Tumor de Wilms / Wilms' tumor

Resumen El tumor de Wilms es el tumor renal maligno más frecuente de la infancia, representa incluso 7% de las neoplasias a esta edad. El tratamiento que ha mostrado efecto en la supervivencia de estos pacientes es, sin duda alguna, la cirugía, con tasas de éxito de hasta 90% durante los primeros estadios de la enfermedad, esta tasa disminuye tras la progresión de los estadios. Sin embargo, la mayoría de los casos que se encuentran en etapas tempranas se presentan como hallazgos radiográficos o a la exploración física como masa abdominal palpable. Se comunica un caso clínico que muestra la importancia del diagnóstico oportuno en estos pacientes.

Abstract Wilms' tumor is the most frequent malignant kidney tumor of childhood, presented over 7% of neoplasms at this age. The treatment that has demonstrated impact on the survival of these patients is, without a doubt, the surgery, with success rates of up to 90% during the first stages of the disease, decreasing this index after the progression of the stages. However, most cases that are found in the early stages are presented as radiographic findings or physical examination as palpable abdominal mass. So, this paper reports a clinical case, which shows the importance of timely diagnosis in these patients.

Tumor renal sobre único riñón funcionante / Renal tumor on single functioning kidney

Se presenta caso de mujer adulta con diagnóstico de tumor renal que asentaba sobre único riñón funcionante, por lo que es sometida a resección quirúrgica parcial. Consulta luego de 6 años de evolución por litiasis renal y sin signos de insuficiencia renal.

We present the case of an adult woman with a renal tumor in a single functioning kidney, that underwent a partial surgical resection. She consulted after 6 years of evolution for kidney stones, not having any signs of kidney failure.

Adenocarcinoma de células claras multiquístico del riñón: presentación de serie clínica anatomopatológica y revisión de la literatura / Multicystic clear cell carcinoma of kidney: clinical series presentation and literature review

El carcinoma multiquístico de células claras del riñón es una variedad infrecuente del carcinoma de células claras, representa un 6 por ciento de los tumores quísticos del riñón y se caracteriza por tener un excelente pronóstico de sobrevida luego de la resección quirúrgica completa. Objetivos: Analizar la frecuencia y aspectos morfológicos del adenocarcinoma multiquístico de células claras del riñón. Material y método: Análisis de 217 nefrectomías por tumor renal desde 1990 hasta el año 2005 porun protocolo preestablecido. Resultados: El carcinoma multiquístico de células claras del riñón correspondió al 5,5 por ciento del total de tumores y al 6,7 por ciento del total de carcinomas de células claras, la mayoría de los tumores se encontraban en el estadio T1a de la TNM con un grado nuclear de Furhman de 1 ó 2. La sobrevida libre de enfermedad a 16 años de seguimiento es del 100 por ciento.Conclusiones: El carcinoma multiquístico de células claras del riñón, es una entidad poco frecuente, de excelente comportamiento biológico y pronóstico, que debe ser considerado dentro de los diagnósticos diferenciales de los tumores quísticos del riñón.

The multicystic carcinoma of clear cells of the kidney is an infrequent variety of the carcinoma of clear cells, represents 6 percent of the cystic tumors of the kidney and is characterized for having an excellent survival after the surgical complete resection. Objective: To analyze the frequency and morphologic aspects of the multicystic adenocarcinoma of clear cells of the kidney. Material and method: Analysis of 217 nefrectomias for renal tumor from 1990 until the year 2005 for a pre-established protocol. Results: The multicystic carcinoma of clear cells of the kidney corresponded to 5.5 percent of the whole of tumors and to 6.7 percent of the whole of carcinomas of clear cells, the majority of the tumours were meetingin the stadium T1a of the TNM with a Furhman’s nuclear grade of 1 or 2. The free survival of disease to 16 years of follow-up is 100 percent. Conclusions: The multicystic carcinoma of clear cells of the kidney, is a slightly frequent entity, of excellent biological behavior and forecast, which it must be considered inside the differential diagnoses of the cystic tumors of the kidney.

Modelo de tumor experimental em rim de ratos

Walker carcinossarcoma 256 has a great interest as experimental model for studies on tumoral biology. OBJECTIVE: develop a kidney tumor model to be used in the evaluation of the biological behavior of neoplasms in vitro and in vivo environments. METHODS: twenty adult male Wistar rats weighting between 250-300 g were obtained from the Federal University of the Ceará Experimental Surgery Laboratory. Upon ether anesthesia, the right kidney of each animal was accessed through a supraumbelical incision and inoculated with a solution containing 3 x 10(5) tumor cells (Walker 256 carcinossarcoma tumor cells). Following anesthetic recovery the rats were returned to their cages, housed individually and allowed to eat and drink ad libitum. RESULTS: the post-operative average survival was 14 days. Tumor growth was encountered in all animals. The rats exhibited destruction of the kidney, invasion of the adjacent structures, but absence of metastasis. CONCLUSION: the kidney Walker tumor model proved to be an excellent tool for experimental studies on tumor behavior, due to its rapid growth and its easy reproduction.

O carcinossarcoma 256 de Walker tem despertado o interesse de muitos pesquisadores como modelo experimental para estudo da biologia tumoral. OBJETIVO: estabelecer um modelo de tumor renal que possa ser usado para estudar in vivo e in vitro, as alterações impostas pelas neoplasias. MÉTODOS: utilizados vinte ratos Wistar, machos, adultos, pesando entre 250-300 g, oriundos do Laboratório de Cirurgia Experimental da Universidade Federal do Ceará. Sob anestesia inalatória procedia-se uma pequena incisão supraumbilical, e com manobra delicada fazia-se a exposição do rim direito. Neste órgão eram inoculadas 3x10(5) células tumorais viáveis. Os animais então eram mantidos em gaiolas individuais com as mesmas condições ambientais e com água e dieta ad libitum. RESULTADOS: o Carcinossarcoma 256 de Walker, implantado no parênquima do rim direito de ratos Wistar apresentou índice de pega de 100%, e crescimento rápido, invadiu por contiguidade as estruturas vizinhas, porém sem apresentar metástases, no entanto, levando os animais a óbito no curso médio de 14 dias. CONCLUSÃO: o modelo de implante de tumor de Walker no parênquima do rim direito de ratos Wistar é eficiente, tem reprodutibilidade, apresentando um índice de pega de 100%, e permitindo seu uso em linhas de pesquisa.