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1.
Med Hypotheses ; 144: 109951, 2020 Nov.
Article in English | MEDLINE | ID: mdl-32535457

ABSTRACT

The relationship between pregnancy and breast cancer risk is not fully understood. Most of the literature has described this interaction in terms of the age at first pregnancy and the number of full-term pregnancies. During the prospective accrual of the "Joven & Fuerte: Program for young women with breast cancer in Mexico" cohort, a series of cases with pregnancy-associated breast cancer and a history of a short inter-pregnancy interval was identified. To date, there is a very limited number of descriptions about the interaction between a short inter-pregnancy interval and breast cancer, but none specifically regarding the association of a short inter-pregnancy interval and pregnancy-associated breast cancer. Based on findings from a prospective cohort of young Mexican breast cancer patients, we hypothesize that a short inter-pregnancy interval may increase the incidence of pregnancy-associated breast cancer, possibly by amplifying the effects of the pregnancy-associated factors involved in the development of breast cancer.


Subject(s)
Breast Neoplasms , Birth Intervals , Breast Neoplasms/epidemiology , Female , Humans , Incidence , Pregnancy , Prospective Studies , Risk Factors
2.
Reprod Health ; 13(1): 83, 2016 Jul 18.
Article in English | MEDLINE | ID: mdl-27430353

ABSTRACT

BACKGROUND: Women with a history of pre-eclampsia have a higher risk of developing pre-eclampsia in subsequent pregnancies. However, the role of the inter-pregnancy interval on this association is unclear. OBJECTIVE: To explore the effect of inter-pregnancy interval on the risk of recurrent pre-eclampsia or eclampia. SEARCH STRATEGY: MEDLINE, EMBASE and LILACS were searched (inception to July 2015). SELECTION CRITERIA: Cohort studies assessing the risk of recurrent pre-eclampsia in the immediate subsequent pregnancy according to different birth intervals. DATA COLLECTION AND ANALYSIS: Two reviewers independently performed screening, data extraction, methodological and quality assessment. Meta-analysis of adjusted odds ratios (aOR) with 95 % confidence intervals (CI) was used to measure the association between various interval lengths and recurrent pre-eclampsia or eclampsia. MAIN RESULTS: We identified 1769 articles and finally included four studies with a total of 77,561 women. The meta-analysis of two studies showed that compared to inter-pregnancy intervals of 2-4 years, the aOR for recurrent pre-eclampsia was 1.01 [95 % CI 0.95 to 1.07, I(2) 0 %] with intervals of less than 2 years and 1.10 [95 % CI 1.02 to 1.19, I(2) 0 %] with intervals longer than 4 years. CONCLUSION: Compared to inter-pregnancy intervals of 2 to 4 years, shorter intervals are not associated with an increased risk of recurrent pre-eclampsia but longer intervals appear to increase the risk. The results of this review should be interpreted with caution as included studies are observational and thus subject to possible confounding factors.


Subject(s)
Birth Intervals , Evidence-Based Medicine , Pre-Eclampsia/prevention & control , Adult , Cohort Studies , Databases, Factual , Eclampsia/epidemiology , Eclampsia/etiology , Eclampsia/prevention & control , Electronic Health Records , Female , Humans , Male , Observational Studies as Topic , Pre-Eclampsia/epidemiology , Pre-Eclampsia/etiology , Pregnancy , Recurrence , Risk , Secondary Prevention , Sexual Partners
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