Estudo de fase II de pregabalina para prevenção de náuseas e vômitos induzidos por quimioterapia / Phase II study of pregabalin for the prevention of chemotherapy induced nausea and vomiting

Para avaliar o papel da pregabalina na proteção das náuseas e vômitos induzidos pela quimioterapia, foi realizado um ensaio clínico de fase II, aleatorizado, duplamente cego, controlado por placebo, para investigar se a pregabalina poderia melhorar o controle completo das náuseas e vômitos (desfecho primário). Inscrevemos 82 pacientes virgens de quimioterapia, programados para receber quimioterapia moderadamente e altamente emetogênica. Todos os doentes receberam ondansetron 8mg por via intravenosa, dexametasona 10mg antes da quimioterapia no primeiro dia e, dexametasona 4 mg por via oral, b.d., nos dias dois e três. Os doentes foram distribuídos aleatoriamente para tomar pregabalina 75 mg ou placebo, bd, desde a noite anterior à quimioterapia até ao quinto dia. A resposta completa global não foi estatisticamente significativa entre os grupos (53,7 versus 48,8%, respetivamente, no grupo da pregabalina e no grupo de controlo (P=0,65)). Também não houve diferença estatística significativa durante a fase aguda (primeiras 24 horas) e a fase tardia (24-120h): 80,5% versus 82,9% (P=0,77), 53,7 versus 51,2% (P=0,82), respectivamente. Neste estudo não foi identificada ação da pregabalina na prevenção de náuseas e vômitos induzidos por quimioterapia. Número de registo no Clinicaltrial.gov: NCT04181346.

To evaluate the role of pregabalin in the protection of chemotherapy-induced nausea and vomiting, we performed a phase II randomized, double-blind, placebo-controlled trial to investigate whether pregabalin could improve the complete control of nausea and vomiting (primary end point). We enrolled 82 chemotherapy-naive patients, scheduled to receive moderately and highly emetogenic chemotherapy. All patients received IV ondansetron 8mg, dexamethasone 10mg before chemotherapy on day one and oral dexamethasone 4mg, b.d., on days two and three. Patients were randomly assigned to take pregabalin 75mg or placebo, bd, from the night before chemotherapy to day five. The overall complete response was not statistically significant between the groups (53.7 versus 48.8%, respectively, in the pregabalin group and the control group (P=0.65)). There was also no significant difference during the acute phase (first 24 hours) and delayed phase (24-120h): 80.5% versus 82.9% (P=0.77), 53.7 versus 51.2% (P=0.82), respectively. There is no role for pregabalin preventing chemotherapy-induced nausea and vomiting. Clinicaltrial.gov registration number: NCT04181346.

Profilaxis antiemética en pacientes con neoplasias hematológicas que reciben protocolos de acondicionamiento para el trasplante de células madre hematopoyéticas: protocolo de estudio para una revisión sistemática / Antiemetic prophylaxis in hematologic malignancies patients receiving conditioning protocols for hematopoietic stem cell transplantation: A study protocol for a systematic review

Objetivo las náuseas y los vómitos inducidos por la quimioterapia siguen siendo un reto importante para los pacientes que recibieron un trasplante de células madre hematopoyéticas. Este estudio tiene como objetivo sintetizar la evidencia disponible sobre los regímenes de profilaxis antiemética en los pacientes con neoplasias hematológicas que recibieron un trasplante de células madre hematopoyéticas, con el fin de identificar el mejor estándar de cuidado. Métodos se llevará a cabo una revisión sistemática utilizando las bases de datos MEDLINE a través de PubMed, EMBASE, Clinical-Trials.gov y Cochrane. Se considerarán los estudios escritos en inglés, francés, italiano o español. Después de seleccionar los estudios de acuerdo con los criterios de inclusión y exclusión, 2 revisores independientes extraerán los datos y evaluarán el riesgo de sesgo en los artículos seleccionados. Este protocolo se ha elaborado de acuerdo con las recomendaciones de las guías PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols). Este protocolo está registrado en PROSPERO (Prospective Register of Ongoing Systematic Reviews) CRD42023406380. Discusión las náuseas y los vómitos inducidos por la quimioterapia son un efecto secundario incapacitante que supone un reto importante para los pacientes con neoplasias hematológicas. A pesar de la publicación de diversas guías sobre profilaxis antiemética, ninguna de ellas incluye recomendaciones específicas para cada régimen de quimioterapia. Por lo tanto, analizar los regímenes de profilaxis antiemética primaria en los pacientes con neoplasias hematológicas que recibieron un trasplante de progenitores hematopoyéticos sería valioso para mejorar la calidad de vida de estos pacientes. (AU)

Objective Chemotherapy-induced nausea and vomiting continue to pose a significant challenge for patients undergoing hematopoietic stem cell transplantation. This study aims to synthesize available evidence on antiemetic prophylaxis regimens in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation, in order to identify the best standard of care. Methods A systematic review will be conducted using MEDLINE via PubMed, EMBASE, ClinicalTrials.gov., and Cochrane databases. Studies written in English, French, Italian or Spanish will be considered. After screening the literature according to the inclusion and exclusion criteria, two independent reviewers will extract data and assess the risk of bias in eligible articles. This protocol has been prepared according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines. This protocol is registered in the Prospective Register of Ongoing Systematic Reviews (PROSPERO) CRD42023406380. Discussion Chemotherapy-induced nausea and vomiting is a debilitating side effect that presents a significant challenge for patients with hematologic malignancies. Despite the publication of various guidelines, none of them includes specific recommendations for each chemotherapy regimen. Therefore, analyzing the primary antiemetic prophylaxis regimens in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation would be valuable in enhancing patients' quality of life. (AU)

Antiemetic prophylaxis in hematologic malignancies patients receiving conditioning protocols for hematopoietic stem cell transplantation: A study protocol for a systematic review. / [Artículo traducido] Profilaxis antiemética en pacientes con neoplasias hematológicas que reciben protocolos de acondicionamiento para el trasplante de células madre hematopoyéticas: protocolo de estudio para una revisión sistemática.

