Embolization of percutaneous left atrial appendage closure devices: Timing, management and clinical outcomes.

BACKGROUND: Left atrial appendage (LAA) occluder embolization is an infrequent but serious complication. OBJECTIVES: We aim to describe timing, management and clinical outcomes of device embolization in a multi-center registry. METHODS: Patient characteristics, imaging findings and procedure and follow-up data were collected retrospectively. Device embolizations were categorized according to 1) timing 2) management and 3) clinical outcomes. RESULTS: Sixty-seven centers contributed data. Device embolization occurred in 108 patients. In 70.4 % of cases, it happened within the first 24 h of the procedure. The device was purposefully left in the LA and the aorta in two (1.9 %) patients, an initial percutaneous retrieval was attempted in 81 (75.0 %) and surgery without prior percutaneous retrieval attempt was performed in 23 (21.3 %) patients. Two patients died before a retrieval attempt could be made. In 28/81 (34.6 %) patients with an initial percutaneous retrieval attempt a second, additional attempt was performed, which was associated with a high mortality (death in patients with one attempt: 2.9 % vs. second attempt: 21.4 %, p < 0.001). The primary outcome (bailout surgery, cardiogenic shock, stroke, TIA, and/or death) occurred in 47 (43.5 %) patients. Other major complications related to device embolization occurred in 21 (19.4 %) patients. CONCLUSIONS: The majority of device embolizations after LAA closure occurs early. A percutaneous approach is often the preferred method for a first rescue attempt. Major adverse event rates, including death, are high particularly if the first retrieval attempt was unsuccessful. CONDENSED ABSTRACT: This dedicated multicenter registry examined timing, management, and clinical outcome of device embolization. Early embolization (70.4 %) was most frequent. As a first rescue attempt, percutaneous retrieval was preferred in 75.0 %, followed by surgical removal (21.3 %). In patients with a second retrieval attempt a higher mortality (death first attempt: 2.9 % vs. death second attempt: 24.1 %, p < 0.001) was observed. Mortality (10.2 %) and the major complication rate after device embolization were high.

Effectiveness and safety of Shenqi Fuzheng injection combined with platinum-based chemotherapy for treatment of advanced non-small cell lung cancer: a systematic review and meta-analysis.

Objective: To evaluate the efficacy and safety of Shenqi Fuzheng Injection (SFI) combined with platinum-based chemotherapy (PBC) for the treatment of advanced non-small cell lung cancer (NSCLC). Methods: Seven electronic databases, including CNKI and Wanfang, were comprehensively searched to screen randomized controlled trials (RCTs) until May 1, 2022. The quality of each trial was evaluated according to the Cochrane Handbook for Systematic Reviews of Interventions, and systematic reviews were conducted according to the PRISMA guidelines. Statistical analysis was performed using Review Manager 5.3, and the results were expressed as relative risk (RR) and 95% confidence interval (95% CI). The primary outcome measures were objective response rate (ORR) and disease control rate (DCR). The secondary outcome measures were quality of life and toxicity. Subgroup analysis was performed according to the number of days of SFI single-cycle treatment and combined PBC regimen. Results: A total of 44 RCTs involving 3475 patients were included in the study. The meta-analysis results showed that, compared with PBC alone, SFI combined with PBC significantly improved the ORR (RR = 1.27, 95% CI = 1.18-1.37, P < 0.00001), DCR (RR = 1.12, 95% CI = 1.08-1.15, P < 0.00001), and quality of life (RR = 1.41, 95% CI = 1.31-1.52, P < 0.00001). It also reduced chemotherapy-induced hemoglobin reduction (RR = 0.57, 95% CI = 0.48-0.67, P < 0.00001), leukopenia (RR = 0.61, 95% CI = 0.53-0.71, P < 0.00001), thrombocytopenia (RR = 0.62, 95% CI = 0.55-0.70, P < 0.00001), and simple bone marrow suppression (RR = 0.55, 95% CI = 0.41-0.73, P < 0.0001). Nausea and vomiting (RR = 0.63, 95% CI = 0.52-0.77, P < 0.00001), diarrhea (RR = 0.48, 95% CI = 0.37-0.64, P < 0.00001), and simple digestive tract reactions (RR = 0.63, 95% CI = 0.49-0.80, P = 0.0002) also decreased with the treatment of SFI. Conclusion: SFI combined with PBC for the treatment of advanced NSCLC improved the ORR, DCR, and quality of life, and reduced the incidence of myelosuppression and gastrointestinal adverse reactions. However, considering the limitations of existing evidence, further verification using high-quality RCTs is required. Systematic review registration: https://inplasy.com/inplasy-2022-7-0026, identifier INPLASY202270026.

