[Essentials for high-quality development of fangjiomics].

The development of modern omics technology has facilitated in-depth research on many disciplines in the field of medicine. For instance, the introduction of omics-related technology has facilitated research on the mechanism of formula's action and led to the innovative development of sophisticated pharmacological analysis methods. However, in general, the previous ideas are only limited to the application level, failing to integrate with the discipline connotation of formulaology. Furthermore, they are unable to fulfill their potential role in the future evolution of formulaology and steer comprehensive research on the clinical efficacy and safety of formulas. We should not forget our origins, which are compatible with other countries, and embrace the future. Therefore, this paper proposes the three essentials of "holism, macro, and practice" to investigate the future direction of high-quality development in fangjiomics.

The synchronic, diachronic cell as the holism of consciousness.

The cell is both synchronic and diachronic, based on ontogeny and phylogeny, respectively. As experimental evidence for this holism, absent gravitational force, differentiated lung and bone cells devolve, losing their phenotypes, losing their evolutionary status, reverting to their nonlocal status. Thus, when evolution is seen as serial homeostasis, it is homologous with Quantum Entanglement as the nonlocal means of maintaining homeostatic balance between particles. This monadic perspective on consciousness is one-hundred and eighty degrees out of synch with the conventional way of thinking about consciousness as a diad, or mind and brain. There have been many attempts to explain consciousness, virtually all of them based on the brain as mind. The working hypothesis is that consciousness is a holism constituted by the unicell, the lipid cell membrane forming a barrier between inside and outside of the cell's environment as a topology. Conceptually, both the unicell and 'two hands clapping' are holisms, but because the cell is constituted by the ambiguity of negative entropy, and 'one hand clapping' requires two hands, they are both pseudo-holisms, constantly striving to be whole again. In the case of the cell, it is incomplete in the sense that there are factors in the ever-changing environment that can homeostatically complete it. That process results in biochemical modification of specific DNA codes in the egg or sperm so that the offspring is able to adapt in subsequent generations epigenetically. The opportunity to trace the evolution of the breath from humans to fish opens up to the further revelation of the interplay between evolution and geological change, tracing it back to invertebrates, sponges, and ultimately to unicellular organisms. And therein is evidence that the Cosmos itself 'breathes', providing the ultimate celestial fundament for this trail of holisms.

The Spemann-Mangold organizer discovery and society.

This paper analyzes the influence of Hans Spemann and Hilde Mangold's discovery of the embryonic organizer on society outside the narrower confines of embryology. It begins by overviewing how in the 1920s-1930s, the organizer discovery fit well into the agenda of both right-wing and left-wing political camps, as it supported holistic theories of biological development that aligned with their ideological views. The paper then explores the organizer's influence on the formation and interdisciplinary discussions of the 1930s Cambridge Theoretical Biology Club. Club member C.H. Waddington's concept of the epigenetic landscape, inspired in part by Spemann and Mangold's work, went on to impact diverse fields including mathematics, psychology, anthropology, architecture, and art. Examples include mathematician René Thom's catastrophe landscapes and the field of ekistics (the science of human settlements). Spemann and Mangold's creation of an embryo chimera by combining tissues from different newt species also helped shape philosophers' and artists' understanding of the relationship between nature and technology as an integrated whole rather than separate entities. Additionally, Spemann's embryonic field concept helped influence field theories in other areas of science, and thinkers have pointed out metaphorical similarities between the organizer experiment and philosophical dialectics, film editing, or historical events. However, several factors likely limited the long-term societal impact of Spemann's holistic perspective, notably the rise of molecular biology and DNA-centric reductionist views of biology in the mid-late 20th century. While such reductionism still dominates public perceptions of biology, there seems to be a renewed openness to holistic perspectives reminiscent of Spemann's views.

The holism of evolution as consciousness.

Quantum Entanglement has been hypothesized to mediate non-local consciousness, underlying which, empirically, is the force of gravity. Upon further reflection, the case can be made for 'the breath' as the physiologic trait that binds all of these properties together, offering further opportunity for hypothesis testing experimentation. Humans have inexplicably made extraordinary intellectual and technical advances within a relatively very short period of time, referred to as the 'great leap forward'. It would be of great value if we could identify how and why we have evolved so rapidly. There is a holotropism that begins with the Big Bang that is centered on the homeostatic control of energy, perpetually referencing the First Principles of Physiology. "The Breath" is how and why our physiology has managed to perpetuate our species, and perhaps why the lung has been 'over-engineered' in order to facilitate the role of breathing in consciousness.

