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1.
Open Vet J ; 14(8): 1789-1793, 2024 Aug.
Article in English | MEDLINE | ID: mdl-39308705

ABSTRACT

Background: The popularity of tortoises kept in captivity is increasing and has caused concern regarding the necessity to establish safe and straightforward anaesthesia for those reptiles. Aim: This study aimed to compare four protocols using levobupivacaine in spinal anaesthesia for the blockade of the caudal neuraxis of red-footed tortoises (Chelonoidis carbonarius). Methods: Twenty-four tortoises were randomly assigned into four groups: G1, levobupivacaine 0.75% (1.15 mg kg-1); G2, levobupivacaine 0.37% (1.15 mg kg-1); G3, levobupivacaine 0.75% (2.3 mg kg-1); and G4, levobupivacaine 0.75% (0.1 ml 5 cm-1 of straight carapace length). Tortoises were evaluated for respiratory rate, muscle relaxation, response to hindlimb or tail pinch, and cloacal reflex. Results: A 1.15 mg kg-1 dose of levobupivacaine 0.37% appears adequate for shorter procedures, whereas a 1.15 mg kg-1 dose of levobupivacaine 0.75% should be appropriate for longer procedures in red-footed tortoises. Conclusion: Our results are the first to show the effects of levobupivacaine on spinal anaesthesia in reptiles. Weight-based doses presented more intense and more homogeneous effects than carapace length-based doses in red-footed tortoises. Spinal anaesthesia of red-footed tortoises was safe and effective with any of the weight-based protocols.


Subject(s)
Anesthesia, Spinal , Anesthetics, Local , Levobupivacaine , Turtles , Animals , Levobupivacaine/administration & dosage , Levobupivacaine/pharmacology , Anesthesia, Spinal/veterinary , Anesthesia, Spinal/methods , Anesthetics, Local/pharmacology , Anesthetics, Local/administration & dosage , Male , Female
2.
Clin Otolaryngol ; 49(2): 270-276, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38030398

ABSTRACT

OBJECTIVES: We aimed to determine the radioguided occult lesion localization (ROLL) reliability in the reoperation of patients with differentiated thyroid cancer (DTC) and persistent or recurrent non-palpable loco-regional disease who underwent surgery at the Instituto Nacional de Cancerología between 2012 and 2021. DESIGN: Observational retrospective cohort study. PARTICIPANTS: We included data from patients with DTC that underwent resection with ROLL. MAIN OUTCOME MEASURES: Reliability analysed as percentage of patients with complete resection of tumour lesion using ROLL, disease-free survival, second loco-regional relapse, adequate resectability and complications. RESULTS: Two hundred and four cases were obtained. Pathological examination revealed papillary thyroid carcinoma in 202 patients, and follicular thyroid carcinoma in 2. Reliability was 96.57% in patients who underwent ROLL. When wide resection was performed-at surgeon's discretion-the reliability increased to 97.5%. CONCLUSIONS: The high reliability obtained suggests that ROLL was effective to localize non-palpable relapsing lesions. To our knowledge, this is the largest sample size published on this topic to date.


Subject(s)
Neoplasm Recurrence, Local , Thyroid Neoplasms , Humans , Reoperation , Retrospective Studies , Reproducibility of Results , Neoplasm Recurrence, Local/diagnostic imaging , Neoplasm Recurrence, Local/surgery , Neoplasm Recurrence, Local/pathology , Thyroid Neoplasms/diagnostic imaging , Thyroid Neoplasms/surgery , Recurrence
3.
Article in Spanish | LILACS, CUMED | ID: biblio-1408183

