Organized hematoma of the sphenoid sinus with epistaxis.

Few reports have been made on organized hematoma (OH) originating in the sphenoid sinus. We report the case of a 24-year-old man who presented to the hospital with consistent epistaxis for 1 month. Preoperative computed tomography and magnetic resonance imaging (MRI) detected an expansive heterogeneous mass with minimal bone destruction and hypointense peripheral rim in T2-weighted images of the left sphenoid sinus as a solitary lesion. An OH was suspected first based on the history of repeated epistaxis and characteristic imaging findings, although quite rare. Preoperative vascular embolism was not performed because its effects on the ocular artery should be considered. With endoscopic sinus surgery under hypotensive anesthesia, the mass was carefully and successfully removed without bleeding and diagnosed as OH based on postoperative pathological examination. When solitary lesions are found in the sphenoid sinus with epistaxis, this disease should be differentiated. If it increases, complications, such as visual impairment, frequently occur, and control of intraoperative bleeding is sometimes difficult. Not only missing the characteristic imaging findings, especially MRI with contrast administration but also evaluating the anatomical relationship between OH and other important organs is important for a successful intervention of sphenoid sinus OH.

Tumores de nariz y senos paranasales en pacientes pediátricos: experiencia de un hospital pediátrico de cuarto nivel en Bogotá, Colombia, 2013-2018 / Nasal and Paranasal Sinus Tumours in the Pediatric Population: Experience from a Pediatric Hospital in Bogotá, Colombia, 2013 ­ 2018

Introducción: los tumores en la cavidad nasal y los senos paranasales son un problema serio en la población pediátrica, principalmente por la inespecificidad de los síntomas que lleva a que pasen de meses a años antes de la sospecha de una patología neoplásica, con un impacto en la calidad de vida del paciente y su entorno. Al sospechar de la presencia de un tumor nasosinusal se requiere la realización de imágenes diagnósticas como la resonancia magnética y la tomografía computarizada de los senos paranasales. Cuando se tiene un diagnóstico etiológico, siempre se debe realizar un abordaje multidisciplinario. Materiales y métodos: realizamos un estudio retrospectivo de corte transversal de la cohorte de pacientes con tumores de nariz y senos paranasales atendidos en un hospital pediátrico de cuarto nivel en Bogotá, Colombia, entre 2013-2018. Resultados: se incluyeron un total de 54 pacientes con tumores malignos y benignos de nariz y senos paranasales, la mayoría fueron hombres con un promedio de edad de ocho años. Generalmente se presentaron con síntomas nasosinusales, el principal fue obstrucción nasal en el 80 % de los pacientes. El diagnóstico mas común fue craneofaringioma en un tercio de los pacientes, seguido por angiofibroma nasofaríngeo y linfoma de Burkitt. Conclusión: es importante conocer los síntomas y características clínicas de los pacientes pediátricos con tumores nasofaríngeos. Por esta razón, se considera importante presentar la casuística y características de los tumores de nariz y senos paranasales recogida durante 5 años, en un hospital pediátrico de cuarto nivel en la ciudad de Bogotá, Colombia

Introduction: Tumors in the nasal cavity and paranasal sinuses in children is a serious problem in the pediatric population, mainly due to the non-specificity of the symptoms that leads to years or months passing before the suspicion of a neoplastic pathology. With an important impact in quality of life not only in the patient but also in its family environment. When suspecting a sinonasal tumor, diagnostic images such as magnetic resonance and computed tomography of the paranasal sinuses are required. When you have an etiological diagnosis always do a multidisciplinary approach. Methods: We conducted a cross-sectional study of the cohort of patients that had been diagnose with tumors of the nasal cavity or paranasal sinuses in a fourth level pediatric hospital in Bogota, Colombia between 2013 - 2018. Results: 54 patients were included, the majority of them were men, with an average age of eight years. They mainly presented with nasal symptoms, the main one being nasal obstruction in 80% of patients. The most common diagnosis was cranipharyngioma in one third of the patients, followed by nasopharyngeal angiofibroma and Burkitt lymphoma. Conclusion: We present this article with the objective of presenting the tumors of nose and paranasal sinuses casuistry collected during 5 years in a fourth level pediatric hospital in the city of Bogotá and the imaging characteristics for the diagnosis of these are reviewed with some clinical cases as examples.