Hepatitis C micro-elimination through the retrieval strategy of patients lost to follow-up.

BACKGROUND AND AIM: World Health Organization sets up an ambitious and attainable goal to eliminate hepatitis C (HCV) by 2030. The previous diagnosed HCV patients lost to follow-up were considered as an important target group for HCV elimination. We conducted a call back program to retrieve the lost to follow-up HCV patients and link them to care in our hospital. By analyzing and comparing our result with that from other studies, we wish to improve our retrieval strategy and provide our experience to the general communities. METHODS: A list of the patients with a medical record showing seropositive for antibody to HCV (anti-HCV Ab) from 2004 to 2017 was retrieved by the department of intelligent technology of our hospital. Three dedicated staff members reviewed the patients' electronic medical records (EMRs) and recruited the patient lost follow-up to the call back program. The staff members contacted the qualified patients by telephone and inquired about their opinions for treating their chronic HCV infection. We also informed the patients about the retrieval strategy and why we contact them. As our National Health Insurance request, we gave all patient one informed consent for hepatitis C treatment. Informed consents have been obtained from all patients. Referrals to our gastroenterology unit (GU) were arranged for the patients who would like to continue their chronic HCV care in our hospital. RESULTS: There were 31,275 anti-HCV positive patients. We included 11,934 patients (38.2%) into the call back system and contacted them by telephone. Based on the response to our call, we ascertained 1277 eligible cases (10.7%) for retrieval. The patients who were younger (< 55), lived in Taoyaun City or had tested positive for anti-HCV Ab at the department of internal medicine department had an increased rate of successful call back. There were 563 patients (44.1%) returning to our GU. Of them, 354 patients (62.9%) were positive for HCV viremia. 323 patients (91.2%) received the DAAs treatment. The SVR12 with Grazoprevir + elbasvir, Glecaprevir + pibrentasvir, Sofosbuvir + ledipasvir and Sofosbuvir + velpatasvir were 97.9%, 98.8%, 100% and 97.5%, respectively. CONCLUSIONS: Call back system can expand our reach to those unaware or ignoring chronic HCV infection patients and link them to treatment.

Empirical factors affecting memory in collaborative versus nominal groups.

When individuals collaborate to try to retrieve some encoded information, not surprisingly, the collaborative group typically remembers more than does any individual. When the non-redundant output from the individuals is combined, however, this nominal group often, surprisingly, remembers more than does the collaborative group. This finding is known as collaborative inhibition. The finding of collaborative inhibition, that collaborative groups remember less would be predicted given the summed non-redundant memories of an equal number of individuals remembering alone, indicates that there is something about remembering in a collaborative group that impairs the performance of the individuals in that group. Research directed toward what that something is has focused on both social and cognitive factors, with the consensus being that cognitive factors play the more important role. An extensive body of work on this topic has accumulated over the past 25+ years, with researchers proposing theoretical explanations and generating empirical data revealing the conditions under which this collaborative inhibition is more versus less likely to occur. The purpose of this review is to summarize those empirical factors to provide a resource for researchers interested in pursuing this work.

The effects of immediate recall and subsequent retrieval strategy on eyewitness memory.