ABSTRACT

Introducción: Las oclusiones arteriales periféricas agudas de menos de 14 días y de causa embólica y trombótica están asociadas a una alta morbimortalidad. La trombólisis dirigida por catéter representa en la actualidad una modalidad de tratamiento efectivo para la oclusión de vasos distales infrageniculares, que históricamente ha tenido malos resultados mediante embolectomía convencional, debido a la oclusión preexistente de vasos colaterales y al daño mecánico al endotelio, que conlleva esta técnica tradicional. Se decidió presentar este caso por ser la primera vez que se practica esta modalidad de tratamiento en Cuba. Objetivo: Exponer los resultados obtenidos con la aplicación de la trombolisis fibrinolitica mediante catéter en un paciente afectado por trombosis arterial periférica aguda. Presentación del caso: Paciente masculino de 57 años de edad con diagnóstico de trombosis arterial aguda de la arteria poplítea del miembro inferior izquierdo, con más de 24 horas de evolución de la isquemia y del compromiso de la viabilidad de la extremidad. Se utilizó el tratamiento fibrinolítico, mediante infusión de 250 000 unidades de Heberkinasa® en tres horas y se logró la mejoría del nivel de amputación. Conclusiones: El tratamiento fibrinolítico con Heberkinasa® fue útil en el paciente tratado porque redujo el nivel de amputación en el paciente, que presentó isquemia irreversible y criterio inicial de amputación supracondílea alto, en la extremidad comprometida(AU)


Introduction: Acute peripheral arterial occlusions of less than 14 days and of embolic and thrombotic cause are associated with a high morbidity and mortality. Catheter-directed thrombolysis currently represents an effective treatment modality for the occlusion of infragenicular distal vessels, which has historically had poor results by conventional embolectomy, due to the pre-existing occlusion of collateral vessels and the mechanical damage to the endothelium, which this traditional technique entails. It was decided to present this case because it is the first time that this modality of treatment is practiced in Cuba. Objective: Present the results obtained with the application of fibrinolytic thrombolysis by catheter in a patient affected by acute peripheral arterial thrombosis. Case presentation: A 57-year-old male patient diagnosed with acute arterial thrombosis of the popliteal artery of the left lower limb, with more than 24 hours of evolution of ischemia and compromised viability of the limb. Fibrinolytic treatment was used, by infusion of 250,000 units of Heberkinase® in three hours and the improvement of the amputation level was achieved. Conclusions: Fibrinolytic treatment with Heberkinase® was useful in the treated patient because it reduced the level of amputation in the patient, who presented irreversible ischemia and initial criteria of high supracondylar amputation in the compromised limb(AU)


Subject(s)
Humans , Male , Middle Aged , Carotid Artery Thrombosis/diagnosis , Embolectomy/methods
4.
Semina Ci. agr. ; 42(1): 241-254, jan.-fev. 2021. tab, graf
Article in English | VETINDEX | ID: vti-31230

ABSTRACT

This study aimed to evaluate the cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in ewes submitted to transcervical cervix transposition with a hegar dilator. Ten Santa Inês breed ewes were studied in a cross over model study where three epidural protocols (GK = ketamine 2.0 mg kg-1; GKM = ketamine 2.0 mg kg-1 + morphine 0.1 mg kg-1; GKX = ketamine 2.0 mg kg-1 + xylazine 0.05 mg kg-1) were compared among each other and with a control treatment (GS= saline 1 mL/7.5 kg). The assessed variables were heart rate, respiratory frequency, ear temperature, non-invasive blood pressure and hemogasometric analysis. All parameters were assessed at baseline and then ewes were sedated with an association of acepromazine (0.1 mg kg -1) and diazepam (0.2 mg kg -1). Ten minutes after sedation all parameters were reassessed and afterwards the epidural injections were performed. Hemogasometry was repeated at 15 and 30 minutes after epidural and the other parameters assessed at 05, 15, 30, 45 and 60 minutes after epidural. GKX showed a slight respiratory depression with lower levels of PO2 and a compensatory increase in respiratory frequency. GKM presented the lower temperature mean. All protocols showed few cardiorespiratory effects when compared with control. Epidural with 2.0 mg kg-1 ketamine isolated was considered the best opti


