Improvement of gait and balance function in chronic post-stroke patients induced by Lower Extremity - Constraint Induced Movement Therapy: a randomized controlled clinical trial.

OBJECTIVE: To evaluate the effects of Lower Extremity - Constraint Induced Movement Therapy on gait function and balance in chronic hemiparetic patients. METHODS: Randomized, controlled, single-blinded study. We recruited chronic post stroke patients and allocated them to Lower Extremity - Constraint Induced Movement Tharapy (LE-CIMT) or Control Group. The LE-CIMT group received this protocol 2.5 hour/day for 15 followed days, including: 1) intensive supervised training, 2) use of shaping as a strategy for motor training, and 3) application of a transfer package. The control group received conventional physiotherapy for 2.5 hours/day for 15 followed days. Outcomes were assessed at baseline, after the interventions, and after 6 months, through 6-minute walk test and Mini-Balance Evaluation Systems Test; 10-meter walk test, Timed Up and Go, 3-D gait analysis, and Lower Extremity - Motor Activity Log. RESULTS: LE-CIMT was superior on the Assistance and confidence subscale of Lower Extremity - Motor Activity Log, Mini-BESTest and 6-minute walk test. The effect size for all outcomes was small when comparing both groups. LE-CIMT showed clinically significant differences in daily activities, balance, and gait capacity, with no clinically significant difference for spatiotemporal parameters. CONCLUSION: The LE-CIMT protocol had positive outcomes on balance, performance, and confidence perception.

Cerebral hemiatrophy and hemiparesis following hemiclonic status epilepticus in Dravet syndrome.

Dravet syndrome is currently considered as an developmental and epileptic encephalopathy and, recently, mandatory, alert, and exclusionary criteria have been proposed. Here, we describe three patients with Dravet syndrome with the typical early presentation including febrile and afebrile alternating hemiclonic seizures due to loss-of-function SCN1A variants. Subsequently, they developed episodes of febrile focal status epilepticus (SE) associated with hemiparesis and cerebral hemiatrophy with posterior focal seizures, as a consequence of Dravet syndrome. This sequence of events has been previously published in patients with Dravet syndrome and does not contradict the recent classification by the International League Against Epilepsy (ILAE). The ILAE guidance identifies "Focal neurological findings" as alert criteria and "MRI showing a causal focal lesion" as exclusionary criteria for making an initial diagnosis of Dravet syndrome at presentation. Our three patients would correspond to a severe phenotype, similar to the well-known presentation of generalized atrophy following prolonged status epilepticus. Common genetic findings in cases of diffuse and unilateral brain involvement may help explain these clinical presentations. Further genotype-phenotype studies may provide additional insights into this electroclinical behavior.

Aphasia improvement without logotherapy during motor neurorehabilitation of post-stroke hemiparesis using virtual reality or modified constraint-induced movement therapy: A retrospective cohort.

BACKGROUND: Some research suggests that post-stroke aphasia can recover "on its own", however, there is evidence of a common neural substrate for motor and language systems. We hypothesize, that motor neurorehabilitation of hemiparesis could be related to simultaneous improvement in aphasia. OBJECTIVE: To measure changes in post-stroke aphasia and its relation with hemiparesis treated with different therapies. METHODS: Database information (n = 32) on post-stroke hemiparesis (Fugl-Meyer Scale evaluated) managed with virtual reality (VR) versus modified constraint-induced movement therapy (mCIMT) or regular therapy (rPT/OT) was analyzed. None received logotherapy (LT) by appointment at four months. INCLUSION CRITERIA: < 3 months after the stroke, aphasia severe (Boston Aphasia Intensity Scale), and all three evaluations. RESULTS: Twenty-one patient records met inclusion criteria (71,4% women and mean age 66,67±3,13 years) who received VR, mCIMT, or rPT/OT (n = 6, 8, and 7, respectively). There was continuous intra-groups improvement in aphasia (p < 0.05), but inter-groups the greater aphasia recovery (p = 0.05) and hemiparesis (p = 0.02) were in VR, with a high correlation in evolution between them (r = 0.73; p = 0.047). CONCLUSION: High clinical correlation between aphasia, without LT, and hemiparesis evolution during motor neurorehabilitation would support common neural connections stimulation. We will conduct a clinical trial, with a larger sample size to contrast our hypothesis.

Bimanual hand use in children and adolescents with unilateral spastic cerebral palsy: an exploratory study.

