed using multiple linear regression. Different patterns emerged for TP, Cr (VI), and Mn exposure determinants. Enclosed or confined work environments were associated with elevated exposure levels, regardless of the provision of local exhaust or general dilution ventilation. Carbon arc, used with gouging and grinding, contributed significantly to TP exposure (p = 0.006). The relative TP source strengths of the two main welding processes were comparable to the literature data. For Cr (VI), stick welding was associated with approximately 50-fold (p < 0.001) higher exposure potential than TIG welding. For Mn, this difference was approximately 2.5-fold. Differences were observed across the three analytes in exposure reduction efficiency of local exhaust ventilation (LEV) compared to natural ventilation, possibly due to ineffective use in confined spaces. These findings contribute to the overall understanding of TP, Cr (VI), and Mn exposures from welding and required controls in an oil refinery setting.

Effects of the Hazardous Area Response Team Training Program on the Knowledge and Confidence in Operational Skills of Prehospital Emergency Medical Personnel in Thailand: A Quasi-Experimental Study.

Background: Hazardous areas are places emitting hazardous materials, terrorist- or war-related, which lead to public health risks in developed and developing countries globally. Hence, prehospital emergency medical personnel who work as frontliners should be trained. Patients and Methods: Data via pretest, posttest, and questionnaire surveys regarding the HART's knowledge of and confidence in operational skills were collected using the 5-point Likert scale. The cohort included prehospital emergency medical personnel aged >18 years. The training program comprised lectures, practicals, and examinations and included three subcourses: emergency medicine in the chemical, biological, radiation, and nuclear hazardous area (EM-CBRN) course; Thailand Tactical Emergency Medical Service (TTEMS) course; and cooperation and preparation for disaster (CPD) course. Results: The HART's mean multiple choice question (MCQ) posttest knowledge score (12.80±3.11) was significantly higher (p<0.001) than the mean pretest knowledge score (7.74±3.71) for the EM-CBRN course. The HART's mean MCQ posttest knowledge score (24.04±2.79) was significantly higher (p<0.001) than the mean pretest knowledge score (14.34±3.92) for the TTEMS course. Further, the HART's mean MCQ posttest knowledge score (21.03±3.49) was significantly higher (p<0.001) than the mean pretest knowledge score (14.40±5.08) for the CPD course. The HART's mean confidence in operational skill score for the EM-CBRN course was significantly higher (p<0.001) after training (4.45±0.59) than before training (2.77±0.90). The HART's mean confidence in operational skill score for the TTEMS course was significantly higher (p<0.001) after training (4.55±0.59) than before training (2.78±0.98). The HART's mean confidence in operational skill score for the CPD course was significantly higher (p<0.001) after training (4.70±0.41) than before training (3.03±0.90). Conclusion: The HART training program significantly affected the HART's knowledge development and confidence in operational skills, particularly the frontline prehospital emergency medical personnel. Therefore, prehospital emergency medical personnel should undergo training, and learning activities must be developed to reinforce capacity and improve knowledge and confidence.

A regional approach for health risk assessment of toxicants in plastic food containers.

Plastic food containers are being used popularly, generating a waste of about 115 million tons in Vietnam. Such waste is causing environmental and health issues. This study conducted a field survey with 250 local people and selected 59 samples out of 135 plastic food containers collected in Go Vap district, Vietnam. Collected plastic samples identified compositions were PET 13.6%, PP 28.8%, PS 16.9%, and 40.7% undefined plastics. Collected plastic samples were classified based on the plastic type using recycling code and quantitatively analyzed with X-ray fluorescence spectroscopy method to assess concentrations of Cd, Sb, Pb, Hg, Sn, Cr, Br, Cl, and S. Most of these collected plastic samples (91.5%) were found to contain 8/9 hazardous substances and most elements contained in these plastics were below their standard thresholds. These elements in plastic samples could be divided as the result into three hazard groups: (1) high hazard group (Sb, Cl, and S); (2) medium hazard group (Cr, Br and Hg); and (3) low hazard groups (Cd, Pb and Sn). Among substances in the high hazard group, element Sb was assessed for its migration because only Sb is regulated in Vietnam in QCVN 12-1: 2011/BYT. Substances of Cl, S, Cr, Br, and Hg (group 1, 2) do not have regulations related to the method of decontamination. Thus, additional health risks need to be assessed using the USEtox model. Finally, this study proposed a screening process to assess the risk of toxicity of elements contained in plastic food containers through ISO 31000:2018. Supplementary Information: The online version contains supplementary material available at 10.1007/s43188-023-00194-0.

[Health risk assessment associated with priority potentially hazardous chemical compounds detected in canned meat and meat-and-vegetable food for infants].