How collectively integrated are ecological communities?

Beyond abiotic conditions, do population dynamics mostly depend on a species' direct predators, preys and conspecifics? Or can indirect feedback that ripples across the whole community be equally important? Determining where ecological communities sit on the spectrum between these two characterizations requires a metric able to capture the difference between them. Here we show that the spectral radius of a community's interaction matrix provides such a metric, thus a measure of ecological collectivity, which is accessible from imperfect knowledge of biotic interactions and related to observable signatures. This measure of collectivity integrates existing approaches to complexity, interaction structure and indirect interactions. Our work thus provides an original perspective on the question of to what degree communities are more than loose collections of species or simple interaction motifs and explains when pragmatic reductionist approaches ought to suffice or fail when applied to ecological communities.

'I might have cried in the changing room, but I still went to work'. Maternity staff balancing roles, responsibilities, and emotions of work and home during COVID-19: An appreciative inquiry.

PROBLEM: Knowing how to help staff thrive and remain in practice in maternity services. BACKGROUND: A chronic shortage of staff in maternity services in the United Kingdom and high levels of stress and burnout in midwifery and medical staff. PURPOSE: To understand how to support and enhance the wellbeing of staff in a small UK maternity service. METHODS: An appreciative inquiry using interviews with n = 39 maternity staff and n = 4 group discussions exploring meaningful experiences, values and factors that helped their wellbeing. RESULTS: Staff members were highly motivated, managing a complex melee of emotions and responsibilities including challenges to professional confidence, mental health, family situation, and conflict between work-life roles. Despite staff shortages, a demanding workload, professional and personal turmoil, and the pandemic participants still found meaning in their work and relationships. DISCUSSION: A 'whole person' approach provided insight into the multiple stressors and emotional demands staff faced. It also revealed staff resourcefulness in managing their professional and personal roles. They invested in relationships with women but were also aware of their limits - the need to be self-caring, employ strategies to switch-off, set boundaries or keep a protective distance. CONCLUSION: Staff wellbeing initiatives, and research into wellbeing, would benefit from adopting a holistic approach that incorporates home and family with work. Research on emotion regulation strategies could provide insights into managing roles, responsibilities, and the emotional demands of working in maternity services. Emotion regulation strategies could be included in midwifery and obstetric training.

Identifying Holistic Nursing Research Priorities for 2023-2026.

The primary goal of holistic nursing research is to develop and expand the knowledge base of holism and healing for nursing praxis. This article provides an overview of the process used to identify the research priorities for holistic nursing research over the next 3 to 5 years. A mixed method design using Appreciative Inquiry and surveys revealed five research priorities and the holistic philosophical foundation for these priorities. Additionally, new challenges in the environment, person, health, and nursing will undoubtedly emerge, requiring nurses to discern the research needs beyond 2026. This work seeks to inspire holistic nurses to consider research related to the American Holistic Nurses Association's five key research priorities.

Putting the "Decision" in Ramsey's "Theories".

Frank Ramsey's philosophy of science is considered abstruse due to the incompleteness and difficulty of his paper "Theories". This has not prevented various authors from arguing that Ramsey is committed to meaning holism for scientific theories, and that his philosophy of science is anti-realist but anti-reductionist. However, it is unclear exactly how meaning holism works for Ramsey, and how he can be both anti-realist and anti-reductionist. I argue that clarity can be gained on both issues by examining Ramsey's philosophy of science through a reconstruction of his decision theory compatible with his later philosophical beliefs. I develop an account of how credences can be formed over singular, theoretical propositions despite those propositions being fictions. Credences are ultimately measured by preferences over conditionals whose antecedents are the verification conditions of theoretical propositions and outcomes are elements of a privileged partition on an agent's possibility space induced by the language of the theory. Those verification conditions are the observational elements formed from the unions of this induced partition. Meaning holism is explained as the sensitivity of theoretical propositions to their verification conditions. And anti-realism and anti-reductionism can be maintained due to theoretical propositions forming a finer partition of possibility space than observational propositions, which prevents the former from being truth-functions of the latter.

