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1.
Vision (Basel) ; 8(1)2024 Mar 05.
Article in English | MEDLINE | ID: mdl-38535759

ABSTRACT

Aim: Angioid streaks (ASs) are a rare retinal condition and compromise visual acuity when complicated with choroidal neovascularization (CNV). They represent crack-like dehiscences at the level of the Bruch's membrane. This objective narrative review aims to provide an overview of pathophysiology, current treatment modalities, and future perspectives on this condition. Materials and Methods: A literature search was performed using "PubMed", "Web of Science", "Scopus", "ScienceDirect", "Google Scholar", "medRxiv", and "bioRxiv." Results: ASs may be idiopathic, but they are also associated with systemic conditions, such as pseudoxanthoma elasticum, hereditary hemoglobinopathies, or Paget's disease. Currently, the main treatment is the use of anti-vascular endothelial growth factors (anti-VEGF) to treat secondary CNV, which is the major complication observed in this condition. If CNV is detected and treated promptly, patients with ASs have a good chance of maintaining functional vision. Other treatment modalities have been tried but have shown limited benefit and, therefore, have not managed to be more widely accepted. Conclusion: In summary, although there is no definitive cure yet, the use of anti-VEGF treatment for secondary CNV has provided the opportunity to maintain functional vision in individuals with AS, provided that CNV is detected and treated early.

2.
Soins Pediatr Pueric ; 45(336): 34-35, 2024.
Article in French | MEDLINE | ID: mdl-38365394

ABSTRACT

Sohane and Sélenn are twins and will soon be 6 years old. They had a birth journey often described as unusual, because they were born far too early, at 31 weeks of amenorrhea. Through the pen of their father, they share their testimony with us, looking back on this complicated period of which they were able to keep memories thanks to the photographs and stories of their parents.


Subject(s)
Parents , Twins , Female , Humans , Child
3.
Ann Chir Plast Esthet ; 69(3): 258-266, 2024 May.
Article in French | MEDLINE | ID: mdl-38000976

ABSTRACT

CONTEXT: Despite the use of total skin grafting in the treatment of loss of skin substances on the palmar surface of the fingers, the palm of the hand and the sole of the foot, the data published in the literature on long-term results in black-skinned patients are non-existent. METHODS: The present study, filling this gap, used data from a prospective cohort of 123 total skin grafts performed on 93 black African patients who benefited from plantar skin grafts versus skin grafts from hairy areas to cover loss of skin substances. of the palmar surface of the fingers, the palm of the hand and the sole of the foot. This study covers a period of 163 months. RESULTS: Sixty-four grafts of hairy areas were carried out in 52 patients, 29 of whom were male and 23 female, for a M/F sex ratio of 1.3; and 59 plantar skin grafts in 41 patients including 21 males and 20 females, M/F sex ratio of 1. The digital palmar surface was the most recipient of the plantar graft, i.e. 35.5% of cases. After a post-operative follow-up of at least 12 months, patients or their entourage judged the functional and aesthetic results of plantar skin grafts to be better and acceptable, unlike the results of hairy area grafts. The texture and color are even better if the total skin graft is taken from an identical histological area. CONCLUSION: In view of these results, we recommend a plantar skin graft for black-skinned patients to cover losses of skin substances on the palmar surface of the fingers, the palm of the hand and the sole of the foot, if indicated.


Subject(s)
Hand Injuries , Skin Transplantation , Humans , Male , Female , Skin Transplantation/methods , Prospective Studies , Hand Injuries/surgery , Skin/injuries , Foot/surgery , Hand/surgery
4.
Ann Chir Plast Esthet ; 69(2): 124-130, 2024 Mar.
Article in English | MEDLINE | ID: mdl-37652836

