Immunogenicity of BNT162b2 vaccine after two and three doses in health personnel and institutionalized elderly people not infected with SARS-CoV-2 / Inmunogenicidad de la vacuna BNT162b2 tras la administración de 2 y 3 dosis en personal sanitario y personas mayores institucionalizadas sin infección previa por SARS-CoV-2

Objective The aim of our research was to compare the evolution of the immune response induced by the BNT162b2 vaccine after the administration of two and three doses in healthcare personnel and in institutionalized elderly people (>65 years of age) without previous SARS-CoV-2 infection. Material and methods A prospective observational study was carried out on a convenience sample made up of health workers and institutionalized elderly people, measuring antibodies against S and N proteins of SARS-CoV-2 two and six months after receiving the second vaccine dose, as well as two months after receiving the third dose. Results A significant reduction of the anti-S humoral immune response was reported six months after the second dose of vaccine in both health workers and residents. The administration of a third dose of vaccine induced a significant increase in this antibody response in both investigated groups reaching a similar proportion of responders two months after this third dose. Conclusions Humoral immunity induced by two doses of the BNT162b2 vaccine in persons without prior SARS-CoV-2 infection wanes over time. The administration of a third dose significantly increases anti-S antibodies being highly recommended, especially in people over 65 years of age (AU)

Objetivo El objetivo de nuestra investigación fue comparar la evolución de la respuesta inmunitaria humoral inducida por la vacuna BNT162b2 tras la administración de 2 y 3 dosis en personal sanitario y en personas mayores institucionalizadas (>65años) sin infección previa por SARS-CoV-2. Material y métodos Se realizó un estudio observacional prospectivo en una muestra de conveniencia conformada por sanitarios y mayores institucionalizados, determinando anticuerpos contra las proteínas S y N del SARS-CoV-2 a los 2 y 6 meses de recibir la segunda dosis de la vacuna, así como a los 2 meses después de recibir la tercera dosis. Resultados Se observó una reducción significativa de la respuesta inmune humoral anti-S 6 meses después de la segunda dosis de vacuna, tanto en sanitarios como en residentes. La administración de una tercera dosis de vacuna indujo un aumento significativo de esta respuesta de anticuerpos en ambos grupos, alcanzándose una proporción similar de individuos respondedores a los 2 meses de esta tercera dosis. Conclusiones La inmunidad humoral inducida por 2 dosis de la vacuna BNT162b2 en personas sin infección previa por SARS-CoV-2 disminuye con el tiempo. La administración de una tercera dosis aumenta significativamente los anticuerpos anti-S siendo muy recomendable, especialmente en personas mayores de 65 años (AU)

Immunogenicity of BNT162b2 vaccine after two and three doses in health personnel and institutionalized elderly people not infected with SARS-CoV-2.

OBJECTIVE: The aim of our research was to compare the evolution of the immune response induced by the BNT162b2 vaccine after the administration of two and three doses in healthcare personnel and in institutionalized elderly people (>65 years of age) without previous SARS-CoV-2 infection. MATERIAL AND METHODS: A prospective observational study was carried out on a convenience sample made up of health workers and institutionalized elderly people, measuring antibodies against S and N proteins of SARS-CoV-2 two and six months after receiving the second vaccine dose, as well as two months after receiving the third dose. RESULTS: A significant reduction of the anti-S humoral immune response was reported six months after the second dose of vaccine in both health workers and residents. The administration of a third dose of vaccine induced a significant increase in this antibody response in both investigated groups reaching a similar proportion of responders two months after this third dose. CONCLUSIONS: Humoral immunity induced by two doses of the BNT162b2 vaccine in persons without prior SARS-CoV-2 infection wanes over time. The administration of a third dose significantly increases anti-S antibodies being highly recommended, especially in people over 65 years of age.