Sinonasal mucosal melanoma: a 10-year experience of 36 cases in China.

BACKGROUND: Sinonasal mucosal melanoma (SNMM) is a rare tumor with a poor prognosis. This study aimed to assess the clinical and imaging features, progression, treatment, and possible prognostic factors of SNMM. METHODS: Thirty-six patients with SNMM were retrospectively reviewed in the Department of Otolaryngology & Head and Neck Surgery of Xinhua Hospital from January 2008 to December 2017. RESULTS: The age of the first diagnosis was 67.4±10.8 years; the most common clinical symptoms included epistaxis, nasal obstruction, headache, and facial pain. Most tumors originated in the nasal cavity (63.9%) and at stage IV (77.8%). Melanin in melanoma showed typical signal intensity on magnetic resonance imaging (MRI), T1WI had high signal while T2WI had low signal. 41.6% of patients had the typical MRI findings. Treatment included surgery, surgery with radiotherapy, and radiotherapy only. The follow-up time ranged from 4 to 96 months, with a median time of 22 months, 1-, 3-, and 5-year OS is 80.6%, 36.1%, and 13.9%, respectively. The 3-year OS was better in cases in the T3 stage than the T4 stage (P=0.02). However, tumors that originated from the paranasal sinus had a poorer prognosis than the nasal cavity (P=0.04). The cases receiving postoperative radiotherapy showed poorer prognosis (P=0.02). Other factors were not found to be associated with prognosis, including gender, age, lymph node metastasis, distant metastasis, computed tomography (CT) enhancement, and typical MRI findings. CONCLUSIONS: The SNMM was a devastating tumor with poor outcomes; most cases were diagnosed at late stages, which may account for poor prognosis. Tumors with melanin feature MRI findings do not have a better prognosis. The treatment of postoperative radiotherapy is still controversial.

Schwannoma on the nasal dorsum and tip with sensory changes.

Schwannomas, which originate from Schwann cells in the peripheral nervous system, are slowgrowing and uncommon benign tumors. Most schwannomas (90%) occur in isolation, and multiple occurrences are a characteristic feature of neurofibromas. Schwannomas of the nose and nasal tip are particularly unusual. Although a few cases of schwannomas of the sinusoidal tract and nasal septum have been reported, schwannomas arising from the nasal dorsum area and tip are extremely rare. Sensory abnormalities are also a very rare symptom. We excised a schwannoma on the nasal dorsum through direct incision and a schwannoma on the nasal tip through open rhinoplasty. No postoperative complications involving recurrence, hematoma, or infection occurred. The possibility of neurological changes should be considered in cases of an abnormality in the peripheral nervous system. Schwannoma must be kept in mind as a possible cause of neurological changes localized to a specific dermatome, and should always be considered in the differential diagnosis of a mass on the nose.

Recurrence patterns of sinonasal cancers after a 5-year disease-free period.

OBJECTIVES/HYPOTHESIS: Sinonasal cancers are rare but have a poor prognosis. Most previous studies of these cancers have focused on 5-year disease-free survival, but recurrences are also known to occur after this period. We examined the post-5-year recurrence patterns in sinonasal cancer patients by histologic type to determine the indicators for extended and close follow-up requirements. STUDY DESIGN: Retrospective chart review. METHODS: A cohort of 241 sinonasal cancer patients was included. Demographic data, cancer site and stage, pathology and treatment results, and follow-up and survival data were collected. RESULTS: Of the 241 patients, a complete remission occurred in 163 (72.4%) patients, but 83 (50.9%) of these cases developed recurrence, which occurred beyond the 5-year follow-up period in 19 cases (11.7%). The most common post-5-year recurrences were adenoid cystic carcinoma (six patients, 33.3%), followed by melanoma (three patients, 21.4%), poorly differentiated carcinoma (two patients, 18.2%), squamous cell carcinoma (six patients, 6.7%), and olfactory neuroblastoma (no patients, 0%). Post-5-year local recurrence was highest in adenoid cystic carcinoma (six patients, 33.3%), followed by melanoma (three patients, 21.4%), poorly differentiated carcinoma (two patients, 18.2%), and squamous cell carcinoma (five patients, 5.5%). Post-5-year regional recurrence occurred in one squamous carcinoma patient (1.1%), and distant metastasis was seen in one adenoid cystic carcinoma patient (5.5%). CONCLUSIONS: Sinonasal cancer shows an 11.7% recurrence rate after a 5-year disease-free period. As this recurrence pattern varies by tumor pathology, a specific follow-up plan is needed for each cancer type. LEVEL OF EVIDENCE: 3 Laryngoscope, 129:2451-2457, 2019.

