ABSTRACT
Introducción: la infección de prótesis aórtica en la cirugía vascular convencional es un evento catastrófico, con una alta tasa de morbilidad y de mortalidad. El tratamiento tradicional ha sido la remoción de la prótesis y la reconstrucción con bypass extraanatómico. En algunos casos, se ha llevado a cabo el reemplazo con prótesis impregnadas en antibiótico; en otros, el reemplazo con vena femoral superficial y también la cirugía abierta con drenaje de las colecciones asociadas y antibioticoterapia de por vida. Caso clínico: se presenta el reporte de un caso de infección protésica tratada con drenajes de las colecciones y antibioticoterapia de larga duración, con un resultado favorable un año después de su complicación. Discusión: en algunos casos, dada la severidad del paciente, es posible intentar un tratamiento conservador de esta nefasta complicación.(AU)
Introduction: in traditional vascular surgery, aortic prosthesis infection is a catastrophic event with high morbidity andmortality rates. Traditional treatment is the removal of the valve followed by extra-anatomic bypass reconstruction. Insome cases, antibiotic-impregnated prosthesis replacement has been performed. In others, superficial femoral veinreplacement, and open surgery with drainage of the associated collections and lifelong antibiotic therapy.Case report: this is the case of a patient with aortic prosthesis infection undergoing draining collections and lifelongantibiotic therapy with a favorable outcome 1 year after the complication.Discussion: in some cases, given the severity of the patient, we can try to treat this dreaded complication conservativel.(AU)
Subject(s)
Humans , Male , Aged , Complementary Therapies , Prostheses and Implants/adverse effects , Prosthesis-Related Infections/drug therapyABSTRACT
BACKGROUND AND OBJECTIVE: Vancomycin powder (VP) has been positively used in spinal surgery to reduce the rate of infections. Hardly any data have been published on hip and knee joint replacement surgery, and its usefulness is questioned. Our objective was to investigate the effectiveness of VP in reducing prosthetic infection and its possible complications. METHODS: Primary hip (THA) and knee (TKA) arthroplasties were reviewed, performed by five surgeons in one hospital centre, between 2017 and 2018. One gram of VP was used on the implant prior to surgical closure based on the surgeon's preferences. With a 5-year follow-up in which the infection rate and local complications were analysed. RESULTS: One thousand one hundred and fifty-one arthroplasties were performed, 748 were TKA and 403 were THA. Nine patients were diagnosed with prosthetic infection, of which five received VP and four did not (p=0.555). Likewise, another 15 patients suffered wound complications, of which 11 received VP and 4 did not (p=0.412). There were no differences, either, in the rest of the complications depending on the use or not of VP (p=0.101). Likewise, the number of patients who needed reintervention was similar (p=0.999). No systemic complications were detected due to the use of VP. CONCLUSIONS: It has not been possible to demonstrate that the use of VP reduces the rates of prosthetic infection in the hip and knee, so we cannot recommend its use.
ABSTRACT
BACKGROUND AND OBJECTIVE: Vancomycin powder (VP) has been positively used in spinal surgery to reduce the rate of infections. Hardly any data have been published on hip and knee joint replacement surgery, and its usefulness is questioned. Our objective was to investigate the effectiveness of VP in reducing prosthetic infection and its possible complications. METHODS: Primary hip (THA) and knee (TKA) arthroplasties were reviewed, performed by five surgeons in one hospital center, between 2017 and 2018. 1g of VP was used on the implant prior to surgical closure based on the surgeon's preferences. With a 5-year follow-up in which the infection rate and local complications were analyzed. RESULTS: One thousand one hundred and fifty one arthroplasties were performed, 748 were TKA and 403 were THA. Nine patients were diagnosed with prosthetic infection, of which five received VP and four did not (P=.555). Likewise, another 15 patients suffered wound complications, of which 11 received VP and 4 did not (P=.412). There were no differences, either, in the rest of the complications depending on the use or not of VP (P=.101). Likewise, the number of patients who needed reintervention was similar (P=.999). No systemic complications were detected due to the use of VP. CONCLUSIONS: It has not been possible to demonstrate that the use of VP reduces the rates of prosthetic infection in the hip and knee, so we cannot recommend its use.