BACKGROUND: Individuals with unilateral spastic cerebral palsy (USCP) often show difficulties using their hands during activities of daily living. OBJECTIVE: To investigate the factors that interfere with hand use during bimanual activities in children and adolescents with USCP. METHODS: We conducted a cross-sectional study with 102 children and adolescents with USCP, aged 6 to 18 years. We collected information with the caregivers about the classification of the child's manual ability, according to the Manual Ability Classification System (MACS); child's age; side of the involvement; Children's Hand-Use Experience Questionnaire- CHEQ2.0. Cluster analysis identified groups of children and adolescents who performed CHEQ activities with or without assistance. Multiple linear regression analyses identified the contribution of the factors: age, sex, MACS level, side of hemiparesis, and clusters of assistance, on the outcomes of efficacy, time, and feeling bothered. RESULTS: MACS and clusters of assistance explained the variance in efficacy (p<0.05; R2=0.31) and time (p<0.05; R2=0.37). MACS explained 22% of the variance in feeling bothered.  Children and adolescents with increased difficulty to perform activities that involve hand use (i.e., MACS III) and who receive assistance during most bimanual activities showed less efficacy of use, were slower in their performance, and presented greater feeling of being bothered. CONCLUSION: Assistance in bimanual activities and MACS level contributed to explain the efficacy of use, time, and feeling bothered in performing bimanual activities. Intervention strategies aimed at promoting the performance of bimanual activities in the daily routine of children with USCP should consider these outcomes.

A comprehensive guide to BCI-based stroke neurorehabilitation interventions.

Brain-Computer Interfaces (BCIs) offer the potential to facilitate neurorehabilitation in stroke patients by decoding user intentions from the central nervous system, thereby enabling control over external devices. Despite their promise, the diverse range of intervention parameters and technical challenges in clinical settings have hindered the accumulation of substantial evidence supporting the efficacy and effectiveness of BCIs in stroke rehabilitation. This article introduces a practical guide designed to navigate through these challenges in conducting BCI interventions for stroke rehabilitation. Applicable regardless of infrastructure and study design limitations, this guide acts as a comprehensive reference for executing BCI-based stroke interventions. Furthermore, it encapsulates insights gleaned from administering hundreds of BCI rehabilitation sessions to stroke patients.•Presents a comprehensive methodology for implementing BCI-based upper extremity therapy in stroke patients.•Provides detailed guidance on the number of sessions, trials, as well as the necessary hardware and software for effective intervention.

Alterações na cinemática angular da marcha de pacientes hemiparéticos após Acidente Vascular Encefálico / Changes in gait angular kinematics of hemiparetic patients After Cerebrovascular Accident

O objetivo deste estudo foi analisar as alterações na cinemática angular da marcha de adultos com hemiparesia após acidente vascular encefálico (AVE). A amostra foi composta por 17 pacientes pós-AVE; e, para a avaliação da marcha, foi utilizado um sistema de captura da trajetória tridimensional da marcha. Quanto aos membros sadio e afetado, as variáveis estudadas foram: velocidade, ângulos máximos de flexão e extensão do quadril e joelho. Para as comparações entre os membros, foi utilizado o teste t pareado; e, para as comparações com valores normais, o teste t para uma amostra, considerando, como critério de decisão, o nível de significância p ≤ 0,05. Os resultados demonstraram, na comparação entre os membros, diferenças significantes na flexão (0,001) e extensão de joelho (0,05). Já na comparação entre o membro afetado e o sadio, destaca-se a diferença significante das angulações de flexão de joelho (<0,000) e extensão de quadril (0,004). Os pacientes com hemiparesia pós-AVE apresentam alterações na cinemática angular da marcha quando comparado o membro afetado com o sadio e com os valores da normalidade. Observou se um padrão de marcha predominantemente flexor, com grande variabilidade entre os pacientes avaliados.

This study aimed to analyze changes in gait angular kinematics of adults with hemiparesis after cerebrovascular accident (CVA). The sample consisted of 17 post- cerebrovascular accident (CVA) patients; and, for gait evaluation, it used a three-dimensional gait trajectory capture system. As for healthy and affected limbs, the variables studied were: speed, maximum angles of flexion, and extension of the hip and knee. For the comparisons between the members, the study used the t-paired test; and, for comparisons with normal values, it used the t test for a sample, whereas, as a decision criterion, the significance level p ≤ 0.05. The results showed, in the comparison between the limbs, significant differences in flexion (0.001) and knee extension (0.05). In the comparison between the affected limb and the healthy one, there is a significant difference in knee flexion angles (<0.000) and hip extension (0.004). Patients with post-CVA hemiparesis present changes in gait angular kinematics when the affected limb is compared with the healthy limb and with normal values. The study observed a predominantly flexor gait pattern, with a considerable variability among the evaluated patients.

