A Glimpse into Gynecologic Practice During the Islamic Golden Age.

The Islamic Golden Age was the time in history from eighth to fourteenth century. This era was marked by expansion of Islamic world to all the Middle East, North Africa, South and East Europe, and Central Asia. The Islamic world was the wealthiest region in the world at that time and that wealth was utilized to promote great flourishing in the arts, philosophy, science, and medicine. The practice of healing was considered the most noble of human undertakings by Islamic scholars. In this era, many great physician-scientists emerged in the Islamic world, albeit several were not Muslims, who examined prior writings, corrected many, and proceeded to produce their own observations and innovations. This article highlights some of the most important contributions to gynecology of some prominent scholars during this shining phase of medical history.

The medieval biological clock? Gendered reproductive aging in medieval western medicine.

This paper examines discussions of women's and men's reproductive aging in a series of western European medical texts written in the period 1100-1300. It uses the modern image of the biological clock to explore how far physicians in earlier periods understood reproductive aging to be a process of slow decline before a final age at which fertility ended (menopause for women, or a less defined 'old age' for men), and how far they viewed women's reproductive aging as different from men's. The article argues that, in contrast to modern medical and popular understandings, medieval physicians assumed men and women were broadly fertile up to a final cut-off point, and had little interest in viewing age-related fertility decline as a slow process beginning well before menopause. This was true in part because there was no realistic prospect of treatment for age-related reproductive disorders. The article also argues that in many respects - although not all - medieval writers viewed men's and women's reproductive aging as similar processes. Overall the model of reproductive aging they offered was flexible and offered room for individual variation. In this way the article demonstrates how changing understandings of the body, reproduction, and aging, demographic and social change, and changing medical treatments influence concepts of reproductive aging.

Gradus Dimetiri: intensity and classification of complexions in 14th-century Italian medicine.

This paper focuses on the scholastic approach to the intensity of complexions and presents some evidence as to how the meaning of complexio evolved in fourteenth-century Italian medicine: namely, how it was conceptualized, visualized, and finally quantified. In the first part, I summarize the philosophical development of complexio, pointing out how the concept differs from simple mixtures, thereby allowing for the mathematisation of compounds and their intensity. I then move on to consider the links between medicine and mathematics and present the schemes provided by Gentile Gentili da Foligno (1280/90 - 1348) as a case study, analysing their philosophical premises and implications for medical treatment more generally. In the final part, I argue that, quite aside from representing early forms of the mathematisation of qualities, schemata and diagrams also captured the medieval ideal of the cosmos, a hierarchical progression of forms ordered in ascending degrees of perfection and nobility.

Development of Obstetric Practice During the Early Islamic Era.

Art of healing was considered the most noble of human undertakings by Islamic scholars. Acquiring medical manuscripts from previous civilizations and translating them into Arabic proceeded at a great pace. This was followed by the emergence of several great physician scientists who examined these writings, corrected many, and proceeded to produce their own, with the addition of significant original paradigm-shifting contributions to all branches of science and medicine. This article highlights some of the most important contributions to obstetrics of several prominent scholars of the early Islamic period (700-1300 A.D.).

[Regarding pandemics: Ibn Jatima from Almería anticipates the physiopathological concept of multi-organ failure in the 14th century]. / A propósito de pandemias: Ibn Jatima de Almería anticipa el concepto fisiopatológico de fallo multiorgánico en el siglo XIV.

In 1348, a pandemic known as Black Death devastated humanity and changed social, economic and geopolitical world order, as is the current case with SARS-CoV-2 coronavirus. The doctor of the Nasrid Kingdom of Granada, Ibn Jatima from Almeria, wrote Treatise on the Plague, in which it may be found epidemiological and clinical similarities between both plagues. In the context of Greco-Arab medicine, he discovered respiratory and contact contagion of Pestis and attributed its physiopathology to a lack of pulmonary cooling of the innate heat, generated in the heart and carried by the blood humor. The process described was equivalent to the oxygen transport system. Furthermore, it was supposed to generate toxic residues, such as free radicals, leading to an irreversible multiple organ failure (MOF), considered a mortality factor as in Covid-19. Due to its similitude, it would be the first antecedent of the MOF physiopathological concept, a finding that enriches the scientific and historical heritage of our clinical specialty.

Hildegard of Bingen (c. 1098-1179) on sleep and dreams in her Causae et curae and Physica: a historical perspective.