ABSTRACT
Introducción: La infección protésica es una de las complicaciones más graves en cirugía ortopédica, por lo que es importante detectar factores relacionados con su aparición. Las revisiones sistemáticas (RS) pronósticas detectan y evalúan factores relacionados con enfermedades, lo que permite una mejor predicción de los riesgos y la implementación de medidas preventivas. Aunque estas RS pronósticas son cada vez más frecuentes, su campo metodológico presenta algunas lagunas de conocimiento. Objetivo: Realizar una revisión de RS de factores pronósticos para infección protésica y describir la evidencia sintetizada. Secundariamente, evaluar el riesgo de sesgo y la calidad metodológica. Material y métodos: Búsqueda bibliográfica en 4bases de datos (en mayo de 2021) para identificar RS pronósticas que evaluaran factores pronósticos para infección protésica. Evaluamos el riesgo de sesgo mediante ROBIS y la calidad metodológica con la herramienta modificada AMSTAR-2. Se realizó un estudio de solapamiento entre RS. Resultados: Incluimos 23 RS que valoraban 15 factores asociados con la infección protésica; de ellos, 13 mostraron asociación significativa. Los más estudiados fueron obesidad, corticoides intraarticulares, tabaquismo y glucemia elevada. El solapamiento entre RS fue elevado para obesidad y muy alto para corticoides intraarticulares, tabaquismo y glucemia elevada. El riesgo de sesgo fue considerado bajo en 8 RS (34,7%), pero la herramienta de evaluación metodológica demostró una baja calidad en general. Conclusiones: La identificación de factores procedimentales modificables ofrecen mejores resultados a los pacientes. Sin embargo, muchas RS son redundantes. La evidencia en factores pronósticos en cirugía ortopédica es débil debido al alto riesgo de sesgo y a la calidad metodológica limitada.(AU)
Background: Prosthetic joint infection is one of the most serious complications in orthopedics. Prognostic systematic reviews (SR) detecting and assessing factors related to prosthetic joint infection, allow better prediction of risk and implementation of preventive measures. Although prognostic SR are increasingly frequent, their methodological field presents some knowledge gaps. Purpose: To carry out an overview of SR assessing risk factors for prosthetic joint infection, describing and synthesizing their evidence. Secondarily, to assess the risk of bias and methodological quality. Material and methods: We conducted a bibliographic search in 4databases (May 2021) to identify prognostic SR evaluating any risk factor for prosthetic joint infection. We evaluated risk of bias with the ROBIS tool, and methodological quality with a modified AMSTAR-2 tool. We computed the overlap degree study between included SR. Results: Twenty-three SR were included, studying 15 factors for prosthetic joint infection, of which, 13 had significant association. The most frequently studied risk factors were obesity, intra-articular corticosteroids, smoking and uncontrolled diabetes. Overlapping between SR was high for obesity and very high for intra-articular corticoid injection, smoking and uncontrolled diabetes. Risk of bias was considered low in 8SRs (34.7%). The modified AMSTAR-2 tool showed important methodological gaps. Conclusions: Identification of procedural-modifiable factors, such as intra-articular corticoids use, can give patients better results. Overlapping between SR was very high, meaning that some SR are redundant. The evidence on risk factors for prosthetic joint infection is weak due to high risk of bias and limited methodological quality.(AU)
Subject(s)
Humans , Prognosis , Infections , Prostheses and Implants , Orthopedics , Orthopedic ProceduresABSTRACT
Introducción: La infección protésica es una de las complicaciones más graves en cirugía ortopédica, por lo que es importante detectar factores relacionados con su aparición. Las revisiones sistemáticas (RS) pronósticas detectan y evalúan factores relacionados con enfermedades, lo que permite una mejor predicción de los riesgos y la implementación de medidas preventivas. Aunque estas RS pronósticas son cada vez más frecuentes, su campo metodológico presenta algunas lagunas de conocimiento. Objetivo: Realizar una revisión de RS de factores pronósticos para infección protésica y describir la evidencia sintetizada. Secundariamente, evaluar el riesgo de sesgo y la calidad metodológica. Material y métodos: Búsqueda bibliográfica en 4bases de datos (en mayo de 2021) para identificar RS pronósticas que evaluaran factores pronósticos para infección protésica. Evaluamos el riesgo