Una revisión acerca del cuidado de la salud mental en las familias de la Unidad de Cuidados Intensivos Neonatales / A Review of the Mental Health Care of Families in the Neonatal Intensive Care Unit

Introducción: el presente trabajo es una revisión de las prácticas que abordan la salud mental perinatal de las familias que atraviesan una internación en Unidades de Cuidados Intensivos Neonatales (UCIN). Los logros en la mayor sobrevida de recién nacidos de alto riesgo implican internaciones prolongadas y el cuidado emocional de sus familias. Estado del arte: el marco conceptual se refiere al cuidado centrado en las personas y su expresión perinatal en el modelo de Maternidades Seguras y Centradas en la Familia (MSCF). Se incluyen experiencias de referentes locales e internacionales que orientan las intervenciones en el campo. Conclusiones: se destaca la importancia del cuidado emocional en escenarios altamente estresantes, dado su impacto en el cuidado y la construcción de los vínculos tempranos entre los recién nacidos (RN) internados y sus referentes primarios. Se mencionan factores psicológicos de riesgo y posibles modos de abordaje. Se plantean acciones de promoción, prevención y asistencia en este contexto. (AU)

Introduction: This paper reviews practices addressing the perinatal mental health of families hospitalized in Neonatal Intensive Care Units (NICU). Achievements in increased survival of high-risk newborns involve prolonged hospitalization and emotional care of their families. State of the art:the conceptual framework refers to person-centered care and its perinatal expression in the Safe and Family-Centered Maternity Model (SFCMM). It includes experiences of local and international referents that guide interventions in the field. Conclusions:the importance of emotional care in highly stressful scenarios is highlighted, given its impact on the care and construction of early bonds between hospitalized newborns (NB) and their primary referents. It mentions psychological risk factors and possible approaches. We propose actions for promotion, prevention, and assistance in this context. (AU)

Mechanisms Underlying the Inhibition of Tyrosine Kinase Inhibitor-Induced Anorexia and Fatigue by Royal Jelly in Renal Cell Carcinoma Patients and the Correlation between Macrophage Colony Stimulating Factor and Inflammatory Mediators.

Inflammation is a common adverse event of anti-cancer therapy. Royal jelly (RJ) modulates inflammation by regulating the levels of tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-ß, and interleukin (IL)-6 produced by macrophages. Macrophage colony stimulating factor (M-CSF) is a crucial regulator of macrophage activities, and we hypothesized that RJ alters M-CSF levels. In this randomized controlled trial, we investigated the association between M-CSF and adverse events in renal cell carcinoma patients treated with tyrosine kinase inhibitors (TKIs) after an oral intake of RJ (n = 16) or placebo (n = 17). The serum levels of M-CSF, TNF-α, TGF-ß, and IL-6 were measured by an enzyme-linked immunosorbent assay, and their temporal changes and correlation between such changes were analyzed. The post-/pretreatment ratio of M-CSF levels was associated with anorexia after 2 weeks and fatigue after 2, 4, and 12 weeks. The M-CSF level in the RJ group was higher than that in the placebo group at the same timepoints. The TNF-α level in the RJ group was lower than that in the placebo group between 6 and 12 weeks, and the TGF-ß level in the RJ group was higher than that in the placebo group; however, contrasting findings were detected after 12 weeks. Additionally, the M-CSF level was significantly correlated with the TGF-ß level after 4 weeks and IL-6 level after 8 and 10 weeks. Among TNF-α, TGF-ß, and IL-6, the post-/pretreatment ratio of TGF-ß after 12 weeks was associated with TKI-induced anorexia, and the ratios after 10 and 12 weeks were associated with fatigue. Our results demonstrated that an oral intake of RJ suppressed anorexia and fatigue via complex mechanisms associated with inflammation-related factors, such as M-CSF and TGF-ß in renal cell carcinoma patients treated with TKIs. In addition, we newly found that such RJ-related effects were dependent on the treatment duration.

Bone marrow-derived interstitial cells of cajal are increased by electroacupuncture in the colon of diabetic mice.

BACKGROUND AND AIM: Insufficiency of interstitial cells of cajal (ICC) in the muscular plexus of colon has been proved in diabetic mice. Electroacupuncture (EA) at ST36 can accelerate ICC supplement in the colon of diabetic mice, but the source of increased ICC has not been clearly explored. Bone marrow cells possess the potential of migration and differentiation into ICC of the intestine. Our aim is to explore the effects of EA on variations of bone marrow-derived ICC in the colon of diabetic mice as well as its mechanism. METHODS: Wild C57BL/6 mice were divided into six groups with random assignment method: control group, diabetic mellitus (DM) group, bone marrow transplantation (BMT) + DM group, BMT + DM + sham EA group, BMT + DM + low-frequency EA group, and BMT + DM + high-frequency EA group. Flow cytometric method was adopted to identify the chimera model. The specific location and expression levels of c-Kit+ green fluorescent protein (GFP+) cells in colon were detected by immunofluorescence. Western blot and quantitative polymerase chain reaction were used to assess the expression level of c-Kit, GFP, membrane-band stem cell factor (mSCF), p-ERK, p-c-Jun, ETV1, stromal cell-derived factor 1 (SDF-1), CXCR4, transforming growth factor ß1 (TGF-ß1), and smad3. RESULTS: c-Kit+ GFP+ cells in the muscular plexus of colon were apparently increased in the EA groups; the protein and mRNA expression level of CXCR4, SDF-1, TGF-ß1, smad3, c-kit, mSCF, p-ERK, p-c-Jun, and ETV1 were elevated in the EA groups. CONCLUSIONS: Electroacupuncture can effectively increase bone marrow-derived ICC in the colon by SDF-1/CXCR4, TGF-ß1/Smad3, and mSCF/Kit-p-ERK/p-c-Jun-ETV1 signal pathway.