Este estudo teve como objetivo avaliar os efeitos cardiorrespiratórios e hemogasométricos da cetamina peridural e suas associações com morfina e xilazina em ovelhas submetidas à manipulação uterina por via transcervical. Foram estudadas dez ovelhas da raça Santa Inês. Três protocolos epidurais foram avaliados: (GK = cetamina 2,0 mg kg−1, GKM = cetamina 2,0 mg kg−1 + morfina 0,1 mg kg−1, GKX = cetamina 2,0 mg kg−1 + xilazina 0,05 mg kg−1). Os três protocolos foram comparados entre si e com um tratamento controle (GS = solução salina 1 mL/7,5kg). As variáveis avaliadas foram frequência cardíaca, frequência respiratória, temperatura auricular, pressão arterial não-invasiva além da análise hemogasométrica. Todos os parâmetros foram avaliados no momento basal e em seguida as ovelhas foram sedadas com associação de acepromazina (0,1 mg kg−1) e diazepam (0,2 mg kg−1). Dez minutos após a sedação, todos os parâmetros foram novamente avaliados e foram realizadas as injeções peridurais. A hemogasometria foi repetida aos 15 e 30 minutos após a peridural e os outros parâmetros avaliados aos 05, 15, 30, 45, e 60 minutos após a peridural. O GKX mostrou sinais de hipoxemia com menores níveis de pO2 e um aumento compensatório na frequência respiratória. O GKM apresentou a média de temperatura mais baixa. Todos os protocolos apresentaram poucos efeitos cardiorrespiratórios em relação ao controle. O protocolo epidural com 2,0 mg kg−1 de cetamina foi considerado a melhor opção para procedimentos curtos como manipulações obstétricas em ovinos devido à estabilidade cardiorrespiratória quando comparado com os protocolos que utilizaram associações.(AU)


Subject(s)
Animals , Sheep/anatomy & histology , Morphine , Xylazine , Ketamine , Cardiopulmonary Resuscitation , Anesthesia/veterinary
5.
Semina ciênc. agrar ; 42(1): 241-254, jan.-fev. 2021. tab, graf
Article in English | VETINDEX | ID: biblio-1501917

ABSTRACT

This study aimed to evaluate the cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in ewes submitted to transcervical cervix transposition with a hegar dilator. Ten Santa Inês breed ewes were studied in a cross over model study where three epidural protocols (GK = ketamine 2.0 mg kg-1; GKM = ketamine 2.0 mg kg-1 + morphine 0.1 mg kg-1; GKX = ketamine 2.0 mg kg-1 + xylazine 0.05 mg kg-1) were compared among each other and with a control treatment (GS= saline 1 mL/7.5 kg). The assessed variables were heart rate, respiratory frequency, ear temperature, non-invasive blood pressure and hemogasometric analysis. All parameters were assessed at baseline and then ewes were sedated with an association of acepromazine (0.1 mg kg -1) and diazepam (0.2 mg kg -1). Ten minutes after sedation all parameters were reassessed and afterwards the epidural injections were performed. Hemogasometry was repeated at 15 and 30 minutes after epidural and the other parameters assessed at 05, 15, 30, 45 and 60 minutes after epidural. GKX showed a slight respiratory depression with lower levels of PO2 and a compensatory increase in respiratory frequency. GKM presented the lower temperature mean. All protocols showed few cardiorespiratory effects when compared with control. Epidural with 2.0 mg kg-1 ketamine isolated was considered the best opti


Este estudo teve como objetivo avaliar os efeitos cardiorrespiratórios e hemogasométricos da cetamina peridural e suas associações com morfina e xilazina em ovelhas submetidas à manipulação uterina por via transcervical. Foram estudadas dez ovelhas da raça Santa Inês. Três protocolos epidurais foram avaliados: (GK = cetamina 2,0 mg kg−1, GKM = cetamina 2,0 mg kg−1 + morfina 0,1 mg kg−1, GKX = cetamina 2,0 mg kg−1 + xilazina 0,05 mg kg−1). Os três protocolos foram comparados entre si e com um tratamento controle (GS = solução salina 1 mL/7,5kg). As variáveis avaliadas foram frequência cardíaca, frequência respiratória, temperatura auricular, pressão arterial não-invasiva além da análise hemogasométrica. Todos os parâmetros foram avaliados no momento basal e em seguida as ovelhas foram sedadas com associação de acepromazina (0,1 mg kg−1) e diazepam (0,2 mg kg−1). Dez minutos após a sedação, todos os parâmetros foram novamente avaliados e foram realizadas as injeções peridurais. A hemogasometria foi repetida aos 15 e 30 minutos após a peridural e os outros parâmetros avaliados aos 05, 15, 30, 45, e 60 minutos após a peridural. O GKX mostrou sinais de hipoxemia com menores níveis de pO2 e um aumento compensatório na frequência respiratória. O GKM apresentou a média de temperatura mais baixa. Todos os protocolos apresentaram poucos efeitos cardiorrespiratórios em relação ao controle. O protocolo epidural com 2,0 mg kg−1 de cetamina foi considerado a melhor opção para procedimentos curtos como manipulações obstétricas em ovinos devido à estabilidade cardiorrespiratória quando comparado com os protocolos que utilizaram associações.