The current study investigated the effects of immediate recall and subsequent interview on mock witnesses' memory of a crime. After watching a video of a crime, 111 participants were randomly allocated to an immediate recall condition (the iWitnessed mobile app, free recall). One week later, participants were randomly allocated to a retrieval condition (timeline aid, category clustering recall, free recall). Results showed that iWitnessed elicited more correct details than free recall at immediate recall (Time 1), without compromising accuracy. However, the immediate recall tool did not affect memory performance at a one-week delay (Time 2). At Time 2, participants with retrieval support (timeline aid, category clustering recall) reported more details than those with no retrieval support (free recall), without compromising accuracy. The findings highlight that high-quality immediate recall and retrieval support during a subsequent interview are necessary to elicit more complete and accurate accounts.

Effectiveness of Categorical Clustering as an Encoding Versus a Retrieval Strategy Among Preschoolers.

The relative effectiveness of categorical clustering as an encoding and retrieval strategy was examined among 92 three- and four-year-olds on a spatial memory task used to examine utilization deficiencies. Specifically, participants were asked to remember the locations of one of two categories of toys (i.e., four animals and four chairs) within in a multicolored square box. Most children spontaneously used a categorical clustering strategy when removing toys from the box (reflecting encoding) and/or replacing them (reflecting retrieval). However, the production of a categorical clustering strategy did not facilitate recall for all participants. Children who engaged in categorical clustering exclusively during encoding were more likely to present with a utilization deficiency by recalling fewer toy locations than those exclusively clustering during retrieval. Recall performance was not enhanced among children who used categorical clustering during both phases.

Remembering with a friend or a stranger: comparing acquainted and unacquainted pairs in collaborative eyewitness interviews.

Previous findings show that collaborative interviews with pairs of eyewitnesses can result in more accurate testimony than individual interviews, and that partners remember more together if they acknowledge, repeat, rephrase and elaborate upon each other's contributions. In the present study, we investigated whether these findings differ for pairs of acquainted and unacquainted partners, respectively. Participants viewed a violent movie in the cinema and took part in three eyewitness interviews approximately five days later. The first and the last interview were always individual. The second interview was individual in the nominal condition (N = 22 pairs), collaborative with a known partner in the acquainted condition (N = 21 pairs), and collaborative with a stranger in the unacquainted condition (N = 20 pairs). We replicated benefits of collaborative eyewitness interviews, in terms of error pruning as well as delayed cross-cuing. However, we found no significant differences between acquainted and unacquainted pairs, neither in recall performance nor in retrieval strategies during the collaborative interview. Regardless of acquaintance, pairs who elaborated upon each other's contributions during the collaborative interview, remembered more together. The findings are evaluated within the theoretical framework of transactive memory. Practical implications for investigative interviewers are discussed.

What's ours is yours: recall of history for lesser-known countries is guided by one's own national history.

The present studies examine how people recall history. Sometimes, certain national histories are well known and sometimes they are not. We propose that, under certain circumstances, culturally distinctive representations of typical national histories can be used to guide recall, particularly in cases where the history is not well known. We focus on three national samples with varied levels of knowledge about each history: Great Britain, India, and the United States. In Study 1, we establish typical historical event templates for each nation consisting of events that a large proportion of participants from each sample identify as important in a typical nation's history. We examine points of divergence between the different groups' typical event templates and the valences of these events. In Study 2, we test and find that, in conditions of less knowledge, participants tend to refer to particular historical events that coincide with events unique to their own group's typical history. In Study 3, we demonstrate that this effect can be found even when a group possesses a reasonable amount of knowledge about the target country. We conclude by discussing the implications in relation to how such a retrieval strategy might inform interpretations of events in the present.

