Multiple craniotomies for the resection of symptomatic multifocal intracranial metastatic cardiac myxoma: A case report.

Background: Myxomas, rare benign mesenchymal lesions, are the most common cardiac tumors. Patients may rarely develop hematogenous metastasis to the brain, which can present as new-onset neurological deficits that correlate with multifocal hemorrhagic lesions on imaging. Limited guidelines presently exist for the treatment of such lesions. This report outlines a unique case involving three craniotomies and failed radiation therapy in the treatment of metastatic cardiac myxoma. Case Description: A 63-year-old woman presented with a right middle cerebral artery embolic stroke secondary to a left atrial myxoma and multifocal hemorrhagic lesions consistent with intracranial metastasis. She had a right frontal craniotomy for tumor resection, followed by stereotactic radiosurgery, though this did not arrest disease progression. She later had a left occipital craniotomy for a symptomatic lesion. More than two years after her initial presentation, she returned with acute-onset symptoms correlating to growth in a left frontal lesion requiring another resection. Following this third craniotomy, imaging has not revealed the progression of metastatic intracranial disease. She is pursuing further treatment through primary cardiac tumor resection. Conclusion: Although rare, hematogenous seeding with subsequent formation of hemorrhagic metastasis is a possible complication of atrial myxoma. While surgical resection, radiation therapy, and chemotherapy have historically been used, no standard of care currently exists. This case demonstrates repeat tumor resection as effective for managing symptomatic intracranial metastatic myxoma in a patient with poor response to radiation therapy and multiple recurrences, with follow-up showing improvement in neurological symptoms and mass effect and absence of recurrence on imaging.

Recurrent cardiac myxoma: A case report.

Cardiac myxomas are the most common benign tumors of the heart. They are most commonly found in the left atrium, followed by a right atrium and rarely in the left ventricle. Herein, we report a rare case of left ventricular myxoma in a patient who had twice undergone removal of left atrial myxoma. Complete removal of the tumor through aortotomy, without causing fragmentation led to the uneventful recovery of the patient.

Sporadic Form of Recurrent Atrial Myxoma: The Blob Strikes Back.

Cardiac myxoma is a benign neoplasm composed of stellate to plump, cytologically bland mesenchymal cells set in a myxoid stroma. Although benign, as they can lead to severe complications, they are often removed surgically. A 39-year-old female presented with a chief complaint of generalized fatigue. Patient had a history of a large 7cm x 2.5cm left atrial myxoma resected at the age of 32 years after she presented with symptoms of dyspnea on exertion. The dyspnea was due to prolapse of the mass through the mitral valve during diastole, leading to functional severe mitral stenosis. The mass was resected with clear margins confirmed on biopsy. On physical examination, heart rate was regular with no murmurs. No signs of congestive heart failure were noted. A 2D echo revealed a mobile structure in the left atrium along with mild mitral regurgitation. Cardiac MRI showed a 21mm x 9mm well defined, pedunculated, mobile mass in the left atrium arising from inter-atrial septum. The mass was hyperintense on T2 weighted images with patchy delayed hyper-enhancement consistent with recurrence of a myxoma. The patient underwent a repeat median sternotomy with the removal of left atrial mass and repair of atrial septum with hemashield patch. The mass was sent for pathological evaluation confirming the diagnosis of recurrent myxoma. On genetic testing, patient tested negative for mutations in PRKAR1A gene (mutated in up to 60%-80% cases with Carney complex), MEN1, RET and sarcoma (TP53) genes. Cardiac myxomas are rare primary benign tumors of the heart with a small recurrence rate. Follow-up studies have rarely reported recurrences after complete resection. However, in our case not only did the patient have the sporadic form of myxoma with recurrence, but it also occurred within three years of the previous resection despite complete removal with clear margins.

Resultados quirúrgicos y seguimiento postoperatorio de mixomas auriculares / Surgical results and monitoring of postoperative atrial myxomas

Resumen: Objetivo: Analizar la casuística del mixoma auricular izquierdo, haciendo énfasis en los resultados y seguimiento. Método: Se revisaron los expedientes clínicos de los pacientes operados de mixomas cardiacos en el Hospital Central Sur de Alta Especialidad (HCSAE) de PEMEX en los últimos 7 años, haciendo hincapié en los resultados y seguimiento. Resultados: El análisis mostró 10 pacientes, de los cuales el 60% fueron mujeres y el 40% varones; las edades fueron de los 12 a los 76 años, con una edad media de 50 años. En las características clínicas de los pacientes predominó la disnea en un 90%, seguido de la fatiga (80%) y dolor torácico (60%). La incidencia fue del 90% para la aurícula izquierda y del 10% en aurícula derecha, hubo tumores de menos de 3 cm hasta mayores de 10 cm (media de 6-7 cm). El informe de patología fue de mixoma en el 100% de los casos, La morbimortalidad temprana fue del 0%, con una estancia hospitalaria promedio de 6 días; una paciente de 12 años tuvo una recidiva y se sometió otra vez a cirugía 5 meses más tarde. La supervivencia a 5 años es del 100%. Conclusiones: Se sabe que la presentación de Mixomas es muy poco frecuente, la experiencia en este Centro de Concentración Nacional, es de un paciente por cada 350 cirugías, en promedio un caso por año con una nula mortalidad y una excelente supervivencia.