Subject(s)
Animals , Anesthesia/veterinary , Ketamine , Morphine , Sheep/anatomy & histology , Cardiopulmonary Resuscitation , Xylazine
6.
Acta sci. vet. (Online) ; 47(suppl.1): Pub. 398, July 3, 2019. ilus, tab
Article in Portuguese | VETINDEX | ID: vti-21124

ABSTRACT

Background: Locoregional anesthesia techniques enable the performance of procedures in the distal portion of the limbs,through the parenteral administration of local anesthetic nerve block. There are devices that can increase the effectivenessof these blocks by accurately locating the nerves. These devices include peripheral nerve stimulators, which enable anesthetic to be injected near the plexus, thus reducing the volume of anesthetic required and allowing for the specific blockadeof a nerve branch by desensitizing exclusively the area of interest. This paper describes the use of nerve stimulator in thebrachial plexus block (BPB) of a calf subjected to amputation of the left foreleg.Case: A newborn calf weighing 30 kg, with a history of injury to the left foreleg, was treated at the Veterinary Hospital ofthe Federal Rural University of the Semi-Arid Region. Clinical and X-ray examinations revealed a fracture in the medialportion of the metacarpus and radiographic alterations indicative of osteomyelitis, so amputation of the affected limb wasrecommended. Prior the beginning, during and after the surgical procedure, the animal was submitted to the evaluation ofits physiological parameters (heart and respiratory rate, capillary refill time, diastolic, systolic and mean blood pressure andrectal temperature). Because it is a newborn animal, it was decided not to pre-operatively fast. After applying preanestheticmedication (xylazine 0.01 mg/kg IV), anesthesia was induced with ketamine (2 mg/kg IV) and midazolam (0.3 mg/kg IV)and maintained with isoflurane. For the brachial plexus block, 0.4 mL/kg (1.5 mg/kg) of 0.375% bupivacaine was usedand aided by a peripheral nerve stimulator to generate 10 mA current, 1 HZ frequency and 100 μs pulse duration, coupledto a nerve stimulation needle, it was possible to observe flexion movements...(AU)


Subject(s)
Animals , Cattle , Amputation, Surgical/methods , Amputation, Surgical/veterinary , Brachial Plexus Block/veterinary , Peripheral Nerves , Electric Stimulation , Anesthesia, Local/veterinary , Forelimb/injuries
7.
Clin Transl Oncol ; 21(1): 31-45, 2019 Jan.
Article in English | MEDLINE | ID: mdl-30617924

ABSTRACT

Although the metastasic breast cancer is still an incurable disease, recent advances have increased significantly the time to progression and the overall survival. However, too much information has been produced in the last 2 years, so a well-based guideline is a valuable document in treatment decision making. The SEOM guidelines are intended to make evidence-based recommendations on how to manage patients with advanced and recurrent breast cancer to achieve the best patient outcomes based on a rational use of the currently available therapies. To assign a level of certainty and a grade of recommendation the United States Preventive Services Task Force guidelines methodology was selected as reference.


