An open-label, exploratory documentation of proving-symptoms of CVN01 (Coronavirus nosode from the clinical sample) in healthy volunteers

Homeopathic Pathogenetic Trials (Proving) are human studies to examine the pathogenetic effects of investigational drugs in high dilution on healthy volunteers. As a part of the new coronavirus nosode development process for prophylactic use, the phase 1 study was conducted. The documentation of proving symptoms for a fast-track nosode development for a pandemic condition was the objectives of this study. An open-label trial to evaluate the safety and proving symptoms of Coronavirus nosode given orally to 10 volunteers (18-65 years age and of both the genders). Volunteers were administered 6 doses of nosode as 6 pills twice daily for 3 consecutive days. Pre and post examinations (physical), vital signs, and laboratory investigations, were done at day 0, 17, 34. Symptoms experienced by the volunteers were recorded. RESULTS Symptoms reported by volunteers were analyzed. The symptoms reported were mild to severe but reversible and matching with the symptoms produced by the viral infection. There were no serious/fatal adverse events during the study. The basic biochemistry and Liver Function tests were not affected by the Nosode. New nosode developed during a pandemic condition produced certain symptoms in the homeopathic pathogenetic trial as a part of the Phase 1 study.

Do Homeopathic Pathogenetic Trials generate recognisable and reproducible symptom pictures?: Results from a pilot pathogenetic trial of Ozone 30c.

BACKGROUND: Homeopathic Pathogenetic Trials (HPTs) are a pillar of homeopathy, a key source of the symptoms characteristic of a particular homeopathic medicine. Homeopaths choose homeopathic medicines by comparing these remedy pictures with the symptoms the patient is presenting. Thus, recognition of these symptom sets underpins the clinical practice of homeopathy. OBJECTIVE: To test whether HPTs generate consistent and recognisable sets of symptoms in consecutive trials. DESIGN: Practising homeopaths, blinded to the homeopathic medicine under investigation, were given the set of symptoms generated during an unpublished HPT and asked to identify the homeopathic medicine used. HOMEOPATHIC TRIAL SUBSTANCE: Ozone, prepared by homeopathic method to the ultramolecular dilution of 30c (10(-60) dilution), was chosen at random from twenty potential medicines. RESULTS: Seven practising homeopaths were asked to make three guesses as to the identity of the remedy. Initially from the full list of possible remedies (N = 2372). Two of the seven homeopaths guessed the identity of the remedy correctly (p < 0.0001). Subsequently, when their choice of possible medicines was restricted to a list of 20, the same two homeopaths selected the correct medicine, however none of the other practising homeopaths did so (p = 0.2). DISCUSSION: The selection of the correct homeopathic medicine from the unrestricted list (N = 2372 medicines) by two homeopaths is noteworthy given that the homeopathic medicine used during the HPT was diluted well beyond Avogadro's number and would not be expected to produce any detectable or recognisable symptomatology. Possible reasons why the remaining five homeopaths did not guess correctly are discussed. CONCLUSION: The results show that practising homeopaths may be able to correctly identify a homeopathic medicine from the set of symptoms generated during an HPT. This suggests that such symptom pictures generated by taking an ultramolecular homeopathic medicine are recognisable and specific to the substance taken. Since identification of the remedy was based on past HPT information held in the materia medica, this demonstrates that HPT-generated symptom pictures are reproducible, thus validating the HPT methodology. These promising preliminary findings warrant replication; possible improvements to the trial design to be incorporated in future studies were identified.

Hepatitis C Nosode: The preparation and homeopathic pathogenetic trial.

BACKGROUND: A double blind, randomized placebo controlled homeopathic pathogenetic trial (proving) of Hepatitis C (Hep C) nosode was conducted with the aim to introduce the new nosode in homeopathic pharmacopeia. METHOD: Documentation included approval by Ethics Committee, Informed Consent Form, Laboratory investigations, safety and ethical measures. The volunteers were trained to write data in prescribed diaries and data were analyzed. A fifteen-step method was used in the preparation of Hep C nosode (genotype I and III), allowing future preparation of an identical nosode. 22 volunteers were entered, 15 received Hep C nosode in 30c potency, 7 received placebo, once a week for four weeks. RESULTS: The Hep C nosode was associated with qualitatively and quantitatively distinct symptoms, which can be applied in clinical practice. A significantly higher incidence of pathogenetic effect of homeopathic medicine compared to placebo was observed. Safety was documented. The nosode produced symptoms comparable with Hep C disease. CONCLUSION: An improved method of nosode preparation was used. A double blind, randomized placebo controlled pathogenetic trial of the Hep C nosode generated guiding symptoms, which may facilitate its prescription in practice. The nosode should be further explored for the treatment of immunologically mediated diseases, infections including Hep C, fibrotic pathology and chronic inflammatory disorders.