ABSTRACT

BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a rare skin tumor. There is no standard recommendation for its surgical management. The currently used histological analysis are HES (hematoxylin eosin saffron) staining and immunohistochemistry for CD34 expression in particular cases. Fluorescent in situ hybridization (FISH) technique is only used to qualify the DFSP as translocated or non-translocated and is not used as a diagnostic method. The aim of our study was to determine by FISH (as a diagnostic method) whether cancerous cells that could not be identified through HES staining±immunohistochemistry were present at the two-centimeter margins that were found to be tumor-free. METHODS: Samples from patients who underwent surgery between 2010 and 2018 were collected. Intralesional and peripheral (at 2cm margins) paraffin slides were included. An average of 7.4 slides per specimen was analyzed. Firstly, the preselected slides were reread by a senior pathologist to confirm the absence of microscopic findings of DFSP at 2cm margins. Secondly a FISH analysis was used as a quantitative diagnostic approach, in order to find the t(17;22) translocation. RESULTS: Among the seven specimens that included 2cm margins, two samples presented one or more translocations, which were not visible in standard morphology assessments at two centimeters tumor-free margins. CONCLUSIONS: FISH analysis can have a new role in defining tumor-free margins. This would reduce the incidence of disease recurrence after resection and improve the post-operative complementary care.


Subject(s)
Dermatofibrosarcoma , Skin Neoplasms , Humans , Margins of Excision , In Situ Hybridization, Fluorescence , Dermatofibrosarcoma/genetics , Dermatofibrosarcoma/surgery , Skin Neoplasms/pathology , Mohs Surgery/methods , Neoplasm Recurrence, Local/surgery
5.
Ann Chir Plast Esthet ; 69(2): 154-159, 2024 Mar.
Article in English | MEDLINE | ID: mdl-37423823

ABSTRACT

INTRODUCTION: Malignant non-melanoma skin cancers (NMSC) are of two main types: basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). In rare occasions, some of the malignant skin lesions show histopathological characteristics of both BCC and SCC and are known as basosquamous carcinomas (BSC). In some cases of large tumors, extensive reconstructive surgery might be needed to correct the skin defect after the primary excision. PRESENTATION OF CASE: We report a case of a 76-year-old Bulgarian male patient who presented with a neglected giant cutaneous tumor with more than a 15-year history of a growing mass in the right deltoid area. On physical exam an enormous exophytic ulcerated and crusted skin lesion measuring around 11×11cm was found. Wide local excision of the lesion with 10-mm resection margins and partial resection of the underlying deltoid muscle were performed due to signs of infiltration. A full-thickness total skin graft from the left inguinal area was harvested to cover the skin defect. Final histopathological examination showed metatypical carcinoma with mixed characteristics of SCC and BCC - BSC, with infiltration of the fatty tissue, deltoid muscle and clear margins of resection, staged as T4R0. Two and a half years after surgery there are no signs of upper arm motor dysfunction and no evidence of local recurrence and distant metastasis on a follow-up PET/CT. DISCUSSION: Following current National Comprehensive Cancer Network's guidelines for primary treatment of BCC, surgical candidates should undergo standard excision with wider surgical margins, postoperative margin assessment and second intention healing, linear repair, or skin graft. Therapeutic strategy for non-operable cases includes administration of radiotherapy or system therapy in the face of Hedgehog pathway inhibitors and programmed cell death protein 1 inhibitor. They can provide an alternative solution to unresectable or difficult-to-treat locally advanced cases of BSC. CONCLUSION: Similarly to BCC and SCC, the first-line treatment option for BCS is surgical excision, but surgical margins should be wider than those for low-risk BCC due to the infiltrative growth pattern of this tumor. Favorable esthetic outcome requires precise planning of the reconstructive technique.


Subject(s)
Carcinoma, Basal Cell , Carcinoma, Squamous Cell , Melanoma , Skin Neoplasms , Male , Humans , Aged , Margins of Excision , Positron Emission Tomography Computed Tomography , Hedgehog Proteins , Skin Neoplasms/surgery , Skin Neoplasms/pathology , Carcinoma, Basal Cell/surgery , Carcinoma, Basal Cell/pathology , Carcinoma, Squamous Cell/surgery
6.
Soins ; 68(880): 39-41, 2023 Nov.
Article in French | MEDLINE | ID: mdl-37931997

ABSTRACT

The skin of patients with hereditary epidermolysis bullosa (HEB) is extremely fragile. When providing care, nurses must be extremely vigilant to avoid inducing lesions. Whether inserting a peripheral venous line, taking blood pressure or monitoring the patient, nurses are likely to injure the patient's skin by compressing it, rubbing it, applying dressings and so on. It is therefore essential that they adapt this care to the person suffering from HEB.


