Linha do tempo do "tratamento precoce" para Covid-19 no Brasil: desinformação e comunicação do Ministério da Saúde / Timeline of Covid-19 "early treatment" in Brazil: disinformation and communications from the Ministry of Health / Línea del tiempo del "tratamiento precoz" para Covid-19 en Brasil: desinformación y comunicación del Ministerio de la Salud

Em fevereiro de 2020, a Organização Mundial da Saúde alertou sobre a gravidade da epidemia de Covid-19 e enfatizou que as iniciativas relacionadas ao seu combate têm sido acompanhadas por uma infodemia. O Ministério da Saúde do Brasil publicou diretrizes em relação ao manejo da doença com o "tratamento precoce". O objetivo deste artigo foi construir uma linha do tempo visual de janeiro de 2020 até abril de 2021 por meio de pesquisa bibliográfica, documental e análise de conteúdo. Sistematizaram-se as principais notícias veiculadas no website do Ministério da Saúde sobre o "tratamento precoce", as evidências científicas sobre os medicamentos relacionados a este e os dados das mortes e fatos relacionados à doença que aconteceram no Brasil. A linha do tempo evidencia a insistência da promoção do "tratamento precoce", no contexto da desinfodemia, pelo Ministério da Saúde na existência de evidências contrárias a essa intervenção.(AU)

In February 2020, the World Health Organisation warned about the gravity of the Covid-19 epidemic, emphasizing that initiatives to combat the problem had been accompanied by an "infodemic". Brazil's ministry of health published guidelines on the management of the disease using "early treatment". The aim of this study was to create a visual timeline from January 2020 to April 2021 based on the review of relevant literature and documents examined using document analysis. We synthesized the main items of news on early treatment published on the Ministry of Health website, scientific evidence on the medications used, and facts related to the disease in Brazil. The timeline evidenced the insistent promotion of early treatment by the Ministry of Health within the context of a "disinfodemic" despite the existence of evidence against this type of intervention.(AU)

En febrero de 2020, la Organización Mundial de la Salud alertó sobre la gravedad de la epidemia de Covid-19 y enfatizó que las iniciativas relacionadas con su combate habían sido acompañadas por una infodemia. El Ministerio de la Salud de Brasil publicó directrices con relación al manejo de la enfermedad con el "tratamiento precoz". El objetivo de este artículo fue construir una línea del tiempo visual desde enero de 2020 hasta abril de 2021 por medio de una investigación bibliográfica, documental y análisis de contenido. Se sistematizaron las principales noticias publicadas en la página web del Ministerio de la Salud sobre el "tratamiento precoz", las evidencias científicas sobre estos medicamentos y los datos de las muertes y hechos relacionados a la enfermedad en Brasil. La línea de tiempo dejará clara la insistencia de la promoción del "tratamiento precoz", en el contexto de la desinfodemia, por parte del Ministerio de la Salud con la existencia de evidencias contrarias a esta intervención.(AU)

The criticism of medicine at the end of its "golden age".

Medicine is increasingly subject to various forms of criticism. This paper focuses on dominant forms of criticism and offers a better account of their normative character. It is argued that together, these forms of criticism are comprehensive, raising questions about both medical science and medical practice. Furthermore, it is shown that these forms of criticism mainly rely on standards of evaluation that are assumed to be internal to medicine and converge on a broader question about the aim of medicine. Further work making medicine's internal norms explicit and determining the aim of medicine would not only help to clarify to what extent the criticism is justified, but also assist an informed deliberation about the future of medicine. To illustrate some of the general difficulties associated with such a task, the paper concludes by critically engaging Edmund Pellegrino's account of the aim of medicine as well as the Hastings Center's consensus report.

Do we over-diagnose ADHD in North America? A critical review and clinical recommendations.