de sesgo mediante ROBIS y la calidad metodológica con la herramienta modificada AMSTAR-2. Se realizó un estudio de solapamiento entre RS. Resultados: Incluimos 23 RS que valoraban 15 factores asociados con la infección protésica; de ellos, 13 mostraron asociación significativa. Los más estudiados fueron obesidad, corticoides intraarticulares, tabaquismo y glucemia elevada. El solapamiento entre RS fue elevado para obesidad y muy alto para corticoides intraarticulares, tabaquismo y glucemia elevada. El riesgo de sesgo fue considerado bajo en 8 RS (34,7%), pero la herramienta de evaluación metodológica demostró una baja calidad en general. Conclusiones: La identificación de factores procedimentales modificables ofrecen mejores resultados a los pacientes. Sin embargo, muchas RS son redundantes. La evidencia en factores pronósticos en cirugía ortopédica es débil debido al alto riesgo de sesgo y a la calidad metodológica limitada.(AU)
Background: Prosthetic joint infection is one of the most serious complications in orthopedics. Prognostic systematic reviews (SR) detecting and assessing factors related to prosthetic joint infection, allow better prediction of risk and implementation of preventive measures. Although prognostic SR are increasingly frequent, their methodological field presents some knowledge gaps. Purpose: To carry out an overview of SR assessing risk factors for prosthetic joint infection, describing and synthesizing their evidence. Secondarily, to assess the risk of bias and methodological quality. Material and methods: We conducted a bibliographic search in 4databases (May 2021) to identify prognostic SR evaluating any risk factor for prosthetic joint infection. We evaluated risk of bias with the ROBIS tool, and methodological quality with a modified AMSTAR-2 tool. We computed the overlap degree study between included SR. Results: Twenty-three SR were included, studying 15 factors for prosthetic joint infection, of which, 13 had significant association. The most frequently studied risk factors were obesity, intra-articular corticosteroids, smoking and uncontrolled diabetes. Overlapping between SR was high for obesity and very high for intra-articular corticoid injection, smoking and uncontrolled diabetes. Risk of bias was considered low in 8SRs (34.7%). The modified AMSTAR-2 tool showed important methodological gaps. Conclusions: Identification of procedural-modifiable factors, such as intra-articular corticoids use, can give patients better results. Overlapping between SR was very high, meaning that some SR are redundant. The evidence on risk factors for prosthetic joint infection is weak due to high risk of bias and limited methodological quality.(AU)
Subject(s)
Humans , Prognosis , Infections , Prostheses and Implants , Orthopedics , Orthopedic ProceduresABSTRACT
BACKGROUND: Prosthetic joint infection is one of the most serious complications in orthopedics. Prognostic systematic reviews (SRs) detecting and assessing factors related to prosthetic joint infection, allow better prediction of risk and implementation of preventive measures. Although prognostic SRs are increasingly frequent, their methodological field presents some knowledge gaps. PURPOSE: To carry out an overview of SR assessing risk factors for prosthetic joint infection, describing and synthesizing their evidence. Secondarily, to assess the risk of bias and methodological quality. MATERIAL AND METHODS: We conducted a bibliographic search in 4 databases (May 2021) to identify prognostic SR evaluating any risk factor for prosthetic joint infection. We evaluated risk of bias with the ROBIS tool, and methodological quality with a modified AMSTAR-2 tool. We computed the overlap degree study between included SR. RESULTS: Twenty-three SRs were included, studying 15 factors for prosthetic joint infection, of which, 13 had significant association. The most frequently studied risk factors were obesity, intra-articular corticosteroids, smoking and uncontrolled diabetes. Overlapping between SR was high for obesity and very high for intra-articular corticoid injection, smoking and uncontrolled diabetes. Risk of bias was considered low in 8 SRs (34.7%). The modified AMSTAR-2 tool showed important methodological gaps. CONCLUSIONS: Identification of procedural-modifiable factors, such as intra-articular corticoids use, can give patients better results. Overlapping between SR was very high, meaning that some SRs are redundant. The evidence on risk factors for prosthetic joint infection is weak due to high risk of bias and limited methodological quality.