OBJECTIVE: Chemotherapy-induced nausea and vomiting continue to pose a significant challenge for patients undergoing hematopoietic stem cell transplantation. This study aims to synthesize available evidence on antiemetic prophylaxis regimens in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation, in order to identify the best standard of care. METHODS: A systematic review will be conducted using MEDLINE via PubMed, EMBASE, ClinicalTrials.gov., and Cochrane databases. Studies written in English, French, Italian or Spanish will be considered. After screening the literature according to the inclusion and exclusion criteria, two independent reviewers will extract data and assess the risk of bias in eligible articles. This protocol has been prepared according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines. This protocol is registered in the Prospective Register of Ongoing Systematic Reviews (PROSPERO) CRD42023406380. DISCUSSION: Chemotherapy-induced nausea and vomiting is a debilitating side effect that presents a significant challenge for patients with hematologic malignancies. Despite the publication of various guidelines, none of them includes specific recommendations for each chemotherapy regimen. Therefore, analyzing the primary antiemetic prophylaxis regimens in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation would be valuable in enhancing patients' quality of life.

Antiemetic prophylaxis in hematologic malignancies patients receiving conditioning protocols for hematopoietic stem cell transplantation: A study protocol for a systematic review.

OBJECTIVE: Chemotherapy-induced nausea and vomiting continue to pose a significant challenge for patients undergoing hematopoietic stem cell transplantation. This study aims to synthesize available evidence on antiemetic prophylaxis regimens in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation, in order to identify the best standard of care. METHODS: A systematic review will be conducted using MEDLINE via PubMed, EMBASE, Clinical-Trials.gov., and Cochrane databases. Studies written in English, French, Italian, or Spanish will be considered. After screening the literature according to the inclusion and exclusion criteria, 2 independent reviewers will extract data and assess the risk of bias in eligible articles. This protocol has been prepared according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines. This protocol is registered in the Prospective Register of Ongoing Systematic Reviews (PROSPERO) CRD42023406380. DISCUSSION: Chemotherapy-induced nausea and vomiting is a debilitating side effect that presents a significant challenge for patients with hematologic malignancies. Despite the publication of various guidelines, none of them include specific recommendations for each chemotherapy regimen. Therefore, analyzing the primary antiemetic prophylaxis regimens in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation would be valuable in enhancing patients' quality of life.

Ependimoma de fosa posterior en una embarazada: diagnóstico diferencial de una hiperémesis. Reporte de caso / Posterior fossa ependymoma in a pregnant woman: differential diagnosis of hyperemesis. Case report

Resumen ANTECEDENTES: Los tumores intracraneales se diagnostican con una frecuencia muy baja durante el embarazo. Entre los síntomas iniciales destacan: cefalea, náuseas y vómitos frecuentes que, a su vez, son característicos del embarazo, de ahí la necesidad de establecer un diagnóstico diferencial correcto. CASO CLÍNICO: Paciente primigesta, de 25 años, 11+4 semanas de embarazo, con un cuadro de vómitos, cefalea, vértigo e inestabilidad, de inicio subagudo en los últimos dos meses. Antecedentes de interés: cefalea de características tensionales en comparación con migraña crónica no estudiada previamente. Durante la exploración se advirtió enlentecimiento en el lenguaje, nistagmo evocado por la mirada de manera bilateral y dolor periocular izquierdo, junto con vómitos incoercibles que no cedían, pese a la dieta absoluta y administración pautada de metoclopramida y pantoprazol. La resonancia magnética nuclear cerebral con contraste mostró una masa tumoral centrada en el cuarto ventrículo. Con base en lo anterior se procedió a la craniectomía suboccipital con exéresis subtotal del tumor y diagnóstico anatomopatológico de ependimoma de fosa posterior grupo A. Se propuso, y la paciente aceptó, la interrupción del embarazo con el propósito de completar el tratamiento coadyuvante con radioterapia. La intervención quirúrgica le dejó importantes secuelas neurológicas que ameritaron un proceso de rehabilitación. CONCLUSIONES: El momento del diagnóstico es decisivo para indicar el tratamiento de las tumoraciones intracraneales, sobre todo si son de naturaleza maligna, puesto que habrá que establecer un equilibrio entre la salud de la madre y la viabilidad de la gestación. En tanto se trata de pacientes con una afección compleja, su atención médica debe ser multidisciplinaria para disminuir los riesgos para la madre y el feto.

Abstract BACKGROUND: Intracranial tumours are diagnosed very rarely during pregnancy. The initial symptoms include headache, nausea and frequent vomiting, which are characteristic of pregnancy, so a correct differential diagnosis is necessary. CLINICAL CASE: Primigravida patient, 25 years old, 11+4 weeks pregnant, with a history of vomiting, headache, dizziness and instability of subacute onset in the last two months. History of interest: tension-type headache compared with chronic migraine, not previously studied. On examination, slowed speech, bilateral gaze-evoked nystagmus and left periocular pain were noted, together with incoercive vomiting that did not resolve despite a strict diet and prescribed metoclopramide and pantoprazole. A contrast-enhanced MRI of the brain showed a tumour mass centred in the fourth ventricle. Based on the above, a suboccipital craniectomy was performed with subtotal excision of the tumour and anatomopathological diagnosis of group A posterior fossa ependymoma. The interruption of pregnancy was proposed and accepted by the patient to complete the adjuvant treatment with radiotherapy. The surgical intervention left her with significant neurological sequelae that merited rehabilitation. CONCLUSIONS: The time of diagnosis is crucial in the management of intracranial tumours, especially if they are malignant, as a balance must be struck between the health of the mother and the viability of the pregnancy. As these are patients with a complex condition, their medical care must be multidisciplinary in order to reduce the risks to the mother and foetus.