Holism and Causal Responsibility: The Role of Number and Valence of Event Consequences.

The present research examines the effect of holistic-analytic thinking style on causal responsibility. Across seven studies (N = 4,103), participants' thinking style was either measured or manipulated. Then, the valence or number of consequences varied in several scenarios involving a cause-consequence relationship. As a dependent measure, participants indicated the degree of responsibility attributed to the cause mentioned in each scenario. The results revealed that holistic (vs. analytic) participants assigned more responsibility to the cause when the consequences presented were a combination of positive and negative outcomes (vs. univalent), and when multiple (vs. single) consequences were triggered in the scenario. To explore the explanatory factor for these results, a final study manipulated the complexity of the consequences, along with the number. The results of this research suggested that holistic (vs. analytic) individuals consider the degree of complexity of consequences to establish causal attribution.

Narrative simulation of social experiences in naturalistic context - A neurocinematic approach.

Narratives may be regarded as simulations of everyday social situations. They are key to studying the human mind in socio-culturally determined contexts as they allow anchoring to the common ground of embodied and environmentally-engaged cognition. Here we review recent findings from naturalistic neuroscience on neural functions in conditions that mimic lifelike situations. We will focus particularly on neurocinematics, a research field that applies mediated narratives as stimuli for neuroimaging experiments. During the last two decades, this paradigm has contributed to an accumulation of insights about the neural underpinnings of behavior and sense-making in various narratively contextualized situations particularly pertaining to socio-emotional encounters. One of the key questions in neurocinematics is, how do intersubjectively synchronized brain activations relate to subjective experiences? Another question we address is how to bring natural contexts into experimental studies. Seeking to respond to both questions, we suggest neurocinematic studies to examine three manifestations of the same phenomenon side-by-side: subjective experiences of narrative situations, unfolding of narrative stimulus structure, and neural processes that co-constitute the experience. This approach facilitates identifying experientially meaningful activity patterns in the brain and points out what they may mean in relation to shared and communicable contents. Via rich-featured and temporally contextualized narrative stimuli, neurocinematics attempts to contribute to emerging holistic theories of neural dynamics and connectomics explaining typical and atypical interindividual variability.

Philosophy of thermodynamics.

Thermodynamics is regarded as a universal but not foundational theory because its laws for macroscopic quantities have not been derived from microscopic entities. Thus, to root thermodynamics into the fundamental substance, atomism is revived, thinking that the light quantum is the indivisible and permanent element. Assuming the same basic building blocks constitute everything, the state of any system can be quantified by entropy, the logarithmic probability measure multiplied by Boltzmann's constant. Then, the change in entropy expresses the system's evolution toward thermodynamic balance with its surroundings. These natural processes consuming free energy in the least time accumulate sigmoidally, resulting in skewed distributions found throughout nature. In this way, thermodynamics makes sense of phenomena across disciplines and provides a holistic worldview to address questions such as what the world is, how we know about it, what is the meaning of life and how we should live. This article is part of the theme issue ''Thermodynamics 2.0: Bridging the natural and social sciences (Part 1)'.

Quantitative medicine: Tracing the transition from holistic to reductionist approaches. A new "quantitative holism" is possible?

The practice of medicine has evolved significantly over time, from a more holistic to a reductionist or mechanistic approach. This paper briefly traces the history of medicine and the transition to quantitative medicine, which has enabled more personalized and targeted treatments, and improved understanding of the underlying biological mechanisms of disease. However, this shift has also presented some challenges and criticisms, including the danger of losing sight of the patient as a unique, whole individual. This paper explores the underlying principles and key contributions of quantitative medicine, as well as the context for its rise, including the development of new technologies and the influence of reductionist philosophies. The challenges and criticisms of this approach, and the need to balance reductionist and holistic approaches in order to achieve a comprehensive understanding of human health will be discussed. Ultimately, by integrating insights from philosophy, physics, and other fields, we may be able to develop new and innovative approaches that bridge the gap between reductionism and holism and improve patient outcomes with the new "quantitative holism."

Psychoanalytic proof: Revisiting Freud's Tally Argument.

