[Morphological and functional assessment of the oral mucosa in children with dystrophic epidermolysis bullosa]. / Otsenka morfologicheskogo i funktsional'nogo sostoyaniya slizistoi obolochki rta u detei s distroficheskim bulleznym epidermolizom.

THE AIM OF THE STUDY: To validate modified oral index (MOI) for the assessment of the oral mucosa in children with dystrophic epidermolysis bullosa (DYB). MATERIALS AND METHOS: The study comprised 27 DYB children aged 4 to 18 years. Morphological component of MOI was documented by an intraoral camera with the registration of pathological elements in various of the oral cavity and differentiated scoring. Functional component included registration of ankyloglossia and microstomia measured by Bristol assessment system and orthodontic caliper, correspondingly, and then referred to normal age-matched values. RESULTS: Oral mucosa condition deteriorates in DYB children with age both in morphological and functional aspects. MOI values more than 40 should be seen as prognostically unfavorable as they are always associated with severe functional restrictions. These restrictions are always present in children older than 6. If present in younger age they may indicate poor functional status in future. CONCLUSION: The MOI may be a useful tool for the assessment of the efficacy of the pharmacological agents' impact on the oral mucosa and disease prognosis. Correlation of MOI and general condition of DYB children needs further investigation.

Generalidades, manejos, cuidados y manifestaciones clínicas del SARS-CoV-2 / Overview, management, care and clinical manifestations of SARS-CoV-2

Se mantienen los estudios para describir los síntomas clínicos del COVID 19, ya se encuentran documentados a nivel general o sistémico la fiebre, dificultad para respirar, tos seca, fatiga, diarrea y algunos otros menos comunes que se llegan a presentar. La sintomatología se presenta en diferentes etapas que van desde asintomáticas hasta severa y crítica. Con un periodo de incubación de hasta 14 días y con un promedio de seis días que es el momento más común de presencia de los signos y síntomas. Algunas de las manifestaciones orales presentes son: pérdida de la sensación del sabor (ageusia), ausencia del olfato, resequedad de la boca (AU)

Studies are ongoing to describe the clinical symptoms of COVID-19, and fever, shortness of breath, dry cough, fatigue, diarrea, and some other less common ones that have been reported are already documented at a general or systemic level. Symptomatology occurs at different stages ranging from asymptomatic to severe and critical. With an incubation period of up to fourteen days and with an average of six days, which is the most common moment of presence of signs and symptoms. Some of the oral manifestations present are: Loss of taste sensation (ageusia), absence of olfaction, dry mouth (AU)