ABSTRACT
Introducción: los linfoceles son una complicación poco frecuente en cirugía vascular, pero pueden representarun gran riesgo en pacientes con material protésico. Caso clínico: presentamos el caso de un varón de 82 años sometido hace 43 a radioterapia por un linfoma noHodgkin que presenta un gran linfocele en contacto con material protésico tras una intervención de revasculari-zación urgente. Se realiza tratamiento escleroterápico con espuma de polidocanol al 3% sin conseguir resultadosatisfactorio, por lo que se decide la sustitución del material protésico por autólogo y mioplastia de sartorio. Discusión: a pesar del fracaso con la escleroterapia de la cavidad, en gran medida debido al gran bloqueo linfáti-co crónico, consideramos esta opción la de elección en casos de linfocele por su baja complejidad, invasividad yexcelente relación riesgo/beneficio.(AU)
Background: lymphoceles are a rare complication in vascular surgery but can represent a great risk in patientswith prosthetic material. Case report: we present the case of an 82-year-old man who underwent radiotherapy 43 years ago for non-Hodg-kin lymphoma who presented a large lymphocele in contact with prosthetic material after an urgent revasculari-zation. Sclerotherapy treatment with 3% polidocanol foam was performed without achieving satisfactory resultsfor what we chose replace the prosthetic with autologous material and sartorius myoplasty. Discussion: despite the failure with sclerotherapy of the cavity, largely due to the great chronic lymphatic blockage,we consider this option the choice in cases of lymphocele due to its low complexity, invasiveness and excellentrisk/benefit ratio..(AU)
Subject(s)
Humans , Male , Aged , Ischemia/drug therapy , Ischemia/therapy , Lymphocele , Sclerotherapy , Prosthesis-Related Infections , Lymphoma, Non-Hodgkin , Inpatients , Physical Examination , RadiotherapyABSTRACT
BACKGROUND: Prosthetic joint infection is one of the most serious complications in orthopedics. Prognostic systematic reviews (SR) detecting and assessing factors related to prosthetic joint infection, allow better prediction of risk and implementation of preventive measures. Although prognostic SR are increasingly frequent, their methodological field presents some knowledge gaps. PURPOSE: To carry out an overview of SR assessing risk factors for prosthetic joint infection, describing and synthesizing their evidence. Secondarily, to assess the risk of bias and methodological quality. MATERIAL AND METHODS: We conducted a bibliographic search in 4databases (May 2021) to identify prognostic SR evaluating any risk factor for prosthetic joint infection. We evaluated risk of bias with the ROBIS tool, and methodological quality with a modified AMSTAR-2 tool. We computed the overlap degree study between included SR. RESULTS: Twenty-three SR were included, studying 15 factors for prosthetic joint infection, of which, 13 had significant association. The most frequently studied risk factors were obesity, intra-articular corticosteroids, smoking and uncontrolled diabetes. Overlapping between SR was high for obesity and very high for intra-articular corticoid injection, smoking and uncontrolled diabetes. Risk of bias was considered low in 8SRs (34.7%). The modified AMSTAR-2 tool showed important methodological gaps. CONCLUSIONS: Identification of procedural-modifiable factors, such as intra-articular corticoids use, can give patients better results. Overlapping between SR was very high, meaning that some SR are redundant. The evidence on risk factors for prosthetic joint infection is weak due to high risk of bias and limited methodological quality.