Patent pattern analysis of Scutellariae Radix / 中草药

Scutellariae Radix is one of the most popular Chinese mateira medica (CMM) with a long history, commonly used for heat-clearing and damp-drying. In this paper, based on the characteristics of CMM, the retrieval strategy was formulated. Then, the global patent data of Scutellariae Radix were retrieved from Innography. A total of 23 426 patents related to Scutellariae Radix have been retrieved worldwide. A set of statistical and bibliometric methods has been used to analyze the technical competition situation from the aspects of development trend, global patent layout, research and development hotspots, core patents and other aspects. The analysis results showed that the patent technology life cycle of Scutellariae Radix is in a rapid growth period. The R&D focuses on prescriptions, health products, and tea drinks of Scutellariae Radix. Four countries, including China, Japan, USA, and South Korea, are the main sources of technology, as well as the most important patent layout. Scutellariae Radix industry has a unique regional development advantage, especially in East of China, Beijing, Tianjin, and Sichuan. From the perspective of development trend, there is a broad space for the development of Scutellariae Radix industry.

Writing Alone or Together: Police Officers' Collaborative Reports of an Incident.

After witnessing an incident, police officers may write their report collaboratively. We examined how collaboration influences the amount and accuracy of information in police reports. Eighty-six police officers participated, in pairs, in a live training scenario. Officers wrote a report about the incident, either with their partner or individually. Reports by two officers working together (collaborative performance) contained less information than reports by two officers working individually (nominal performance), with no difference in accuracy. After the first report, officers who had worked individually wrote a collaborative report. Police officers who recorded their own memories prior to collaboration included less incorrect information in the collaborative report than police officers who wrote a collaborative report immediately after the incident. Finally, content-focused retrieval strategies (acknowledge, repeat, rephrase, elaborate) during the officers' discussion positively predicted the amount of information in collaborative reports. Practical recommendations for the police and suggestions for further research are provided.

Recounting a Common Experience: On the Effectiveness of Instructing Eyewitness Pairs.

Pairs of eyewitnesses with a content-focused interaction style remember significantly more about witnessed incidents. We examined whether content-focused retrieval strategies can be taught. Seventy-five pairs of witnesses were interviewed thrice about an event. The first and third interview were conducted individually for all witnesses. The second interview was individual, collaborative without instruction, or collaborative with instruction. Pairs in the latter condition were instructed to actively listen to and elaborate upon each other's contributions. The strategy instruction had no effect on retrieval strategies used, nor on the amount or accuracy of reported information. However, pairs who spontaneously adopted a content-focused interaction style during the collaborative interview remembered significantly more. Thus, our findings show that effective retrieval strategies cannot be taught, at least not with the current instructions. During the second interview, we observed collaborative inhibition and error pruning. When considering the total amount of information reported across the first two interviews, however, collaboration had no inhibitory effect on correct recall, yet the error pruning benefits remained. These findings suggest that investigative interviewers should interview witnesses separately first, and then interview pairs of witnesses collaboratively.

Enhancing individual and collaborative eyewitness memory with category clustering recall.

Most crimes have multiple eyewitnesses. The police typically interview co-witnesses separately. In time-sensitive investigations, this could slow down evidence accumulation. Having co-witnesses collaboratively recall a crime could potentially expedite evidence accumulation. However, past research shows that collaborative group members often have conflicting retrieval strategies that disrupt each other, degrading overall recall. This cost could potentially be overcome by aligning group members' retrieval strategies with category clustering recall (CCR), which is a retrieval strategy where information is recalled from a series of forensically relevant categories (e.g., recalling the protagonists' appearance, then actions). This study examined the costs and benefits of collaborative eyewitness memory by having collaborative pairs of strangers, nominal pairs (i.e., two individuals whose recall is pooled) and lone individuals watch a crime and recall it using free recall or CCR. The collaborative pairs recalled the crime faster than the nominal pairs. They also recalled more correct information than individuals but less than nominal pairs, irrespective of the retrieval method. There is therefore a speed-recall completeness trade-off when collaborative groups recall crimes. Importantly, all participants recalled more correct information when using CCR. This provides initial evidence suggesting that CCR is superior to free recall. Further research examining CCR's benefits is recommended.