Barriers to self-administered home-based task-oriented practice post-stroke: development and content validity of a new instrument.

PURPOSE: To develop a new instrument to identify barriers to self-administered home-based task-oriented practice post-stroke and test its content validity. MATERIALS AND METHODS: The sample consisted of individuals with stroke and neurological rehabilitation professionals. The study consisted of two steps: (1) Instrument development, involving three processes; a data search in the literature, interviews with the target population and an open questionnaire (online) sent to professionals; and (2) Testing the content validity of the instrument by asking individuals with stroke and professionals about the comprehensiveness and relevance of the items and additionally asking individuals with stroke about the comprehensibility of the items. For each item in the instrument, the threshold validity scores were ≥0.80 in the Content Validity Index and ≥0.75 for the Kappa agreement. RESULTS: The preliminary version was developed with 46 items. The content validation was performed in three rounds. The last version of the instrument Barriers to self-administered home-based task-oriented practice post-stroke (BASH-TOP-Stroke) contained 34 items in five response categories, in which the higher the value presented, the greater the number of barriers. The content validity for the items was excellent. CONCLUSIONS: The study provides a new instrument to help identify barriers to self-administered home-based task-oriented practice post-stroke.

Barriers to self-administered task-oriented home-based exercises can be specific to this form of practice.Understanding barriers to self-administered task-oriented home-based exercises is essential to increase the amount of practice for optimizing motor recovery.The Barriers to self-administered home-based task-oriented practice post-stroke (BASH-TOP-Stroke) questionnaire was developed to evaluate barriers to self-administered task-oriented home-based exercises in individuals post-stroke.BASH-TOP-Stroke has excellent content validity based on patients and professionals and could help to identify strategies that may reduce barriers to self-administered home-based task-oriented practice after stroke.

Gait Training with Functional Electrical Stimulation Improves Mobility in People Post-Stroke.

(1) Background: Stroke is one of the leading causes of disability. To identify the best treatment strategies for people with stroke (PwS), the aim of the current study was to compare the effects of training on a treadmill with functional electrical stimulation (TT-FES) with training on a treadmill (TT), and to analyze the effects of sequence of training on mobility and the parameters of walking ability. (2) Methods: Prospective, longitudinal, randomized and crossover study, in which 28 PwS were distributed into groups, namely the A-B Group (TT-FES followed by TT) and B-A Group (TT followed by TT-FES), using the foot drop stimulator, and were measured with functional tests. (3) Results: We found improved mobility, balance, non-paretic limb coordination, and endurance only in the group that started with TT-FES. However, sensorimotor function improved regardless of the order of training, and paretic limb coordination only improved in the B-A Group, but after TT-FES. These data indicate that the order of the protocols changed the results. (4) Conclusions: Although biomechanical evaluation methods were not used, which can be considered a limitation, our results showed that TT-FES was superior to isolated training on a treadmill with regard to balance, endurance capacity, and coordination of the non-paretic limb.

A case report: Upper limb recovery from stroke related to SARS-CoV-2 infection during an intervention with a brain-computer interface.

COVID-19 may increase the risk of acute ischemic stroke that can cause a loss of upper limb function, even in patients with low risk factors. However, only individual cases have been reported assessing different degrees of hospitalization outcomes. Therefore, outpatient recovery profiles during rehabilitation interventions are needed to better understand neuroplasticity mechanisms required for upper limb motor recovery. Here, we report the progression of physiological and clinical outcomes during upper limb rehabilitation of a 41-year-old patient, without any stroke risk factors, which presented a stroke on the same day as being diagnosed with COVID-19. The patient, who presented hemiparesis with incomplete motor recovery after conventional treatment, participated in a clinical trial consisting of an experimental brain-computer interface (BCI) therapy focused on upper limb rehabilitation during the chronic stage of stroke. Clinical and physiological features were measured throughout the intervention, including the Fugl-Meyer Assessment for the Upper Extremity (FMA-UE), Action Research Arm Test (ARAT), the Modified Ashworth Scale (MAS), corticospinal excitability using transcranial magnetic stimulation, cortical activity with electroencephalography, and upper limb strength. After the intervention, the patient gained 8 points and 24 points of FMA-UE and ARAT, respectively, along with a reduction of one point of MAS. In addition, grip and pinch strength doubled. Corticospinal excitability of the affected hemisphere increased while it decreased in the unaffected hemisphere. Moreover, cortical activity became more pronounced in the affected hemisphere during movement intention of the paralyzed hand. Recovery was higher compared to that reported in other BCI interventions in stroke and was due to a reengagement of the primary motor cortex of the affected hemisphere during hand motor control. This suggests that patients with stroke related to COVID-19 may benefit from a BCI intervention and highlights the possibility of a significant recovery in these patients, even in the chronic stage of stroke.