ABSTRACT
Antecedentes y objetivo: Diferentes autores han puesto de manifiesto la utilidad del análisis histológico en el diagnóstico de la infección protésica; sin embargo, todavía hoy, su validez clínica es motivo de controversia. El objetivo del presente manuscrito es describir y analizar la validez clínica del análisis histológico en el diagnóstico de infección protésica en el paciente sometido a un recambio protésico de cadera o rodilla. Material y métodos: Se presenta un estudio retrospectivo que incluye 133 recambios protésicos de cadera y rodilla realizados en nuestro centro entre 2008 y 2020. Se realizó un análisis estadístico descriptivo, bivariado y se determinó la validez clínica del análisis histológico. Resultados: La validez clínica del análisis histológico ofreció una sensibilidad del 48%, una especificidad del 91%, un valor predictivo positivo del 55% y un valor predictivo negativo del 88%. Conclusiones: La determinación de la validez clínica del análisis histológico pone de manifiesto una especificidad elevada. Dicho análisis supone una herramienta diagnóstica apropiada para detectar pacientes sanos, con ausencia de infección.(AU)
Background and aim: Different authors have demonstrated the usefulness of the histological analysis in the diagnosis of prosthetic joint infection; however, its clinical validity is still controversial. The aim of this article is to describe and analyze the clinical validity of histological analysis in the diagnosis of prosthetic infection in patients undergoing hip or knee prosthetic replacement. Material and methods: We present a retrospective study including 133 hip and knee prosthetic replacements performed in our center between 2008 and 2020. A descriptive, bivariate statistical analysis was performed and the clinical validity of the histological analysis was determined. Outcomes: The clinical validity of the intraoperative histology offered a sensitivity of 48%, a specificity of 91%, a positive predictive value of 55% and a negative predictive value of 88%. Conclusions: The determination of the clinical validity of histological analysis shows a high specificity. This analysis is an appropriate diagnostic tool for detecting healthy patients, with no infection.(AU)
Subject(s)
Humans , Male , Female , Middle Aged , Aged , Histology , Prosthesis-Related Infections/diagnosis , Arthroplasty, Replacement, Hip , Arthroplasty, Replacement, Knee , Retrospective Studies , Epidemiology, DescriptiveABSTRACT
Background and aim: Different authors have demonstrated the usefulness of the histological analysis in the diagnosis of prosthetic joint infection; however, its clinical validity is still controversial. The aim of this article is to describe and analyze the clinical validity of histological analysis in the diagnosis of prosthetic infection in patients undergoing hip or knee prosthetic replacement. Material and methods: We present a retrospective study including 133 hip and knee prosthetic replacements performed in our center between 2008 and 2020. A descriptive, bivariate statistical analysis was performed and the clinical validity of the histological analysis was determined. Outcomes: The clinical validity of the intraoperative histology offered a sensitivity of 48%, a specificity of 91%, a positive predictive value of 55% and a negative predictive value of 88%. Conclusions: The determination of the clinical validity of histological analysis shows a high specificity. This analysis is an appropriate diagnostic tool for detecting healthy patients, with no infection.(AU)
Antecedentes y objetivo: Diferentes autores han puesto de manifiesto la utilidad del análisis histológico en el diagnóstico de la infección protésica; sin embargo, todavía hoy, su validez clínica es motivo de controversia. El objetivo del presente manuscrito es describir y analizar la validez clínica del análisis histológico en el diagnóstico de infección protésica en el paciente sometido a un recambio protésico de cadera o rodilla. Material y métodos: Se presenta un estudio retrospectivo que incluye 133 recambios protésicos de cadera y rodilla realizados en nuestro centro entre 2008 y 2020. Se realizó un análisis estadístico descriptivo, bivariado y se determinó la validez clínica del análisis histológico. Resultados: La validez clínica del análisis histológico ofreció una sensibilidad del 48%, una especificidad del 91%, un valor predictivo positivo del 55% y un valor predictivo negativo del 88%. Conclusiones: La determinación de la validez clínica del análisis histológico pone de manifiesto una especificidad elevada. Dicho análisis supone una herramienta diagnóstica apropiada para detectar pacientes sanos, con ausencia de infección.(AU)
Subject(s)
Humans , Male , Female , Middle Aged , Aged , Histology , Prosthesis-Related Infections/diagnosis , Arthroplasty, Replacement, Hip , Arthroplasty, Replacement, Knee , Retrospective Studies , Epidemiology, DescriptiveABSTRACT
BACKGROUND AND AIM: Different authors have demonstrated the usefulness of the histological analysis in the diagnosis of prosthetic joint infection; however, its clinical validity is still controversial. The aim of this article is to describe and analyze the clinical validity of histological analysis in the diagnosis of prosthetic infection in patients undergoing hip or knee prosthetic replacement. MATERIAL AND METHODS: We present a retrospective study including 133 hip and knee prosthetic replacements performed in our center between 2008 and 2020. A descriptive, bivariate statistical analysis was performed and the clinical validity of the histological analysis was determined. OUTCOMES: The clinical validity of the intraoperative histology offered a sensitivity of 48%, a specificity of 91%, a positive predictive value of 55% and a negative predictive value of 88%. CONCLUSIONS: The determination of the clinical validity of histological analysis shows a high specificity. This analysis is an appropriate diagnostic tool for detecting healthy patients, with no infection.