Subject(s)
Epidermolysis Bullosa , Humans , Epidermolysis Bullosa/pathology , Patients , Pressure , Basic Helix-Loop-Helix Transcription Factors
7.
Soins Pediatr Pueric ; 44(334): 21-25, 2023.
Article in French | MEDLINE | ID: mdl-37813517

ABSTRACT

Gaining a better understanding of fathers' experiences in the maternity ward, and more specifically around childbirth, enables a better understanding of the process of becoming a father. The stakes are high, since these shared moments form part of the bonds that support the development of father-baby communication.


Subject(s)
Fathers , Parturition , Male , Humans , Pregnancy , Female , Delivery, Obstetric , Hospitals , Communication
8.
Praxis (Bern 1994) ; 112(7-8): 426-430, 2023 Jun.
Article in German | MEDLINE | ID: mdl-37282521

ABSTRACT

Electrical Accidents Abstract: When persons seek medical help after an electrical injury, physicians have to inquire on the type (AC/DC) and strength of current (>1000V is considered "high voltage") as well as the exact circumstances (loss of consciousness, falls) of the accident. In the advent of high-voltage accidents, loss of consciousness, arrhythmias, abnormal ECG or elevated troponin levels, in-hospital rhythm monitoring is warranted. In all other cases, the type of extra cardiac injury primarily directs the management. Superficial skin marks may disguise more extensive thermal injuries of inner organs.


Subject(s)
Electric Injuries , Humans , Electric Injuries/diagnosis , Electric Injuries/therapy , Accidents , Arrhythmias, Cardiac/diagnosis , Arrhythmias, Cardiac/etiology , Arrhythmias, Cardiac/therapy , Troponin , Unconsciousness
9.
Ann Pathol ; 43(5): 412-416, 2023 Sep.
Article in French | MEDLINE | ID: mdl-36858940

ABSTRACT

A 75 years old patient presented with a papular easily bleeding lesion of the lower lip that had been growing for two months. He was known for alcoholic cirrhosis complicated with hepatocellular carcinoma treated since one year. A working diagnostic hypothesis of benign vascular lesion was proposed. Microscopic examination showed a neoplastic dermal proliferation that had been fully excised, made of lobules segregated by thin fibrous septae. The neoplastic architecture was trabecular and delineating spaces forming pseudo-rosettes. Tumour cells were monomorphic, cuboidal or cylindric with abundant eosinophilic and granulous cytoplasm and centered by a lone nucleus that often contained a prominent nucleolus. Some spaces were filled with a brownish-greenish pigmented material. Immunohistochemical study showed that tumour cells were positive with the hepatocyte paraffin 1 antibody as well as cytokeratin 8 antibody. Chromogranin A and synaptophysin stainings were negative. Thus we concluded to a lip metastasis from the previously known hepatocellular carcinoma. Skin metastasis arise in around 3% of cases of hepatocellular carcinoma. They account for less than 1% of all cutaneous metastasis. Overall appearance of cutaneous metastasis of hepatocellular carcinoma is associated with a poor prognosis and an aggravated risk of metastasis to other locations and organs and a median overall survival of less than 5 months. Since incidence of hepatocellular carcinoma is rising pathologists might face more frequently in years to come to cutaneous metastasis whose varied clinical presentations make a diagnostic challenge.