Subject(s)
Breast Neoplasms/therapy , Neoplasm Recurrence, Local/therapy , Practice Guidelines as Topic/standards , Breast Neoplasms/pathology , Clinical Trials as Topic , Combined Modality Therapy , Disease Management , Female , Humans , Neoplasm Recurrence, Local/pathology , Prognosis , Societies, Medical
8.
Acta sci. vet. (Impr.) ; 47(suppl.1): Pub.398-2019. ilus, tab
Article in Portuguese | VETINDEX | ID: biblio-1458162

ABSTRACT

Background: Locoregional anesthesia techniques enable the performance of procedures in the distal portion of the limbs,through the parenteral administration of local anesthetic nerve block. There are devices that can increase the effectivenessof these blocks by accurately locating the nerves. These devices include peripheral nerve stimulators, which enable anesthetic to be injected near the plexus, thus reducing the volume of anesthetic required and allowing for the specific blockadeof a nerve branch by desensitizing exclusively the area of interest. This paper describes the use of nerve stimulator in thebrachial plexus block (BPB) of a calf subjected to amputation of the left foreleg.Case: A newborn calf weighing 30 kg, with a history of injury to the left foreleg, was treated at the Veterinary Hospital ofthe Federal Rural University of the Semi-Arid Region. Clinical and X-ray examinations revealed a fracture in the medialportion of the metacarpus and radiographic alterations indicative of osteomyelitis, so amputation of the affected limb wasrecommended. Prior the beginning, during and after the surgical procedure, the animal was submitted to the evaluation ofits physiological parameters (heart and respiratory rate, capillary refill time, diastolic, systolic and mean blood pressure andrectal temperature). Because it is a newborn animal, it was decided not to pre-operatively fast. After applying preanestheticmedication (xylazine 0.01 mg/kg IV), anesthesia was induced with ketamine (2 mg/kg IV) and midazolam (0.3 mg/kg IV)and maintained with isoflurane. For the brachial plexus block, 0.4 mL/kg (1.5 mg/kg) of 0.375% bupivacaine was usedand aided by a peripheral nerve stimulator to generate 10 mA current, 1 HZ frequency and 100 μs pulse duration, coupledto a nerve stimulation needle, it was possible to observe flexion movements...


Subject(s)
Animals , Cattle , Amputation, Surgical/methods , Amputation, Surgical/veterinary , Anesthesia, Local/veterinary , Brachial Plexus Block/veterinary , Electric Stimulation , Peripheral Nerves , Forelimb/injuries
9.
Ann Hepatol ; 17(6): 969-979, 2018 Oct 16.
Article in English | MEDLINE | ID: mdl-30600299

ABSTRACT

INTRODUCTION AND AIM: Combined hepatocellular-cholangiocarcinoma (HCC-CCA) is a rare liver malignancy distinct from either hepatocellular carcinoma (HCC) or cholangiocarcinoma. Liver transplantation (LT) is not recommended for HCC-CCA because of suboptimal outcomes. Non-invasive diagnosis of HCC-CCA is extremely challenging; thus, some HCC-CCAs are presumed as HCC on imaging and listed for LT with the correct diagnosis ultimately made on explant pathology. We compared HCC-CCA with HCC to determine the utility of response to pre-transplant loco-regional therapy (LRT) in predicting outcomes for HCC-CCA after LT as a potential means of identifying appropriate HCC-CCA patients for LT. MATERIAL AND METHODS: Retrospective review of 19 patients with pathologically confirmed HCC-CCA were individually matched to 38 HCC patients (1:2) based on age, sex, and Milan criteria at listing was performed. The modified response evaluation criteria in solid tumors was used to categorize patients as responders or non-responders to pre-transplant LRT based on imaging performed before and after LRT. Overall survival (OS) and recurrence-free survival (RFS) were examined. RESULTS: OS at 3 years post-transplant was 74% for HCC-CCA and 87% for HCC. RFS at 3 years was 74% for HCC-CCA, and 87% for HCC. Among responders to LRT, the 3-year OS was 92% for HCC-CCA and 88% for HCC; among non-responders, 3-year OS was 43% for HCC-CCA and 83% for HCC. Higher 3-year OS was observed among HCC-CCA responders (77%) compared with HCC-CCA non-responders (23%). CONCLUSIONS: OS was similarly high among.