There has been a marked increase in the prevalence of attention-deficit/hyperactivity disorder (ADHD) in the last 25 years in North America. Some see this trend as positive and believe that it reflects a better identification of ADHD and even think that the disorder is still under-diagnosed. Others, however, contend that ADHD is over-diagnosed. To help mental health clinicians to maintain an informed and nuanced perspective on this debate, this critical review aims to (1) summarize empirical results on factors that might contribute to increase the number of ADHD diagnoses and (2) propose clinical recommendations coherent with these findings to improve clinical practices for ADHD assessment and treatment. We conclude that artifactual factors such as current formulation of diagnostic criteria, clinical practices, and inordinate focus on performance, which is rampant in North America, likely contribute to inflated prevalence rates.

State-level structural sexism and cesarean sections in the United States.

The United States (U.S.) has one of the highest cesarean rates in the world yet little research considers structural factors, like racism and sexism, associated with the higher than recommended cesarean rate. New research operationalizes and quantifies structural sexism across U.S. states, which allows for consideration of how social norms and values around women and their bodies relate to the overmedicalization of birth through cesarean sections. We obtained restricted natality data for 2018 from the U.S. National Center for Health Statistics. In 2018, among people 15-49 years, 987,187 births fit the criteria for low-risk of cesarean section. Structural sexism scores were derived from 6 elements covering economic, political, cultural, and physical arenas that were totaled and standardized to create an aggregate index for each state and DC (scores range from -1.06 to 1.4). Using multivariable logistic and multilevel mixed effects logistic regression models, we examined the associations between structural sexism and low-risk cesarean section for all fifty states and the District of Columbia, controlling for relevant confounders. We found that structural sexism in 2018 was highest in historically religious mountain states and the South. Nationally, the low-risk cesarean rate was 25.1%. Multilevel models show that people living in states with higher structural sexism scores were more likely to have a cesarean section (OR = 1.22, 95% CI: 1.07-1.39). Structural sexism is related to low-risk cesarean rates in U.S., providing evidence that social ideas and norms about women and their bodies are related to overmedicalization of birth. Health policymakers, providers and scholars should pay attention to structural drivers, including structural sexism, as a factor that affects overmedicalization of birth and subsequent health outcomes for pregnant people and their infants.

The French Society of Internal Medicine's Top-5 List of Recommendations: a National Web-Based Survey.

BACKGROUND: The international project "Choosing Wisely" aims to target unnecessary and potentially harmful examinations and treatments. OBJECTIVE: To define the French Internal Medicine Top-5 list. DESIGN: Based on a review of existing Top-5 lists and personal experience, a working group of the French National Society of Internal Medicine selected 27 diagnostic and therapeutic procedures. They were submitted through a national web-based survey to French internists who rated from 1 to 5 the perceived frequency, uselessness, and risk of each procedure. A composite score was calculated as the unweighted addition of the three scores. PARTICIPANTS: Four hundred thirty internists answered the web-based survey (14% of all French internists including residents). All the French regions and status of the profession were represented. KEY RESULTS: For the 27 submitted procedures, the mean score (± SD) was 3.25 (± 0.48) for frequency, 3.10 (± 0.43) for uselessness, and 2.63 (± 0.84) for risk. The Top-5 list obtained with the composite score was as follows: 1. Do not prescribe long-term treatment with proton pump inhibitors without regular reevaluation of the indication 2. Do not administer preventive treatments (e.g., for dyslipidemia, hypertension…) in elderly people with dementia when potential risks outweigh the benefits 3. Do not administer hypnotic medications as first-line treatment for insomnia 4. Do not treat with an anticoagulant for more than 3 months a patient with a first venous thromboembolism occurring in the setting of a major transient risk factor 5. Do not screen for Lyme disease without an exposure history or related clinical examination findings We found that the composite score was strongly correlated to the risk score (rs = 0.88, p < 10-5) and not to the frequency (rs = 0.06, p = 0.75) or uselessness score (rs = 0.17, p = 0.38). CONCLUSIONS: This Top-5 list provides an opportunity to discuss appropriate use of health care practices in internal medicine.

How to distinguish medicalization from over-medicalization?