Efectividad de la profilaxis antiemética en el posoperatorio de pacientes operados por cirugía de mínimo acceso

Anestesia, náuseas y vómitos postoperatorios van unidas prácticamente desde que la anestesia general se introdujo en la práctica clínica quirúrgica, y todavía en la actualidad sigue presentando una incidencia inaceptablemente alta. Con el objetivo de evaluarla efectividad de la medicación preanestésica antiemética con ondansetrón en comparación con dexametasona, en la prevención de la aparición de náuseas y vómitos postoperatorios, se realizó un estudio prospectivo, cuasiexperimental, con grupo control no equivalente en pacientes operados por cirugía de mínimo acceso en el hospital provincial general "Carlos Manuel de Céspedes″ de Bayamo, entre septiembre 2017 hasta diciembre 2020, distribuidos aleatoriamente en dos grupos de 78 pacientes cada uno: el grupo I tratado con ondansetrón, y el grupo II tratado con dexametasona. Fueron utilizados el test del Xi-cuadrado (X2), y la prueba de diferencias de proporciones, con un valor de p = 0,05; los pacientes entre 40 a 49 años de edad, el sexo femenino, ASA II, sin antecedentes de náuseas y vómitos; y con estratificación de riesgo intermedio de nausea y vómitos, fueron más frecuente en el grupo al que se le administró dexametasona. En el grupo I, el mayor número de pacientes tuvo intensidad leve y un número reducido de pacientes requirieron rescate antiemético con dimenhidrinato. En el grupo II, el mayor número de pacientes reportó intensidad moderada seguida de fuerte, requiriendo rescate antiemético. Se concluyó que la administración de ondansetrón en monoterapia es más efectiva en la prevención de la aparición de náuseas y vómitos postoperatorios que la administración de dexametasona.

Postoperative anaesthesia, nausea and vomiting have been linked practically since general anaesthesia was introduced into clinical surgical practice, and still today it continues to have an unacceptably high incidence. With the objective of evaluating the effectiveness of preanesthetic antiemetic medication with ondansetron compared to dexamethasone, in the prevention of the appearance of postoperative nausea and vomiting, a prospective, quasi-experimental study was carried out with a control group not equivalent in patients operated by minimally accessible surgery in the general provincial hospital "Carlos Manuel de Céspedes" of Bayamo. between September 2017 to December 2020, randomly distributed into two groups of 78 patients each: group I treated with ondansetron, and group II treated with dexamethasone. The Xi-square test (X2) and the proportions differences test were used, with a value of p = 0.05; patients between 40 and 49 years of age, female, ASA II, with no history of nausea and vomiting; and with intermediate risk stratification of nausea and vomiting, were more frequent in the group administered dexamethasone. In group I, the largest number of patients had mild intensity and a small number of patients required antiemetic rescue with dimenhydrinate. In group II, the largest number of patients reported moderate intensity followed by strong intensity, requiring antiemetic rescue. It was concluded that ondansetron monotherapy is more effective in preventing postoperative nausea and vomiting than dexamethasone administration.

Anestesia pós-operatória, náuseas e vômitos têm sido associados praticamente desde que a anestesia geral foi introduzida na prática clínica cirúrgica, e ainda hoje continua a ter uma incidência inaceitavelmente alta. Como objetivo de avaliar a eficácia da medicação antiemética pré-anestésica com ondansetrona comparada à dexametasona na prevenção do aparecimento de náuseas e vômitos pós-operatórios, foi realizado um estudo prospectivo, quase experimental, com um grupo controle não equivalente em pacientes operados por cirurgia minimamente acessível no hospital geral provincial "Carlos Manuel de Céspedes" de Bayamo entre setembro de 2017 a dezembro de 2020, distribuídos aleatoriamente em dois grupos de 78 pacientes cada: grupo I tratado com ondansetron e grupo II tratado com dexametasona. Foram utilizados o teste do xi-quadrado (X2) e o teste de diferenças de proporções, com valor de p = 0,05; pacientes entre 40 e 49 anos, sexo feminino, ASA II, sem história de náuseas e vômitos; e com estratificação de risco intermediário para náuseas e vômitos, foram mais frequentes no grupo que recebeu dexametasona. No grupo I, o maior número de pacientes apresentou intensidade leve e um pequeno número de pacientes necessitou de resgate antiemético com dimenidrinato. No grupo II, o maior número de pacientes relatou intensidade moderada seguida de intensidade forte, necessitando de resgate antiemético. Concluiu-se que a monoterapia com ondansetrona é mais efetiva na prevenção de náuseas e vômitos pós-operatórios do que a administração de dexametasona.

Ambulatory surgery for strabism and its relationship with the different techniques / Cirugía ambulatoria del estrabismo y su relación con las diferentes técnicas

Objective: To assess the functionality and usefulness of ambulatory surgery in pediatric patients operated on for strabismus, as well as the incidence of postoperative complications or hospital admission. Material and methods: A descriptive observational retrospective study was carried out with 92 patients operated on at a tertiary hospital between January 2017 and December 2018. Results: Most patients were ASA I. A laryngeal mask was used in 69.6 % of patients with a prevalence of use of sevoflurane (in 94.6 % of patients) and muscle relaxant (rocuronium in 96.7 % of patients). From the point of view of strabismus surgery, 72.8 % of patients presented with horizontal strabismus, and were esotropias. Most of them with 2 muscles intervened and undergoing surgery for the first time. 21.7 % of patients, presented with other types of strabismus such as IV nerve palsy, Duane or Brown Syndrome. With regard to the results, the admission rate was 4.3 %. In the immediate postoperative period in the Postanesthesic Care Unit (PACU), they did not present with pain and only 6.5 % of the patients suffered Postoperative nausea or vomiting (PONV). Regarding the presence of complications (pain, significant discomfort, tearing, difficulty opening the eyes…), in the ophthalmology consultation on the first postoperative day, they were noted in 2.2 % of the patients. Conclusion: Uniformity criteria such as handling by the same surgeon and the same anesthetic protocol have been essential. Regarding the results, we observed that the number of surgeries performed, the type of strabismus and certain techniques such as Faden, had an effect on the presence of pain. In our study, the low complication rate and low admission rate confirm the success of the ambulatory surgery for this type of surgery (AU)