Subject(s)
Arthritis, Infectious , Arthroplasty, Replacement, Hip , Arthroplasty, Replacement, Knee , Prosthesis-Related Infections , Humans , Retrospective Studies , Prosthesis-Related Infections/diagnosis , Predictive Value of Tests , Sensitivity and Specificity , ReoperationABSTRACT
BACKGROUND AND AIM: Different authors have demonstrated the usefulness of the histological analysis in the diagnosis of prosthetic joint infection; however, its clinical validity is still controversial. The aim of this article is to describe and analyse the clinical validity of histological analysis in the diagnosis of prosthetic infection in patients undergoing hip or knee prosthetic replacement. MATERIAL AND METHODS: We present a retrospective study including 133 hip and knee prosthetic replacements performed in our centre between 2008 and 2020. A descriptive, bivariate statistical analysis was performed and the clinical validity of the histological analysis was determined. OUTCOMES: The clinical validity of the intraoperative histology offered a sensitivity of 48%, a specificity of 91%, a positive predictive value of 55% and a negative predictive value of 88%. CONCLUSIONS: The determination of the clinical validity of histological analysis shows a high specificity. This analysis is an appropriate diagnostic tool for detecting healthy patients, with no infection.
Subject(s)
Arthritis, Infectious , Arthroplasty, Replacement, Hip , Arthroplasty, Replacement, Knee , Prosthesis-Related Infections , Humans , Retrospective Studies , Prosthesis-Related Infections/diagnosis , Predictive Value of Tests , Sensitivity and SpecificityABSTRACT
Introducción:la presentación clínica más frecuente de infección protésica aórtica, secundaria a una fístula aortoentérica (FAE) es la hemorragia gastrointestinal.Se presenta un caso de debut atípico de infección protésica en un paciente con un absceso glúteo y sepsis que la demuestra en estudio complementario.Caso clínico:se trata de un paciente de 69 años, con antecedentes de bypass femoropoplíteo a 1.ª porción en ambas extremidades inferiores y de bypass aortobifemoral (2017). Ante el hallazgo de infección protésica, fue intervenido de un explante de la prótesis aortobifemoral por laparotomía transversa y drenaje de absceso de psoas derecho. Se observó fístula a nivel de tercera porción duodenal distal, no observada en la gastroscopia preoperatoria, que se reparó con sutura primaria y patch yeyunal. Se tomaron cultivos de absceso glúteo, observando Candida krusei y Brevibacterium ravenspurgense, pautando antibioterapia intravenosa en el posoperatorio. En los días posteriores se intervino de una amputación supracondílea de pierna derecha por empeoramiento de la isquemia en dicha extremidad.Discusión:la FAE es una complicación rara y potencialmente mortal de la reparación del aneurisma aórtico abdominal. A pesar de no existir ensayos controlados para estandarizar el manejo, la mejor terapia sigue siendo la explantación completa del injerto con reemplazo por material autólogo o reconstrucción extraanatómica.(AU)
Introduction:gastrointestinal bleeding is the most frequent clinical debut of aortic graft infections, secondary to an aortoenteric fistula (AEF). We show a case of an atypical debut of prosthetic infection as an incidental finding in image, requested by gluteal abscess and sepsis.Case report:a 69-year-old patient, with a medical record of femoropopliteal bypass at 1st portion in both lower extremities and aortobifemoral bypass (2017). When finding the graft infection, he was operated for an extraction of aortobifemoral graft by transverse laparotomy and drainage of right psoas abscess. A fistula was not noticed in preoperative gastroscopy seen at the level of the 3rd distal portion and repaired with a primary suture and jejunal patch. Gluteal abscess samples were taken, showing Candida krusei and Brevibacterium ravenspurgense. Intravenous antibiotic therapy was prescribed in the postoperative period. In the following days, he underwent a supracondylar amputation of the right leg due to worsening of the ischemia in said limb.Discussion:AEF is a rare and life-threatening complication of abdominal aortic aneurysm repair. Despite the absence of controlled trials to standardize the management, the best therapy remains the complete graft explantation with replacement by autologous material or extraanatomic reconstruction.(AU)
Subject(s)
Humans , Male , Middle Aged , Abscess , Prosthesis-Related Infections , Ischemia , Inpatients , Physical Examination , Sepsis , Fistula , Surgical Procedures, OperativeABSTRACT