Pathogenetic trial of boric acid in bean and tomato plant / athogenetic trial of boric acid in bean and tomato plant

Background: homeopathy is held in organic agriculture as a means to control disease and plagues. However, different from doctors, who have works on materia medica and repertories available to choose the most suitable homeopathic medicine for each patient, agronomists do not yet have an equivalent Homeopathic Materia Medica of Plants (HMMP) describing symptoms observed in plants. Aim: the aim of this study was to carry out a homeopathic pathogenetic trial (HPT) in plants comparing the effects elicited by boric acid in ponderable dose and dilution 6cH in two different plant species, namely bean and tomato cultivars. Methods: 4 tests were carried out, 2 on tomato and 2 on bean plants, which received 1 to 6 applications of treatments. Results: there were differences between both species regarding their sensitiveness to boric acid. None of the tomato plants that received Boron 6cH showed symptoms, differently from bean plants. On the other hand, in tests of ponderable doses of boric acid, tomato plants exhibited 3 symptoms more than bean plants. A higher number of bean plants exhibited symptoms with boric acid in ponderable dose than in dilution 6cH). Nos ensaios com feijoeiro, um maior número de plantas apresentou sintomas após o tratamento com ácido bórico na dose ponderal do que com ácido bórico 6cH. Conclusions: these results suggest that the elaboration of a HMMP must take into account the species in which symptoms were obtained. Moreover, HPTs in plants must be carried out with both ponderable doses and high dilutions in order for differences in sensitiveness among species be better identified.(AU)

Introdução: A homeopatia é considerada como uma prática para manejo de doenças e pragas na agricultura orgânica. No entanto, ao contrário dos médicos que dispõe das Matérias Médicas e Repertórios para a escolha do medicamento homeopático mais adequado para o paciente, os agrônomos não dispõem de uma Matéria Médica Homeopática de Plantas (MMHP) com sintomas observados em vegetais. Objetivos: O objetivo deste trabalho foi realizar uma experimentação patogenética homeopática em vegetais, comparando os sintomas apresentados por uma cultivar de feijoeiro e uma cultivar de tomateiro após a administração de ácido bórico em dose ponderal e na dinamização 6cH. Métodos: Foram conduzidos quatro experimentos, dois com tomateiro e dois com feijoeiro, sendo que as plantas receberam entre uma a seis pulverizações dos tratamentos. Resultados: Observaram-se diferenças entre as espécies quanto à sensibilidade ao ácido bórico: nenhuma planta de tomateiro que recebeu Boro 6cH apresentou sintomas, diferentemente do feijoeiro. Por outro lado, nos ensaios com ácido bórico em dose ponderal o tomateiro apresentou três sintomas a mais que o feijoeiro. Nos ensaios com feijoeiro, um maior número de plantas apresentou sintomas após o tratamento com ácido bórico na dose ponderal do que com ácido bórico 6cH. Conclusões: Estes resultados sugerem que na elaboração de uma Matéria Médica Homeopática de Plantas (MMHP) deve ser considerada a espécie vegetal na qual os sintomas foram obtidos. Além disso, as experimentações patogenéticas homeopáticas em vegetais devem ser realizadas tanto com doses ponderais quanto com doses dinamizadas, a fim de que as diferenças na sensibilidade entre espécies possam ser mais bem detectadas.(AU)

Introducción: La homeopatia es usada en la práctica para el manejo de enfermedades y plagas en la agricultura orgánica. Pero, al contrario de los médicos que disponen de Materias Médicas y Repertorios para la elección del medicamento homeopático mas adecuado para el paciente, los agrónomos no disponen de una Materia Médica Homeopática de Plantas (MMHP) com sintomas observados em vegetales. Objetivos: El objetivo de este trabajo fue realizar una experimentación patogenética homeopática en vegetales, comparando los sintomas presentes en un cultivo de frijoles y de tomates después de administrar ácido bórico en dosis ponderales y en la dinamización 6 CH. Métodos: fueron realizados cuatro experimentos, dos con tomateros y dos con frijoleros y las plantas recibieron seis pulverizaciones con las sustancias del tratamiento.Resultados: Seobservaron diferencias entre las espécies en relación a la sensibilidad al ácido bórico: ninguna planta de tomatero que recibió Boro 6 CH presentó sintomas, al contrario de los frijoleros. Por outro lado en los ensayos con ácido bórico ponderal los tomateros presentaron tres sintomas más que los frijoleros. En los ensayos con frijoleros um mayor número de plantas presentó sintomas después del tratamiento con ácido bórico en la dosis ponderal en relación a los tratados com Boro 6 CH. Conclusión: estos resultados sugieren que en la elaboración de una Materia Médica Homeopática de Plantas (MMHP) debe ser considerada la espécie vegetal en la que los sintomas fueron obtenidos. Además, las experimentaciones patogenéticas homeopáticas en vegetales deben ser realizadas tanto con dosis ponderales como con dosis dinamizadas a fin de que las diferencias en la sensibilidad entre espécies puedan ser mejor detectadas..(AU)