Objetivo: Evaluar el funcionamiento y utilidad de la cirugía mayor ambulatoria (CMA) en pacientes pediátricos intervenidos de estrabismo, así como la incidencia de complicaciones postoperatorias o ingreso hospitalario. Material y métodos: Se ha realizado un estudio retrospectivo observacional descriptivo, con 92 pacientes intervenidos en el Hospital Álvaro Cunqueiro de Vigo; entre enero de 2017 y diciembre de 2018. Resultados: La mayor parte de los pacientes eran ASA I. Se utilizó mascarilla laríngea en el 69,6 % con prevalencia de empleo de sevoflurano (94,6 %) y relajante muscular (rocuronio en un 96,7 %) Desde el punto de vista de la cirugía estrabológica, el 72,8 % de los pacientes presentaron estrabismo horizontal, tratándose en su mayoría de una primera intervención, endotropias y afectación de hasta dos músculos. El 21,7 % de los pacientes presentaron otros tipos de estrabismo como: paresia IV, síndrome de Duane o Brown, etc. En cuanto a los resultados, la tasa de ingresos fue de un 4,3 %. En el postoperatorio inmediato en la CMA, no presentaron dolor y solo el 6,5% de los pacientes presentaros náuseas o vómitos. En cuanto a la presencia de complicaciones, en la consulta oftalmológica en el primer día postoperatorio (dolor, molestias importantes, lagrimeo, dificultad apertura ocular, etc.), fueron recogidas en un 2,2 % de los pacientes. Conclusión: Han resultado esenciales unos criterios de uniformidad como el manejo por el mismo cirujano y un mismo protocolo anestésico. En cuanto a los resultados, observamos influencia en la presencia de dolor según el número de intervenciones, tipo de estrabismo o técnicas (como Faden). En nuestro estudio, la baja tasa de complicaciones y baja tasa de ingreso confirman el éxito de la CMA para este tipo de intervenciones (AU)

Cannabis medicinal y cáncer: beneficios en dolor oncológico y otros síntomas relacionados / Medical cannabis and cancer: benefits for cancer pain and other related symptoms

El cannabis tiene el potencial de modular algunos de los síntomas más prevalentes en el cáncer, ya sean derivados del propio tumor o de los tratamientos antitumorales. Sin embargo, la escasez de evidencia científica sobre su eficacia y el estigma histórico ocasiona un problema para que los profesionales médicos puedan elegirlo como una opción terapéutica para sus pacientes. Esta revisión refleja la influencia del cannabis medicinal en los síntomas más prevalentes y debilitantes en cáncer, incluyendo el dolor, las náuseas y los vómitos inducidos por quimioterapia, la neuropatía periférica inducida por quimioterapia, y la anorexia y la pérdida de apetito. Asimismo, se repasa la evidencia actual del cannabis como agente anticanceroso.(AU)

Cannabis has the potential to modulate some of the most common symptoms of cancer, either from the tumour itself or from its treatments. However, the paucity of scientific evidence for its effectiveness and the historical stigma causes a problem to clinicians for choosing it as a therapeutic option for their patients. This review reflects the influence of medical cannabis on the most common and debilitating symptoms in cancer, including pain, chemotherapy-induced nausea and vomiting, chemotherapy-induced peripheral neuropathy, and anorexia and loss of appetite. Additionaly we do a review of the medical cannabis as an anticancer agent.(AU)

Características clínicas y epidemiológicas de la estenosis hipertrófica del píloro en un hospital de Lima, Perú / Clinical and epidemiological characteristics of hypertrophic pyloric stenosis in a hospital in Lima, Perú

RESUMEN Objetivo: Determinar las características clínicas y epidemiológicas de la estenosis hipertrófica de píloro en un hospital de Lima, Perú. Materiales y métodos: Se realizó un estudio descriptivo, retrospectivo correspondiente a los años 2013 al 2019, en el servicio de Cirugía Pediátrica del Hospital Docente Madre Niño "San Bartolomé". Se recolectaron datos de las historias clínicas con diagnóstico de estenosis hipertrófica de píloro. Resultados: Participaron un total de 59 pacientes, de los cuales 79,7 % fueron varones, 68,4 % primogénitos, con una media de edad de 31.3 +/- 13.6 días de nacido. 100 % presentó vómitos, 44,1 % reptación abdominal y solo 35,6 % presentó oliva pilórica palpable. Tiempo quirúrgico promedio 51.39 minutos, estancia hospitalaria promedio de 6.35, se presentó complicaciones mayores en un 13,6 %, con una mortalidad de 3,4 %. Conclusiones: Es importante el inicio precoz de la vía oral, así como el manejo postquirúrgico en estos pacientes para disminuir su estancia hospitalaria y el desarrollo de complicaciones ventilatorias posquirúrgicas.

ABSTRACT Objective: To determine clinical and epidemiological characteristics of hypertrophic pyloric stenosis in a hospital in Lima, Peru. Materials and Methods: A descriptive and retrospective study encompassing years 2013 to 2019 was performed in the Pediatric Surgery Service of San Bartolome Teaching Mother and Child Hospital. Data from clinical records of patients diagnosed with hypertrophic pyloric stenosis was collected. Results: Records from fifty-nine patients were obtained, 79% were male, 68.4% were first born, and their mean age was 31.3 ± 13.6 days. All patients (100 %) had vomit, 44.1% had abnormal abdominal movement, and only 35.6% had palpable pyloric olive. The average surgical correction time was 51.39 minutes, and the average hospital stay was 6.35 days, major complications occurred in 13.6% of all children, and the mortality rate was 3.4%. Conclusions: Early initiation of oral intake is important, as well as post-surgical management in these patients, in order to reduce their in-hospital stay and the development of post-surgical ventilatory complications.