Subject(s)
Carcinoma, Hepatocellular , Liver Neoplasms , Skin Neoplasms , Male , Humans , Aged , Carcinoma, Hepatocellular/pathology , Skin Neoplasms/pathology , Immunohistochemistry , Antibodies , Liver Neoplasms/pathology
10.
Int J Cosmet Sci ; 45(2): 177-186, 2023 Apr.
Article in English | MEDLINE | ID: mdl-36453854

ABSTRACT

OBJECTIVE: The biological safety of natural jade materials and assembled jade-activated materials on cells and their anti-inflammatory and damage repair functions, as well as the repair function on sensitive skin, were studied utilizing in vitro cell biology and in vivo. METHODS: Human skin fibroblasts were used as model cells to conduct cytotoxicity experiments in vitro, and the effects on the expression of inflammatory factors and growth factor-related genes in fibroblasts were explored. The gene expression values of inflammatory factors IL-1, IL-6, TNF-α and cytokines epidermal growth factors, fibroblast growth factors and COL1A1 in fibroblasts were measured by polymerase chain reaction test. Thirty women with sensitive skin were selected to apply a mask containing jade extract three times a week. After two weeks, non-invasive measures related to skin sensitivity were tested. RESULTS: We confirmed the presence of anti-inflammatory effects in both jade materials, with the effects of the assembled activated jade material being superior to that of the natural jade material. Jade extracts significantly increased the gene expressions of EGF, FGF and COL1A1 in HDF. The results of the in vivo study showed that the mask containing jade extract could significantly increase the skin hydration and decrease the rate of transepidermal water loss and skin lactic acid sting test scores after two weeks of use. Subjective evaluations confirmed improvements in skin dryness, smoothness and fineness. No new sensitization occurred in subjects, and the product was non-irritating. No adverse skin reactions were observed during the test. CONCLUSIONS: The jade materials were able to downregulate the expression of inflammatory factor genes, up-regulate the expression of growth factor genes, and improve the anti-inflammation and repair ability of skin. Furthermore, the test results of participants with sensitive skin after using the mask containing jade extract showed that the mask has repairing ability.


OBJECTIF: L'innocuité du jade naturel, et des substances assemblées activées par le jade, sur les cellules, leurs effets anti-inflammatoire et réparateur, ainsi que leur action réparatrice sur les peaux sensibles ont été étudiés au moyen de la biologie cellulaire in vitro et in vivo. MÉTHODES: Des fibroblastes de peau humaine (HDF - Human Dermal Fibrolasts) ont été utilisés comme cellules modèles pour réaliser des tests de cytotoxicité in vitro, et les effets sur l'expression des facteurs inflammatoires et des gènes associés aux facteurs de croissance dans les fibroblastes ont été étudiés. Les valeurs de l'expression génique des facteurs inflammatoires IL-1, IL-6, TNF-α, des facteurs de croissance épidermique des cytokines (EGF - Epidermal Growth Factor), des facteurs de croissance des fibroblastes (FGF - Fibroblast Growth Factor), et du COL1A1 (Gène Collagen, type I, alpha 1) dans les fibroblastes ont été mesurées au moyen d'un test de réaction en chaîne par polymérase. Trente femmes présentant une peau sensible ont été sélectionnées pour appliquer un masque contenant de l'extrait de jade trois fois par semaine. Au bout de deux semaines, des mesures non invasives de la sensibilité de la peau ont été réalisées. RÉSULTATS: Nous confirmons la présence d'effets anti-inflammatoires pour les deux substances, avec de meilleurs résultats pour la substance assemblée activée par le jade comparé à ceux du jade naturel. Les extraits de jade ont significativement augmenté l'expression de l'EGF, du FGF, et du COL1A1 dans les HDF. Les résultats de l'étude in vivo ont révélé que le masque contenant de l'extrait de jade pouvait améliorer significativement l'hydratation de la peau, réduire le pourcentage de perte en eau trans-épidermique et améliorer les résultats du test de piqûre d'acide lactique (LAST - Lactic Acid Sting Test) de la peau après deux semaines d'utilisation. Les évaluations subjectives ont confirmé des améliorations de la sécheresse cutanée, de la douceur et de la finesse du grain de la peau. Aucune nouvelle sensibilisation n'est apparue chez les sujets, et le produit s'est avéré non-irritant. De même, aucune réaction cutanée indésirable n'a été observée pendant le test. CONCLUSIONS: Le jade a été capable de réguler à la baisse l'expression des gènes associés aux facteurs inflammatoires, de réguler à la hausse l'expression des gènes associés aux facteurs de croissance, et d'améliorer les capacités anti-inflammatoire et réparatrice de la peau. De plus, après utilisation du masque contenant de l'extrait de jade, les résultats des tests chez les participantes ayant une peau sensible ont démontré que ce masque avait une capacité réparatrice.