Descripción de la discapacidad y sus determinantes en personas con hemiparesia/hemiplejia del suroccidente de Colombia / Description of disability and its determinants in people with hemiparesia/hemiplegia in southwestern of Colombia / Descrição da deficiência e seus determinantes em pessoas com hemiparesia/hemiplegia do sul ocidente da Colômbia

Resumen Objetivo: el propósito del estudio fue conocer el grado de discapacidad y sus determinantes socioeconómicos, clínicos y de acceso a los servicios de salud y rehabilitación en personas con hemiplejía o hemiparesia en la ciudad de Popayán, Cauca. Metodología: estudio descriptivo, correlacional y transversal. Participaron 52 personas mayores de edad, con hemiplejia o hemiparesia. Se aplicó el cuestionario de evaluación de la discapacidad WHODAS 2.0. Resultados: El 100 % de las personas estudiadas tiene discapacidad, el promedio total de discapacidad fue de 44,7 %, correspondiente a discapacidad moderada. Los participantes mostraron dificultades en todos los dominios de funcionamiento, con dificultad moderada en los dominios cognición, cuidado personal, actividades cotidianas y dificultad severa para movilidad y participación. Conclusión: la hemiparesia y hemiplejia provocan discapacidad en diferentes grados de severidad, determinada por el estado patológico y la interacción e influencia de múltiples factores socioeconómicos, clínicos y de acceso a los servicios de salud y rehabilitación.

Abstract Objective: The purpose of the study was to determine the degree of disability and its socioeconomic and clinical determinants as well as the access to health and rehabilitation services in people with hemiplegia or hemiparesis in the city of Popayán, Cauca, Colombia. Methodology: descriptive, correlational and cross-sectional study. The sample consisted of 52 people of legal age, with a diagnosis of hemiplegia or hemiparesis. The WHODAS 2.0 disability assessment questionnaire was applied. Results: A hundred percent of the people studied had a disability, and the disability average total was 44.7%, corresponding to moderate disability. The participants showed difficulties in all domains of functioning, with moderate difficulty in the cognition, personal care and daily activities domains, and severe difficulty with mobility and participation. Conclusions: Hemiparesis and hemiplegia cause disability in different degrees of severity determined by the pathological state and the interaction and the influence of multiple socioeconomic, clinical factors and access to health and rehabilitation services.

Resumo Objetivo: o propósito do estudo foi conhecer o grau de deficiência e seus determinantes socioeconômicos, clínicos e de aceso aos serviços de saúde e reabilitação em pessoas com hemiplegia ou hemiparesia na cidade de Popayán, Cauca. Metodologia: estudo descritivo, correlacional e transversal. Participaram 52 pessoas maiores de idade, com hemiplegia ou hemiparesia. Aplicou-se o questionário de avaliação da deferência WHODAS 2.0. Resultados: O 100 % das pessoas estudadas tem deficiência, a média total de deficiência foi de 44,7 %, correspondente à deficiência moderada. Os participantes amostraram dificuldades em todos os domínios de funcionamento, com dificuldade moderada nos domínios cognição, cuidado pessoal, atividades cotidianas e dificuldade severa para mobilidade e participação. Conclusão: a hemiparesia e hemiplegia provocam deficiência em diferentes graus de severidade, determinada pelo estado patológico e a interação e influência de múltiplos fatores socioeconômicos, clínicos e de aceso aos serviços de saúde e reabilitação.

Clinical and diagnostic imaging findings in a bengal tiger (Panthera tigris tigris) with cervical spondylomyelopathy: A case report.