The influence of multiple trials and computer-mediated communication on collaborative and individual semantic recall.

Collaborative inhibition is a phenomenon where collaborating groups experience a decrement in recall when interacting with others. Despite this, collaboration has been found to improve subsequent individual recall. We explore these effects in semantic recall, which is seldom studied in collaborative retrieval. We also examine "parallel CMC", a synchronous form of computer-mediated communication that has previously been found to improve collaborative recall [Hinds, J. M., & Payne, S. J. (2016). Collaborative inhibition and semantic recall: Improving collaboration through computer-mediated communication. Applied Cognitive Psychology, 30(4), 554-565]. Sixty three triads completed a semantic recall task, which involved generating words beginning with "PO" or "HE" across three recall trials, in one of three retrieval conditions: Individual-Individual-Individual (III), Face-to-face-Face-to-Face-Individual (FFI) and Parallel-Parallel-Individual (PPI). Collaborative inhibition was present across both collaborative conditions. Individual recall in Recall 3 was higher when participants had previously collaborated in comparison to recalling three times individually. There was no difference between face-to-face and parallel CMC recall, however subsidiary analyses of instance repetitions and subjective organisation highlighted differences in group members' approaches to recall in terms of organisation and attention to others' contributions. We discuss the implications of these findings in relation to retrieval strategy disruption.

Using whiteboards to support college students' learning of complex physiological concepts.

Research underscores the importance of retrieval-based practice and application of knowledge for meaningful learning. However, the didactic lecture format continues to persist in traditional university physiology courses. A strategy called whiteboarding, where students use handheld dry erase boards and work in small groups to actively retrieve, discuss, and apply concepts presented in the lecture, has the potential to address challenges associated with actively engaging students in science courses for greater learning. The purpose of this study was to empirically examine the potential benefits of whiteboarding for increasing students' understanding of animal physiology concepts. Student performance on physiology questions assessing concepts taught using lecture only vs. concepts taught using lecture and whiteboarding were compared within the term that whiteboarding was used, as well as across whiteboard and lecture-only terms taught by the same instructor. Results showed that when whiteboarding was incorporated in the course, student performance on items that assessed concepts corresponding to the whiteboarding activities were significantly higher compared with performance on items that assessed concepts taught through lecture only. These patterns in student performance were found within and across terms. Taken together, findings point to whiteboarding as an effective tool that can be integrated in traditional lecture courses to promote students' understanding of physiology.

A peptide-retrieval strategy enables significant improvement of quantitative performance without compromising confidence of identification.

Reliable quantification of low-abundance proteins in complex proteomes is challenging largely owing to the limited number of spectra/peptides identified. In this study we developed a straightforward method to improve the quantitative accuracy and precision of proteins by strategically retrieving the less confident peptides that were previously filtered out using the standard target-decoy search strategy. The filtered-out MS/MS spectra matched to confidently-identified proteins were recovered, and the peptide-spectrum-match FDR were re-calculated and controlled at a confident level of FDR≤1%, while protein FDR maintained at ~1%. We evaluated the performance of this strategy in both spectral count- and ion current-based methods. >60% increase of total quantified spectra/peptides was respectively achieved for analyzing a spike-in sample set and a public dataset from CPTAC. Incorporating the peptide retrieval strategy significantly improved the quantitative accuracy and precision, especially for low-abundance proteins (e.g. one-hit proteins). Moreover, the capacity of confidently discovering significantly-altered proteins was also enhanced substantially, as demonstrated with two spike-in datasets. In summary, improved quantitative performance was achieved by this peptide recovery strategy without compromising confidence of protein identification, which can be readily implemented in a broad range of quantitative proteomics techniques including label-free or labeling approaches. SIGNIFICANCE: We hypothesize that more quantifiable spectra and peptides in a protein, even including less confident peptides, could help reduce variations and improve protein quantification. Hence the peptide retrieval strategy was developed and evaluated in two spike-in sample sets with different LC-MS/MS variations using both MS1- and MS2-based quantitative approach. The list of confidently identified proteins using the standard target-decoy search strategy was fixed and more spectra/peptides with less confidence matched to confident proteins were retrieved. However, the total peptide-spectrum-match false discovery rate (PSM FDR) after retrieval analysis was still controlled at a confident level of FDR≤1%. As expected, the penalty for occasionally incorporating incorrect peptide identifications is negligible by comparison with the improvements in quantitative performance. More quantifiable peptides, lower missing value rate, better quantitative accuracy and precision were significantly achieved for the same protein identifications by this simple strategy. This strategy is theoretically applicable for any quantitative approaches in proteomics and thereby provides more quantitative information, especially on low-abundance proteins.

