Efecto de diferentes esquemas de terapia de deprivación androgénica sobre la densidad mineral ósea de pacientes con cáncer de próstata / Effect of different schemes of androgen deprivation therapy on bone mass density in prostate cancer patients

Objetivos: Evaluar aspectos del metabolismo óseo basal en pacientes con cáncer de próstata y el efecto, en práctica clínica habitual, de diferentes esquemas de tratamiento (intermitente o continuo) con agonistas de la hormona liberadora de hormona luteinizante (LH-RH) y del denosumab en la evolución de la densidad mineral ósea (DMO).MétodosEstudio observacional retrospectivo de una cohorte de pacientes con cáncer de próstata en tratamiento con agonistas LH-RH, valorados en el servicio de reumatología de un hospital de tercer nivel. Se recogieron datos demográficos, índice de FRAX, esquema de tratamiento LH-RH, tratamiento de osteoporosis, datos de laboratorio y de DMO. Se usaron modelos de regresión lineal de efecto mixto analizando la interacción de los esquemas de tratamiento LH-RH, denosumab y la evolución de DMO.ResultadosSe incluyeron 83 pacientes (73±8años). Evaluación basal: el 16% de los pacientes presentaron osteoporosis densitométrica y además un 27% un riesgo elevado de fractura (FRAX). El 80% tenían niveles de vitaminaD <30ng/l. La pauta intermitente de agonistas LH-RH y los niveles elevados de vitaminaD se asociaron a mejor DMO basal. No se detectó asociación entre la evolución de la DMO y las pautas de tratamiento de agonistas LH-RH, pero sí se encontró una correlación positiva con denosumab.ConclusionesUna elevada proporción de pacientes presentaban un alto riesgo de fractura o niveles insuficientes de vitaminaD no detectados previamente. El estudio tanto del metabolismo óseo como del riesgo de fractura son convenientes en estos pacientes. En práctica clínica habitual el efecto sobre la DMO del denosumab se detecta a corto plazo, mientras que el del esquema intermitente con agonistas LH-RH es menos evidente. (AU)

Objectives: To evaluate the aspects of the basal bone health status in prostate cancer patients. Furthermore, to evaluate in a real-world setting the effect of different schemes (intermittent or continuous) of androgen deprivation therapy (ADT) and the effect of denosumab in bone mass density (BMD).MethodsObservational, retrospective study of a cohort of prostate cancer patients in treatment with luteinizing hormone-releasing hormone (LH-RH) agonists, evaluated in the rheumatology department of a tertiary center. Demographics, FRAX score, LH-RH treatment scheme, osteoporosis treatment, laboratory data and BMD were collected. Mixed effect regression models to analyze the interaction between LH-RH treatment scheme, denosumab and BMD evolution were used.ResultsEighty-three patients (mean age 71±8years) were included. At the basal evaluation, 16% of patients presented densitometric osteoporosis and 27% of patients presented high fracture risk. Eighty percent of patients had inadequate vitaminD levels. VitaminD >30ng/mL was correlated with higher T-scores. There was no association between LH-RH treatment scheme and BMD evolution, however there was a positive association with denosumab.ConclusionA high proportion of patients presented elevated fracture risk or inadequate vitaminD levels, not previously recognized. Bone health assessment and fracture risk evaluation are convenient in these patients. In a real-world setting, the effect of denosumab in BMD is detected, however the effect of intermittent LH-RH schema treatment is less evident. (AU)

[Effect of different schemes of androgen deprivation therapy on bone mass density in prostate cancer patients]. / Efecto de diferentes esquemas de terapia de deprivación androgénica sobre la densidad mineral ósea de pacientes con cáncer de próstata.

OBJECTIVES: To evaluate the aspects of the basal bone health status in prostate cancer patients. Furthermore, to evaluate in a real-world setting the effect of different schemes (intermittent or continuous) of androgen deprivation therapy (ADT) and the effect of denosumab in bone mass density (BMD). METHODS: Observational, retrospective study of a cohort of prostate cancer patients in treatment with luteinizing hormone-releasing hormone (LH-RH) agonists, evaluated in the rheumatology department of a tertiary center. Demographics, FRAX score, LH-RH treatment scheme, osteoporosis treatment, laboratory data and BMD were collected. Mixed effect regression models to analyze the interaction between LH-RH treatment scheme, denosumab and BMD evolution were used. RESULTS: Eighty-three patients (mean age 71±8years) were included. At the basal evaluation, 16% of patients presented densitometric osteoporosis and 27% of patients presented high fracture risk. Eighty percent of patients had inadequate vitaminD levels. VitaminD >30ng/mL was correlated with higher T-scores. There was no association between LH-RH treatment scheme and BMD evolution, however there was a positive association with denosumab. CONCLUSION: A high proportion of patients presented elevated fracture risk or inadequate vitaminD levels, not previously recognized. Bone health assessment and fracture risk evaluation are convenient in these patients. In a real-world setting, the effect of denosumab in BMD is detected, however the effect of intermittent LH-RH schema treatment is less evident.