An adult neutered male Bengal tiger (Panthera tigris tigris) presented with abnormal gait. Neurological examination showed poor left ambulatory hemiparesis, spontaneous proprioceptive deficit in the left anterior limb, and decreased flexor reflex in the forelimbs. The neurological symptoms suggested a caudal cervical spinal cord lesion. Pathological findings included increased cholinesterase and protein levels in the cerebrospinal fluid. Computed tomography examination revealed C2-C3 intervertebral disc herniation, C5-C6 intervertebral disc herniation associated with a reduction of the intervertebral space, and mild ventral dislocation of the C6 vertebra compared to C5. In addition, severe bilateral shoulder osteoarthritis and a hypoattenuating nodule in the left thyroid gland with an open etiology were observed. These findings were interpreted as indicating cervical spondylomyelopathy (CSM). Treatment included analgesic and steroidal anti-inflammatory therapy as well as movement restriction. Follow-up at 4 weeks showed modest improvement. Thus, CSM should be included in the differential diagnosis of tigers with neurological cervical signs.

Um tigre-de-bengala macho castrado adulto (Panthera tigris tigris) foi apresentado com uma marcha anormal. O exame neurológico mostrou hemiparesia deambulatória deficiente à esquerda, déficit proprioceptivo espontâneo no membro anterior esquerdo e diminuição do reflexo flexor nos membros anteriores. Os sintomas neurológicos sugeriram uma lesão da medula espinhal cervical caudal. Os achados patológicos incluíram aumento do nível de colinesterase e proteínas na bioquímica do LCR. O exame de TC revelou uma hérnia de disco intervertebral C2-C3, uma hérnia de disco intervertebral C5-C6 associada a uma redução do espaço intervertebral e leve deslocamento ventral da vértebra C6 em comparação com C5. Além disso, osteoartrite grave do ombro bilateral e um nódulo hipoatenuante da glândula tireoide esquerda com etiologia aberta. Esses achados foram interpretados como uma espondilomielopatia cervical (CSM). A terapia médica incluiu tratamento analgésico e anti-inflamatório esteroidal, bem como restrição de movimento. O acompanhamento por 4 semanas mostrou uma melhora modesta. A CSM deve ser incluída no diagnóstico diferencial em tigres com sinais neurológicos cervicais.

Alterações na cinemática da marcha hemiparética: um estudo comparativo / Changes in the kinematics of hemiparetic gait: a comparative study

O objetivo principal deste estudo foi analisar as alterações da marcha de adultos com hemiparesia após acidente vascular encefálico (AVE) e comparar com sujeitos saudáveis. A amostra foi composta por 14 participantes do grupo AVE e 14 participantes pareados do grupo-controle (CON). Foi realizada uma análise tridimensional da marcha mediante um sistema de cinemetria. Os parâmetros analisados foram a velocidade, o comprimento da passada, a largura da passada, a cadência e o tempo da passada, sendo utilizado o teste t independente para as comparações entre os grupos e considerando p < 0,05 como critério de decisão. Os participantes do grupo AVE apresentaram valores médios significantemente inferiores em todos os parâmetros analisados. Além disso, os pacientes do grupo AVE também tiveram valores muito inferiores quando comparados aos de outros estudos com pacientes pós-AVE, possivelmente devido ao curto período entre o AVE (média de 14,14 meses) e a avaliação da marcha.

The main objective of this study was to analyze the gait alterations of adults with hemiparesis after cerebrovascular accident (CVA) and compare it with healthy subjects. The sample consisted of 14 participants from the stroke group and 14 matched participants from the control group (CON). A three-dimensional gait analysis was performed using a kinemetry system. The parameters analyzed were velocity, stride length, stride width, cadence, and stride time, using the independent t test for comparisons between groups and considering p < 0.05 as a decision criterion. Participants in the stroke group had significantly lower mean values in all analyzed parameters. In addition, patients in the CVA group also had much lower values when compared to other studies with post-CVA patients, possibly due to the short period between the CVA (mean of 14.14 months) and the gait assessment.

Immediate changes in post-stroke gait using a shoe lift on the nonaffected lower limb: A preliminary study.