Saint Hildegard of Bingen (c. 1098-1179) was a 12th century Benedictine abbess, a visionary, a composer, a poet, a healer, and one of few medieval women who produced treatises on medicine. In her medical writings, Causae et curae and Physica, the abbess described, among other topics, physical functions and mechanisms of sleep, dreams and waking, emphasizing the importance of sleep for the human body. She regarded sleep as both a passive and an active process. Hildegard warned her readers about sleeping too little or too much, evaluated possible causes of insomnia and nightmares, and discussed potential treatments for these sleep disorders. In this paper, we analyze Hildegard's writings in the context of Greco-Roman physiological theories, which were held to the end of the Middle Ages and later. We also discuss questions concerning the abbess's putative education, the originality of her works, and the significance of her writings in the context of current knowledge on sleep medicine.

A propósito de pandemias: Ibn Jatima de Almería anticipa el concepto fisiopatológico de fallo multiorgánico en el siglo XIV / Regarding pandemics: Ibn Jatima from Almería anticipates the physiopathological concept of multi-organ failure in the 14th century

En el año 1348 una pandemia de la llamada «peste negra» asoló la humanidad y cambió el orden social, económico y geopolítico del mundo, tal como sucede actualmente con la causada por el coronavirus SARS-CoV-2. El médico del reino nazarí de Granada, Ibn Jatima de Almería, escribió un Tratado sobre la peste en el cual se encuentran semejanzas epidemiológicas y clínicas entre ambas plagas. Así, dentro del contexto de la medicina greco-árabe, descubrió el contagio respiratorio y por contacto de la peste, y atribuyó su fisiopatología a una insuficiente refrigeración pulmonar del calor innato generado en el corazón y vehiculizado por el humor sanguíneo, equivalente al sistema de trasporte de oxígeno, lo cual generaba residuos tóxicos, como los radicales libres, que abocaba a un fallo multiorgánico (FMO) irreversible, factor de mortalidad como en la Covid-19. Por su similitud, sería el primer antecedente conocido del concepto fisiopatológico de FMO, hallazgo que enriquece nuestro patrimonio científico-histórico de la especialidad. (AU)

In 1348, a pandemic known as Black Death devastated humanity and changed social, economic and geopolitical world order, as is the current case with SARS-CoV-2 coronavirus. The doctor of the Nasrid Kingdom of Granada, Ibn Jatima from Almeria, wrote Treatise on the Plague, in which it may be found epidemiological and clinical similarities between both plagues. In the context of Greco-Arab medicine, he discovered respiratory and contact contagion of Pestis and attributed its physiopathology to a lack of pulmonary cooling of the innate heat, generated in the heart and carried by the blood humor. The process described was equivalent to the oxygen transport system. Furthermore, it was supposed to generate toxic residues, such as free radicals, leading to an irreversible multiple organ failure (MOF), considered a mortality factor as in Covid-19. Due to its similitude, it would be the first antecedent of the MOF physiopathological concept, a finding that enriches the scientific and historical heritage of our clinical specialty. (AU)

Regarding pandemics: Ibn Jatima from Almería anticipates the physiopathological concept of multi-organ failure in the 14th century.

In 1348, a pandemic known as Black Death devastated humanity and changed social, economic and geopolitical world order, as is the current case with SARS-CoV-2 coronavirus. The doctor of the Nasrid Kingdom of Granada, Ibn-Jatima from Almeria, wrote "Treatise on the Plague", in which it may be found epidemiological and clinical similarities between both plagues. In the context of Greco-Arab medicine, he discovered respiratory and contact contagion of Pestis and attributed its physiopathology to a lack of pulmonary cooling of the innate heat, generated in the heart and carried by the blood humor. The process described was equivalent to the oxygen transport system. Furthermore, it was supposed to generate toxic residues, such as free radicals, leading to an irreversible multiple organ failure (MOF), considered a mortality factor as in Covid-19. Due to its similitude, it would be the first antecedent of the MOF physiopathological concept, a finding that enriches the scientific and historical heritage of our clinical specialty.

For the Benefit of Students: Memory and Anatomical Learning at Bologna in the Fourteenth to Early Sixteenth Centuries.