Is medicalization always harmful? When does medicine overstep its proper boundaries? The aim of this article is to outline the pragmatic criteria for distinguishing between medicalization and over-medicalization. The consequences of considering a phenomenon to be a medical problem may take radically different forms depending on whether the problem in question is correctly or incorrectly perceived as a medical issue. Neither indiscriminate acceptance of medicalization of subsequent areas of human existence, nor criticizing new medicalization cases just because they are medicalization can be justified. The article: (i) identifies various consequences of both well-founded medicalization and over-medicalization; (ii) demonstrates that the issue of defining appropriate limits of medicine cannot be solved by creating an optimum model of health; (iii) proposes four guiding questions to help distinguish medicalization from over-medicalization. The article should foster a normative analysis of the phenomenon of medicalization and contribute to the bioethical reflection on the boundaries of medicine.

[How to avoid overmedicalization of the elderly patient ?] / Comment éviter la surmédicalisation du patient âgé ?

Over-medicalization is a broad concept, which also concerns the elderly patient. It encompasses both over-diagnosis and over-treatment. An increasing awareness of this issue has emerged since 2013, with the first " Preventing Overdiagnosis " conference. Currently, Evidence-Based Medicine does not prevent over-diagnosis. Indeed, the presence of geriatric characteristics such as multiple comorbidities, polypharmacy and frailty can lead to misdiagnosis and to potentially deleterious treatment. Subclinical hypothyroidism and Alzheimer's disease are two examples of pitfalls in the interpretation of biological and para-clinical data that may lead to the administration of useless treatment. Different issues are discussed to identify the causes of over-medicalization and to better prevent it.

La surmédicalisation est un concept large, qui concerne également le patient âgé. Elle englobe à la fois le surdiagnostic et sa conséquence à savoir le surtraitement. Une sensibilisation à ce sujet a émergé depuis 2013, date du premier congrès " Preventing Overdiagnosis ". Actuellement, l'Evidence-Based Medicine ne permet pas d'éviter le surdiagnostic chez le patient âgé. En effet, la présence de caracté- ristiques gériatriques telles que les multiples comorbidités, la polymédication et la fragilité peut mener à l'élaboration d'un diagnostic erroné et à l'instauration d'un traitement potentiellement délétère. L'hypothyroïdie subclinique et la maladie d'Alzheimer sont deux exemples de pièges potentiels à l'interprétation de données biologiques et paracliniques pouvant mener à l'administration d'un traitement futile. Différentes pistes sont abordées pour identifier les causes de la surmédicalisation et mieux la prévenir.

Is "chronic kidney disease" a disease?

Several philosophers of medicine have attempted to answer the question "what is disease?" In current clinical practice, an umbrella term "chronic kidney disease" (CKD) encompasses a wide range of kidney health states from commonly prevalent subclinical, asymptomatic disease to rare end-stage renal disease requiring transplant or dialysis to support life. Differences in severity are currently expressed using a "stage" system, whereby stage 1 is the least severe, and stage 5 the most. Early stage CKD in older patients is normal, of little concern, and does not require treatment. However, studies have shown that many patients find being informed of their CKD distressing, even in its early stages. Using existing analyses of disease in the philosophy literature, we argue that the most prevalent diagnoses of CKD are not, in fact, diseases. We conclude that, in many diagnosed cases of CKD, diagnosing a patient with a "disease" is not only redundant, but unhelpful.

Iatrogenesis: A review on nature, extent, and distribution of healthcare hazards.

Modern medicine is given overarching importance to tackle disease in the human body than environmental determinants. Although, most of the literature confirms that the determinants of disease are there in the environment. Yet in the modern times what is being emphasized is highly limited and reductionist approach of curing ailments in the human body only, which is one of the desired interventions but is full of other side effects and risks leading to iatrogenic reactions. Most of the literature establishes that modern medicine is one of the major threats to the world health. Besides treating disease at the clinical level, rational, and well-thoughtout changes in the overall environment can positively impact the nature, extent, and distribution of disease.

From Defensive Medicine to Quaternary Prevention: The Transition That Pakistan Needs.