Subject(s)
Bile Duct Neoplasms/therapy , Carcinoma, Hepatocellular/therapy , Cholangiocarcinoma/therapy , Liver Neoplasms/therapy , Liver Transplantation , Neoadjuvant Therapy , Neoplasms, Complex and Mixed/therapy , Aged , Bile Duct Neoplasms/diagnostic imaging , Bile Duct Neoplasms/mortality , Bile Duct Neoplasms/pathology , Carcinoma, Hepatocellular/diagnostic imaging , Carcinoma, Hepatocellular/mortality , Carcinoma, Hepatocellular/pathology , Cholangiocarcinoma/diagnostic imaging , Cholangiocarcinoma/mortality , Cholangiocarcinoma/pathology , Clinical Decision-Making , Disease Progression , Female , Humans , Liver Neoplasms/diagnostic imaging , Liver Neoplasms/mortality , Liver Neoplasms/pathology , Liver Transplantation/adverse effects , Liver Transplantation/mortality , Magnetic Resonance Imaging , Male , Middle Aged , Neoadjuvant Therapy/adverse effects , Neoadjuvant Therapy/mortality , Neoplasm Recurrence, Local , Neoplasm Staging , Neoplasms, Complex and Mixed/diagnostic imaging , Neoplasms, Complex and Mixed/mortality , Neoplasms, Complex and Mixed/pathology , Patient Selection , Progression-Free Survival , Retrospective Studies , Risk Factors , Time Factors , Treatment Outcome , Tumor Burden
10.
Acta sci. vet. (Impr.) ; 46: 1-7, 2018. ilus, graf
Article in Portuguese | VETINDEX | ID: biblio-1457832

ABSTRACT

Background: Clinical care of cats with urethral obstruction is a common routine in feline clinical medicine and the re-establishment of urinary flow is essential for long-lasting correction of the pathophysiological alterations presented. For this chemical restraint is usually employed, that together with the alteration, increases the anesthetic risk of these patients. Improvement in anesthetic techniques, especially the loco-regional, may contribute to reducing the anesthetic risk of these patients and facilitate maneuvers to clear the obstruction. Thus the objective of the present study was to describe and assess the bilateral block technique of the pudendal nerve in 16 cats with urethral obstruction.Materials, Methods & Results: Sixteen male crossbred cats were used, with partial or total urethral obstruction, attended at the Veterinary Hospital of the Federal University of Campina Grande, PB, Brazil. The anesthetic block of the pudendal nerve trunk was carried out by placing the local anesthetic close to the ventral foramen of the second sacral vertebra, using a 13 x 0.45 mm needle attached to a 1 mL syringe. To assess the effectiveness of the bilateral block, the analgesia promoted was assessed using the substitute (“Reaction to Palpating the Surgical Wound” of subscale 1 (pain expression) of the “Compound Multi-dimensional Scale to Assess Post Operational Pain in Cats”. This assessment was made before the bilateral block (M0) and 10 min afterwards (M1) and the scores ranged from 0 to 3. In addition, a segmental assessment of the urethra was made, where, by passing a probe the sensitivity was assessed of the urethral ostium, penile and pelvic urethra and the relaxing of the external urethral sphincter. This assessment was made at M1 and classified as present or absent.[...]


Subject(s)
Male , Animals , Cats , Anesthetics, Local/therapeutic use , Urethral Obstruction/surgery , Urethral Obstruction/veterinary , Lower Urinary Tract Symptoms/veterinary , Urinary Tract/pathology
11.
Acta sci. vet. (Online) ; 46: 1-7, 2018. ilus, graf
Article in Portuguese | VETINDEX | ID: vti-728663

ABSTRACT

Background: Clinical care of cats with urethral obstruction is a common routine in feline clinical medicine and the re-establishment of urinary flow is essential for long-lasting correction of the pathophysiological alterations presented. For this chemical restraint is usually employed, that together with the alteration, increases the anesthetic risk of these patients. Improvement in anesthetic techniques, especially the loco-regional, may contribute to reducing the anesthetic risk of these patients and facilitate maneuvers to clear the obstruction. Thus the objective of the present study was to describe and assess the bilateral block technique of the pudendal nerve in 16 cats with urethral obstruction.Materials, Methods & Results: Sixteen male crossbred cats were used, with partial or total urethral obstruction, attended at the Veterinary Hospital of the Federal University of Campina Grande, PB, Brazil. The anesthetic block of the pudendal nerve trunk was carried out by placing the local anesthetic close to the ventral foramen of the second sacral vertebra, using a 13 x 0.45 mm needle attached to a 1 mL syringe. To assess the effectiveness of the bilateral block, the analgesia promoted was assessed using the substitute (“Reaction to Palpating the Surgical Wound” of subscale 1 (pain expression) of the “Compound Multi-dimensional Scale to Assess Post Operational Pain in Cats”. This assessment was made before the bilateral block (M0) and 10 min afterwards (M1) and the scores ranged from 0 to 3. In addition, a segmental assessment of the urethra was made, where, by passing a probe the sensitivity was assessed of the urethral ostium, penile and pelvic urethra and the relaxing of the external urethral sphincter. This assessment was made at M1 and classified as present or absent.[...](AU)