The anatomical textbook in the late Middle Ages was one part of a greater pedagogical process that involved students' seeing, hearing, reading, and eventually knowing information about the human body. By examining the role of the anatomical textbook and accompanying bodily images in anatomical learning, this article illuminates the complexity and self-consciousness of anatomical education in the medieval university, as professors focused on ways to enhance student memory of the material. Traditionally, the history of anatomy has been heavily influenced by the anatomical Renaissance of the late-sixteenth century, highlighting a focus on innovative medical knowledge and the scientific method. However, if we engage a pedagogical lens when looking at these medieval authors, it becomes quickly obvious that the whole point of university medicine was not to explore unknown boundaries and discover new ideas of medicine, but rather to communicate the current and established body of knowledge to those not familiar with it.

Madness, Medicine and Miracle in Twelfth-Century England.

This monograph provides a fresh perspective on how madness was defined and diagnosed as a condition of the mind in the Middle Ages and what effects it was thought to have on sufferers. Records of miracles that were believed to have been performed by saints reveal details of illnesses and injuries that afflicted medieval people. In the twelfth century, such records became increasingly medicalized and naturalized as the monks who recorded them gained access to Greek and Arabic medical material, newly translated into Latin. Nonetheless, by exploring nuances and patterns across the cults of five English saints, this book shows that hagiographical representations of madness were shaped as much by the individual circumstances of their recording as they were by new medical and theological standards.

The pathological and the normal: Mapping the brain in medieval medicine.

Medieval medicine from the late eleventh century onward generally accepted the tripartite model of the brain. This study shifts our attention from the theoretical discussions of the mind and brain as ideal abstractions to more practical discussions of the perceived dysfunctions associated with a variety of brain diseases. When dealing with practical nosological concerns, medical writers began to recognize the deficiencies and overly reductive aspects of the model. Disease categories such as melancholia or stupor raised issues about how and where to locate these conditions in the brain by questioning which cognitive functions were damaged. One text in particular, Arnald of Villanova's De parte operativa, written ca. 1300, provides a case study that reviewed and critiqued earlier understandings of the relation between the pathological and normal brains.

Avicena, príncipe de los médicos. Vida, obra y legado para la medicina contemporánea / Avicena, the doctors' prince. Life, works and legacy for the contemporary medicine

La historia de la Medicina está directamente relacionada con el surgimiento del hombre. Desde los tiempos de Hipócrates, antes de nuestra era, cuando existía la incertidumbre de definirla como arte o ciencia, no hubo un médico que entregara tanto aporte verdaderamente investigativo, con carácter científico como Avicena, sabio indiscutible del Medioevo, de los siglos X y XI de la época contemporánea. Su herencia a la humanidad fue muy importante, en especial sobre Filosofía y Medicina, aunque consolidó conceptos y conocimientos de prácticamente todas las áreas del saber. Su nombre llegó casi a ser sinónimo de la propia Medicina. Su monumental obra contribuyó, sin dudas, al desarrollo y a la sedimentación de la civilización humana, trascendó las fronteras del tiempo hasta la actualidad. Fue un hombre multifacético admirable, pero especialmente un médico teórico y práctico incomparable, que con su claridad de ideas y con elevado rigor científico, se trasladó de modo extraordinario hasta la época actual. Su frescura de pensamiento, sus razonamientos, su creatividad científica de fuerza titánica y un estilo único, fueron y aún son, elementos fundamentales para la expansión y el desarrollo de la ciencia universal. En nuestro medio existe poca información sobre la personalidad y la obra de tan distinguida persona, por lo que se realiza la siguiente revisión con el objetivo de profundizar en estos aspectos de su vida y divulgarlos al personal médico en formación(AU)

The history of the Medicine is directly related with the man's emergence. From the times of Hipócrates, before our era, when the uncertainty existed of defining it as art or science, there was not a doctor that gave to this so much truly investigative contribution, with scientific character as Avicena, unquestionable sage of the Middle Ages, of the centuries X and XI of the contemporary time. Its inheritance to the humanity was very important, particularly on Philosophy and Medicine, although it consolidated concepts and knowledge of practically all the areas of the knowledge. Their name ended up almost being synonymous of the own Medicine. Their monumental work contributed, without doubts, to the development and the sedimentation of the human civilization, transcending the frontiers of the time until the present. It was an admirable multifaceted man, but very especially an incomparable theoretical and practical doctor that with their clarity of ideas and with high scientific rigor, it transferred incredibly and in an extraordinary way until the current time. Their thought freshness, their reasoning, their scientific creativity of titanic force and an unique style, they were and they are still, fundamental elements for the expansion and the development of the universal science. In our means little information exists about the personality and so distinguished person's work, for which we carried out the following bibliographical review with the objective to deepen in these aspects of his life and to disclose them to the medical personnel in formation(AU)

Giovanni Boccaccio's (1313-1375) disease and demise: The final untold tale of liver and heart failure.