Dexametasona vs Metoclopramida para la prevención de náuseas y vómitos postoperatorios. Hospital Municipal Boliviano Holandés, 2017 - 2018 / Dexametasone versus Metoclopramide for the prevention of postoperative nausea and vomiting. The "Municipal Boliviano Holandés" Hospital, 2017- 2018

El objetivo del estudio es determinar la eficacia de la Dexametasona frente a la Metoclopramida en la prevención de náuseas y vómitos posoperatorios en pacientes sometidos a procedimiento quirúrgico bajo anestesia general. Se realizó un estudio descriptivo, comparativo, observacional. Se estudiaron pacientes adultos entre 18 y 60 años de edad, los cuales se dividieron en dos grupos. Grupo A se les administro Dexametasona 8 mg IV y a otro grupo B Metoclopramida 10 mg IV, posterior a la inducción anestésica. Ambos grupos fueron comparables en cuanto a sus características según los resultados se evidencia que en el grupo A de la Dexametasona se presentó menos náuseas y vómitos postoperatorios. Después de realizar el estudio se concluye que con la dexametasona existe menos incidencia de náuseas y vómitos con la dosis administrada, por lo tanto, este medicamento es eficaz para el manejo de este tipo de pacientes a comparación de la metoclopramida.

The objective of this study is to determine the efficacy of Dexamethasone versus Metoclopramide in the prevention of postoperative nausea and vomiting in patients undergoing a surgical procedure under general anesthesia. A descriptive, comparative, observational study was carried out. Adult patients between 18 and 60 years of age were studied, who were divided into two groups. Group A received Dexamethasone 8 mg IV and another group B Metoclopramide 10 mg IV, after anesthetic induction. Both groups were comparable in terms of their characteristics. It is evidenced that in group A dexamethasone there was less postoperative nausea and vomiting. Conducting the study, it is concluded that with dexamethasone there is less incidence of nausea and vomiting with the administered dose, so it is concluded that it is effective for the management of this type of patients compared to metoclopramide.

Effects of auriculotherapy in the treatment of nausea and vomiting: a systematic review / Efectos de la auriculoterapia en el tratamiento de las náuseas y los vómitos: una revisión sistemática / Efeitos da auriculoterapia no tratamento de náuseas e vômitos: revisão sistemática

ABSTRACT Objectives: to identify the effectiveness of auriculotherapy in the treatment of nausea and vomiting through a systematic review of the scientific literature. Methods: it was performed a systematic review of the literature making use of the following data basis: The Scopus, PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Web of Science, LILACS and Cochrane databases were used. Articles from complete research from randomized controlled clinical trials that describe using auriculotherapy in nausea and vomiting treatment were selected, without restriction of date or language. Results: eleven articles were selected for analysis. The majority approached the population in surgical situations, followed by patients undergoing chemotherapy and pregnant women. As for results, 81% (n=8) of the articles reported that nausea and vomiting were lower in incidence and/or intensity in the intervention group. Conclusions: the review provided relevant data on the effects of auriculotherapy in nausea and vomiting treatment, with a decrease in the intensity and frequency of these symptoms in different populations.

RESUMEN Objetivos: identificar la efectividad de la auriculoterapia en el tratamiento de náuseas y vómitos mediante una revisión sistemática de la literatura científica. Métodos: se realizó una revisión sistemática de la literatura en las bases de datos Scopus, PubMed, CINAHL, Web of Science, LILACS y Cochrane. Se seleccionaron artículos de investigación completa de ensayos clínicos controlados aleatorios que describen el uso de la auriculoterapia en el tratamiento de náuseas y vómitos, sin restricción de fecha o idioma. Resultados: se seleccionaron 11 artículos para su análisis. La mayoría se acercó a la población en situaciones quirúrgicas, seguida de pacientes en quimioterapia y embarazadas. En cuanto a los resultados, el 81% (n=8) de los artículos informaron que las náuseas y los vómitos fueron de menor incidencia y/o intensidad en el grupo de intervención. Conclusiones: la revisión aportó datos relevantes sobre los efectos de la auriculoterapia en el tratamiento de las náuseas y los vómitos, con disminución de la intensidad y frecuencia de estos síntomas en diferentes poblaciones.

RESUMO Objetivos: identificar a eficácia da auriculoterapia no tratamento de náuseas e vômitos através de uma revisão sistemática da literatura científica. Métodos: foi realizada uma revisão sistemática da literatura nas bases de dados Scopus, PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Web of Science, LILACS e Cochrane. Foram selecionados artigos de pesquisas completas de ensaios clínicos randomizados controlados e que descrevem o uso da auriculoterapia no tratamento de náuseas e vômitos, sem restrição de data ou idioma. Resultados: foram selecionados 11 artigos para análise. A maioria abordou população em situações cirúrgicas, seguidos de pacientes em quimioterapia e gestantes. Quanto aos resultados, 81% (n=8) dos artigos reportaram que náuseas e vômitos foram menores em incidência e/ou intensidade no grupo intervenção. Conclusão: a revisão forneceu dados relevantes sobre os efeitos da auriculoterapia no tratamento de náuseas e vômitos, apresentando diminuição de intensidade e frequência desses sintomas em diferentes populações.

Evaluation of patient quality care in Spain in prevention of nausea and vomiting induced by chemotherapy.

OBJECTIVE: To characterise current management of chemotherapy-induced nausea and vomiting in Spain, as well as professional adherence to antiemetic guidelines. MATERIALS AND METHODS: Retrospective observational study. A multicenter has been designed including 360 patient case files from 18 hospitals. The involvement of pharmacists and nurses was studied, and also indicators of structure, process, and selected outcomes previously recruited from antiemetic guidelines. RESULTS: We found 94.4% of hospitals used a written protocol for managing chemotherapy-induced nausea and vomiting and only 44.4% had educational programs for patients regarding this. Patients were prescribed antiemetic prophylactic treatment for delayed emesis in varying degree between highly and moderately emetogenic chemotherapy (77.8% and 58.9%, respectively). Dexamethasone was the most prescribed antiemetic drug for patients receiving highly and moderately emetogenic chemotherapy (98.3% and 90%, respectively), followed by ondansetron (68.9% and 95%, respectively). Nursing was more involved than pharmacy units in evaluating emetic risk factors in patients (64.7% vs 21.4%), and tracking symptom onset (88.2% vs 57.1%) and adherence to treatment (94.1% vs 28.6%). Pharmacy units were more involved than nursing in choosing the antiemetic treatment (78.6% vs 47%). CONCLUSIONS: Although antiemetic guidelines were used by all hospitals, there were differences in management of chemotherapy-induced nausea and vomiting. Increased education directed towards patients and oncology professionals is needed to improve adherence.