Introduction: Gait impairment is one of the most important post-stroke complications and is associated with reduced mobility, limitations in activities of daily living and decreased quality of life. Gait recovery is an important goal in post-stroke rehabilitation and shoe lifts have been used on the nonaffected lower limb (NLL) to reduce compensatory strategies such as vaulting, pelvic hiking and hip circumduction during the swing phase of the affected lower limb. Moreover, in clinical practice shoe lifts seem to reduce tripping and the risk of falls.Objective: Evaluate walking speed and functional mobility with and without a 1.5 cm shoe lift under the non-affected lower limb in post-stroke gait.Methods: Forty-two subjects with hemiparesis after stroke were evaluated on a single day, under two conditions: with and without a 1.5 cm shoe lift. The assessment sequence was randomized and clinical tests (Ten-meter walk Test - 10MWT and Timed Up and Go - TUG) were performed one after the other.Results: There was a significant increase in walking speed in the 10MWT and shorter TUG times, with mean differences of 0.78 (CI95% 0.15-1.41, P ≤ 0.001, EF = 0.55) and 0.57 seconds (-0.11-1.25, P = .022, EF = 0.35), respectively.Conclusion: The results showed that the immediate use of 1.5 cm shoe lifts seems to improve gait speed and functional mobility in chronic stroke patients. Further studies should focus on understanding the kinematics strategies and gait pattern alterations caused by shoe lifts under the NLL of post-stroke individuals.

Effects of lower extremity constraint-induced movement therapy on gait and balance of chronic hemiparetic patients after stroke: description of a study protocol for a randomized controlled clinical trial.

BACKGROUND: Protocols involving intensive practice have shown positive outcomes. Constraint induced movement therapy (CIT) appears to be one of the best options for better outcomes in upper limb rehabilitation, but we still have little data about lower extremity constraint-induced movement therapy (LE-CIT) and its effects on gait and balance. OBJECTIVE: To evaluate the effects of an LE-CIT protocol on gait functionality and balance in chronic hemiparetic patients following a stroke. METHODS: The study adopts a randomized, controlled, single-blinded study design. Forty-two patients, who suffered a stroke, who were in the chronic phase of recovery (>6 months), with gait disability (no community gait), and who were able to walk at least 10 m with or without the advice or support of 1 person, will be randomly allocated to 2 groups: the LE-CIT group or the control group (intensive conventional therapy). People will be excluded if they have speech deficits that render them unable to understand and/or answer properly to evaluation scales and exercises selected for the protocol and/or if they have suffered any clinical event between the screening and the beginning of the protocol. Outcome will be assessed at baseline (T0), immediately after the intervention (T1), and after 6 months (T2). The outcome measures chosen for this trial are as follows: 6-min walk test (6minWT), 10-m walk test (10mWT), timed up and go (TUG), 3-D gait analysis (3DGA), Mini Balance Evaluation Systems Test (Mini-BESTest), and as a secondary measure, Lower Extremity Motor Activity Log will be evaluated (LE-MAL). The participants in both groups will receive 15 consecutive days of daily exercise. The participants in the LE-CIT group will be submitted to this protocol 2.5 h/day for 15 consecutive days. It will include (1) intensive supervised training, (2) use of shaping as strategy for motor training, and (3) application of a transfer package (plus 30 min). The control group will receive conventional physiotherapy for 2.5 h/day over 15 consecutive days (the same period as the CIT intervention). Repeated measures analyses will be made to compare differences and define clinically relevant changes between groups. RESULTS: Data collection is currently on-going and results are expected in 2021. DISCUSSION: LE-CIT seems to be a good protocol for inclusion into stroke survivors' rehabilitation as it has all the components needed for positive results, as well as intensity and transference of gains to daily life activities. TRIAL REGISTRATION: www.ensaiosclinicos.gov.br RBR-467cv6 . Registered on 10 October 2017. "Effects of Lower Extremities - Constraint Induced Therapy on gait and balance function in chronic hemipretic post-stroke patients".

Brain-Computer Interface Coupled to a Robotic Hand Orthosis for Stroke Patients' Neurorehabilitation: A Crossover Feasibility Study.