The issue of overprescribing laboratory investigations is an old one in the world of medical practice and it has unfortunately seen a tremendous increase with the digitalisation of medicine, in more recent times. Phrased usually as 'defensive medicine,' this kind of overmedicalisation steers medical practice away from the ethical, skill-refining fronts on the part of doctors and imposes an unnecessary financial burden on the patients' pockets, adding to their suffering. Pakistan has not been able to save itself either, from the impropriety that roots out of what is now almost a norm in medical practice. The existent low literacy and awareness rates in the masses of the country, coupled with the cultural respect for doctors and lack of financial resources amongst the poor patients to stand up to doctors or the hospitals, have all made it even easier for physicians to get away with ordering whatever investigations they choose. The issue is a grave one and its rampancy demands that attention is drawn to it and efforts are made to transition into the practice of evidence-based medicine and quaternary prevention.

Evolutionary Psychiatry II-Mental Functions and Diseases from the Evolutionary Perspective / 신경정신의학

Previously (Part I) the authors introduced the evolutionary biology and psychology. In the present part (Part II) of the review article, we discuss what disease is, and how diseases are explained in terms of the evolutionary perspective. Various psychologic phenomena and psychopathologic conditions are also illuminated under this evolutionary light. Through this approach, the authors hope that clinicians would search for the “normality” as well as pathology in patients, and would utilize this insight to understand and treat them accordingly.

The Difficult Choice of "Not Doing" Comment on "Quaternary Prevention, an Answer of Family Doctors to Overmedicalization".

The article of Marc Jamoulle shows the importance of the contribution of general practitioners (GPs) in improving the quality and the efficiency of the health systems. Starting from the concept of quaternary prevention for reducing excessive costs in the preventive procedures, he suggests a change of paradigm in every daily activity of the GP in order to have a stronger ethical approach to the patient. This means spending more time in the consultation in order to better understand her/his real needs and share a common decision for minimizing the costs and solving the patient's problems in agreement with her/his believes and values.

Reasons for routine episiotomy: A mixed-methods study in a large maternity hospital in Phnom Penh, Cambodia.

First documented in 1741, the practice of episiotomy substantially increased worldwide during the 20th century. However, research shows that episiotomy is not effective in reducing severe perineal trauma and may be harmful. Using a mixed-methods approach, we conducted a study in 2013-14 on why obstetricians and midwives in a large maternity hospital in Phnom Penh, Cambodia, still do routine episiotomies. The study included the extent of the practice, based on medical records; a retrospective analysis of the delivery notes of a random sample of 365 patients; and 22 in-depth interviews with obstetricians, midwives and recently delivered women. Of the 365 women, 345 (94.5%, 95% CI: 91.7-96.6) had had an episiotomy. Univariate analysis showed that nulliparous women underwent episiotomy more frequently than multiparous women (OR 7.1, 95% CI 2.0-24.7). The reasons given for this practice by midwives and obstetricians were: fear of perineal tears, the strong belief that Asian women have a shorter and harder perineum than others, lack of time in overcrowded delivery rooms, and the belief that Cambodian women would be able to have a tighter and prettier vagina through this practice. A restrictive episiotomy policy and information for pregnant women about birthing practices through antenatal classes should be implemented as soon as possible.

Quaternary prevention: a gaze on medicalization in the practice of family doctors / Prevenção quaternária: um olhar sobre a medicalização na prática dos médicos de família / Prevención cuaternaria: una mirada a la medicalización en la práctica de los médicos de familia

The medicalization is a complex and widespread social phenomenon which involves different agents and institutions, such as the pharmaceutical and medical industry, governments, health systems, health professionals, and citizens. In this regard, doctors and health professionals play an important role in reproducing and struggling with medicalization, by recognizing that medicine and health care can generate as much harm as benefits. Family doctors have to deal with overmedicalization and its associated phenomena (i.e. overdiagnosis, overtreatment, disease mongering) on a daily basis as they act as gatekeepers of health systems. As the first point of contact, family physicians and their health teams get the demands and social needs brought by individuals and communities under their care, which usually are influenced by the health marketing and an interventionist medical perspective. This article discusses some key concepts of medicalization and its determinants, especially the contributions of biomedical science and its epistemological basis to the phenomenon. It also briefly develops some thoughts on the medicalization, in the Brazilian context. Finally, it analyses the quaternary prevention approach to medicalization which proposes changes in its object and attitude to medical practice in order to avoid unnecessary interventions, thus, protecting patients from the excesses of medicine.