Subject(s)
Skin Diseases , Skin , Humans , Female , Cytokines/metabolism , Plant Extracts/pharmacology , Anti-Inflammatory Agents/pharmacology , Fibroblasts/metabolism
11.
Ann Chir Plast Esthet ; 68(1): 77-80, 2023 Jan.
Article in French | MEDLINE | ID: mdl-36114083

ABSTRACT

Nevoid hyperkeratosis of the nipple areola complex (NAC) is a rare dermatological pathology of unknown etiology, first described in 1923. It is a benign condition characterized by verrucous thickening and brownish discoloration of the NAC. We described the case of a 26-year-old woman with bilateral nevoid hyperkeratosis of the NAC. Several lines of treatment have been used with varying efficacy: conservative (calcipotriol and local retinoids), semi-conservative (CO2 laser) and surgical (excision and total skin graft). The final result is very satisfactory and without recurrence at 1 year follow-up.


Subject(s)
Breast Diseases , Keratosis , Female , Humans , Adult , Nipples/surgery , Breast Diseases/drug therapy , Breast Diseases/pathology , Breast Diseases/surgery , Keratosis/surgery , Keratosis/drug therapy , Keratosis/pathology , Skin/pathology , Skin Transplantation
12.
Prog Urol ; 33(1): 27-47, 2023 Jan.
Article in English | MEDLINE | ID: mdl-36202729

ABSTRACT

PURPOSE: We assessed the efficacy of some predictive factors that can be measured with non-contrast computed tomography and may affect ESWL success with a systematic review and meta-analysis. MATERIALS AND METHODS: All data sources were broadly investigated up to April 2022. Data were extracted from the relevant studies and analyzed with RevMan software. In a random effects model, standard mean difference (SMD) and risk ratio (RR) values were given with 95% confidence intervals. RESULTS: In total, pooled analysis included 7148 patients in 43 studies. The combined effect estimate showed significant differences between the ESWL success and ESWL failure groups in terms of Hounsfield unit (HU), Hounsfield density (HD), skin to stone distance (SSD), ureteral wall thickness (UWT), stone volume, stone area, abdominal fat parameters, diameter of proximal ureter, and hydronephrosis. However, perinephric stranding and renal cortical thickness were not found to be statistically significant between the study groups. CONCLUSIONS: HU, HD, SSD, UWT, stone volume, stone area, abdominal fat parameters, diameter of proximal ureter and hydronephrosis are effective factors for prediction of ESWL success. It is important to decide on treatment before the procedure for stones with appropriate diameter for ESWL.


Subject(s)
Hydronephrosis , Lithotripsy , Ureteral Calculi , Humans , Treatment Outcome , Retrospective Studies , Lithotripsy/methods , Tomography, X-Ray Computed/methods , Ureteral Calculi/diagnostic imaging , Ureteral Calculi/therapy
13.
Soins Pediatr Pueric ; 43(329): 28-31, 2022.
Article in French | MEDLINE | ID: mdl-36435520

ABSTRACT

A study looked at the representations of skin-to-skin contact among parents and caregivers in seven neonatal units in France and Belgium. Their ways of understanding skin-to-skin contact have some common elements, without completely overlapping. The work carried out could prove useful for professionals who, thanks to it, would be likely to obtain a better understanding and adhesion of the families to the practice of this relational care.


Subject(s)
Caregivers , Neonatology , Infant, Newborn , Humans , Parents , Skin Care , France
15.
Rev. latinoam. psicopatol. fundam ; 25(3): 643-665, 2022.
Article in Portuguese | LILACS-Express | LILACS, Index Psychology - journals | ID: biblio-1424070

ABSTRACT

O objetivo do presente artigo é analisar a estreita relação entre o fenômeno das automutilações e a problemática dos limites, tendo como ponto de partida o ataque à pele como condição de possibilidade para essa prática. A pele remete à sensorialidade e às primeiras noções de eu, tendo como função proteger nossa individualidade e fundamentar nossa troca com o outro. Ela contém uma premissa de integração, constituindo-se como uma fronteira que marca os limites da própria existência. Nas automutilações, a agressão à pele denuncia um prejuízo na construção da diferenciação entre sujeito e objeto, deixando em evidência uma confusão nos limites do sujeito. Nossa hipótese é a de que o recurso ao corpo, mais especificamente o ataque à pele, nas automutilações, surge como uma tentativa de contenção do eu em momentos nos quais o sujeito sente que pode haver o risco da perda da integridade narcísica.