Amisulprida una nueva profilaxis contra las náuseas y vómitos postoperatorios: una revisión de la literatura / Amisulpride new prophylaxis against postoperative nausea and vomiting: a review of the literature

Introducción: las náuseas y vómitos postoperatorios (PONV) son una complicación postoperatoria común de la anestesia, por lo que la búsqueda de nuevas profilaxis efectivas ha aumentado durante los últimos años, en este contexto se perfila como una opción efectiva el amisulprida, antipsicótico que actúa bloqueando los receptores dopaminérgicos D2 y D3, en dosis bajas. Métodos: se realizó una búsqueda en bases de datos establecidas como: Pubmed, Embase, Google Scholar, Medline y la Cochrane central registed of controlled trials. Con las siguientes definiciones clave: "NV" or "postoperative nausea and vomiting" or "postoperative nausea" or "postoperative vomiting" and "Amisulpride" or "APD421", con el fin de cumplir el objetivo general de verificar la efectividad de amisulprida como medicamento profiláctico en manejo de PONV. Resultados: se evaluaron 3 estudios multicéntricos randomizados controlados, con alto grado de confiabilidad y buena calidad metodológica. Se evidencia que el amisulprida es un medicamento profiláctico efectivo contra PONV y con buen perfil de seguridad. Discusión/Conclusión: el amisulprida es un medicamento profiláctico eficaz para prevención de PONV, en dosis óptima de 5 mg, administrado durante el intraoperatorio de cirugías electivas en que se utilice anestesia general en pacientes de moderado a alto riesgo de PONV según escala de Apfel.

Introduction: postoperative nausea and vomiting (PONV) are common postoperative complications of anaesthesia, that is why the search for new effective prophylaxis has increased in recent years. Between the drugs that have been tested for this purpose, Amisulpride, an antipsychotic that blocks D2 and D3 dopaminergic receptors, seems to be an effective option when used in low doses. Methods: This search was done by using databases such as Pubmed, Embase, Google Scholar, Medline and the Cochrane central register of controlled. With the following keywords: "NV" or "postoperative nausea and vomiting" or "postoperative nausea" or "postoperative vomiting" and"Amisulpride" or "APD421", with the purpose of verifying the effectiveness of Amisulpride as prophylactic medication in PONV man-agement, which is our main objective. Results: 3 randomised, controlled, multicenter, with high reliability and good methodological quality studies were evaluated. Evidence suggests that Amisulpride is effective as a prophylactic medication against PONV, and it also has a good safety profile. Discussion/Conclusion: Amisulpride administered in an optimal dose of 5 mg during intraoperative elective surgeries that required general anaesthesia, showed to be effective in preventing PONV as a prophylactic drug in patients with moderate to high risk of PONV according to the Apfel scale.

Predictive Factors of Admission in Outpatient Laparoscopic Surgery. / Factores con valor predictivo de ingreso en cirugía laparoscópica ambulatoria.

INTRODUCTION: The aim of the study is to analyze the rate of no planificated hospitalization after ambulatory surgical procedures by laparoscopy, and identify associated risk factors to failure in the ambulatory manage of this patients. METHODS: A prospective observational study was performed during 18 months and included 297 patients treated with ambulatory laparoscopies performed at University Hospital La Fe of Valencia. The need for hospital admission, same day after surgery, was considered the main variable. Variables were recorded for preoperatives, intraoperatives o postoperatives factors. To identify risk factors and variables associated with complications, statistical analyses were calculated with logistic regression models. RESULTS: After laparoscopic surgery, the 8.1% of patients required hospitalization. This rate was significantly superior in gynecologic surgery, patients with previous surgery complications, superior ASA classified (II and III) and smokers. Likewise, patients with pneumoperitoneum time over 45minutes presented a higher hospitalization rate; also founded in patients with anesthetic or surgery complications (including conversion to laparotomy). At least, the rate of hospitalization was significantly superior in relation with postoperative nausea and vomiting (PONV). CONCLUSION: The rate of patients who need hospitalization after ambulatory laparoscopic surgery was 8.1%, of which 5.5% were general surgeries and 12.1% were gynecologic surgeries. The mots relationated factors with ambulatory manage failure, analyzed with multiple regression, were the appearance of surgery complications, the pneumoperitoneum time over 100minutes and the PONV.

Multidisciplinary Management of the Adverse Effects of Apremilast. / Manejo de los efectos adversos de apremilast desde un abordaje multidisciplinar.

We present a series of general and specific recommendations based on pathophysiologic considerations for managing the most common adverse effects of apremilast that lead to treatment discontinuation: diarrhea, nausea, and headache. The recommendations are based on a review of the literature and the experience of a multidisciplinary team of 14 experts including dermatologists, rheumatologists, neurologists, gastroenterologists, pharmacists, and nurses. We propose a series of simple algorithms that include clinical actions and suggestions for pharmacologic treatment. The adverse effects of apremilast can be managed from a multidisciplinary approach. The purpose of optimizing management is to bring clinical benefits to patients.

Utilidad del ondansetrón vs dexametasona como profilaxis antiemética posoperatoria durante la cirugía mayor ginecológica / Usefulness of ondansetron versus dexamethasone as postoperative antiemetic prophylaxis during major gynecologic surgery