Subject(s)
Animals , Male , Cats , Urethral Obstruction/surgery , Urethral Obstruction/veterinary , Anesthetics, Local/therapeutic use , Lower Urinary Tract Symptoms/veterinary , Urinary Tract
12.
Orinoquia ; 20(2)dic. 2016.
Article in English | LILACS-Express | LILACS | ID: biblio-1534949

ABSTRACT

A 1-year-old male Cocker Spaniel, weighing 10.5 kg, was referred for elective orchiectomy. An intratesticular injection of lidocaine was performed as a part of multimodal anesthetic protocol that also included: acepromazine, meloxicam, tramadol and ketamine. During the intraoperative period the cardiorespiratory parameters (heart rate, respiratory rate, and mean arterial blood pressure), the intraoperative anesthetic (ketamine) and analgesic (fentanyl) consumption, and the presence of autonomous nociceptive responses were evaluated. Increases of baseline cardiorespiratory parameters above 10% or the presence of autonomous nociceptive responses would be considered as indicative of insufficient analgesic coverage, for which 1 µg/kg IV of fentanyl would be employed. The evaluated cardiorespiratory variables were stable, and no autonomous nociceptive responses were observed. For this reason no additional ketamine boluses nor rescue analgesics were administered. It is suggested that intratesticular lidocaine, as a part of the multimodal analgesic protocol employed, contributed to improve the analgesic coverage during orchiectomy in this dog.


Um cão da raça Cocker Spaniel de um ano de idade e 10,5kg de peso foi encaminhado para orquiectomia eletiva. Foi realizada a administração de Lidocaína intratesticular como parte de um protocolo de anestesia multimodal que também incluía Acepromazina, Meloxicam, Tramadol e Ketamina. Durante o período intraoperatório foram avaliados os parâmetros cardiorrespiratórios (frequência cardíaca, frequência respiratória e pressão arterial média), o consumo intraoperatório de anestésicos (ketamina) e analgésicos (fentanil), e a presença de respostas nociceptivas autónomas. Incrementos nos valores basais dos parâmetros cardiorrespiratórios superiores a 10% ou a presença de respostas nociceptivas autónomas foram consideradas como indicativo de cobertura analgésica insuficiente, para o qual seria usado 1 µg/kg IV. As variáveis cardiorrespiratórias avaliadas se mantiveram estáveis e não se observaram respostas nociceptivas autónomas. Por essa razão não se administrou quantidades adicionais de ketamina nem analgesia de resgate. Sugere-se que a lidocaína intratesticular, como parte do protocolo de anestesia multimodal empregado, contribuiu para melhorar a cobertura analgésica durante a orquiectomia nesse cão.


Un canino de raza Cocker Spaniel de 1 año de edad y 10.5 kg de peso fue referido para orquiectomía electiva. Se realizó la administración de lidocaína intratesticular como parte de un protocolo de anestesia multimodal que también incluyó acepromacina, meloxicam, tramadol y ketamina. Durante el periodo intraoperatorio fueron evaluados los parámetros cardiorespiratorios (frecuencia cardiaca, frecuencia respiratoria, y presión arterial media), el consumo intraoperatorio de anestésicos (ketamina) y analgésicos (fentanilo), y la presencia de respuestas nociceptivas autónomas. Incremetos en los valores basales de los parámetros cardiorespiratorios superiores al 10% o la presencia de respuestas nociceptivas autónomas fueron considerados como indicativo de cobertura analgésica insuficiente, para lo cual se emplearía 1 µg/kg IV. Las variables cardiorrespiratorias evaluadas se mantuvieron estables y no se observaron respuestas nociceptivas autónomas. Por esta razón no se administraron bolos adicionales de ketamina ni analgesia de rescate. Se sugiere que la lidocaína intratesticular, como parte de un protocolo de anestesia multimodal empleado, contribuyó a mejorar la cobertura analgesica durante la orquiectomía en este perro.