Resumos This paper analyzes the close relationship between self-mutilation and the problem of limits, understanding the attack on the skin as a condition of possibility for this practice. The skin, which leads us to sensoriality and the first notions of self, acts to protect our individuality and support our interactions with the Other. It contains a premise of integration, constituting a boundary that marks the limits of existence itself. In self-mutilations, the attack on the skin reveals a loss in the the differentiation between subject and object, revealing a confusion in the subject's limits. The text posits that the recourse of the body, by attacking the skin, in self-mutilations, emerges as an attempt to contain the self in moments when the subject feels at risk of losing their narcissistic integrity.


Cet article analyse la relation étroite entre le phénomène d'automutilation et le problème des limites, en comprenant l'attaque de la peau comme une condition de possibilité de cette pratique. La peau, qui renvoie à la sensorialité et aux premières notions de soi, agit pour protéger notre individualité et soutenir nos interactions avec l'Autre. Elle contient une prémisse d'intégration, constituant une frontière qui marque les limites l'existence elle-même. Dans les automutilations, l'atteinte à la peau révèle une perte dans la construction de la différenciation entre sujet et objet, témoignant d'une confusion dans les limites du sujet. Le texte postule que le recours au corps, en attaquant la peau, dans les automutilations, émerge comme une tentative de contenir le soi dans les moments où le sujet sent en danger de perdre son intégrité narcissique.


El objetivo de este artículo es analizar la estrecha relación entre el fenómeno de las automutilaciones y el problema de los límites, teniendo como punto de partida el ataque a la piel como condición de posibilidad para esta práctica. La piel se refiere a la sensorialidad y a las primeras nociones del yo, teniendo como función proteger nuestra individualidad y fundamentar nuestro intercambio con el otro. Contiene una premisa de integración, constituyendo una frontera que marca los límites de la existencia misma. En las automutilaciones, la agresión a la piel revela una pérdida en la construcción de la diferenciación entre sujeto y objeto, evidenciando una confusión en los límites del sujeto. Nuestra hipótesis es que recurrir al cuerpo, más específicamente atacar la piel, en las automutilaciones, aparece como un intento de contener al yo en momentos en los que el sujeto siente que puede haber riesgo de pérdida de la integridad narcisista.

16.
Ann Chir Plast Esthet ; 67(1): 7-13, 2022 Feb.
Article in French | MEDLINE | ID: mdl-35078674

ABSTRACT

BACKGROUND: The Face is the most frequent localization for cutaneous carcinoma. The nose accounts for about 30% of these tumors. Nose tissue loss repair has to pursue 3 types of objectives: carcinologic, aesthetic and functional. The aim of this article is to identify a decision tree to guide the choice of surgical reconstruction technique based on localization and size of the defect. PATIENTS AND METHODS: We performed a retrospective analysis in Angers' CHU from 2013 to 2019 including 229 patients referred for cutaneous tumors excision in need of reconstruction. We analyzed the type of reconstruction, size of the tissue loss and localization of the defect in terms of nose aesthetic subunits. RESULTS: Among the 229 patients included, the most frequent localization was nose tip (32%). 44% of patients were reconstructed with skin grafts or composite graft, 56% with flaps (48% local flaps and 4% association of both methods). Limited central resections of nose tip were reconstructed with skingraft. The Rybka flap and bilobed flap were the preferred choice for lateral reconstruction of nose tip. Largest tip defects were reconstructed using Rieger flap or forehead flap. The dorsum was often reconstructed with local flap: glabellar on the upper part, Rieger on the lower part. Lateral side was perfectly reconstructed with island flap. Nose wings needed framework: composite graft was the judicious choice in case of limited tissue loss whereas forehead flap with framework or Schmid-Meyer flap were chosen for larger defects. CONCLUSION: Our past experience in nasal reconstruction has provided us with an original decision tree to guide surgeons in choosing the right reconstruction technique according to the size and localization of the defect.