Pathogenetic trial of boric acid in bean and tomato plant / athogenetic trial of boric acid in bean and tomato plant

Background: homeopathy is held in organic agriculture as a means to control disease and plagues. However, different from doctors, who have works on materia medica and repertories available to choose the most suitable homeopathic medicine for each patient, agronomists do not yet have an equivalent Homeopathic Materia Medica of Plants (HMMP) describing symptoms observed in plants. Aim: the aim of this study was to carry out a homeopathic pathogenetic trial (HPT) in plants comparing the effects elicited by boric acid in ponderable dose and dilution 6cH in two different plant species, namely bean and tomato cultivars. Methods: 4 tests were carried out, 2 on tomato and 2 on bean plants, which received 1 to 6 applications of treatments. Results: there were differences between both species regarding their sensitiveness to boric acid. None of the tomato plants that received Boron 6cH showed symptoms, differently from bean plants. On the other hand, in tests of ponderable doses of boric acid, tomato plants exhibited 3 symptoms more than bean plants. A higher number of bean plants exhibited symptoms with boric acid in ponderable dose than in dilution 6cH). Nos ensaios com feijoeiro, um maior número de plantas apresentou sintomas após o tratamento com ácido bórico na dose ponderal do que com ácido bórico 6cH. Conclusions: these results suggest that the elaboration of a HMMP must take into account the species in which symptoms were obtained. Moreover, HPTs in plants must be carried out with both ponderable doses and high dilutions in order for differences in sensitiveness among species be better identified.

Introdução: A homeopatia é considerada como uma prática para manejo de doenças e pragas na agricultura orgânica. No entanto, ao contrário dos médicos que dispõe das Matérias Médicas e Repertórios para a escolha do medicamento homeopático mais adequado para o paciente, os agrônomos não dispõem de uma Matéria Médica Homeopática de Plantas (MMHP) com sintomas observados em vegetais. Objetivos: O objetivo deste trabalho foi realizar uma experimentação patogenética homeopática em vegetais, comparando os sintomas apresentados por uma cultivar de feijoeiro e uma cultivar de tomateiro após a administração de ácido bórico em dose ponderal e na dinamização 6cH. Métodos: Foram conduzidos quatro experimentos, dois com tomateiro e dois com feijoeiro, sendo que as plantas receberam entre uma a seis pulverizações dos tratamentos. Resultados: Observaram-se diferenças entre as espécies quanto à sensibilidade ao ácido bórico: nenhuma planta de tomateiro que recebeu Boro 6cH apresentou sintomas, diferentemente do feijoeiro. Por outro lado, nos ensaios com ácido bórico em dose ponderal o tomateiro apresentou três sintomas a mais que o feijoeiro. Nos ensaios com feijoeiro, um maior número de plantas apresentou sintomas após o tratamento com ácido bórico na dose ponderal do que com ácido bórico 6cH. Conclusões: Estes resultados sugerem que na elaboração de uma Matéria Médica Homeopática de Plantas (MMHP) deve ser considerada a espécie vegetal na qual os sintomas foram obtidos. Além disso, as experimentações patogenéticas homeopáticas em vegetais devem ser realizadas tanto com doses ponderais quanto com doses dinamizadas, a fim de que as diferenças na sensibilidade entre espécies possam ser mais bem detectadas.

Introducción: La homeopatia es usada en la práctica para el manejo de enfermedades y plagas en la agricultura orgánica. Pero, al contrario de los médicos que disponen de Materias Médicas y Repertorios para la elección del medicamento homeopático mas adecuado para el paciente, los agrónomos no disponen de una Materia Médica Homeopática de Plantas (MMHP) com sintomas observados em vegetales. Objetivos: El objetivo de este trabajo fue realizar una experimentación patogenética homeopática en vegetales, comparando los sintomas presentes en un cultivo de frijoles y de tomates después de administrar ácido bórico en dosis ponderales y en la dinamización 6 CH. Métodos: fueron realizados cuatro experimentos, dos con tomateros y dos con frijoleros y las plantas recibieron seis pulverizaciones con las sustancias del tratamiento.Resultados: Seobservaron diferencias entre las espécies en relación a la sensibilidad al ácido bórico: ninguna planta de tomatero que recibió Boro 6 CH presentó sintomas, al contrario de los frijoleros. Por outro lado en los ensayos con ácido bórico ponderal los tomateros presentaron tres sintomas más que los frijoleros. En los ensayos con frijoleros um mayor número de plantas presentó sintomas después del tratamiento con ácido bórico en la dosis ponderal en relación a los tratados com Boro 6 CH. Conclusión: estos resultados sugieren que en la elaboración de una Materia Médica Homeopática de Plantas (MMHP) debe ser considerada la espécie vegetal en la que los sintomas fueron obtenidos. Además, las experimentaciones patogenéticas homeopáticas en vegetales deben ser realizadas tanto con dosis ponderales como con dosis dinamizadas a fin de que las diferencias en la sensibilidad entre espécies puedan ser mejor detectadas..