Brain-Computer Interfaces (BCI) coupled to robotic assistive devices have shown promise for the rehabilitation of stroke patients. However, little has been reported that compares the clinical and physiological effects of a BCI intervention for upper limb stroke rehabilitation with those of conventional therapy. This study assesses the feasibility of an intervention with a BCI based on electroencephalography (EEG) coupled to a robotic hand orthosis for upper limb stroke rehabilitation and compares its outcomes to conventional therapy. Seven subacute and three chronic stroke patients (M = 59.9 ± 12.8) with severe upper limb impairment were recruited in a crossover feasibility study to receive 1 month of BCI therapy and 1 month of conventional therapy in random order. The outcome measures were comprised of: Fugl-Meyer Assessment of the Upper Extremity (FMA-UE), Action Research Arm Test (ARAT), motor evoked potentials elicited by transcranial magnetic stimulation (TMS), hand dynamometry, and EEG. Additionally, BCI performance and user experience were measured. All measurements were acquired before and after each intervention. FMA-UE and ARAT after BCI (23.1 ± 16; 8.4 ± 10) and after conventional therapy (21.9 ± 15; 8.7 ± 11) were significantly higher (p < 0.017) compared to baseline (17.5 ± 15; 4.3 ± 6) but were similar between therapies (p > 0.017). Via TMS, corticospinal tract integrity could be assessed in the affected hemisphere of three patients at baseline, in five after BCI, and four after conventional therapy. While no significant difference (p > 0.05) was found in patients' affected hand strength, it was higher after the BCI therapy. EEG cortical activations were significantly higher over motor and non-motor regions after both therapies (p < 0.017). System performance increased across BCI sessions, from 54 (50, 70%) to 72% (56, 83%). Patients reported moderate mental workloads and excellent usability with the BCI. Outcome measurements implied that a BCI intervention using a robotic hand orthosis as feedback has the potential to elicit neuroplasticity-related mechanisms, similar to those observed during conventional therapy, even in a group of severely impaired stroke patients. Therefore, the proposed BCI system could be a suitable therapy option and will be further assessed in clinical trials.

A influência de atividades de dupla tarefa na cinemática da marcha de indivíduos com hemiparesia espástica / The influence of dual task activities in the gait kinematics of individuals with spastic hemiparesis

Objetivo: analisar a influência de atividades de dupla tarefa na cinemática da marcha de indivíduos com hemiparesia espástica. Metodologia: amostra de 12 indivíduos, com idade entre 30 e 71 anos. Primeiramente, as tarefas simples foram realizadas: marcha simples (tarefa motora), tarefa de fluência verbal (tarefa cognitiva) e tarefa visuoespacial (tarefa cognitiva). Após, as duplas tarefas foram realizadas, onde foi realizada a marcha ao mesmo tempo das tarefas cognitivas. Para a avaliação da marcha, foi utilizado um sistema de captura da trajetória tridimensional da marcha e as variáveis estudadas foram cadência, velocidade, comprimento da passada, largura do passo, tempo da passada, apoio simples e apoio duplo. Para a análise dos resultados utilizou-se estatística descritiva, o teste t pareado e o teste de Correlação de Pearson (p<0,05). Resultados: na comparação com a marcha simples, durante as atividades de dupla tarefa os indivíduos apresentarem piores resultados nas variáveis cinemáticas da marcha. Durante a dupla tarefa de fluência verbal, as principais diferenças quando comparado com a marcha simples foram: velocidade, cadência, o tempo da passada, comprimento da passada e apoio simples. Já a dupla tarefa cognitiva visuoespacial demonstrou as principais diferenças na: velocidade, comprimento da passada e apoio simples. Houve correlação forte e significativa do Mini Exame do Estado Mental com a tarefa de fluência verbal simples e com a dupla tarefa; assim como para a tarefa visuoespacial simples e na dupla tarefa. Conclusão: conclui-se que ocorreu alteração em alguns parâmetros cinemáticos da marcha quando associado à dupla tarefa, com maior influência negativa da tarefa cognitiva de fluência verbal quando comparadas com a visuoespacial.

Objective: o analyze the influence of dual task activities on gait's kinematics in individuals with plastic hemiparesis. Methodology: included 12 individuals, aged between 30 and 71 years old. Firstly, simple tasks were performed: simple gait (motor task), verbal fluency task (cognitive task) and visuospatial task (cognitive task). Afterwards, the dual tasks were performed, where the gait was performed at the same time as the cognitive tasks. For gait assessment, a three-dimensional gait trajectory capture system was used and the variables studied were cadence, velocity, stride length, stride width, stride time, single support and double support. Descriptive statistics, paired t-test and Pearson's correlation test were used to analyze the results (p<0.05). Results: in comparison with single gait, during dual task activities, individuals showed worse results in gait's kinematic variables. During the dual task of verbal fluency and gait, the main differences when compared to simple gait were: velocity, cadence, stride time, stride length and simple support. Already visual-spatial cognitive task and gait demonstrated the main differences in: velocity stride length, simple support. There was a strong and significant correlation between Mini Mental State Examination with the simple verbal fluency task and with the double task; as well as for the simple visuospatial task and with the double task. Conclusion: it was concluded that modifications on some gait's kinematic parameters of gait occurred when associated with the double task, with a greater negative influence of the cognitive task of verbal fluency when compared with the visuospatial task.