13.
Rev. Assoc. Med. Bras. (1992, Impr.) ; Rev. Assoc. Med. Bras. (1992, Impr.);54(2): 127-131, mar.-abr. 2008. graf, tab
Article in Portuguese | LILACS | ID: lil-482902

ABSTRACT

OBJETIVO: A cirurgia de resgate é primeira opção terapêutica, principalmente nas lesões de estadio clínico inicial. O objetivo do estudo é avaliação da sobrevida livre de doença após resgate cirúrgico de tumores de cavidade bucal e orofaringe. MÉTODOS: Estudo retrospectivo de 276 pacientes tratados com cirurgia, sendo que 127 desenvolveram recidiva loco-regional. Noventa e sete pacientes eram de estadiamento clínico inicial e 178 de estadiamento clínico avançado. Vinte e cinco casos de lábio, 173 cavidade bucal e 78 de orofaringe. A radioterapia pós-operatória foi realizada em 121 pacientes com dose média de 60,8 Gy. RESULTADOS: Oitenta e nove pacientes foram submetidos a tratamento de resgate, sendo que 76 destes foram à cirurgia. As recidivas loco-regionais de cavidade bucal foram submetidas ao resgate cirúrgico em 65 por cento casos. A sobrevida livre de doença pós-cirurgia de resgate foi de 13 por cento nas recidivas até seis meses e 48 por cento nas recidivas após 12 meses de seguimento (p=0,0009). O tipo de resgate e o intervalo livre de doença foram fatores independentes de sobrevida na análise multivariada. CONCLUSÃO: A sobrevida livre de doença pós-resgate nos estadios clínicos iniciais (I e II) foi de 70 por cento.


OBJECTIVE: Salvage surgery is the first therapeutic option for recurrent tumors of the mouth and oropharynx, mainly in early stage tumors. This study intends to evaluate the disease free survival interval after salvage treatment for recurrent tumors of the mouth and oropharynx. METHODS: Retrospective analysis of 276 patients with squamous cell carcinoma of the mouth and oropharynx treated with surgery. One hundred and twenty seven patients developed loco-regional recurrence. Ninety-seven were staged as early tumors and 178 as advanced ones. The tumor site was the lip in 25 cases, oral cavity in 173 and oropharynx in 78. Postoperative radiotherapy was indicated in 121 cases with a mean dose of 60.8Gy. RESULTS: Eighty-nine patients underwent salvage treatment (surgery in 76 patients). Loco-regional recurrences were treated with salvage surgery in 65 percent of cases. Disease free survival after salvage surgery was 13 percent in cases with recurrences diagnosed up to 6 months and 48 percent in those who recurred after 12 months of follow-up (p=0.0009). Modality of salvage treatment and the disease free interval were independent variables of survival in the multivariate analysis. CONCLUSION: In cases clinically staged as I and II, the disease free survival in five years after salvage treatment was 70 percent.


Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Young Adult , Carcinoma, Squamous Cell/surgery , Mouth Neoplasms/surgery , Neoplasm Recurrence, Local/surgery , Oropharyngeal Neoplasms/surgery , Oropharynx/surgery , Salvage Therapy , Brazil/epidemiology , Carcinoma, Squamous Cell/mortality , Carcinoma, Squamous Cell/radiotherapy , Disease-Free Survival , Mouth Neoplasms/mortality , Mouth Neoplasms/pathology , Mouth Neoplasms/radiotherapy , Multivariate Analysis , Neoplasm Metastasis , Neoplasm Recurrence, Local/mortality , Neoplasm Recurrence, Local/radiotherapy , Oropharyngeal Neoplasms/mortality , Oropharyngeal Neoplasms/radiotherapy , Oropharynx/pathology , Young Adult
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