This paper explores the notion of proof in clinical psychoanalysis by reconsidering an argument Freud made concerning the relation between successful psychoanalytic treatment and truth, dubbed the "Tally Argument" by the philosopher Adolf Grünbaum. I first reiterate criticisms of Grünbaum's reconstruction of this argument, which bring out the degree to which he has misunderstood Freud. I then offer my own interpretation of the argument and the reasoning that underlies its key premise. Drawing from this discussion, I explore three forms of proof, each inspired also by analogies with other disciplines. Laurence Perrine's "The Nature of Proof in the Interpretation of Poetry" stimulates my discussion of inferential proof, the relevant form of which involves proving an interpretation through a strong enough Inference to the Best Explanation. Mathematical proof stimulates my discussion of apodictic proof, of which psychoanalytic insight is a fitting example. Finally, holism in legal reasoning stimulates my discussion of holistic proof, which provides a reliable means by which therapeutic success can verify epistemic conclusions. These three forms of proof can play a crucial role in ascertaining psychoanalytic truth.

The two principles that shape scientific research.

This paper argues that all scientific research is framed by one of two organizing principles that underpin and shape almost every aspect of scientific research as well as nonscientific inquiry. The most commonly employed principle within mainstream science is content determines content. This is a closed, circular principle that is usually unstated within hypotheses but plays a major role in developing methodologies and arriving at conclusions. The second more open principle is context determines content. This principle represents the implied background embedded within hypotheses. The difference between these two principles revolves around the issue of context, with the first principle closing off contexts by ignoring, erasing, or devaluing them, while the second more holistic principle explicitly takes them into account. Each of these research principles has a focus on the explicit detailed nature of 'content' while differing in relation to the source and cause of such content. We argue that the more open and holistic principle of context determines that content is superior in producing reliable evidence, results and conclusions.

[From the body-mind holism to psychosomatic medicine: theory and practice of acupuncture and moxibustion].

The traditional life concept of "body-mind holism" in Chinese medicine has drawn a special attention with the development of modern psychosomatic medicine. The "body-mind holism" is valuable in the guidance for clinical acupuncture practice, but, it is only remained on the theoretical significance by the medical masters in the past dynasties. In the paper, based on the understanding of Huangdi Neijing (Yellow Emperor's Internal Classic), the similarities and differences are compared between the body-mind theory and psychosomatic medicine. In association with clinical observation, from three aspects, i.e. body-mind pathogenesis, acupoint detection and observing the mind, and body-mind treatment, the guidance of "body-mind holism" is explored for the clinical diagnosis and treatment of acupuncture and moxibustion; the referents of "body" and "mind" are clarified in views of disease, diagnosis and treatment; and the treatment strategies of acupuncture and moxibustion are discussed in the perspective of "body-mind holism".

Ethical challenges and principles in integrated care.

INTRODUCTION: Integrated care is an established approach to delivery in parts of the healthcare infrastructure, and an ideal which, it is claimed, should be realized system-wide. Its ethical weight derives from its defence of a view about how healthcare ought to operate. Although the goal of integration is laudable, it is ethically and practically complex, involving trade-offs. SOURCES OF DATA: Considerable evidence attests to widespread enthusiasm for integration, given the need to prevent harm and extend the reach of scarce resources. Equally, evidence increasingly highlights the obstacles to successfully translating this ideal into practice. AREAS OF AGREEMENT: The principle that healthcare should be seamless, ensuring that patients do not come to harm through gaps in care enjoys broad agreement. There is a similar consensus that placing the patient's perspective at the centre of decision-making is vital, since this enables identification of these gaps. AREAS OF CONTROVERSY: Integrating care by making it seamless entails blurring boundaries of care domains. This risks undermining the locus of responsibility for care decisions via confusion about who has ownership of specialist knowledge where domains overlap. There is a lack of consensus about how successful integration should be measured. GROWING POINTS: More research into the relative cost-effectiveness of upstream public health investment in preventing chronic ill-health caused by modifiable lifestyle factors vs integrating care for people already ill; further research into ethical implications of integration in practice, which can be obscured by the simplicity of the fundamental normative principle guiding integration in theory.

Holistic Framework to Contextualize Dietary Quality Assessment: A Critical Review.