Sintomas patogenéticos de serotonina: relato de um grupo de auto-experimentadores / Proving symptoms of serotonin: report of a group of self-experimenters

O valor da auto-experimentação realizada pelo homeopata é inestimável, segundo Hahnemann, seja para o auto-conhecimento, para seu o aprendizado como observador e, principalmente, para a vivência dos princípios homeopáticos. Assim, formou-se, em 2005, em Londrina um grupo de auto-experimentação, composto por vários profissionais homeopatas. Vinte auto-experimentadores (12 no primeiro grupo, em 2005, e 8 no segundo grupo, em 2008) provaram sulfato de serotonina na preparação homeopática 30cH e, posteriormente, os sintomas observados pelos dois grupos foram comparados com aqueles descritos na literatura para a síndrome serotoninérgica (SS). O medicamento Serotonina 30cH despertou 370 sintomas, expressos pelos 20 auto-experimentadores, sendo que os sintomas foram reunidos em 47 grupos. Desses sintomas, muitos apareceram nos dois grupos, compostos por experimentadores diferentes, em momentos diversos. O resultado da comparação entre os sintomas da SS e aqueles surgidos nas auto-experimentações mostrou que dos 32 sintomas da SS relatados pela literatura consultada, 17 deles ocorreram nas auto-experimentações. A auto-experimentação foi uma oportunidade ímpar para a vivência dos princípios homeopáticos e um excelente exercício de auto-observação. A riqueza dos sintomas experimentados aliada à reprodução dos mesmos na segunda experimentação e à coincidência com vários sintomas da SS tornam a serotonina agitada e diluída um medicamento homeopático para ser utilizado na clínica.

The value of the self-experimentation the homeopathic physician carries out on him/herself is priceless, according to Hahnemann, be it to acquire self-knowledge, to learn how to observe or chiefly, to experience the homeopathic principles. Consequently, it was formed in 2005 in Londrina a group of self-experimentation, composed by several homeopathic professionals. Twenty self-experimenters (12 in the first group, in 2005, and 8 in the second group, in 2008) tested serotonin sulfate in homeopathic high dilution 30cH; later on, the symptoms observed by both groups were compared with the ones described in the literature in serotonin syndrome (SS). Homeopathic medicine Serotonin 30cH awakened 370 symptoms among 20 experimenters, which were grouped in 47 classes. From these symptoms, many appeared in volunteers from both groups, which were composed by different volunteers in differen moments. The result of the comparison between the symptoms of SS and the ones reported in the self-experimentations showed that, from de 32 symptoms of SS reported by the literature, 17 also happened in our study. This self-experimentation was an unique opportunity to experience the homeopathic principles...

Brief homeopathic pathogenetic experimentation: a unique educational tool in Brazil.

In homeopathy, many difficulties are encountered in understanding theoretical presuppositions because they represent different paradigms from those of hegemonic science. In our medical school, we developed a brief homeopathic pathogenetic experimentation course to be added as curricular content and a didactic method in homeopathic disciplines to add practical experience to the theoretical approach of homeopathic presuppositions. In accordance with the premises laid out by Hahnemann, the father of homeopathy, brief pathogenetic experimentation was offered on a voluntary basis for students who were free of chronic diseases and who had not regularly used medication in the last 3 months. The clinical test, either crossed or sequential (randomized and blind), was used as a study model. Single weekly doses of a homeopathic medicine of 30 cH or placebo were taken by participants during 4 weeks after which crossover of the experimented substances took place for another 4 weeks. Polycrest medicines were used so that symptoms developed by the participants could be compared to those described in Homeopathic Materia Medica. Thirty-three of the 50 students who studied homeopathy as an elective discipline over the last 4 years at the School of Medicine of the University of São Paulo (FMUSP) participated. Participants described symptoms according to specific methodology including many comments with peculiar characteristics and notable idiosyncrasies. All these students endorsed the course because it contributed to their understanding of how dynamized substances produced symptoms in healthy participants as well as the cure of symptoms according to the casual similitude principle. Brief homeopathic pathogenetic experimentation proved to be an effective method to observe the idiosyncratic manifestations of human individuality based on qualitative methodology, thus building a basis of understanding of homeopathy.