ABSTRACT
Surgical organizations dedicated to the improvement of patient outcomes have led to a worldwide paradigm shift in perioperative patient care. Since 2012, the Enhanced Recovery After Surgery (ERAS®) Society has published guidelines pertaining to perioperative care in numerous disciplines including elective colorectal and gynecologic/oncology surgery patients. The ERAS® and ERAS-USA® Societies use standardized methodology for collecting and assessing various surgical parameters in real-time during the operative process. These multi-disciplinary groups have constructed a bundled framework of perioperative care that entails 22 specific components of clinical interventions, which are logged in a central database, allowing a system of audit and feedback. Of these 22 recommendations, nine of them specifically involve the use of medications or pharmacotherapy. This retrospective comparative pharmacotherapy project will address the potential need to (1) collect more specific pharmacotherapy data within the existing ERAS Interactive Audit System® (EIAS) program, (2) understand the relationship between medication regimen and patient outcomes, and (3) minimize variability in pharmacotherapy use in the elective colorectal and gynecologic/oncology surgical cohort. Primary outcomes measures include data related to surgical site infections, venous thromboembolism, and post-operative nausea and vomiting as well as patient satisfaction, the frequency and severity of post-operative complications, length of stay, and hospital re-admission at 7 and 30 days, respectively. The methodology of this collaborative research project is described.
ABSTRACT
Objetivo: Avaliar o efeito da infecção e da deiscência da ferida operatória sobre o controle local do carcinoma epidermóide das vias aerodigestivas superiores, identificando fatores associados à ocorrência destas complicações. Método: Estudo retrospectivo de 239 pacientes com carcinoma epidermóide de boca, orofaringe e hipofaringe tratados cirurgicamente no Departamento de Cirurgia de Cabeça e Pescoço e Otorrinolaringologia do Hospital Heliópolis entre 1990 e 1996, onde foram avaliados o hemograma e oproteinograma pré-operatório em relação ao risco de desenvolvimento de deiscência e infecção da ferida operatória e comparadas as taxas de recidiva local entre os pacientes com e sem deiscência/infecção da feridaoperatória. Resultados: A doença em estádio avançado (estádio IV) e a relação albumina/globulina inferior a1,2 foram mais freqüentes entre os pacientes que desenvolveram deiscência/infecção (DI) da ferida operatória. A taxa de recidiva local foi de 49% nos pacientes que apresentaram DI e 42% naqueles sem DI. Conclusão: os pacientes com doença em estádio avançado e aqueles com relação albumina/globulina inferior a 1,2apresentam maior risco de deiscência/infecção da ferida operatória. A presença de deiscência/infecção não apresentou relação com as taxas de recidiva local.
Bacground: To evaluate the effect of infection and dehiscence of operative wound in local control of squamous cell carcinoma of upper aerodigestive tract, identifying factors related to these complications. Methods: A retrospective study of 239 patients with squamous cell carcinoma of mouth, oropharynx andhypopharynx treated at Departament of Surgery of Head and Neck Surgery and Otorrinolaringology of Heliópolis Hospital between 1990 and 1996. Preoperative hemogram and proteinogram were evaluated in relation to the risk of dehiscence and infection of the operative wound. The rates of local recurrence were compared among patients with and without dehiscence/infection of the operative wound. Results: Advanced stage disease (stage IV) and albumin/globulin ratio less than 1.2 were more frequent amongpatients that developed dehiscence/infection (DI) of the operative wound. The rate of local recurrence was 49% for patients with DI and 42% for those without DI. Conclusion: Patients with advanced stage disease and those with albumin/globulin ratio less than 1.2 have a higher risk of dehiscence /infection of the operative wound. Dehiscence and/or infection did not demonstrate relationship with local recurrence.