Subject(s)
Nose Neoplasms , Rhinoplasty , Decision Trees , Humans , Nose/surgery , Nose Neoplasms/surgery , Retrospective Studies , Surgical Flaps
17.
Hand Surg Rehabil ; 41(1): 142-148, 2022 02.
Article in English | MEDLINE | ID: mdl-34600132

ABSTRACT

The objective of this study was to estimate the time to removal of a suture from the palmar surface of a dark-skinned adult hand. A descriptive and analytical study included a cohort of 146 patients, 57% male, with a mean age of 37 ± 14 years, covering a period of 10 years. The mean time to removal of sutures on the palmar surface of the dark-skinned adult hands was 21 ± 2 days. Complete epithelialization of the suture path was the clinical indication for the ideal day for removal. After removal, closure was total in 90% of cases (132 hands) and partial in 9% (14 hands). The day of suture removal was significantly (p = 0.006) related to wound healing (complete closure). Eighty-five percent of patients without complete wound closure at suture removal had history of use of skin-lightening products. Tobacco use significantly lengthened time to suture removal (p < 0.001). There was a correlation between patient age and time to suture removal. On multivariate analysis, three factors were predictive of suture removal later than day 21: being a manual worker (44% of patients) (p 0.006), suture location in a palmar fold area (<0.001) and the age of patient, the 41-50 years (p = 0.001) and >50 years (p < 0.001).


Subject(s)
Suture Techniques , Sutures , Adult , Female , Humans , Male , Middle Aged , Prospective Studies , Time Factors , Wound Healing , Young Adult
18.
Ann Pharm Fr ; 80(4): 426-439, 2022 Jul.
Article in French | MEDLINE | ID: mdl-34481784

ABSTRACT

OBJECTIVES: The objective is to conduct a review of pediatric exposure to substances whose endocrine disrupting (ED), carcinogenic, mutagenic, or reprotoxic (CMR) character has been confirmed or remains controversial, through their use in pharmaceutical forms intended for the cutaneous route, as well as regulatory measures diligent at the national and European levels. METHODS: A bibliographical search was carried out on the databases PubMed, Web of Science, Cochrane Library, supplemented by a search for recommendations from French and European authorities. References were selected following an assessment of their relevance to our topic. RESULTS: Seventy-one references were selected. Pediatric exposure to endocrine disruptors and CMR substances remains through products formulated for their use, but also through indirect exposure to products commonly used by adults. Exposure arises both from the choice of excipients (parabens, phenoxyethanol), packaging materials (bisphenols, phthalates) and the qualitative or quantitative nature of the active ingredients (iodine, boron, pyrethroids, organic sunscreens). CONCLUSION: The health professional must be able to develop a critical mind on such substances in order to inform and promote therapeutic adherence, guaranteeing the safety of the child's care.


Subject(s)
Endocrine Disruptors , Adult , Carcinogens/toxicity , Child , Endocrine Disruptors/toxicity , Europe , France , Humans , Mutagens/toxicity , Pharmaceutical Preparations
19.
Cureus ; 14(12): e32184, 2022 Dec.
Article in English | MEDLINE | ID: mdl-36620820

ABSTRACT

Unilateral breast erythema, edema, and peau d'orange are classically associated with inflammatory breast cancer. However, occasionally this constellation of symptoms is seen with other causes. Maintaining a broad differential can therefore save a prospective patient from months of worry about a possible cancer diagnosis, untreated symptoms, and unnecessary and expensive tests. Here we present the case of a 75-year-old woman with a history of pacemaker placement complicated by left upper extremity deep venous thrombosis (DVT) who subsequently developed left breast peau d'orange, swelling, and erythema. After initially being worked up for inflammatory breast cancer, including multiple breast biopsies, she was then referred to specialists in cardiology, allergy, pulmonology, rheumatology, dermatology, lymphedema therapy, and vascular surgery undergoing an exhaustive workup that spanned nearly a year. Eventually, a venogram was performed, which revealed complete occlusion of her left subclavian vein. After undergoing angioplasty and stenting, her symptoms resolved.