Interrupción, intermitencia y recorte de la asistencia en la escuela secundaria / Interruption, intermittence and reduction of attendance of classes in secondary school / Interrupção, intermitente e corte de frequência às aulas no ensino médio

Resumen (analítico) El propósito de este artículo es describir los procesos discontinuos que atraviesan las experiencias escolares de los/as jóvenes en relación con la asistencia escolar en una escuela secundaria técnica de la ciudad de Rosario (Argentina). Problemática que ha cobrado un renovado interés público y académico a partir de la sanción de la obligatoriedad de la educación secundaria. El estudio fue realizado desde un enfoque socioantropológico que recupera la tradición etnográfica de la antropología desde una perspectiva crítica. Se advierte que los procesos discontinuos identificados pueden favorecer la interrupción de la escolarización, es decir, el alejamiento de la escuela durante un período más o menos prolongado de tiempo. Pero, aunque no es total, esa lógica de discontinuidad también atraviesa las experiencias de quienes continúan cursando.

Abstract (analytical) The purpose of this article is to describe the discontinuous processes that affect the school experiences of young people in relation to their attendance at a technical secondary school in the city of Rosario (Argentina). This problem has gained renewed public and academic interest due to the obligation of compulsory secondary education. The study was carried out using a socio-anthropological approach, drawing on the ethnographic tradition of Anthropology based on a critical perspective. The discontinuous educational processes that were identified can contribute to the interruption of schooling, specifically when students do not attend school for a prolonged period of time. This logic of discontinuity also crosses the experiences of those who continue with their studies.

Resumo (analítico) O objetivo deste artigo é descrever os processos descontínuos que atravessam as experiências escolares dos jovens em relação à frequência escolar em uma escola técnica secundária na cidade de Rosario (Argentina). Problema que assume um renovado interesse público e académico com a sanção da obrigatoriedade do ensino secundário. O estudo foi realizado a partir de uma abordagem socioantropológica que recupera a tradição etnográfica da antropologia de uma perspectiva crítica. Notase que os processos descontínuos identificados podem acabar favorecendo a interrupção da escolaridade, ou seja, a retirada da escola por um período mais ou menos prolongado. Mas, embora não seja total, notamos que essa lógica da des-continuidade também atravessa as experiências daqueles que continuam estudando.

Physiological Effects of Blue Pulsed LED in an Indoor Lighting Environment / Efectos Fisiológicos de Luz LED Azul Intermitente en un Ambiente de Iluminación en Interiores

Abstract Purpose: An experiment was conducted to investigate the physiological effects of a continuous blue pulsed light emitting diode (BP-LED) added to a task lamp in an actual indoor lighting environment and its influence in alertness having as a final purpose to develop a commercial product that could be applied in situations similar to those depicted in the present work. Design methodology: Previous research studies have stated that the addition of pulsed light evokes physiological changes that may induce alertness. The participants were exposed to four different lighting conditions. Electroencephalograms (EEG), pupil sizes, heart rates (HR), performance tests, and subjective reactions were measured. Findings: Low colour temperature light and the BP-LED revealed an improved alertness according to the data from the EEG recordings. The intervention of the BP-LED in a high colour temperature ambiance was beneficial in maintaining high levels of alertness compared to the conditions where the BP-LED was not used. It was tested that the use of a BP-LED in a task lamp may be beneficial in improving or maintaining alertness levels in an indoor workplace ambiance. Originality and Value: Designing of an adequate workplace task lamp light that improves alertness for in-house, office, or classroom situations in which it is essential.

Resumen Propósito: Un experimento fue llevado a cabo para investigar los efectos fisiológicos que una luz azul LED pulsada de manera intermitente (BP-LED), adicionada a una lámpara de escritorio, y en un ambiente interior; pueda influir en el estado de alerta de una persona con la finalidad de desarrollar un producto comercial que pueda ser aplicado para los casos desarrollados y otros posibles escenarios. Metodología de Diseño: En estudios anteriores se establece que la adición de luz en pulsaciones evoca cambios fisiológicos que pueden inducir al estado de alerta. Los participantes experimentaron cuatro escenarios de iluminación. Se registraron mediciones con respecto a encefalografía (EEG), tamaño pupilar, ritmo cardiaco, prueba de performance, así como evaluación subjetiva. Hallazgos: Los datos de EEG revelaron un mayor estado de alerta durante la exposición a iluminación cálida aunado a luz BP-LED. La intervención de luz fría y BP-LED denotó ser benéfica en el nivel de estado de alerta en comparación con las condiciones donde el BP-LED no intervino. Se logró evaluar que el uso de BP-LED en una lámpara de escritorio puede ser benéfico para mejorar o mantener el estado de alerta cuando sea usado en un espacio interior. Originalidad y Valor: Propuesta para diseñar una luminaria de escritorio; para uso casero, laboral o de estudio; que mejore el estado de alerta de las personas.