Measurement properties of the Reaching Performance Scale for Stroke.

AIM: Reaching Performance Scale for Stroke (RPSS) evaluates the upper limb reach-to-grasp movement quality and compensatory movements. The objective of the study was to test the reliability, construct validity, and interpretability of the Brazilian-Portuguese RPSS. METHODS: Fifty-one individuals (mean age 62 ± 10.8 years), with acute-to-chronic stroke (range: 1-300 months) were video recorded while performing a reach-to-grasp task of a cone placed both close and far from the individual. Their degree of motor impairment ranged from 4 to 59 points in the Fugl-Meyer scale. RESULTS: Reaching Performance Scale for Stroke showed excellent intra- (ICC2,1 = 1.00) and interrater (ICC2,1 = 0.98-0.99) reliability, and redundant internal consistency (Cronbach's α = 0.98). The construct validity between RPSS and Fugl-Meyer scale was strong (Spearman rho = 0.88-0.89; p < 0.0001). The scale was able to discriminate individuals with mild or moderate upper limb impairment from those with severe impairment. We found ceiling and floor effects. CONCLUSIONS: Reaching Performance Scale for Stroke showed excellent reliability and redundant internal consistency. The construct validity with the Fugl-Meyer scale was strong. Reaching Performance Scale for Stroke was able to discriminate individuals with different levels of upper limb impairment.IMPLICATIONS FOR REHABILITATIONPost-stroke individuals develop compensatory strategies to perform reaching movements with the paretic upper limb.The Reaching Performance Scale for Stroke provides a quantitative and qualitative evaluation of the reach-to-grasp movement.The Reaching Performance Scale for Stroke is suitable for use with Brazilian-Portuguese speakers and has adequate reliability and validity.

Brain-Computer Interfaces for upper limb motor rehabilitation of stroke patients / Interfaces Cerebro-Computadora para la Rehabilitación Motora de Miembro Superior de Pacientes con Enfermedad Vascular Cerebral

Abstract Brain-Computer Interfaces (BCI) decode users' intentions from the central nervous system and could be applied for upper limb motor rehabilitation of patients that have suffered stroke, one of the main causes of disability worldwide. Despite that research groups have reported the efficacy of these systems, a consensus has not yet been reached regarding their true potential. For this reason, a review of up-to-date assessments of BCI for upper limb stroke rehabilitation is presented from the perspective of analyzing common and different design variables presented across studies. Clinical and pilot studies with a control group were included in the review. Most BCI interventions assessments were performed with robotic assistive devices as feedback, followed by neuromuscular electrical stimulation (NMES) and visual feedbacks. Compared to other experimental interventions, the effects of a BCI intervention have been reported in a low number of patients. In addition, high variability between studies' designs such as stroke etiology and interventions' duration, do not allow to assess the potential of BCI for stroke rehabilitation. However, a trend towards significant rehabilitation outcomes with BCI systems can be highlighted, encouraging research groups to better coordinate in order to make valuable contributions to the field.

Resumen Las interfaces cerebro-computadora (BCI) decodifican del sistema nervioso central las intenciones de los usuarios, y pueden ser aplicadas para la rehabilitación motora del miembro superior de pacientes con enfermedad vascular cerebral (EVC), una de las principales causas de discapacidad a nivel mundial. A pesar de que diversos grupos han reportado la eficacia de estos sistemas, no se ha logrado un consenso sobre su verdadero potencial. Por esta razón, una revisión de la evaluación reciente de las BCI para rehabilitación del miembro superior en la EVC es presentado desde la perspectiva de analizar diferencias y similitudes entre las variables reportadas en los estudios. En la esta revisión se incluyeron estudios clínicos y pilotos con un grupo control. La mayor parte de los estudios utilizaron sistemas robóticos como retroalimentación, seguido por estimulación eléctrica neuromuscular y retroalimentación visual. En comparación con otras terapias experimentales, los efectos de intervenciones con BCI se han reportado en pocos pacientes. Además, la alta variabilidad en el diseño de los estudios, como la etiología de la EVC y la duración de las intervenciones, no permiten comparar los efectos de las terapias BCI. Sin embargo, se puede resaltar una tendencia hacia recuperaciones motoras significativas con BCI, motivando a grupos de investigación a coordinarse de mejor forma para continuar realizando contribuciones al campo.