A Case of Schwannoma Originated from the Posterior Nasal Septum / 대한이비인후과학회지

Schwannomas are slow-growing, benign neurogenic tumors arising from the sheath of myelinated nerve fibers. They usually occur in the head and neck region. Only 4% of schwannomas found in the head and neck region originate in the sinonasal tract. Schwannoma of the nasal septum is rarer, and only few cases have been previously reported in the literature. We experienced a rare case of the schwannoma of the posterior nasal septum in a 71-year-old woman. She was treated successfully by transnasal endoscopic surgery. No recurrence was detected within 18 months follow-up period.

[A case of extramedullary plasmacytoma of the nasal cavity].

A case of extramedullary plasmacytoma of the nasal cavity was reported and its mainly clinical manifestations were nasal obstruction, running nose and olfactory degeneration. Nasal endoscopy and paranasal sinus CT indicated tract tumor in left nasal (the nature to be investigated), the pathological result after surgical resection of the tumor suggests extramedullaryplasmacytoma (left nasal cavity).Clinical diagnosis was extramedullaryplasmacytoma (left nasal cavity), chronic sinusitis (left). Radiotherapy was continued after discharge and the follow-up was satisfactory.

Cranially-based nasolabial flaps for the reconstruction of nasal surgical defects.

BACKGROUND: Cranially-based nasolabial flaps are a good alternative for the reconstruction of nasal defects. METHODS: A cranially-based nasolabial flap was used in 18 patients to reconstruct defects of the nose from 2010 to 2016, and the long-term results are presented in this report. RESULTS: Fifteen of the flaps completely survived. All the patients had a bulky appearance, but they did not want to undergo a second operation for cosmesis. The dissection of the flap took approximately 20 minutes, and the total operation lasted for 1 hour. The patients were hospitalized for 1-7 days, and the postoperative follow-up period was 1-28 months (mean, 17 months). CONCLUSIONS: The cranially-based nasolabial flap possesses all the advantages of the traditional forehead flap, and can safely be used in selected cases.

Cranially-based nasolabial flaps for the reconstruction of nasal surgical defects

BACKGROUND: Cranially-based nasolabial flaps are a good alternative for the reconstruction of nasal defects. METHODS: A cranially-based nasolabial flap was used in 18 patients to reconstruct defects of the nose from 2010 to 2016, and the long-term results are presented in this report. RESULTS: Fifteen of the flaps completely survived. All the patients had a bulky appearance, but they did not want to undergo a second operation for cosmesis. The dissection of the flap took approximately 20 minutes, and the total operation lasted for 1 hour. The patients were hospitalized for 1–7 days, and the postoperative follow-up period was 1–28 months (mean, 17 months). CONCLUSIONS: The cranially-based nasolabial flap possesses all the advantages of the traditional forehead flap, and can safely be used in selected cases.

Ectopic Esthesioneuroblastoma of the Sphenoclivus: A Rare Entity.