Assessment of public health safety associated with chemical contaminants consumed with food is an important component for solving the tasks of ensuring the sanitary and epidemiological well-being of the population. For these purposes, it is necessary to establish priority potentially dangerous compounds among the identified undeclared and unintended chemical contaminants for further consumers risk assessment. In conditions of unacceptable levels of health risk, it is necessary to decide whether it is advisable to develop new or change existing hygiene standards for these substances. The aim of the study was to assess the health risk associated with priority potentially dangerous unintended chemical components of contamination in canned meat and meat-and-vegetable products for infants (using the example of N-nitrosoamines). Material and methods. The selection of priority chemical compounds and public health risk assessment were carried out in accordance with the procedure for identifying undeclared and potentially dangerous unintended chemicals in food and using modified approaches based on the results of previous studies. Health risk assessment for infants consuming canned meat and meat-and-vegetables containing priority chemicals was carried out in accordance with the methodology approved by the Eurasian Economic Commitee, as well as using the Guidelines for assessing risks to public health when exposed to environmental pollutants. To characterize the calculated risk levels, the classification proposed in the draft document «Guidelines for assessing risks to public health when exposed to environmental pollutants¼ was used. Results. N-nitrosoamines are classified as chemical contaminants that are a priority for public health risk assessment, identified on the basis of the potential hazard category. A comparative health risk assessment for the target group consumers of canned meat and meat-and-vegetables sold on the territory of the Russian Federation and the Socialistic Republic of Vietnam showed the presence of an unacceptable risk to the health of the Russian population in relation to non-carcinogenic adverse health effects associated with the intake of N-nitrosodimethylamine (NDMA) (hazard quotient HQ=1.1) and N-nitrosodibuthylamine (HQ=5.25). Many experimental (animal) researches confirm the formation of negative effects and potential harm to humans, formed by the consumption of N-nitrosoamines with food. At the same time, the level of the exposure of N-nitrosoamines during oral administration was assessed mainly from the side of carcinogenic effects, however, this study reflects the hazard, including from non-carcinogenic risks associated not only with NDMA and N-nitrosodiethylamine, for which there is a hygienic standard, but also for other N-nitrosoamines, for which there is no hygienic regulation. In turn, the European Food Safety Agency's (EFSA) study notes that it is necessary to conduct a risk assessment for human health in relation to other N-nitrosoamines identified in food, and, if necessary, rationing of these compounds, which is also confirmed by this study. Conclusion. The conducted health risk assessment of the target population of Russia (infants from 6 months to 3 years) consuming the studied types of products containing N-nitrosoamines showed the presence of unacceptable levels of non-carcinogenic health risks in relation to the development processes and impaired liver function. In connection with the identified risks to the health of the target population, it is advisable to establish maximum permissible levels not only for the amount of NDMA and N-nitrosodiethylamine, but also for other N-nitrozoamines identified by the results of the study, with their subsequent regulation.

Computer programs used in the field of hospital pharmacy for the management of dangerous drugs: systematic review of literature.

Background: This review wants to highlight the importance of computer programs used to control the steps in the management of dangerous drugs. It must be taken into account that there are phases in the process of handling dangerous medicines in pharmacy services that pose a risk to the healthcare personnel who handle them. Objective: To review the scientific literature to determine what computer programs have been used in the field of hospital pharmacy for the management of dangerous drugs (HDs). Methods: The following electronic databases were searched from inception to July 30, 2021: MEDLINE (via PubMed), Embase, Cochrane Library, Scopus, Web of Science, Latin American and Caribbean Literature in Health Sciences (LILACS) and Medicine in Spanish (MEDES). The following terms were used in the search strategy: "Antineoplastic Agents," "Cytostatic Agents," "Hazardous Substances," "Medical Informatics Applications," "Mobile Applications," "Software," "Software Design," and "Pharmacy Service, Hospital." Results: A total of 104 studies were retrieved form the databases, and 18 additional studies were obtained by manually searching the reference lists of the included studies and by consulting experts. Once the inclusion and exclusion criteria were applied, 26 studies were ultimately included in this review. Most of the applications described in the included studies were used for the management of antineoplastic drugs. The most commonly controlled stage was electronic prescription; 18 studies and 7 interventions carried out in the preparation stage focused on evaluating the accuracy of chemotherapy preparations. Conclusion: Antineoplastic electronic prescription software was the most widely implemented software at the hospital level. No software was found to control the entire HD process. Only one of the selected studies measured safety events in workers who handle HDs. Moreover, health personnel were found to be satisfied with the implementation of this type of technology for daily work with these medications. All studies reviewed herein considered patient safety as their final objective. However, none of the studies evaluated the risk of HD exposure among workers.