Introducción: Las náuseas y vómitos posoperatorios son una secuela no deseada durante la etapa de recuperación anestésica. Objetivo: Evaluar la utilidad de la dexametasona en comparación con el ondansetrón para la prevención de las náuseas y vómitos posoperatorios después de procedimientos quirúrgicos ginecológicos mayores, bajo anestesia general orotraqueal. Método: Se realizó un estudio observacional analítico, prospectivo, en 84 pacientes mayores de 19 años, en el Hospital Clínico Quirúrgico Miguel Enríquez desde octubre de 2018 hasta septiembre de 2019, divididas de forma secuencial, en orden de llegada a la unidad quirúrgica, en dos grupos. Al grupo 1 se le administró dexametasona (4 mg endovenosa); al grupo 2 (4 mg de ondansetrón), 30 min antes de finalizar la cirugía. Resultados: Predominó de forma significativa el riesgo medio de náuseas y vómitos posoperatorios en los pacientes con edades comprendidas entre 41 y 50 años. Predominó la condición de excelente y buena (pgt;0,05) en cuanto a la efectividad del tratamiento profiláctico. La cefalea prevaleció de forma significativa en el grupo 2. La mayor parte de las pacientes no presentó eventos adversos. Conclusiones: El ondansetrón y la dexametasona son útiles para la profilaxis de las náuseas y vómitos posoperatorios en pacientes intervenidas de cirugía mayor ginecológica, bajo anestesia general orotraqueal por lo que se considera un tratamiento seguro, con eventos adversos leves y de fácil control(AU)

Introduction: Postoperative nausea and vomiting are an unwanted sequel during the anesthetic recovery stage. Objective: To evaluate the usefulness of dexamethasone compared with ondansetron for the prevention of postoperative nausea and vomiting after major gynecological surgical procedures, under general orotracheal anesthesia. Method: A prospective, analytical and observational study was carried out with 84 patients older than 19 years of age, at Miguel Enríquez Hospital Clinical-Surgical Hospital, from October 2018 to September 2019, divided sequentially, in order of arrival at the surgical unit, into two groups. The group 1 was administered dexamethasone (4 mg intravenously), and the group 2 was administered ondansetron (4 mg), 30 min before the end of the surgery. Results: The average risk of postoperative nausea and vomiting prevailed significantly among patients aged 41-50 years. Excellent and good conditions predominated (pgt;0.05) in terms of effectiveness of prophylactic treatment. Headache prevailed significantly in the group 2. Most of the patients did not present adverse events. Conclusions: Ondansetron and dexamethasone are useful for postoperative nausea and vomiting prophylaxis among patients who received major gynecological surgery, under general orotracheal anesthesia, a reason why it is considered a safe treatment, with mild adverse events and easy control(AU)

Effect of acupuncture on the prevention of nausea and vomiting after laparoscopic cholecystectomy: a randomized clinical trial / Efeitos da acupuntura para a prevenção de náuseas e vômitos após colecistectomia laparoscópica: estudo clínico randomizado

Abstract Background and objectives: Postoperative nausea and vomiting (PONV) is a common and undesirable complication observed after laparoscopic cholecystectomy (LC). We investigated the effects of auriculoacupuncture (AA) on the prevention of postoperative nausea and vomiting in the immediate postoperative period of uncomplicated laparoscopic cholecystectomy. Methods: Sixty-eight patients were randomly divided into two groups, auriculoacupuncture (n = 35) and control (n = 33), and then they were evaluated prospectively. The needle was placed before anaesthesia induction and remained for 20 minutes. Nausea intensity was evaluated using an analogic visual scale and PONV events were registered immediately after anaesthesia care unit admission and in the second, fourth and sixth hours after the surgery. Results: The auriculoacupuncture group had a significantly smaller incidence of nausea and vomiting than the control group throughout the whole postoperative period (16/35 vs. 27/33, p= 0.03 and 4/35 vs. 15/33, p= 0.005, respectively); the AA group had fewer nausea events 2 h (p= 0.03) and 6 h (p= 0.001) after surgery and fewer vomiting events 2 h (p= 0.01) and 6 h (p= 0.02) after surgery. Conclusions: Auriculoacupuncture can partially prevent postoperative nausea and vomiting when compared to metoclopramide alone after uncomplicated laparoscopic cholecystectomy. Auriculoacupuncture can be recommended as an adjuvant therapy for postoperative nausea and vomiting prevention in selected patients.

Resumo Justificativa e objetivos: Náuseas e vômitos são complicações comuns e indesejáveis no pós-operatório de colecistectomia laparoscópica (CL). Nós investigamos os efeitos da auriculoacupuntura (AA) para a prevenção de náuseas e vômitos no período pós-operatório (NVPO) imediato da CL não complicada. Métodos: 68 pacientes foram aleatoriamente divididos em dois grupos, auriculoacupuntura (n = 35) e controle (n = 33), e foram avaliados prospectivamente. A agulha foi aplicada antes da indução anestésica e permaneceu no lugar por 20 minutos. A intensidade da náusea foi avaliada mediante escala visual analógica e episódios de NVPO foram registrados imediatamente após a admissão na unidade de recuperação anestésica e duas, quatro e seis horas após a cirurgia. Resultados: O grupo AA apresentou significativamente menos episódios de NVPO do que o grupo controle durante todo o período pós-operatório (16/35 vs. 27/33, p = 0,03 e 4/35 vs. 15/33, p = 0,005, respectivamente). O grupo auriculoacupuntura apresentou episódios de náuseas menos intensos às 2 horas (p = 0,03) e 6 horas (p = 0,001) após a cirurgia e menos episódios de vômitos 2 horas (p = 0,01) e 6 horas (p = 0,02) após a cirurgia. Conclusão: A auriculoacupuntura aliviou náuseas e vômitos no pós-operatório em número significante de pacientes, mas não foi capaz de prevenir náuseas e vômitos no pós-operatório em todos os pacientes. Ela pode ser recomendada como terapia adjuvante para prevenção de náuseas e vômitos no pós-operatório no pós-operatório de colecistectomia laparoscópica em pacientes selecionados.