Percepção sobre abandono afetivo em idoso institucionalizado / Perception of emotional neglect in institutionalized elderly / Percepción del abandono afectivo en adultos mayores institucionalizado

Objetivo: Compreender a percepção dos idosos institucionalizados quanto ao abandono afetivo por parte de seus familiares.Método: Trata-se de um estudo exploratório, comabordagemqualitativa. Conduzido por meio de entrevistas semiestruturadas. A organização e análise dos dados foram baseadas na técnica de Minayo. O estudo foi realizado em uma Instituição de Longa Permanência para Idosos, localizada em uma cidade do nordeste de Santa Catarina.Resultados: Participaram do estudo nove idosos, com idades entre 60 e 89 anos, com diferentes estados civis (viúvos, casados e divorciados), variando sua escolaridade do nível básico ao superior, além de serem aposentados ou pensionistas. Foram identificadas quatro categorias analíticas: (1) vivência na instituição, (2) motivos para a institucionalização, (3) relacionamento familiar e (4) percepção do abandono familiar.Conclusão: alguns idosos enfatizaram sentir-se esquecidos na instituição, o que os deixa tristes e deprimidos. É crucial para a prática de a enfermagem compreender a realidade dos idosos nas Instituições de Longa Permanência, pois essa compreensão está diretamente ligada à prestação de cuidados em todos os níveis de assistência à saúde

Objective: To understand the perception of institutionalized elderly individuals regarding the emotional abandonment by their family members.Methodology: This is an exploratory study, using qualitative methods. Conducted through semi-structured interviews. Data organization and analysis were based on Minayo's technique. The study was conducted at a Long-Term Care Institution for the Elderly located in a city in northeastern Santa Catarina.Results: Nine elderly individuals participated in the study, ranging in age from 60 to 89 years old, with different marital statuses (widowed, married, and divorced), ranging in education from basic to higher levels, and being retirees or pensioners. Four analytical categories were identified: (1) experience in the institution, (2) reasons for institutionalization, (3) family relationships, and (4) perception of family abandonment.Conclusion: Some elderly individuals emphasized feeling forgotten in the institution, which makes them feel sad and depressed. Understanding the reality of the elderly in Long-Term Care Institutions is crucial for nursing practice, as this understanding is directly linked to providing care at all levels of healthcare assistance in the Health Care Network

Objetivo: Comprender la percepción de las personas mayores institucionalizadas con respecto al abandono afectivo por parte de sus familiares. Metodología:Se trata de un estudio exploratorio, utilizando métodos cualitativos. Realizado a través de entrevistas semiestructuradas. La organización y análisis de los datos se basaron en la técnica de Minayo. El estudio se llevó a cabo en una Institución de Larga Estadía para Personas Mayores lubicada en una ciudad del noreste de Santa Catarina. Resultados:Nueve personas mayores participaron en el estudio, con edades comprendidas entre 60 y 89 años, con diferentes estados civiles (viudos, casados y divorciados), variando en educación desde niveles básicos hasta superiores, y siendo jubilados o pensionistas. Se identificaron cuatro categorías analíticas: (1) experiencia en la institución, (2) motivos para la institucionalización, (3) relaciones familiares y (4) percepción del abandono familiar. Conclusión:Algunas personas mayores enfatizaron sentirse olvidadas en la institución, lo que los hace sentir tristes y deprimidas. Es crucial para la práctica de enfermería comprender la realidad de los adultos mayores en las Instituciones de Larga Estancia, ya que esta comprensión está directamente vinculada con la prestación de cuidados en todos los niveles de asistencia sanitaria en la Red de Atención a la Salud.

Caregiver's distress related to the patient's neuropsychiatric symptoms as a function of the care-setting.

Prevalence of neuropsychiatric symptoms (NPS) and correlation between its intensity and caregiver distress were evaluated as a function of the care-setting in a cross-sectional study including 72 patient-caregiver dyads. The Neuropsychiatric Inventory and the Caregiver Distress Scale were administered. The most prevalent symptoms were: in the formal care-setting, agitation/aggression and depression/dysphoria (42.4%), and in the informal care-setting, aberrant motor behavior (59.0%). While changes in appetite and eating behaviors, depression/dysphoria and irritability/lability were more prevalent in the formal care-setting (p < .0001, p = .011, p = .021), aberrant motor behavior was more prevalent in the informal care-setting (p = .007). NPS were positively correlated with caregiver distress. High patients' scores in hallucinations, sleep and night-time disturbances, anxiety, and aberrant motor behavior were the best predictors of professional caregiver's distress. Agitation/aggression, delusions, disinhibition, apathy/indifference, depression/dysphoria, and elation/euphoria were the best predictors of informal caregiver's distress. Findings may have important clinical implications.