Research progress in the detection of common foodborne hazardous substances based on functional nucleic acids biosensors.

With the further improvement of food safety requirements, the development of fast, highly sensitive, and portable methods for the determination of foodborne hazardous substances has become a new trend in the food industry. In recent years, biosensors and platforms based on functional nucleic acids, along with a range of signal amplification devices and methods, have been established to enable rapid and sensitive determination of specific substances in samples, opening up a new avenue of analysis and detection. In this paper, functional nucleic acid types including aptamers, deoxyribozymes, and G-quadruplexes which are commonly used in the detection of food source pollutants are introduced. Signal amplification elements include quantum dots, noble metal nanoparticles, magnetic nanoparticles, DNA walkers, and DNA logic gates. Signal amplification technologies including nucleic acid isothermal amplification, hybridization chain reaction, catalytic hairpin assembly, biological barcodes, and microfluidic system are combined with functional nucleic acids sensors and applied to the detection of many foodborne hazardous substances, such as foodborne pathogens, mycotoxins, residual antibiotics, residual pesticides, industrial pollutants, heavy metals, and allergens. Finally, the potential opportunities and broad prospects of functional nucleic acids biosensors in the field of food analysis are discussed.

Preventing occupational chemical eye injuries: important lessons from poison information centres.

BACKGROUND: Occupational exposure to hazardous substances is a major public health problem. In the workplace, eye exposures are common and can be a major cause of morbidity and disability. This commentary discusses the role of poison information centres in providing valuable information on the circumstances and causes of these incidents. OCCUPATIONAL HEALTH SURVEILLANCE: As many eye exposures are easily preventable, there is a need to establish better safety practices in the workplace. Currently, both governments and labour organizations primarily employ injury statistics for the purpose of occupational health surveillance. Identifying risk factors associated with acute exposures in the workplace requires a comprehensive approach using a variety of information resources. Using information from poison information centres can provide invaluable insight into the specifics of the exposure, including the route(s) of exposure, the substances involved and the cause of the exposure. CIRCUMSTANCES OF OCCUPATIONAL EYE EXPOSURES: Exposure to hazardous substances can occur at various time points during work. A prospective study performed by the Dutch Poisons Information Centre showed that cleaning is a high-risk activity for occupational eye exposure. Patients were often exposed to chemical mixtures that frequently contained alkalis or acids. CHEMICAL EYE INJURIES: Symptoms following eye contact with chemicals can vary greatly depending on factors such as the type and concentration of the substance(s) involved, the duration of exposure and the time and duration of irrigation (first-aid measure). Eye contact will usually cause irritation, but in more severe cases, chemical burns will result. Recent studies demonstrate that occupational eye exposures often result in only relatively mild symptoms, such as pain, redness, lacrimation or temporary loss of vision. More severe symptoms, such as corneal abrasion, were reported rarely, which may be explained by prompt eye irrigation. ROOT CAUSES OF OCCUPATIONAL EYE EXPOSURES: To control risks to workers, a hierarchy of prevention and control measures has been established, which employers must take. If elimination or substitution of the dangerous substance is not possible, the exposure can be prevented or reduced by taking organizational (e.g., providing work instructions), technical (e.g., ventilation) and personal (e.g., wearing personal protective equipment) measures. The study performed by the Dutch Poisons Information Centre showed that organizational factors (such as lack of work instructions) and personal factors (such as time pressure and fatigue, and not (adequately) using personal protective equipment), were the main causes of occupational eye exposure. CONCLUSIONS: Poison information centres provide valuable information that can be used to develop prevention strategies to reduce the number of acute occupational exposures in the future. A multidisciplinary approach is essential to ensure that these preventive measures are actually applied in practice. Therefore, all organizations involved (including governments, labour organizations, medical professionals, occupational physicians, occupational hygienists, safety experts and poison information centres) must work closely together.

Single extraction and integrated non-target data acquisition with data mining workflow for analysis of hazardous substances in agricultural plant products.

Identifying contaminants in agricultural plant food products (APFPs) is a major problem. In this study, we developed a single-step extraction and integrated non-target data acquisition (INDA) workflow for increasing hazardous substances coverage. D-optimal experimental designs were applied to optimize filter plate extraction (FPE) for one-single extraction of multipolar hazardous substances. The vDIA mode was used to collect all precursor ion fragments within the range to supplement data loss caused by DDA mode. The underlying principle of vDIA is to increase the utilization rate of MS2 spectra that are likely to identify a maximum number and minimum amounts of hazardous substances. Compared with traditional DDA mode alone, a combination of the two modes increased the rate of identification of hazardous substances by 18.5%. The molecular network of hazardous substance provided by GNPS could enable some metabolites and structure-related products to discover potentially hazardous substance.