Molecular demonstration of intermittent shedding of Leptospira in cattle and sheep and its implications on control / Demonstração molecular da intermitência eliminando Leptospira em vacas e ovelhas e suas implicações no controle

ABSTRACT: For a long time, it has been stated that urine leptospiral shedding is intermittent, which was observed primarily by culturing. However, culturing presents serious limitations, mainly low sensitivity, and failure on detection of leptospires cannot be neglected. PCR presents several advantages, mainly higher sensitivity. The present study aimed to analyze the occurrence of intermittency on leptospiral shedding by PCR in naturally and experimentally infected animals. In this study two experiments were conducted, the first with 60 cows naturally infected from an endemic herd. The second one was conducted in three sheep experimentally infected, each one with a different strain of Leptospira (strains Copenhageni L1-130, Canicola LO-4 and Pomona Fromm). Considering cattle, 43.3% presented negative in all tests, the remaining (56.7%) were positive at least once. From these, only one (1.6%) was positive in all samples, and seven (11.8%) were positive only in the last sampling, making it impossible to evaluate the intermittency. Noteworthy, 26 cows (43.3%) presented the typical intermittent pattern of leptospiral shedding in urine. In sheep, all experimentally infected animals presented the typical intermittent shedding patterns, independently of the inoculated leptospiral strain. We considered that a careful serial analysis of urine samples for a more definitive and reliable individual diagnosis would be required for a successful antimicrobial therapy and control of leptospirosis on a herd.

RESUMO: Durante muito tempo, foi afirmado que a eliminação de leptospiras na urina era intermitente, o que havia sido demonstrado principalmente por meio do cultivo microbiano. No entanto, a cultura apresenta graves limitações, principalmente com relação à baixa sensibilidade. Em contraste, a PCR apresenta várias vantagens em relação ao cultivo bacteriológico para leptospiras, sendo esta ferramenta cada vez mais utilizada para o diagnóstico de animais eliminadores da bactéria em diversos sítios. Assim, o presente estudo teve como objetivo analisar a ocorrência de intermitência na eliminação de leptospiras por meio de PCR em animais natural e experimentalmente infectados. Para este estudo foram realizados dois experimentos, sendo o primeiro com 60 vacas naturalmente infectadas de um rebanho sabidamente endêmico e o segundo em três ovelhas experimentalmente infectadas, cada uma com uma estirpe diferente de Leptospira (estirpes Copenhageni L1-130, Canicola LO-4 e Pomona Fromm). Considerando-se os bovinos, 43,3% apresentaram negatividade em todos os testes, sendo os demais 56,7% positivos ao menos uma vez. Destes, apenas um (1,6%) foi positivo em todas as amostras, e sete (11,8%) foram positivos somente na última coleta, o que impossibilitou a avaliação da intermitência. Não obstante, 26 vacas naturalmente infectadas (43,3%) apresentaram o padrão de eliminação tipicamente intermitente de leptospiras na urina. Das três ovelhas experimentalmente infectadas, todas apresentaram eliminação intermitente da bactéria na urina, independentemente da estirpe inoculada. Consideramos que seria necessária uma cuidadosa análise seriada de amostras de urina para um diagnóstico individual mais definitivo e confiável para uma terapia antimicrobiana bem-sucedida e o controle da leptospirose em um rebanho.

Avaliação da eficácia e da possibilidade da contaminação da água em eliminadores de ar fabricados em polipropileno, quando instalados em cavaletes de ligações de água potável: estudo de caso: Juiz de Fora, MG / Assessment of the efficacy and of the water contamination possibility of polypropylene made air-removal equipment, installed on a drinking water connection: case study: Juiz de Fora, MG

Este trabalho teve como objetivo avaliar a eficácia e a possibilidade de contaminação da água em determinado tipo de equipamento eliminador de ar, fabricado em polipropileno. Sua operação foi estudada em nove pontos de consumo no município de Juiz de Fora - MG, com reclamações recorrentes de consumidores sobre intermitência no abastecimento. O trabalho de campo teve duração de 11 meses. Para avaliar a eficácia do equipamento, foi instalado, em série com o cavalete da ligação de água, um novo cavalete composto por dois hidrômetros, separados pelo eliminador de ar. Comparados os consumos acumulados pelos dois hidrômetros nos pontos, verificou-se uma variação de + 4,51% a - 2,02%. Pelos resultados obtidos, pode-se afirmar que o emprego do eliminador de ar na rede de abastecimento de água de Juiz de Fora - MG não apresentou benefício significativo para o consumidor. Contudo, 91% dos equipamentos testados apresentaram possibilidade de contaminação da água.

This work aimed to assess the efficacy and the water contamination possibility of a particular type of air-removal equipment, made of polypropylene. Its functioning was analysed at nine different consumption points in the city of Juiz de Fora, MG, there being recurrent complaints from consumers about constant interruptions in water supply. The field work had a duration of 11 months. In order to assess the efficacy of the equipment, a new sawhorse was installed in a row with the water connection sawhorse. The new sawhorse was composed of two hydrometers, with the air-removal equipment between them. Having compared the consumption levels recorded by the two hydrometers at the points, it was founded a variation ranging from + 4.51% to -2.02%. The obtained results may state that the use of the air-removal equipment in Juiz de Fora did not cause any significant beneficial effect as far as consumers are concerned. However, 91% of the tested air-removal equipments showed possibility of water contamination.