Giovanni Boccaccio's fatal disease(s) and cause of death have long remained a mystery. Now, for the first time, a thorough multidisciplinary reassessment has finally been carried out. By combining philological and clinical approaches, it is at last possible to suggest a solid retrospective diagnosis based upon a study of his correspondence, poetry and iconography, as well as references to his physical decay in coeval and later sources. It would appear that he suffered over the last three years of his life from hepatic and cardiac failure, conditions that resulted in edema and potentially even hepatic carcinoma. Focusing on an unusually well-documented case from the Middle Ages, this analysis of exceptionally high informative value reconstructs the symptoms of his medical conditions and finally permits us to clarify and explain the historical feaures, presentations and evolutionary history of the case at hand.

Thomas of Wroclaw (1297-1378) - Medieval bishop and scholar of English origin.

Peter of Tilleberi (Tilbury), later known as bishop Thomas of Wroclaw, after completing his studies (in Bologna or in Montpellier) worked as a physician in northern Italy and probably in Spain. Later through Germany and Bohemia, he came to Wroclaw in 1336 where he joined the Order of St. Dominic. In 1352, Thomas was made an auxiliary bishop of the diocese of Wroclaw. After the episcopal consecration, Thomas stopped living in the abbey, but all the time he was well known both as a priest and physician. He is known as an author of several treatises on medical sciences. His most important work entitled Michi competit (i.e. It suits me) is composed of four parts: Regimen sanitatis (i.e. Hygiene), Aggregatum (i.e. Aggregation), Antidotarium (i.e. Medicine directory) and Practica medicinalis (i.e. Medical practices). Moreover, he is the author of other treatises including, for example, De phlebotomia et de iudiciis cruoris (i.e. On phlebotomy and blood content) and De urinis (i.e. On urine). Some Polish scientists claim that bishop Thomas of Wroclaw with his knowledge and industriousness functioned as a university faculty of medicine even though the University of Cracow had not been established yet.

The pharmacology of medieval sedatives: the "Great Rest" of the Antidotarium Nicolai.

ETHNOPHARMACOLOGICAL RELEVANCE: Past practices of compound drugs from different plant ingredients enjoyed remarkable longevity over centuries yet are largely dismissed by modern science as subtherapeutic, lethal or fanciful. AIM OF THE STUDY: To examine the phytochemical content of a popular medieval opiate drug called the "Great Rest" and gauge the bioavailability and combined effects of its alkaloid compounds (morphine, codeine, hyoscyamine, scopolamine) on the human body according to modern pharmacokinetic and pharmacodynamic parameters established for these compounds. CALCULATIONS AND THEORY: We reviewed the most recent studies on the pharmacodynamics of morphine, codeine, hyoscyamine and scopolamine to ascertain plasma concentrations required for different physiological effects and applied these findings to dosage of the Great Rest. RESULTS: Given the proportional quantities of the alkaloid rich plants, we calculate the optimal dose of Great Rest to be 3.1±0.1-5.3±0.76 g and reveal that the lethal dose of Great Rest is double the therapeutic concentration where all three alkaloid compounds are biologically active. CONCLUSION: This study helps establish the effective dose (ED50), toxic dose (TD50) and lethal dose (LD50) rates for the ingestion of raw opium, henbane and mandrake, and describes their probable combined effects, which may be applied to similar types of pre-modern pharmaceuticals to reveal the empirical logic behind past practices.

Historical essay: An Arabic surgeon, Ibn al Quff's (1232-1286) account on surgical pain relief.

This is a review of Ibn al Quff's account of surgical pain relief in his surgical book Al Omdah, in which he mentioned the word anesthetic (Al moukhadder) and the involvement of physician (al tabbaaee) to give mixture of drugs to prevent pain in a surgical condition to relieve the patient from pain or to make surgical management possible. Hich indicated one rare occasion to such description in Arabic medical texts. Methods of administration of these drugs were inhalation, ingestion and by rectal suppositories. The drugs used in anesthetic sponges include all the drugs that are recorded in the modern literature of anesthesia. They are as follows: opium, mandrake, Hyocymus albus, belladonna, Cannabis sativus, Cannabis indica, wild lettuce. The anesthetic sponge, mentioned in many references as an inhalation method, may be of symbolic value to surgery.