Case retrieval in PubMed for improving the retrieval effectiveness of literature novelty assessors / 中华医学图书情报杂志

The retrieval of literature novelty assessment projects was divided into unlimited retrieval and limited retrieval according to the retrieval terms.The redundant retrieval mode,complicated retrieval process,poor compatibility,and lack of summary that affect the retrieval effectiveness of literature novelty assessors were analyzed.The overall retrieval ability and literature analysis ability of literature novelty assessors were put forward for improving their retrieval effectiveness.

Acknowledge, repeat, rephrase, elaborate: Witnesses can help each other remember more.

Crimes are often observed by multiple witnesses. Research shows that witnesses can contaminate each other's memory, but potential benefits of co-witness discussion have not yet been investigated. We examined whether witnesses can help each other remember, or prune each other's errors. In a research design with high ecological validity, attendees of a theatre play were interviewed approximately one week later about a violent scene in the play. The couples that signed up for our study had known each other for 31 years on average. Participants were first interviewed individually and then took part in a collaborative interview. We also included a control condition in which participants took part in two individual interviews. Collaboration did not help witnesses to remember more about the scene, but collaborative pairs made significantly fewer errors than nominal pairs. Further, quantitative and qualitative analyses of retrieval strategies during the discussion revealed that couples who actively acknowledged, repeated, rephrased, and elaborated upon each other's statements remembered significantly more information overall. Taken together, our findings suggest that, under certain circumstances, discussion between witnesses is not such a bad idea after all.

Retrieval strategy for dentistry literatures based on medical subject headings / 中华医学科研管理杂志

Objective To investigate a retrieval strategy for dentistry literature based on medical subject headings (MeSH). Methods We analysed the MeSH Tree Structures of PubMed in 2009 and combined it with the core glossary of dentistry to find out highly frequent dental words in MeSH. Then 6 words were singled out from the whole MeSh Tree to apply for a retrieval strategy for dentistry literatures. Results 102,500 pieces of dentistry literature were obtained from the year 2006 to 2008. Conclusions This research strategy can improve the efficiency of literature search in dentistry field for clinical or laboratory researches.

Application status of odds ratio for medical animal experiments / 中国药理学通报

Aim To study the application status of odds ratio for medical animal experiments.Methods Odds ratio and seven kinds of animal models were used as retrieval strategy to search medical animal experiment related papers in several Chinese and English databases.Papers relating to each kind of animal model and using odds ratio in abstract and text were counted. Data from different databases were compared. Calculation of odds ratio was exemplified and the significance of different odds ratio values was illustrated in this paper.Results Few medical animal experiments cited odds ratio as statistics.Conclusions The importance of odds ratio has not been fully recognized in Chinese references.

Standardization Realization and Application of CBM Retrieval Strategies for Commonly Used Words in Medical Sci-Tech Novelty Assessment / 医学信息学杂志

The paper expounds the function and significance of establishing CBM retrieval strategies for commonly used words, it could not only promote the quality and efficiency but also have important significance to upgrade and standardize the quality of novelty as-sessment report.