Esthesioneuroblastoma is a rare malignant neoplasm of oflactory neuroepithelium and usually located at the olfactory cleft at superior nasal cavity. Ectopic localization of esthesioneuroblastoma is even rarer and usually posed with a diagnostic dilemma and delay in the diagnosis and management, We report a rare case of ectopic esthesioneuroblastoma of the sphenoclivus with the presentation of intermittent unilateral epistaxis, intermittent intractable headache without anosmia. Nasal endoscopy findings showed a pulsatile mass at the anterior face of the sphenoid sinus with extension posteriorly towards the clivus region and occupying the floor of the sphenoid sinus. Endonasal transclival endoscopic excision of tumour was performed which involved otorhinolaryngology surgeon and neurosurgeon with intraoperative navigation imaging and frozen section. The histopathological findings was esthesioneuroblastoma. Due to its rarity and unusual presentation, the diagnosis of ectopic esthesioneuroblastoma is difficult and can be misdiagnosed with the other type of malignancy. Therefore, the histopathological result is important in confirming the type of tumour and can lead to the next step of management.

[Prognosis analysis of multidisciplinary treatment on nasal mucosa malignant melanoma].

Objective:The aim of this study is to investigate the facters affecting prognosis of primary sinonasal mucosal malignant melanoma and analyze the optimal therapeutic strategies.Method:Among the 33 patients with sinonasal mucosal malignant melanoma,twenty-six patients received surgical treatment,nineteen patients accepted radiotherapy,and twenty-one patients had the biotherapy.The Kaplan-Meier and log-rank methods was used to assess the prognosis of different treatment.Result:the patient's 3-year-survival rate was 48.3% and 5-year-survival rate was 30.3%.Surgical treatment is the important factor for the 5-year-survival rate(P <0.05),while the chemotherapy and biotherapy had no effect on overall survival rate(P>0.05).Conclusion:The surgical treatment is the preferred method of treatment,and endoscopic surgery has the satisfactory effect.Adjuvant radiotherapy can improve local tumor control rates.Immunotherapy is the development direction of treatment for nasal mucosal malignant melanoma.

Clinical analysis of 29 cases of nasal mucosal malignant melanoma.

The present study aimed to investigate the clinical features of nasal mucosa malignant melanoma, including the histopathological features and factors affecting prognosis. A retrospective analysis of the clinical data obtained from the Department of Otolaryngology Head and Neck Surgery, Tianjin Huanhu Hospital (Tianjin, China) between October 1999 and June 2013 was performed using the Kaplan-Meier method. In total, 29 cases of nasal mucosal malignant melanoma were analyzed. The overall 3- and 5-year survival rates were 48.3 and 27.6%, respectively. The study group consisted of 18 males and 11 females, with a median age of 61.5 years. Overall, 19 patients underwent surgery, 28 received radiotherapy and 17 received chemotherapy. The American Joint Committee on Cancer staging system (AJCC) was used to retrospectively stage the tumors. In total, 8 were tumor stage (T)1, 10 were T2, 6 were T3 and 5 were T4. The results revealed that the T stage, surgical treatment, location of the tumor and the presence of black pigmentation affected the 5-year survival rate of the patients. By contrast, radiotherapy and chemotherapy had no effect on the overall survival rate. Overall, endoscopic or endoscopic-assisted surgery were the preferred methods of treatment, and histological features, including the presence of tumor melanin pigmentation, affected the prognosis of the patients. This study indicated that the AJCC staging system is able to effectively predict the prognosis of patients with nasal mucosa malignant melanoma.

The utility of routine polyp histopathology after endoscopic sinus surgery.

BACKGROUND: Routine histopathological assessment is standard practice for nasal polyp specimens obtained during endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS). Retrospective studies suggest that routine histopathology of nasal polyps shows few unexpected diagnoses that alter patient management. Our objective was to study the use of routine pathological analysis, and its cost to the healthcare system, in a prospective manner. METHODS: A multicenter prospective assessment was performed from data collected between 2007 and 2013. Only cases of patients undergoing ESS for bilateral CRS were included. We excluded unilateral disease cases, and cases in which diagnoses other than polyps were suspected either preoperatively or intraoperatively. We then compared the preoperative diagnosis with the final histopathology and identified the rate of unexpected pathologies. A cost analysis was performed. RESULTS: Only 4 of 866 pathological specimens were identified as having a clinically significant unexpected diagnosis. All unexpected pathologies in this series were benign. These 4 cases account for 0.46% of all specimens reviewed. This translates to a number needed to screen of 217 cases of bilateral CRS to discover 1 unexpected pathology. The associated cost for making an unexpected diagnosis was $19,192.73. CONCLUSION: Routine histopathology of nasal polyps in ESS for bilateral CRS with polyps yields few unexpected and management-altering diagnoses. It carries a significant cost to the healthcare system. In cases of bilateral CRS with no other concerning clinical features, clinicians should exercise judgment in submitting polyp specimens for pathology rather than routinely sending polyps for histopathologic analysis.