Cuidados de enfermería para un trabajo de parto humanizado / Nursing care for a humanidez childbirth

La investigación y promoción sobre los cuidados de enfermería es indispensable para la difusión y el avance del conocimiento científico y tecnológico.En este trabajo se dan a conocer las políticas sanitarias argentinas y la Ley Nº 25.929 sobre Parto Humanizado, que pretende, brindar una atención médica oportuna y de calidad, promoviendo la iniciativa Maternidad Segura y Centrada en la Familia (MSCF), con el fin de incrementar su probabilidad de aceptación, puesta en práctica, garantizando la protección de los derechos de cada uno de los involucrados en el proceso. Siendo el médico encargado legal de comunicar, diagnosticar y de proponer las medidas a seguir y enfermería la responsable del cuidado, un cuidado humanizado, que traspasa el simple procedimiento, apoyándose en prácticas útiles y benéficas, a través de la comunicación y de la relación interpersonal entre el profesional y la mujer gestante, su familia o grupo social en las distintas etapas de la vida, su situación de salud y de entorno.

Parto institucional, seguro y centrado en la familia. Evaluación de la experiencia en el Hospital y Maternidad Santa Rosa / Institutional, safe and family centered delivery. Evaluation of the experience in the Hospital and Maternity Santa Rosa

Todas las instituciones donde se producen nacimientos deben ser capaces de resolver emergencias que pueden presentarse tanto en partos normales como en partos patológicos y garantizar así el cumplimiento de las condiciones obstétricas y neonatales esenciales (CONES). La implementación de estas condiciones es fundamental para el logro de los objetivos propuestos por el modelo de maternidad segura y centrada en la familia (MSCF). El artículo presenta los resultados de un relevamiento reciente llevado a cabo en la Maternidad Santa Rosa (AU)

All institutions where births are produced should be able to solve emergencies that can appear both in normal deliveries and in pathological deliveries, and in this way guarantee the fulfilment in the essential obstetric and neonatal conditions. The implementation of these conditions is fundamental to the achievement of the objectives proposed by the safe and familycentred model of maternity. The article presents the results of a recent survey carried out at the Santa Rosa Maternity

Up-regulation of the Ang II/AT1 receptor may compensate for the loss of gastric antrum ICC via the PI3k/Akt signaling pathway in STZ-induced diabetic mice.

The classic renin-angiotensin system (RAS) is a complex system in which angiotensin II (Ang II) has been identified as an important endogenous regulator that influences both smooth muscle contraction and cell growth. Although a local RAS is known to exist in the gastrointestinal tract, it is unclear whether Ang II is involved in the loss of gastric interstitial cells of Cajal (ICC) in diabetic mice. The present study was designed to investigate the effect of Ang II on ICC survival in streptozotocin (STZ)-induced diabetic mice. Western blot, immunofluorescence, isometric muscle recording, enzyme-linked immunosorbent assay (ELISA) and a cell counting kit-8 were used in this research. Our results demonstrate that the c-Kit and membrane-bound stem cell factor (mSCF) protein expression levels in gastric smooth muscle were decreased in STZ-induced diabetic mice. However, the angiotensin receptor type 1 (AT1R) expression levels in gastric smooth muscle and angiotensin-converting enzyme (ACE) expression levels in gastric mucosa were increased. The effect of Ang II on the tonic contraction of gastric smooth muscle was potentiated in diabetic mice, and the plasma Ang II level was enhanced. Ang II increased mSCF expression, cell proliferation, and Akt-Ser473 phosphorylation in cultured gastric smooth muscle cells (GSMCs). These effects were reduced by specific inhibitors ZD7155 (an AT1R antagonist) and LY294002 (a PI3-kinase inhibitor). Our results suggest that Ang II increases mSCF expression and cell proliferation in cultured GSMCs in a PI3K/Akt signaling-dependent manner. ACE and AT1R up-regulation in the stomach may help compensate for ICC loss in STZ-induced diabetic mice.

The Effect of Several Cykokines to Growth of Mast Cells / 中国免疫学杂志

Using in vitro cultured mouse bone marrow mast cells as experimental model,effects of sev-eral cytokines to the growth of mast cells were observed.The results show that mSCF can sup-port the growth of long term cultured homogenous mast cells,but cannot stimulate the initiativegrowth of primary cultured bone marrow cells IL—3 and Epo can also support growth of mastcells.