Abstract: Objective: To analyze the casuistics of left atrial myxoma with emphasis on results and follow-up. Method: We reviewed the clinical records of patients operated in the Hospital Cardiac Myxomas South Central High Specialty (HCSAE) of PEMEX in the last 7 years, with an emphasis on results and follow-up. Results: The analysis showed 10 patients, of whom 60% were female and 40% male, with ages from 12 to 76 years, with a mean age of 50 years. In the clinical characteristics of patients predominated dyspnea in 90%, followed by fatigue (80%) and chest pain (60%). The incidence was 90% for the left atrium and 10% for the right atrium, had tumors less than 3 cm to up to over 10 cm (average of 6 to 7 cm). The pathology report was myxoma in the 100% of cases, the morbidity and early mortality was 0%, with a mean hospital stay of 6 days, and a patient of 12 years of age recurred and underwent surgery five months later. The 5-year survival was 100%. Conclusions: The incidence of myxomas is well known for rare presentation, the experience in this national medical center is one patient for every 350 operations, one case per year with no mortality and excellent survival.

[Surgical results and monitoring of postoperative atrial myxomas]. / Resultados quirúrgicos y seguimiento postoperatorio de mixomas auriculares.

OBJECTIVE: To analyze the casuistics of left atrial myxoma with emphasis on results and follow-up. METHOD: We reviewed the clinical records of patients operated in the Hospital Cardiac Myxomas South Central High Specialty (HCSAE) of PEMEX in the last 7 years, with an emphasis on results and follow-up. RESULTS: The analysis showed 10 patients, of whom 60% were female and 40% male, with ages from 12 to 76 years, with a mean age of 50 years. In the clinical characteristics of patients predominated dyspnea in 90%, followed by fatigue (80%) and chest pain (60%). The incidence was 90% for the left atrium and 10% for the right atrium, had tumors less than 3cm to up to over 10cm (average of 6 to 7cm). The pathology report was myxoma in the 100% of cases, the morbidity and early mortality was 0%, with a mean hospital stay of 6 days, and a patient of 12 years of age recurred and underwent surgery five months later. The 5-year survival was 100%. CONCLUSIONS: The incidence of myxomas is well known for rare presentation, the experience in this national medical center is one patient for every 350 operations, one case per year with no mortality and excellent survival.

Left ventricular myxoma: Missed vs metastatic.

Left ventricular myxomas account for 2.5% of all cardiac myxoma cases. There are very few case reports on left ventricular myxoma (LVM) presented after complete surgical resection of left atrial myxoma. Here we report a case of a 58-year-old male presented to the hospital for transient limb weakness, numbness and dysarthria. Magnetic resonance image of the brain revealed multiple thromboembolic cerebrovascular accidents. Transthoracic echocardiogram (TTE) revealed a left atrial myxoma. It was resected completely with good surgical margins. After one and half year he started having dizziness, and transient right sided weakness. Computer tomography scan of the head revealed a progression of thromboembolic disease. TTE revealed a LVM that was confirmed by transesophageal echocardiogram. It was resected with good surgical margins 3 wk after recurrent cerebrovascular accident.

Mixoma recidivante: Diagnóstico ecocardiográfico bi y tridimensional / Recurrent myxoma: Bi and three-Dimensional echocardiography approach

Se presenta el caso clínico y ecocardiográfico de una paciente en edad pediátrica con mixomas recidivantes, que se manifiesta a los 16 años con embolismo cerebral. Se detecta mixoma auricular izquierdo y se realiza resección quirúrgica y electrocoagulación. A los 40 meses de seguimiento inicia con disnea de grandes esfuerzos, auscultándose soplo expulsivo aórtico. El ecocardiograma bidimensional muestra la presencia de 3 masas tumorales: en aurícula y ventrículo izquierdo y en ventrículo derecho. El mixoma de ventrículo izquierdo obstruía casi en su totalidad la válvula aórtica. Se discuten la utilidad de la ecocardiografía bi y tridimensional como método diagnóstico inicial.

The case of a 16-years old female patient with left atrial myxoma and cerebral embolism is reported. She was subjected to surgical excision of the mass. At 40 months of follow-up she initiates with dyspnea and an aortic murmur is detected. The transthoracic and transesophageal echocardiographic analysis revealed the presence of three tumors: in the left atrium, left and right ventricle. The myxoma of the left ventricle obstructs the aortic valve. We discuss the usefulness of bi-and three-dimensional echocardiography as initial diagnostic method.