A Case of Chondro-Osseous Respiratory Epithelial Adenomatoid Hamartoma Originated from Nasal Cavity

Hamartoma is a non-malignant malformation or developmental anomaly of tissue development that may occur anywhere in the body but is rarely reported in the nasal cavity, paranasal sinuses, or nasopharynx. Chondro-osseous respiratory epithelial adenomatoid hamartoma (CO-REAH) of the nasal cavity is exceedingly rare, and can be confused both grossly and microscopically with more serious sinonasal tumors. We present the case of a 58-year-old man with a nasal cavity mass, which was removed by an endonasal approach. Radiographic and histological studies permitted a diagnosis of CO-REAH in this case.

A Case of Fibro-Osseous Hamartoma Originated from Nasal Cavity / 대한이비인후과학회지

Hamartoma occurs in all areas of the body, especially in the liver, spleen, kidney and lung. However, it was rarely reported in the nasal cavity, paranasal sinuses, or nasopharynx. The histopathological and clinical differential diagnosis of fibro-osseous hamartoma of the sinonasal tract includes ossifying fibroma, fibrous dysplasia and osteoma. We present the case of a 57-year-old man with nasal obstruction in right side, which was treated with complete resection by endoscopic approach. A combination of clinical, radiographic and histological information permitted a diagnosis of a benign fibro-osseous hamartoma in this case.

Nasal Chondromesenchymal Hamartoma: A Case Report

We report a case of nasal chondromesenchymal hamartoma. A 14-year-old boy presented with a 5 cm sized mass in the left maxillary sinus, facial swelling and a loose tooth. A subtotal left maxillectomy with a bone graft was performed. The excised mass was composed of partly encapsulated, solid and cystic fragments of soft tissues. The mass contained chondroid and myxoid areas consisting of mesenchymal tissues including hyaline cartilage, osteoid and spindle cells in various proportions. The hyaline cartilage component was the most prominent. The spindle cell component had a fibrous matrix with variable myxoid or sclerotic changes. Thick hyalinized eosinophilic osteoid-like trabeculae were focally present. Immunohistochemically, all the mesenchymal cells tested positive for vimentin. The chondrocytes tested positive for the S-100 protein, and the spindle cell component showed focal immunoreactivity for smooth muscle actin and desmin. However, the cells were negative to pan-cytokeratin and p63.

Reconstruction of Nasal Defects with Local Flap: Analysis of 7 Cases / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Reconstruction of the nasal defect caused by resection of nose neoplasm or trauma represents a particular challenge to reconstructive surgeons. Each tissue defect has to be evaluated individually in terms of the best possible substitution or alteration from both aesthetic and functional points of view. The method of reconstruction varies according to the location, size, and depth of the defect. Of various methods, local Rap is frequently used because the nasal contours are variable with convex and concave surfaces in close proximity, and there is little lax skin from which to borrow tissue for closure, and the skin of the nose has a texture and color not easily matched by skin elsewhere. Of various local flaps, transposition flap and forehead flap are most frequently used for reconstruction of the nasal defect. The authors carried out retrospectively a clinical study on seven cases of nasal reconstruction that used local flaps after resection of malignant tumors of the nose with a brief review of the literature. MATERIALS AND METHODS: A single surgeon's results in seven consecutive patients were clinically analyzed retrospectively. RESULTS: There were no significant complications. Good aesthetic and functional outcomes were observed with nasal defects reconstructed with the local flaps. CONCLUSION: Local flaps were the most useful choice for reconstructive rhinoplasty. Transposition flaps and forehead flaps, in particular, were particularly useful for each cosmetic unit of the nose.