A medicalização é um fenômeno social complexo e disseminado no qual estão envolvidos diferentes agentes e instituições, tais como a indústria médica/farmacêutica, governos, profissionais/sistemas de saúde e cidadãos. Por sua vez, médicos e profissionais de saúde desempenham importante papel na reprodução e no enfrentamento da medicalização, haja visto que a medicina e os cuidados em saúde podem gerar tanto danos como benefícios. Médicos de família lidam diariamente com a sobremedicalização e seus fenômenos associados (i.e.sobrediagnóstico, sobretratamento, comercialização de doenças) por desempenharem função-filtro nos sistemas de saúde. Por ser o primeiro ponto de contato, esses profissionais e suas equipes acolhem as demandas e necessidades sociais trazidas pelas pessoas e comunidades sob seus cuidados, que comumente estão influenciadas por uma perspectiva médica intervencionista e pelo marketing da saúde. Este artigo discute alguns conceitos principais da medicalização e seus determinantes, em especial as contribuições da ciência biomédica e suas bases epistemológicas para o fenômeno. Ele também desenvolve, sucintamente, algumas reflexões sobre a medicalização na prática do médico de família e comunidade, no contexto brasileiro. Por fim, analisa o enfoque da prevenção quaternária acerca da medicalização, que propõe mudanças de objeto e de atitude na prática médica, evitando, assim, intervenções desnecessárias e protegendo os pacientes dos excessos da medicina.

La medicalización es un fenómeno social complejo y diseminado que involucra a diferentes agentes e instituciones, tales como la industria farmacéutica y médica, los gobiernos, los profesionales/sistemas de salud y los ciudadanos. En este sentido, los médicos y profesionales de la salud desempeñan un papel importante en la reproducción y en el enfrentamiento de la medicalización, dado el hecho de que la medicina y la asistencia sanitaria pueden generar tanto daños como beneficios. Los médicos de familia tienen que lidiar diariamente con la sobremedicalización y sus fenómenos asociados (es decir, el sobrediagnóstico, sobretratamiento, tráfico de enfermedades), ya que desempeñan función-filtro en los sistemas de salud. Como primer punto de contacto, estos profesionales y sus equipos de salud reciben las demandas y necesidades sociales interpuestos por las personas y comunidades bajo su cuidado, que suelen ser influenciados por la comercialización de la salud y una perspectiva médico-intervencionista. Este artículo discute algunos conceptos clave de la medicalización y sus determinantes, en especial las contribuciones de la ciencia biomédica y su base epistemológica para el fenómeno. También desarrolla brevemente algunas reflexiones sobre la medicalización de la práctica diaria de los médicos de familia y comunidad en el contexto brasileño. Por último, se analiza el enfoque de la prevención cuaternaria a la medicalización, que propone cambios en su objeto y en la actitud de la práctica médica con el fin de evitar intervenciones innecesarias, y por lo tanto, proteger a los pacientes de los excesos de la medicina.

Demand and supply factors affecting the rising overmedicalization of birth in India.

OBJECTIVE: To understand the interaction between health systems and individual factors in determining the probability of a cesarean delivery in India. METHODS: In a retrospective study, data from the 2007-2008 District Level Household and Facility Survey was used to determine the risk of cesarean delivery in six states (Punjab, Delhi, Maharashtra, Andhra Pradesh, Kerala, and Tamil Nadu). Multilevel modeling was used to account for district and community effects. RESULTS: After controlling for key risk factors, the analysis showed that cesareans were more likely at private than public institutions (P<0.001). In terms of demand, higher education levels rather than wealth seemed to increase the likelihood of a cesarean delivery. District-level effects were significant in almost all states (P<0.001), demonstrating the need to control for health system factors. CONCLUSION: Supply factors might contribute more to the rise in cesarean delivery than does demand. Further research is needed to understand whether the quest for increased institutional deliveries in a country with high maternal mortality might be compromised by pressures for overmedicalization.