Exercício físico para prevenção de quedas: ensaio clínico com idosos institucionalizados em Goiânia, Brasil / Physical exercises to prevent falls: a clinical trial with institutionalized elderly in the city of Goiânia in Brazil

Este estudo teve como objetivo avaliar um programa de intervenção com exercícios físicos em grupo na prevenção de quedas em idosos residentes em instituições de longa permanência. Trata-se de um ensaio clínico não randomizado realizado com 20 idosos institucionalizados na cidade de Goiânia, Brasil. As intervenções ocorreram durante cinco meses, sendo que o programa de exercícios proposto foi baseado em estudos anteriores. Medidas padronizadas foram utilizadas para avaliar quedas, equilíbrio e marcha, força muscular, flexibilidade e medo de quedas. A partir do período de 12 meses do início da intervenção houve redução significativa no número de quedas (p = 0,046). A partir do programa foram observadas diferenças significantes para pontuação das manobras de equilíbrio (p = 0,001), pontuação total das manobras de equilíbrio e marcha (p = 0,007), força muscular de preensão palmar (p = 0,001) e de membros inferiores (p < 0,001), flexibilidade do movimento de flexão dos ombros (p = 0,001). A intervenção realizada mediante um programa de exercícios mostrou-se adequada, porém, não suficiente para melhorar a marcha, flexibilidade multiarticular da coluna e quadril e medo de quedas, bem como para reduzir o número de idosos que sofreram quedas a partir do início do estudo.

The scope of this study was to evaluate an intervention program with group physical exercises to prevent falls in the elderly in long-term care institutions. This is a non-randomized clinical trial conducted with 20 institutionalized elderly people in the city of Goiânia in Brazil. The interventions occurred over the period of five months, though the proposed exercise program was based on earlier studies. Standardized measures were used to assess falls, balance and gait, muscle strength, flexibility and fear of falling. After the period of 12 months from the start of intervention there was a significant reduction in the number of falls (p = 0.046). Based on the program, significant differences were observed for point allocation of the maneuvers of balance (p = 0.001), total scores of the maneuvers of balance and gait (p = 0.007), muscle strength of hand grip (p = 0.001) and of lower limbs (p < 0.001), flexibility of movement of shoulder flexion (p = 0.001). The intervention using an exercise program proved to be adequate, albeit insufficient to improve the gait, multiple joint flexibility of the spine and hip and fear of falling, or to reduce the number of elderly people who suffered falls from the beginning of the study.

Quedas e fatores associados em idosos institucionalizados no município de Pelotas (RS, Brasil) / Falls and associated factors in institutionalized elderly people in Pelotas (RS, Brazil)

O crescimento da população idosa tem despertado o interesse dos profissionais de saúde por ser o envelhecimento um processo importante à saúde. Um estudo com delineamento transversal de base institucional foi realizado com indivíduos de 65 anos ou mais residentes em instituições de idosos no município de Pelotas (RS) com o objetivo de verificar a prevalência de quedas e verificar alguns fatores associados a esse evento. A prevalência de quedas encontrada foi de 33,5 por cento, sendo o quarto o local de maior prevalência (37 por cento). Do total de indivíduos que relataram alguma queda, 16,9 por cento fraturaram-se devido à queda. Cerca de 70 por cento das quedas ocorreram na instituição. O tornozelo e o quadril foram os locais anatômicos de maior prevalência desse agravo, com 33,3 por cento. Concluímos que a prevalência de quedas em idosos institucionalizados é alta e os agravos decorrentes das mesmas são preocupantes. Fazem-se necessárias medidas de intervenção por parte dos gestores e profissionais da saúde no sentido de minimizar esses índices e de proporcionar melhor qualidade de vida para os idosos institucionalizados.

The ageing of the population generates interest among health professionals, because of its importance for health. A cross-sectional study was carried out including institutionalized subjects aged over 65 from Pelotas (RS, Brazil). The aim was to investigate the prevalence of falls and associated factors. The prevalence of falls was 33.5 percent; the most frequent place in which falls occurred was the bedroom (37 percent). Of all falls, 16.9 percent resulted in a fracture. Approximately 70 percent of the falls took place at the institution in which the subjects live. Ankles and hips were the most frequently anatomic sites fractured (33,3 percent). The prevalence of falls among the elderly was high and the consequences of such falls are worrying. Prevention strategies by healthcare professionals and managers are urgently needed in order to minimize the burden of falls and thus enhance the quality of life of institutionalized elderly people.