Moving Toward Integrative, Multidimensional Research in Modern Psychiatry: Lessons Learned From Fragile X Syndrome.

The field of psychiatry is approaching a major inflection point. The basic science behind cognition, emotion, behavior, and social processes has been advancing rapidly in the past 20 years. However, clinical research supporting the classification system in psychiatry has not kept up with these scientific advances. To begin organizing the basic science of psychiatry in a comprehensive manner, we begin by selecting fragile X syndrome, a neurogenetic disease with cognitive-behavioral manifestations, to illustrate key concepts in an integrative, multidimensional model. Specifically, we describe key genetic and molecular mechanisms (e.g., gamma-aminobutyric acidergic dysfunction and metabotropic glutamate receptor 5-associated long-term depression) relevant to the pathophysiology of fragile X syndrome as well as neural correlates of cognitive-behavioral symptoms. We then describe what we have learned from fragile X syndrome that may be applicable to other psychiatric disorders. We conclude this review by discussing current and future opportunities in diagnosing and treating psychiatric diseases.

Metodologia de Autopesquisa / Self-Research Methodology / Metodología de Autoinvestigación

O artigo objetiva propor uma metodologia aplicada à autopesquisa, usando os critériosde investigação científica da ciência convencional enquanto modelo referencial.A proposição metodológica baseia-se na experiência analítica dos relatos paraperceptivos,observados pelo autor, no período de julho de 2006 a dezembro de 2012, durantea Dinâmica Interassistencial Paracirúrgica (DIP), realizada semanalmente na OrganizaçãoInternacional de Consciencioterapia (OIC), nas técnicas autoconsciencioterá-picas aplicadas durante uma década de autoinvestigação e na revisão bibliográfica demetodologia científica convencional. Atém-se à organização autoinvestigativa, seusobjetivos, hipóteses, coleta de dados e à investigação multidimensional, buscandoevidências que fundamentem as conclusões autodiagnósticas. Aborda a importânciada contextualização multidimensional à cosmovisão analítica autopesquisística, apresentandotécnicas de paraevidenciação, necessárias à estruturação hipotética autodiagnóstica.Sugere uma Metodologia Autoinvestigativa, visando assegurar o autodiagnósticomais condizente com a realidade intraconsciencial. Conclui que a organizaçãometodológica amplia a autocriticidade e que a técnica da fundamentação autopesquisísticaassegura uma hipótese autodiagnóstica mais fidedigna(AU)

The article looks forward to propose an applied methodology to self-research, usingthe criteria of scientific investigation of conventional science as referential model.The methodological proposition bases itself on the analytical experience of the paraperceptivereports, observed by the author, in the period from July of 2006 to Decemberof 2012, during weekly Interassistential Parasurgery Dynamics (IPD), at the InternationalOrganization of Conscientiotherapy (OIC), in the self-conscientiotherapeutictechniques applied during a decade of self-investigation and in the bibliographical visionof conventional scientific methodology. They get tied to the self-investigative organization,their objectives, hypotheses, collection of data and the multi-dimensionalinvestigation, looking for evidences to base the self-diagnostics conclusions. It approachesthe importance of the multidimensional contextualization to the analyticalcosmic-vision self-research, presenting paraevidence techniques, necessary to thestructuring hypothetical self-diagnostic. It suggests a Self-investigative Methodology,seeking to assure the self-diagnosis in keeping with intraconsciential reality. It concludesthat the methodological organization enlarges the self-critic, and that the techniqueof the self-research base assures a hypothesis more self-diagnostic trustworthy(AU)

El artículo objetiva proponer una metodología aplicada a la auto investigación,usando los criterios de investigación científica de la ciencia convencional en cuantomodelo referencial. La proposición metodológica se basa en la experiencia analíticade los relatos paraperceptivos, observados por el autor, en el período de julio de 2006 a diciembre de 2012, durante la Dinámica Interasistencial Paracirúrgica (DIP), realizadasemanalmente en la Organización Internacional de Conciencioterapia (OIC), enlas técnicas auto conciencioterápicas aplicadas durante una década de auto investigacióny en la revisión bibliográfica de metodología científica convencional. Se atienena la organización auto investigativa, sus objetivos, hipótesis, colecta de datos y a lainvestigación multidimensional, buscando evidencias que fundamenten las conclusionesauto diagnósticas. Aborda la importancia de la contextualización multidimensionala la cosmovisión analítica auto investigativa, presentando técnicas de paraevidenciación,necesarias a la estructuración hipotética auto diagnóstica. Sugiere unaMetodología Auto investigativa, visando asegurar el auto diagnóstico más concordantecon la realidad intraconciencial. Concluye que la organización metodológica ampliala auto criticidad y que la técnica de la fundamentación auto investigativa asegurauna hipótesis auto diagnóstica más fidedigna(AU)