Dalbavancina es un agente antibacteriano perteneciente al grupo de los lipoglicopéptidos semisintéticos de larga vida media, con gran actividad sobre microorganismos grampositivos y con un perfil de efectos adversos aceptable. Hasta la fecha, ha sido autorizada para el tratamiento de infecciones de piel y tejidos blandos en adultos, sin indicación en infecciones de hueso y articulaciones.La mayoría de los casos de infección protésica articular descritos en la literatura con dalbavancina en tratamiento prolongado, han sido durante un periodo no superior a 4 semanas.Se describen una serie de casos de infección osteoarticular de material protésico tratados de forma prolongada y como rescate con dalbavancina. (AU)
Dalbavancin is an antibacterial agent that belongs to the group of semi-synthetic lipoglicopeptides of long half-life, with great activity in gram-positive microorganisms and with an acceptable adverse effects profile. To date, it has been authorized for the treatment of skin and soft tissue infections in adults, with no indication of bone and joint infections.Most cases of joint prosthetic infection described in the literature with dalbavancin in prolonged treatment have been for a period not exceeding 4 weeks.A series of cases of prosthetic joint infection treated for a long time and as salvage with dalbavancin are described. (AU)
Subject(s)
Humans , Bacterial Infections/complications , Bacterial Infections/therapy , Joint Prosthesis , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/adverse effects , Anti-Bacterial Agents/therapeutic use , StaphylococcusABSTRACT
It is very important to treat prosthetic infections correctly in order to ensure a higher success rate. Debridement with implant retention (DAIR) is widely used in acute and late infections, however patients who fail after this surgery are known to have a higher risk of failure in subsequent surgeries. Therefore, it is important to find a scale that enables us to predict the risk of DAIR failure. Hence the KLIC and CRIME80 scores for acute and late acute infections, respectively. This study analysed the validity of both scores in acute late periprosthetic knee infections. We observed that the KLIC score has no predictive value for this type of infection, but the CRIME80 score does.
Subject(s)
Arthroplasty, Replacement, Knee/adverse effects , Debridement , Knee Joint , Prosthesis-Related Infections/surgery , Acute Disease , Aged , Aged, 80 and over , Anti-Bacterial Agents/therapeutic use , Debridement/adverse effects , Debridement/methods , Female , Humans , Knee Prosthesis , Male , Middle Aged , Predictive Value of Tests , Prosthesis-Related Infections/drug therapy , Prosthesis-Related Infections/microbiology , Reproducibility of Results , Retrospective Studies , Risk Assessment/methods , Treatment FailureABSTRACT
BACKGROUND: Aorto-enteric fistula is a rare and potentially lethal entity. Its presentation may be as an enteric-paraprosthetic fistula, due to injury in the gut caused by direct contact with the vascular prosthesis. OBJECTIVE: We report a case of enteric-paraprosthetic fistulae with the unusual finding of Candida parapsilosis as the only isolated pathogen. CLINICAL CASE: A 65-year-old male, smoker, with aortobifemoral revascularisation with dacron due to aortoiliac occlusive disease, and re-intervention for thrombosis of left arm at 6 months. Hospitalisation at 22 months was required due to a toxic syndrome, which was diagnosed as enteric-paraprosthetic fistulae after complementary studies. The graft was removed and an extra-anatomic revascularisation was performed. Microbiology specimens taken from the duodenal segment in contact with the prosthesis showed the prosthetic segment and peri-prosthetic fluid were positive to C. parapsilosis. DISCUSSION: The finding of C. parapsilosis in all cultures taken during surgery, along with negative blood cultures and no other known sources of infection, is of interest. It is an unusual pathogen with low virulence and limited as regards other Candida species. Our patient had no clinical data common to cases of infection with C. parapsilosis, and the mechanism of graft infection is unknown. CONCLUSION: Graft infection by C. parapsilosis may be anecdotal. However, its consequences can also be severe. Microbiological tests can be useful to adjust antimicrobial therapy in the post-operative period, but their usefulness for determining the aetiology is doubtful, as it may be just an incidental finding.