Risk factors for post-caesarean nausea and vomiting: a prospective prognostic study / Fatores de risco para náusea e vômitos após cesariana: estudo prognóstico prospectivo

Abstract Background: Postoperative Nausea and Vomiting (PONV) risk factors have not been defined for obstetric patients. In this study, our objective was to identify potential risk factors for PONV after cesarean sections performed under spinal anesthesia. Methods: One cohort of patients submitted to cesarean under spinal anesthesia was used to investigate potential risk factors for PONV. The best numerical risk factors were dichotomized using chi-squared method. A conditional independence (incremental association method) casual network was used to select the best predictors for PONV. Results: Two hundred and fifty of 260 patients remained in the study. Odds ratio for PONV of younger maternal age (< 25 years: 2.9 [1.49−5.96]), lower spinal bupivacaine dose (< 13 mg, inf [2.4-inf]), lower spinal morphine dose (< 80 mg, 0.03 [0−0.97]), history of motion sickness (2.5 [1.27−5.25]), significant nausea during the first trimester (0.3 [0.16−0.64]), intraoperative nausea and vomiting (8.2 [3.67−20.47]), and lower gestational age (< 38 weeks, 2.0 [1.01−4.08]) were statistically significant. The causal network selected absence of significant nausea during the first gestational trimester, intraoperative nausea, and gestational age < 38 weeks as the main direct risk factors for PONV. Conclusions: Intraoperative nausea and maternal age < 25 years were the main risk factors for PONV after cesareans under spinal anesthesia. Absence of self-reported nausea during the first trimester was a protective factor for post-cesarean nausea and vomiting.

Resumo Introdução: Os fatores de risco para náusea e vômitos pós-operatórios (NVPO) ainda não foram definidos para pacientes de obstetrícia. Neste estudo, nosso objetivo foi identificar potenciais fatores de risco para NVPO após parto cesariano realizado sob raquianestesia. Método: Uma coorte de pacientes submetidas a cesariana sob raquianestesia foi usada para investigar potenciais fatores de risco para NVPO. Os melhores fatores de risco numéricos foram dicotomizados por meio do método qui-quadrado. Uma rede casual de independência condicional (método de associação adicional) foi usada para selecionar os melhores preditores de NVPO. Resultados: Das 260 pacientes iniciais, 250 completaram o estudo. A razão de chances para NVPO foi estatisticamente significante para menor idade materna (< 25 anos: 2,9 [1,49−5,96]), dose mais baixa de bupivacaina raquidiana (< 13 mg, inf [2,4-inf]), dose mais baixa de morfina raquidiana (< 80 mg, 0,03 [0−0,97]), histórico de enjoo de movimento (2,5 [1,27−5,25]), náuseas importantes durante o primeiro trimestre (0,3 [0,16−0,64]), náusea e vômitos intraoperatórios (8,2 [3,67−20,47]) e menor idade gestacional (< 38 semanas, 2,0 [1,01−4,08]). A rede causal selecionou ausência de náuseas significativas durante o primeiro trimestre gestacional, náusea intraoperatória e idade gestacional < 38 semanas como os principais fatores de risco diretos para NVPO. Conclusões: Náusea intraoperatória e idade materna < 25 anos foram os principais fatores de risco para NVPO após cesariana sob raquianestesia. A ausência de náusea autorreferida durante o primeiro trimestre foi um fator protetor para náusea e vômitos após cesariana.

[Effect of acupuncture on the prevention of nausea and vomiting after laparoscopic cholecystectomy: a randomized clinical trial]. / Efeitos da acupuntura para a prevenção de náuseas e vômitos após colecistectomia laparoscópica: estudo clínico randomizado.

BACKGROUND AND OBJECTIVES: Postoperative nausea and vomiting (PONV) is a common and undesirable complication observed after laparoscopic cholecystectomy (LC). We investigated the effects of auriculoacupuncture (AA) on the prevention of postoperative nausea and vomiting in the immediate postoperative period of uncomplicated laparoscopic cholecystectomy. METHODS: Sixty-eight patients were randomly divided into two groups, auriculoacupuncture (n = 35) and control (n = 33) and then they were evaluated prospectively. The needle was placed before anaesthesia induction and remained for 20 minutes. Nausea intensity was evaluated using an analogic visual scale and PONV events were registered immediately after anaesthesia care unit admission and in the second, fourth and sixth hours after the surgery. RESULTS: The auriculoacupuncture group had a significantly smaller incidence of nausea and vomiting than the control group throughout the whole postoperative period (16/35 vs. 27/33, p = 0.03 and 4/35 vs. 15/33, p = 0.005, respectively); the AA group had fewer nausea events 2hours (p = 0.03) and 6hours (p = 0.001) after surgery and fewer vomiting events 2hours (p = 0.01) and 6hours (p = 0.02) after surgery. CONCLUSIONS: Auriculoacupuncture can partially prevent postoperative nausea and vomiting when compared to metoclopramide alone after uncomplicated laparoscopic cholecystectomy. Auriculoacupuncture can be recommended as an adjuvant therapy for postoperative nausea and vomiting prevention in selected patients.

[Risk factors for post-caesarean nausea and vomiting: a prospective prognostic study]. / Fatores de risco para náusea e vômitos após cesariana: estudo prognóstico prospectivo.

BACKGROUND: Postoperative Nausea and Vomiting (PONV) risk factors have not been defined for obstetric patients. In this study, our objective was to identify potential risk factors for PONV after cesarean sections performed under spinal anesthesia. METHODS: One cohort of patients submitted to cesarean under spinal anesthesia was used to investigate potential risk factors for PONV. The best numerical risk factors were dichotomized using chi-squared method. A conditional independence (incremental association method) casual network was used to select the best predictors for PONV. RESULTS: Two hundred and fifty of 260 patients remained in the study. Odds ratio for PONV of younger maternal age (< 25 years: 2.9 [1.49-5.96]), lower spinal bupivacaine dose (< 13 mg, inf [2.4-inf]), lower spinal morphine dose (< 80 mg, 0.03 [0-0.97]), history of motion sickness (2.5 [1.27-5.25]), significant nausea during the first trimester (0.3 [0.16-0.64]), intraoperative nausea and vomiting (8.2 [3.67-20.47]), and lower gestational age (< 38 weeks, 2.0 [1.01-4.08]) were statistically significant. The causal network selected absence of significant nausea during the first gestational trimester, intraoperative nausea, and gestational age < 38 weeks as the main direct risk factors for PONV. CONCLUSIONS: Intraoperative nausea and maternal age < 25 years were the main risk factors for PONV after cesareans under spinal anesthesia. Absence of self-reported nausea during the first trimester was a protective factor for post-cesarean nausea and vomiting.