20.
J Anal Psychol ; 66(3): 678-694, 2021 Jun.
Article in English | MEDLINE | ID: mdl-34231891

ABSTRACT

These extraordinary months due to COVID-19 and the Black Lives Matter protests, set as they are against a backdrop of the increasingly worrying climate emergency, have brought fear, anxiety and discord across the globe. But we have also experienced a deepening of our understanding of our connectedness, protests against injustice, expressions of social concern and a demand for change. The concept of the cultural complex as developed by Singer & Kimbles (2004) offers a helpful means of connecting the psychology of the individual psyche and the political phenomena of power relations. Using a small example to illustrate how it might operate at a local level, I suggest that a fundamental shift is taking place raising profound levels of anxiety as we move from the known to the unknown. The bipolar nature of these complexes means the extremes are surfacing bringing fears of the very real possibility of more entrenched attacks on democracy from the far right and the hunkering down behind armed borders. But there is also hope that different ways of living together may be developing from the ground up, ways that are rooted in our sense of interdependence - with each other and our planetary home.


Ces mois extraordinaires du fait de la COVID-19 et des manifestations du mouvement Black Lives Matter - sur un fond d'urgence de plus en plus inquiétante concernant le climat - ont généré de la peur, de l'angoisse et de la discorde dans le monde entier. Mais nous avons également fait l'expérience de l'approfondissement de notre compréhension de notre interdépendance, de manifestations contre l'injustice, d'expressions de sollicitude sociétale et de requête pour du changement. Le concept de complexe culturel tel qu'il apparait chez Kimbles et Singer (2004) offre un moyen utile de relier la psychologie de l'individu et le phénomène politique des relations de pouvoir. Utilisant un petit exemple pour illustrer comment cela fonctionnerait au niveau local, je suggère qu'un glissement fondamental se produit, qui fait venir à la surface des niveaux profonds d'angoisse tandis que nous passons du connu à l'inconnu. La nature bipolaire de ces complexes implique que les extrêmes font surface amenant des peurs liées à la possibilité tout à fait réelle d'attaques plus tenaces de la démocratie de la part de l'extrême droite et d'un retranchement derrière des frontières armées. Mais il existe aussi l'espoir que des manières différentes de vivre ensemble se développent à partir de la base, des manières enracinées dans un sentiment d'interdépendance - les uns envers les autres et envers notre maison planétaire.


Estos meses extraordinarios debido al COVID-19 y a las protestas del movimiento Black Lives Matter, sobre un fondo de preocupación creciente a raíz de la emergencia climática, ha traído miedo, ansiedad y desacuerdos a través del planeta. Pero también hemos experimentado una profundización en nuestra comprensión de nuestra conectividad, protestas contra la injusticia, expresiones de preocupación social y una demanda de cambio. El concepto de complejo cultural desarrollado por Kimbles y Singer (2004) ofrece una vía posible para conectar la psicología de la psique individual y el fenómeno político de las relaciones de poder. Utilizando un pequeño ejemplo para ilustrar como esto podría operar a nivel local, sugiero que está teniendo lugar un cambio fundamental, elevando profundos niveles de ansiedad a medida que nos movemos desde lo conocido a lo desconocido. La naturaleza bipolar de estos complejos significa que los extremos están emergiendo a la superficie, trayendo miedos a la posibilidad real de ataques más consolidados a la democracia desde la extrema derecha, y el acto de refugiarse detrás de fronteras armadas. Pero también hay esperanza de que puedan estar desarrollándose modos diferentes de convivencia desde la base, modos enraizados en nuestro sentido de interdependencia - con cada otro/a y con nuestro hogar planetario.


Subject(s)
Black or African American , COVID-19 , Political Activism , Racism , Unconscious, Psychology , Adult , England , Humans
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