Numerous dietary quality indices exist to help quantify overall dietary intake and behaviors associated with positive health outcomes. Most indices focus solely on biomedical factors and nutrient or food intake, and exclude the influence of important social and environmental factors associated with dietary intake. Using the Diet Quality Index- International as one sample index to illustrate our proposed holistic conceptual framework, this critical review seeks to elucidate potential adaptations to dietary quality assessment by considering-in parallel-biomedical, environmental, and social factors. Considering these factors would add context to dietary quality assessment, influencing post-assessment recommendations for use across various populations and circumstances. Additionally, individual and population-level evidence-based practices could be informed by contextual social and environmental factors that influence dietary quality to provide more relevant, reasonable, and beneficial nutritional recommendations.

After Neoliberalism: Social Theory and Sociology in the Interregnum.

Charles Thorpe argues sociology lacks a "language of society as a whole." He holds that positivist sociologists de-legitimated holistic theories or broad normatively oriented "social theories," leaving the discipline without discursive means to critically assess and deliberate its overall directions and those of society. Thorpe does not address holistic theory directly or explain how it differs analytically from standard "sociological theory." My intent is to clarify these matters by extending facets of his argument to illuminate the interdependence between holistic theorizing and empirical-historical social science, which is necessary to create the type of "reflexive sociology" that Thorpe argues would make sociology more cosmopolitan and capable of addressing the turbulent sociopolitical conditions in the interregnum after neoliberalism.

Development and validation of a food-related analysis-holism scale (F-AHS).

Recent studies have indicated analytic-holistic cognitive style differences of consumers can significantly impact perceptions, opinions, and behaviors toward foods. Interestingly, these studies have also offered evidence that the sole measurement tool to assess analytic-holistic tendencies, the analysis-holism scale (AHS), may not accurately apply to food-experience-related research scenarios. Due to these notions, Studies 1 and 2 employed the use of 465 and 487 participants, respectively, to develop, refine, and finalize a food-related AHS (F-AHS) using exploratory and confirmatory factor analyses and prior research on analytic-holistic differences and scale development. Study 3 was conducted to validate the newly developed F-AHS, based on the results of Studies 1 and 2, by replicating the procedures and analyses from prior research while using the F-AHS instead of the AHS to segment participants (N = 130). The results of Study 3 provided consistent evidence that the F-AHS better separated participants into analytic and holistic groups than the AHS through larger analytic-holistic differences that more closely aligned with prior analytic-holistic research. Our findings showed that the F-AHS is capable of separating consumers into analytic and holistic cognitive style groups and is better suited to sensory and consumer-related applications than the AHS. PRACTICAL APPLICATION: Our findings provide researchers with an optimized tool to separate consumers into analytic and holistic groups in food-experience-related situations. The food-related analysis-holism scale can then be used in both academia and industry to separate consumers based on cognitive style to better understand how and why consumers show variations in perception, acceptance, and behavior in food-related experiences.

Immunity and security using holism, ambient intelligence, triangulation, and stigmergy: Sensitivity analysis confronts fake news and COVID-19 using open set transduction.

This paper introduces a multi-faceted security methodology based on Holism, Ambient Intelligence, Triangulation, and Stigmergy (HATS) to combat the spread of current pandemics such as fake news and COVID-19. HATS leverages the apparent complementarity and similarity of physical and mental pandemics using adversarial learning and transduction to promote immunity on both using conformal prediction and principled symbiosis. As such, HATS confronts both mental and physical adversity found in misinformation and disinformation. It confers herd immunity using holism and triangulation that call to advantage on sensitivity analysis using open set transduction and meta-reasoning. Ambient intelligence and stigmergy further mediate meta-reasoning and re-identification in building and sharing immunity. As change is constant and everything is fluid, as truth is not always reality and reality is not always truth, and as truth is imponderable and lie can become truth, two things have to happen. First, reconditioning and reconfiguration engage random deficiency to discern familiarity from strangeness and a-typicality. Second, transfer learning using trans-adaptation and transposition, serve adaptation and interoperability. Together, this empowers open set transduction in facing adaptive persistent threats such as deception and denial when it engages moving target defense using modification and de-identification. Immunology and security further come together using to advantage the coupling of active and adversarial learning.