Subject(s)
Aortic Diseases/etiology , Blood Vessel Prosthesis/adverse effects , Candida parapsilosis/isolation & purification , Candidiasis/etiology , Duodenal Diseases/etiology , Fistula/etiology , Intestinal Fistula/etiology , Postoperative Complications/etiology , Prosthesis-Related Infections/etiology , Aged , Aorta, Abdominal/surgery , Aortic Diseases/microbiology , Candidiasis/microbiology , Device Removal , Duodenal Diseases/microbiology , Fistula/microbiology , Humans , Intestinal Fistula/microbiology , Male , Postoperative Complications/microbiology , Prosthesis-Related Infections/microbiology , Reoperation , Thrombosis/surgeryABSTRACT
OBJECTIVE: To determine the impact of each cause of revision surgery in total hip arthroplasty during the period 2009-2013. To analyse the relationship between these causes with different variables. MATERIALS AND METHODS: A study was conducted on 127 patients who had hip replacement revision surgery in our hospital during this period. Parameters, such as age, sex, date of primary arthroplasty, prosthetic replacement date, and main cause of the revision were recorded. Those revisions performed within 5 years after the primary arthroplasty were considered as early rescue. RESULTS: The most common cause of rescue was aseptic loosening in 38 (30%) followed by instability in 30 (24%). In terms of age at the time of rescue, statistically significant differences were found, with it being significantly higher in patients re-operated for a fracture. Differences in age at first surgery were found to be 7 years younger than those with late rescue (63.40) with respect to early (70.21). DISCUSSION: Similar results to ours have been observed in other published series, except for the higher incidence of instability in early rescue. CONCLUSIONS: This study demonstrates aseptic loosening and instability as the most frequent causes of revision surgery in our hospital. Age is a very influential factor in relation to longevity of primary arthroplasty. Complications were higher in when the primary hip replacement is implanted in older patients.
Subject(s)
Arthroplasty, Replacement, Hip , Hip Prosthesis/adverse effects , Prosthesis Failure , Prosthesis-Related Infections/surgery , Reoperation/statistics & numerical data , Adult , Aged , Aged, 80 and over , Female , Follow-Up Studies , Humans , Incidence , Male , Middle Aged , Outcome Assessment, Health Care , Prosthesis-Related Infections/epidemiology , Retrospective StudiesABSTRACT
PURPOSE: The use of bone cement is widespread in orthopaedic surgery. Most of the mechanical tests are performed in dry medium, making it difficult to extrapolate the results. The objective of this study is to assess if the mechanical properties of polymethylmethacrylate (PMMA), obtained in previous reports, are still present in a liquid medium. MATERIAL AND METHOD: An experimental study was designed with antibiotic (vancomycin) loaded PMMA. Four groups were defined according to the medium (dry or liquid) and the pre-conditioning in liquid medium (one week or one month). Wear and flexural strength tests were performed according to ASTM and ISO standards. Volumetric wear, friction coefficient, tensile strength, and Young's modulus were analyzed. All samples were examined by scanning electron microscopy. RESULTS: The samples tested in liquid medium showed lower wear and flexural strength values (P<.05). The kind of wear was modified from abrasive to adhesive in those samples studied in liquid medium. The samples with a pre-conditioning time showed lower values of wear (P<.05). CONCLUSIONS: Caution is recommended when extrapolating the results of previous PMMA results. The different mechanical strength of the cement in a liquid medium, observed in saline medium, is much closer to the clinical situation.
